Kan taksa chhunga "sipai", natna laka min humhim tur nia sawite hian a chang chuan kan kal bo a, kan taksa peng hrisel tak takte hi an rawn bei tan ta a nih chuan eng nge thleng ang tih i ngaihtuah ngai em? Chu chu a vanduaithlak hle a, mahse a takah chuan thil danglam tak chu vawiinah hian kan sawi dawn a ni. Chutiang a nih chuan kan immune system, defense army chuan chhan awm lovin kan liver chu a rawn bei tan ta a ni. Hei hi damdawi lama Autoimmune Hepatitis kan tih chu a ni.
A awlsam zawngin, Autoimmune Hepatitis hi eng nge ni?
Kan ram humhalhtu sipai an awm tih han ngaihtuah teh. Chu sipai hna awm chhun chu pawn lam hmelma (i.e. virus leh bacteria ang chi natna hrik) laka ram humhim hi a ni. Kan taksa immune system chu chutiang chu a ni. A fimkhur reng a, taksa chhunga hrik lutte zawngin a tichhe vek a ni.
Mahse, Autoimmune Hepatitis-ah hian thil mak tak mai a thleng thin. He immune system hi thil engemaw a kalsual a, kan liver cells te chu "hmêlma" angin a hre chiang hle. Tichuan he sipai, a nih loh leh antibodies hian ram dang hmêlma a beih ang bawkin kan liver cell sual nei lote chu a rawn bei tan ta a ni.
Hetianga liver hi a beih chhunzawm zel chuan a hring a, a hring chhuak thin. Hei hi hepatitis kan ti a. Hun kal zelah he chhiatna hi a pung thei a, thin (liver) pawh nasa takin a tichhe thei a ni.
A pawimawh ber chu hei hi damdawi famkim awm lo mah se, enkawl dan dik a nih chuan he natna hi a thunun thei hle a, thin chhiatna a veng thei a, nun hrisel tak a nei thei bawk. Enkawl loha dah a nih chauhvin hlauhawm a lo ni ta a ni.
Hei hi natna tlanglawn tak a ni lo. Zirchianna atanga a lan danin mi 100,000 zinga mi 10 atanga 50 inkar velin he natna hi an vei thin.
Autoimmune hepatitis chi hrang hrang a awm em?
Ni e, chi hnih a awm a. Heng chi hnih hi kan taksa hriselna (immune system) siam antibodies chi hrang hrang a\angin kan thliar hrang a ni. Hei hi a buaithlak deuh a, mahse i doctor-in a sawi em tih hriat a tha.
| Lampang | Tu nge a tuar ber? | Antibodies bik, a inzawm tlat |
|---|---|---|
| Type 1 a ni | Hei hi a tam ber chi a ni. Tu tan pawh a awm thei a, mahse hmeichhia kum 40 hnuai lam ah a awm tam ber. | Anti-smooth muscle antibodies (anti-SMA) leh a dang thenkhat. |
| Type 2 a ni | Hei hi a tlem hle a, mahse type 1 aiin a na deuh thei a, naupan lai atanga hmuhchhuah a ni tlangpui. | Anti-liver-kidney microsomal-1 (anti-LKM-1) antibodies te hi a awm a, hei hi a chhuahna tur hmun tur a ni. |
He natna lan chhuah dan engte nge ni?
Hemi chungchanga thil pakhat chu mi zawng zawng hian symptom an nei vek lo. I nei tih pawh i hre lo mai thei. I doctor chuan natna dang thisen test a tih hian a hmu mai thei. Mi thenkhat tan chuan liver function a nghawng tan hnuah symptoms a lang thei.
Symptoms i neih tak tak chuan i hriat hmasak ber chu sawifiah theih loha hahna hi a ni. Nilengin i mut hnuah pawh i chau hle mai thei.
Chu bakah, heng symptoms te hi i hmu thei bawk:
- Vun leh mit sen (Jaundice) .
- Vun a hrual chhuak
- Vun rawng chi hrang hrang lo lang
- Joint natna
- Pum a na
- Nausea leh luak chhuak
- Chaw chakna
- Zun dum (tea tui rawng ang chi) .
- Pale emaw gray emaw stools a awm
Engvangin nge hetiang natna hi a lo awm?
Researcher-te chuan eng thil nge a thlen tih chiang takin an la hre lo. Mahse autoimmune disease a ni tih kan hria. Chu chu kan immune system-a thil dik lo vang a ni tihna a ni. A thlentu nia ngaih thil engemaw zat a awm a:
- Genetic predisposition: Mi thenkhat chuan autoimmune natna vei theihna genetic predisposition an nei a. Chumi awmzia chu i chhungkuaa mi tu emawin a neih chuan nang pawhin i neih theihna chance tlem i nei thei tihna a ni.
- Viral infection: Tun hmaa Viral infection Epstein-Barr, herpes, parvovirus B19, emaw hepatitis A, B, C emaw i neih tawh chuan immune system chu "activate" in hetiang hian a tisual thei a ni.
