Nunna chhanhim thei thilpek hlu ber - Thisen stem cell pek chungchang zawng zawng

I hnaih tak, i chhungte emaw, i ṭhian emaw pawh ni se, Leukemia ang chi thisen cancer na tak a vei tih han ngaihtuah teh. Chutiang thu chu tu mahin kan hre duh lo a ni lawm ni? Mahse chutiang a nih chuan chu mi nunna chhanhim thei tur chuan nangmah chauh i ni mai thei. Ni e, nunna thilpek chu i pe thei a ni. Chu thilpek hlu ber chu thisen stem cell pek hi a ni. Hemi chungchang hi a tir atang khan sawi ila, awlsam takin.

Thisen stem cell pek hi eng nge ni?

A awlsam zawngin sawi ila, thisen stem cell pek hi mi hrisel tak hnen atanga he cell chi bik hi lak chhuah a, damlo hnena dah luh a ni. Heng stem cells te hi kan taksaa "master cells" an ni. Chumi awmzia chu kan thisena cell chi hrang hrangah an lo thang lian thei tihna a ni a, chutah chuan thisen sen, thisen var, leh platelet te pawh a tel a ni .

Kum tin leukemia ang chi natna khirh tak tak avangin mi sang tam tak an thi thin. Chutiang damloteah chuan an ruhro (bone marrow)-a stem cells te chu a chhe vek emaw, a thawk tha lo emaw a ni. Tichuan, mi hrisel tak atanga lak chhuah stem cell te chu damlo hnenah pek a ni a, an taksaah thisen hrisel thar siam turin an siam a ni. Hei hi stem cell transplant an ti a.

Mi pakhat chuan heng cell te hi a enkawlnaah a pe thei a, a chhungte hnai tak a pui thei a, a la tawn ngai loh mi nunna chhanhim turin donor angin a inziak lut thei bawk a, khawvel hmun dangah pawh a pe thei bawk.

Engvangin nge mi pakhatin heng stem cells te hi a mamawh ang?

Stem cell transplant hi thisen cancer chi hrang hrang leh thisen kaihhnawih natna dang nei tan chuan a hlawkpui hle thei a ni. Hetiang tih danah hian doctor-te chuan damlo taksa atanga stem cell chhia te chu an paih chhuak a, chu chu stem cell hrisel tak takin an thlak thin. Chumi hnuah chuan cell tharte chu an lo thang lian a, thisen cell hrisel tak tak an siam tan ta a ni.

A hnuaia tarlan te hi stem cell transplant hmanga enkawl damdawi lam harsatna lian ber ber thenkhat tarlan a ni.

Engtin nge he ‘match’ hi i hmuh?

Hei hi a pawimawh ber leh harsa ber a ni. Mi pakhat hnen atanga stem cells lak a, midang hnena pek mai mai theih a ni lo. Mi pahnih cell inkarah hian match tha tak a awm a ngai a ni.

Doctor-te chuan he match hi an enfiah a , Human Leukocyte Antigens (HLA) tih hming pu thil pakhat an enfiah a ni. He HLA hi kan taksa cell tinah ‘barcode’ bik angin han ngaihtuah teh. Kan immune system hian he barcode hi a en a, "hei hi ka cell ngei a ni" nge "hei hi ram dang thil a ni" tih a hriat theih.

Stem cell transplant-ah chuan a petu leh a dawngtu HLA barcode chu a theih ang anga inang vek tur a ni. Chumi hnuah chauh chuan a dawngtu taksain cell tharte chu hnawl lovin a pawm ang.

Doctor-te chuan hetiang hian donor an zawng a:

1. Chhungkaw member hnai tak: Unau leh nu leh pa ang mite hi ngaihtuah hmasak an ni a, HLA match an neih tam zawk avangin.

2. Unrelated donors: Chhungkaw match a awm loh chuan national emaw international donor registry te enfiahin match an zawng thin. Khawvel hmun hrang hrangah donor maktaduai tam tak chu hetiang hian an inziak lut a ni.

3. A then matched (Haploidentical) donors te chu:A châng chuan, a dawngtu HLA match chanve chiah, chhûngkaw member aṭangin cell hmuh theih a ni.

Donor i ni thei ang em? Hei hi a kalphung a ni.

Ni e, i hrisel a nih chuan nang pawhin he thil ropui takah hian thawhhlawk theihna hun remchang ropui tak i nei a ni. Donor anga inziak lut dan hi i ngaihtuah angin a buaithlak lo. Step tlemte chauh a ngai.

