Kan taksa ‘police officer’: Regulatory T cells (Tregs) chungchang hi i zir mai ang u!

Kan taksa chhungah hian thil mak engzat nge thleng tih i ngaihtuah ngai em? Kan hriat loh chuan kan taksa chhungah hian indona lian tak a thleng fo thin. He indona hi kan immune system-in a kalpui a ni. Kan ram humhalhtu sipai ang a ni. He sipai hna chu pawn lam atanga lo chhuak virus leh bacteria ang chi hmelma zawng chhuak leh tihchhiat hi a ni. Mahse, a chang chuan he sipaite hian tlem an chetsual lutuk a, kan taksa chhunga cell tha tak takte chu an rawn bei tan thin. Hetiang hun lai hian he sipaite hi thunun tur leh thupek dik tak pe thei tur an awm a ngai a ni lawm ni? Vawiin hian chu hna pawimawh ber thawktu cell chi khat bik kan sawi dawn a ni. Chu chu Regulatory T cells, a tawi zawngin Tregs a ni.

A awlsam zawngin, heng Regulatory T cells (Tregs) te hi engte nge ni?

I immune system hi sipai chak tak leh chak tak angin ngaihtuah rawh. He sipaiah hian sipai chi hrang hrang an awm a. Chung zingah chuan Regulatory T cell te hi he sipai zinga top officer, a nih loh leh police officer ang mai an ni. An hna ber chu immune system-a cell dangte (sipai) te chu overactive emaw agitated emaw lo turin control a ni.

Hengte hi a takah chuan kan taksaa thisen var chi khat an ni. Immune system hnathawh dan an enfiah reng a ni. Khawi emaw laiah immune system hian a overreact a nih chuan, chu chu kan cell ngei pawh a beih tum a nih chuan heng Tregs cells te hi an lut a, chu process chu an titawp tihna a ni. "Okay, okay, chu chu a tawk. Chu chu kan ta a ni, attack suh," tih ang mai an ni.

A awlsam zawngin Tregs hi kan immune system balance vawng rengtu cell chi pawimawh tak a ni a, thil dik leh dik lo thlangin a chhanhim a ni.

Chuti a nih chuan, heng ‘antigen’ te hi eng nge ni?

Immune system hi sipai a ni kan ti a. Chuti a nih chuan he sipai hian tute nge a beih? Antigens te an do thin . Antigens hi immune system hmelma an ni. Chungte chu kan taksa tana pawi thei thil, hnam dang thil a ni thei. He hmelma hi taksaa a luh chuan kan immune system hian a hrechiang a, a do turin proteins antibodies an tih chu a siam chhuak thin.

Heng antigens te hi chi thum a awm a. Eng nge an nih i en ang u.

Treg cells te thiltihtheihna mak tak chu heng antigens zingah hian eng antigen nge attack tur tih leh eng antigen nge khawih loha dah tur tih chiang taka thlan chhuah hi a ni .

Treg chi hrang hrangte chu engte nge ni?

Heng Treg cells hi subtype tam tak awm mahse, zirchiangtute chuan group lian pahnih ah an then a, group tin hian hna pahnih an nei a ni.

Regulatory T cells hian kan taksaah eng service nge an pek tak tak?

Tunah chuan Tregs hi immune system hotu an ni tih kan hre ta. Rawngbawlna hlu tak tak min pe thin. Eng nge an nih hi han thlir ila:

• Immune response a control: Immune system chu ramdang hmelma leh cancer cell mamawh zat chauh beih turin a kaihruai a, target-ah chiang takin a bei thei a ni.
• Kan taksa venhim: A pawimawh ber chu mahni cell hrisel tak takte beih tawh loh hi a ni. Doctor-te chuan hei hi ‘mahni inngaihtlawmna’ an ti a ni. Chu chu kan taksa hian a thil neihte tuar thiam turin kan zirtir tihna a ni. Hei hi autoimmune natna vei laka kan inven theih dan a ni.
• Inflammation a control: Taksa chhunga a tul lo taka inflammation leh swelling control-na atan a pui a, tissue tihchhiat a veng bawk.
• Organ transplant-ah a pui: Miin taksa peng thar (kidney emaw thinlung emaw ang chi) transplant a dawn hian kan taksa chuan hnam dang angin a hmu a, hnawl a tum thin. Tregs cells hian immune system a ti thlamuang a, organ thar chu a pawm theih nan a pui bawk.