- Environment factors: Toxin thenkhat emaw, environment-a thil thleng dang emaw hian immune system a ti chak lutuk thei a ni.
- Damdawi thenkhat:A tlem berah chuan damdawi thenkhat (entir nan, nitrofurantoin, minocycline, leh atorvastatin) te hian he natna hi a thlen thei a ni.
Pawimawh tak: He damdawi hi i hmuh vang mai maia damdawi i ei tawh zawng zawng ei kha bansan nghal suh. A hlauhawm thei hle. Ringhlelna i neih chuan i doctor nen inbia hmasa la, a thurawn zawm rawh.
Autoimmune Hepatitis hi a kai theih em?
Ni lo.. Ni lo tak zet. Hei hi natna hrik kai theih a ni lo. Hepatitis chi hrang hrang, Hepatitis A, B, leh C ang chi virus avanga lo awm hi mi pakhat atanga mi dangah a kai theih a ni. Mahse Autoimmune Hepatitis hi kan taksa chhunga thil thleng a ni. Chuvangin he natna vei mi i khawih emaw, ei leh in emaw i insem chuan engti kawng mahin he natna hi i kai lovang.
He natna vei theihna hlauhawm ber chu tute nge ni?
Zirna atanga a lan dan chuan he natna hi hmeichhiaah a hluar ber a ni. Damlo 10 zinga 7 chu hmeichhia an ni. Tin, he natna hi kum 15 leh 40 inkar zingah a awm tam ber bawk.
Tin, autoimmune natna dang nei tawh chu Autoimmune Hepatitis vei theihna a sang zawk bawk.
| Autoimmune Hepatitis nena inzawm Autoimmune Natna dangte |
|---|
| Type 1 zunthlum vei a ni |
| Ulcerative colitis (rilru lian a ulcer awm) . |
| Celiac natna (gluten allergy) 1.1. |
| Vitiligo (vunah a hring hring) . |
| Sjögren’s syndrome (mit leh hmui vawt thlentu natna) . |
| Graves natna (thyroid gland chak lutuk) . |
| Rheumatoid arthritis natna a ni |
Enkawl loh chuan eng harsatna nge a awm?
Hei hi kan rilru kan dah vek a ngai a ni. Autoimmune Hepatitis hi uluk taka enkawl a nih loh chuan thin (liver) a chhiatna chu a pung zauh zauh thei a, harsatna lian tham a thlen thei bawk.
- Cirrhosis: Hun kal zelah liver a chhiat chuan liver cell hrisel tak takte chu scar tissue-in a thlak a. Liver chu lungpui ang maiin a khauh ta hle mai. Hei hian a hna a thawk tha thei lo a ni.
- Liver failure: Cirrhosis a nasat chuan liver hian hna a thawk tawh lo vek thei a ni. Hei hi nunna atana hlauhawm tak a ni.
- Liver cancer: Cirrhosis vei te hian liver cancer an vei theihna a sang hle.
- Varicose veins: Liver kal tlanga thisen kal a tihkhawtlai chuan chaw kawng leh pum chhunga veins-a pressure a sang a, a hring chhuak thin. Hengte hi a rupture chuan thisen chhuahna nasa tak a thlen thei a ni.
- Ascites: Liver hian hna a thawk tha lo a nih chuan pum chhungah tui a awm tan thin.
He natna hi Doctor ten engtin nge an hriat chian?
Heng symptoms te hi i neih emaw, chhan dang avanga test-naah i liver-ah harsatna a awm tih a hriat chuan i doctor chuan he natna hi a ringhlel mai thei. Diagnostic process hian step engemaw zat a huam a.
1. A chipchiar zawka zawh che: Doctor chuan i natna lan chhuah dan te, i chhungkuaa tu emaw hian he natna hi an nei em tih te, damdawi i ei dan te, zu i in leh in loh chungchang te zawhna tam tak a zawt ang che.
2. Taksa endikna: I mit leh vun a sen (jaundice) a awm leh awm loh endik a ni ang a, i pum chu thin emaw ril emaw a hring emaw, pum chhunga tui a awm leh awm loh enfiah a ni ang a, ke a hring emaw a awm leh awm loh enfiah a ni ang.
3. Specialized test: Natna finfiah nan test eng emaw zat neih a ni.
| Fiahna | Hemiah hian eng nge i hmuh? |
|---|---|
| Thisen test a ni | Liver tichhe thei natna dang, viral hepatitis ang chi a awm loh nan fimkhur rawh. |
| Liver hnathawh dan enfiahna | I liver enzyme level te enfiah thin ang che. Liver a chhiat chuan heng enzyme te hi thisenah an pung khawm thin. |
| Antibody test a ni | Thisenah hian kan cell ngei beitu antibody bik (anti-SMA, anti-LKM-1 ang chi) a awm leh awm loh enfiah thin ang che. |
| Scan a ni | Ultrasound emaw, CT scan emaw, MRI scan emaw hmangin liver a pianzia, a lian leh te, a chhiatna a awm leh awm loh a enfiah thei a ni. |
| Liver biopsy (liver hmun te tak te enfiah) . | Hei hi 100% a natna finfiahna test a ni. Liver hmun te tak te tak te chu needle te tak te hmangin lak a ni a, microscope hmangin an enfiah thin. Hei hian natna a nasat zia chiang takin kan hre thei a ni. |
Hei hi eng enkawlna nge ni?