• Registration: I tih hmasak ber tur chu donor registration agency kaltlangin application fill up hi a ni. Hei hian i hriselna chanchin leh i biak theihna tur chipchiar takin i sawi a ngai dawn a ni.
• HLA test: A dawtah chuan i HLA type hriat nan test i ni ang. Hei hi a awlsam hle. I hmui chhung chu cotton swab te tak te hmangin an swab ang a, chuta tang chuan cell sample an la ang. Hemi atan hian in lama hruai tur kit pawh i hmu thei mai thei bawk.
• Match nghah: I HLA information registry-a i luh hnuah damlo pakhatin a match che i nghah a ngai a ni. Hei hian thla tam tak a daih thei a, kum tam tak pawh a daih thei bawk.
• Match hmuh a nih chuan: Damlo match tha tak i hmuh chuan chu institution chuan a rawn biak ang che. Chumi hnuah chuan thisen test engemaw zat i tih belh a ngai dawn a, match i nih leh nih loh finfiah nan.
• Counselling leh Consent: Engkim a kal tha a nih chuan a kalphung zawng zawng, a hlauhawmna leh a hlawkna te chu hrilhfiah a ni ang. Tichuan, i informed consent chu lak a ni ang.
• Final Medical Examination: Thilpek i pek hmain i hrisel tawk em tih hriat nan medical examination kimchang i nei ang.

Tute nge stem cells donate thei lo?

Kum bithliah leh hriselna dinhmun thenkhat chuan mi zawng zawngin stem cell an pe thei lo. Heng dante hi thilpek petu leh dawngtu te humhimna atan siam a ni. Hetah hian thawhlawm thawh theih loh chhan lian ber ber thenkhat tarlan a ni.

He list hi a chhan tlemte chauh a ni. Thilpek pek i duh a, mahse hriselna lama harsatna i neih chuan i doctor nen inbiakna neih a tha ber.

Thawhlawm thawh ni hma leh pek ni chhung hian eng nge thleng?

Ni engemaw zat kalta khan min pe rawh.

Donor tha tak i ni tih finfiah a nih hnuah chuan donation hma ni 4-5 chhungin nitin injection pek i ni ang. He injection ah hian Filgrastim a awm a.Hei hi damdawi an tih a ni. A tih chu i ruhro a tichak a, i thisenah stem cell tam tak a chhuah tir a ni. Tichuan awlsam takin chu cell te chu i thisen atangin kan la khawm thei ang.

Heng injection te hian side effect tenau thenkhat a nei thei a:

• Ruh a na
• Lu na
• A khawsik tlem a awm.
• Luhai
• Mut harsat

Thilpek pek lai hian

Hetiang kalphung hi "harvesting" an ti bawk. Thisen atanga platelet lakkhawm ang mai a ni.

• Chair emaw khum nuam takah emaw dah i ni ang.
• I kut pahnih vein-ah cannula pahnih dah a ni ang.
• Khawthlang lamah chuan i thisen thenkhat chu la in machine bik hmanga thawn a ni. He machine hian thisen atanga stem cells chauh a filter a, a then hrang a ni.
• Stem cells te an inthen hnuah thisen la awm chu i kut danga cannula hmangin i taksaah a kir leh thin.

Hetiang zawng zawng hi ni khatah darkar 4-6 vel a ni. Damlo mamawh zat stem cells lakkhawm nan ni 3-4 vel a ngai a ni. Hemi chhung hian lehkhabu chhiar leh phone hman zalen i ni.

Hei hian eng hlawkna leh hlauhawmna nge a neih?

Stem cell donation hlawkna ber leh awmchhun chu midang nunna i chhanhim hi a ni. Chu mi chu nangmah ngei pawhin i unau a ni thei a, i la tawn ngai loh pawh a ni thei bawk. Engti kawng pawhin, chu mi chu natna khirh tak aṭanga dam leh theihna hun vawi hnihna i pe a ni. Chu chu hriatna hlu tak a ni.

Risk lam erawh chu a hniam hle. Thawhlawm thawh dan hi a him hle a ni. Hei hian nakin lawka thisen kaihhnawih natna emaw cancer emaw i vei theihna a tipung lo. I taksa chuan stem cells donated te chu rang takin a siam thar leh thin.