Hêng cell mak tak takte hi khawi aṭanga lo chhuak nge?

Heng Tregs te hi kan taksa chhunga thymus gland atanga siam a ni. Hei hi mi tam takin an hriat ngai loh gland a ni mai thei. Kan rilru hmalam, lung pahnih inkar, hnute ruh (sternum) hnung lama awm a ni.

Thymus gland hian hormone thymosin an tih chu a siam chhuak a. He hormone hian Tregs cells te chu a ti thang lian thei a ni. Kan ruhroa siam thisen var (a bik takin lymphocyte ) te chu thymus gland atanga an kal chuan T cell an lo ni ta a ni. Heng T cell te hi an puitlin hnu chuan lymph node ah an kal a, duty turin an inpeih ta a ni.

Mak tak mai chu thymus gland hian puitling kan nih hma chauhvin T cells a siam chhuak thin. Chumi hnuah chuan gland chu a lo tlem zauh zauh a, thauin a thlak leh ta a ni.

Tregs hi condition dang atan a tangkai em?

Ni e, a dik tak zet! Tunah hian damdawi lama thupui lar ber pawl a ni. Tunah hian zirchiangtute chuan heng Tregs cells te hi natna chi hrang hrang enkawlna atana hman theih a nih leh nih loh hriat tumin hma an la mek a ni. A bik takin allergy, cancer, leh autoimmune natna te hi a ni.

Taksa chhunga heng Tregs cells te hi tihpun a nih chuan immune system hnathawh duh loh zawng chu control theih a ni ang tih an ring. Hemi hmang hian nakin lawkah a hnuaia natnate hi thunun theih emaw, tihdam theih emaw pawh a ni ang.

• Lupus a ni
• Multiple Sclerosis (MS) natna a awm thei lo.
• Thyroiditis natna a ni
• Type 1 zunthlum vei a ni
• Rheumatoid arthritis natna a ni
• Ulcerative colitis a awm thei

Kan Tregs cells te hi a hrisel theih nan eng nge kan tih theih ang?

Kan taksa hriselna (immune system) inthlauhna vawng rengtu heng cell hlu tak takte hi kan vawn that hi kan kutah a awm a ni. Chutiang ti tur chuan thil danglam bik kan tih a ngai lo. A pawimawh ber chu nunphung pangngai, hrisel tak zawm hi a ni.

• Zu in dan kha thunun rawh: Zu i in a nih chuan a tlem berah ti thin ang che.
• Ei leh in tha tak ei rawh: Thlai, thei leh thlai chi hrang hrang ei tam rawh.
• Exercise neih fo: Ni khatah minute 30 tal exercise chak tak ti thin ang che.
• Mut tawk: Ni khata darkar 7-8 vel mut that hi a pawimawh hle.
• I taksa rihna hrisel tak vawng reng rawh: I san zawng tana taksa rihna hrisel vawn reng hian natna tam tak lakah a venghim thei che a ni.
• Stress enkawl: Yoga leh meditation ang chi thil hmangin rilru hriselna vawng reng rawh.
• Meizial zuk loh tur: Meizial i zuk chuan vawiin hian bansan rawh.
• A hun taka vaccine lak: Vaccine tul tak tak lak hian immune system a tichak a ni.
• Kut sil fo tur: Hri lo laka invenna tha ber chu kut sil fo hi a ni.

Ka doctor hnenah Tregs enkawlna ka dil thei ang em?

Hei hi mi tam takin zawhna an neih a ni. Tunah hian Treg cell hmanga enkawlna hi damdawi in pangngai leh clinic pangngaiah a awm lo. Heng enkawlnate hi research stage (clinical trials)-ah an la awm reng a ni.

Researcher te chuan taksaa Treg cells hi him leh tangkai taka tihpun dan tur an la ngaihtuah mek a ni. An zirchian dan thenkhat chu hetiang hi a ni:

• Damdawi chi hrang hrang
• Vaccine pek dan tur
• Cell therapy: Taksa pawn lama Treg cell awmte tihdanglam a, taksa chhunga luhtir leh
• Fecal transplant a ni

Chuvangin, hengte hi nakin lawka kan beisei theih tur enkawlna hlu tak tak a lo ni mai thei.