Enkawlna tum ber chu overactive immune system control leh liver chhiatna tihtawp a ni. Hemi atan hian damdawi chi hnih hman a ni.
1. Corticosteroids te hi a tha hle
Hengte hi steroid damdawi an ni. Taksa chhunga inflammation tihziaawmna rang takin hna an thawk a ni. I doctor chuan dose sang takin a tan tir ang che a, i dinhmun a that chhoh zel chuan dose chu a tihtlem zauh zauh ang che. Damdawi hman tlanglawn ber chu prednisone a ni . Hei hian mi tam zawk tan a thawk tha hle laiin, side effect thenkhat a nei thei bawk. Thil dang pawh a awm a, budesonide , mahse cirrhosis vei tan chuan a tha lo.
2. Immunosuppressant te a ni
A hming ang bawkin heng damdawi te hian immune system a titawp a, chu chu a ti slow tihna a ni. Steroid nen a ruala tan theih a ni a, steroid dose tihhniam hnuah pek theih a ni bawk. Azathioprine leh CellCept® te hi damdawi hman tlanglawn ber pahnih an ni.
Steroid aiin side effect an neih tlem avangin long-term maintenance therapy atan an hmang thin. I dam chhungin heng damdawi te hi a hun hunah i ei a ngai mai thei.
Enkawlna atanga result hmuh nan eng chen nge a ngaih?
Enkawlna tum ber chu remission neih a ni a, chu chu symptom zawng zawng leh test result zawng zawng chu a pangngaiah a kir leh tihna a ni. Hei hi tihhlawhtlin nan thla tam tak emaw, kum tam tak emaw pawh a ngai thei.
Natna hi kum hnih tal remission-a a awm tawh chuan doctor chuan damdawi chu tihtawp a rel thei a ni. Amaherawhchu, inenkawlna an chawlhsan hnuah natna a lo let leh theihna (relapse) theihna a awm. Remission-a kal zinga 50% vel chuan natna hi an nei leh ang a, damdawi an ei tan leh a ngai dawn a ni.
Mi thenkhat tan chuan damdawi hmanga natna hi a reh kim lo. Chutiang hunah chuan doctor chuan damdawi chi dang a enchhin ang. A tlem hle a, damlo thenkhat chuan enkawlna an dawng lo thei lo. Natna a nasat emaw, harsatna nasa tak a thlen emaw chuan, a hnuhnung ber chu liver transplant a ni thei .
He natna vei tu tan hmalam hun chu eng ang nge ni ang?
Hei hi mi tam takin harsatna an neih a ni. Thudik tak chu, enkawl loh chuan he natna hi a hlauhawm hle. Enkawl loh chuan damlo 50% vel chu kum 5 chhungin an thi.
Mahse, enkawl dan dik a nih chuan thil awmdan chu a danglam vek a ni. Enkawlna dawng zinga 91% chu kum 10 hnuah pawh an la dam. Kum 20 hnuah pawh 70% an la dam. Chumi awmzia chu enkawlna nen chuan hlawhtling tak, hun rei tak chhung nun i hmang thei tihna a ni.
Hetiang natna khirh tak nena nun hi rilru lamah a harsa thei hle. Mahse i enkawl dan tur i hriat chian a, i doctor nen thawhhona tha tak neiin i hriselna i thunun thei a ni. Informed, committed treatment hi i hmalam hun siam thatna tha ber a ni.
Take-Home Thuchah a ni
- Autoimmune Hepatitis hi nangmah ngeiin i immune system-in i liver a bei thin natna a ni. Virus avanga lo awm a ni lo va, mi pakhat atanga mi dangah kai theih a ni lo.
- Sawifiah loha hahna leh jaundice hi natna lan chhuah dan tlangpui a ni a, mahse mi thenkhat chuan engmah an nei lo mai thei.
- Hei hi damdawi famkim awm lo mah se, damdawi hian natna hi a thunun thei hle a, thin (liver) tihchhiat belh zel tur a veng thei bawk.
- Enkawlna hi hun rei tak chhunga tih tur a ni. I damdawi ei kha titawp ngai suh la, i doctor thurawn tel lo chuan a dose pawh thlak ngai suh.
- Enkawlna mumal leh mumal tak i neih chuan he natna hi dam rei tak, hrisel tak leh hlim takin i nung thei a ni.
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