Dopamine agonists te hi eng nge ni? Heng damdawi te hi a awlsam zawngin i zir dawn teh ang!

I chhungkuaah hian Parkinson natna ang chi movement disorder nei an awm em? A nih loh leh i doctor hian nangmah emaw, i hriat mi emaw hnenah damdawi chi khat dopamine agonists tih chu a hrilh tawh em? A hming hi a buaithlak deuhin a lang thei a, mahse lungngai suh. Vawiin hian i hriatthiam theih tur khawpa awlsam takin kan sawi dawn a ni. He thu hi i thianpa nen in inbia ang maiin chhiar la.

A awlsam zawngin, heng dopamine agonists te hi engte nge ni?

Hei hi hrethiam tur chuan kan thluak hnathawh dan tlem han zir hmasa ila. Kan nervous system-ah hian cell kan nei a. Chûng cell-te chu chemical bik hmangin an inbiak tawn a, a nih loh leh an inbia a ni. Hengte hi neurotransmitter kan ti a. Chûngte chu tirhkoh ang mai an ni.

Kan nerve cell chu kawngkhar pakhat, a chhungah turtle awm angin han ngaihtuah teh. Chu kawngkhar hawn tur chuan chabi dik tak a mamawh a ni. Chutiang bawkin cell tin hian a chung lamah ‘receptors’ an tih thil an nei a, chu chu turtle ang maiin a ni. Neurotransmitters te hi chu turtle te nena inmil key ang mai an ni. Chabi i dah chuan turtle chu a inhawng a, kawngkhar a inhawng ang bawkin, neurotransmitter chu receptor nen a inzawm chuan cell chu a thawk chhuak ta a ni.

Dopamine hi kan thluaka key pawimawh tak a ni a, neurotransmitter a ni. Thil i zir hian, hlim leh lungawina i neih hian he dopamine hi chu chutiang rilru put hmang siamtu chu a ni. Tin, kan taksa ruhte a che tha thei tur chuan dopamine hi a pawimawh hle bawk.

Tûnah chuan kan thupuiah kan lut leh ang. Dopamine Agonist te hi eng nge ni ? A awlsam zawngin, hengte hi dopamine ang maia thawk damdawi an ni . Strict takin sawi ila, dopamine an ni lo va, kan thluak cell te hi bum an ni. Heng damdawi molecule te hi an pianzia hi dopamine molecule nen a inang em em a, chu chu kan sawi tawh cell-a receptor-ah chuan an in fit chiah a ni. Chuvangin, he damdawi hi i ei hian a kal a, dopamine-in a hawn tur kawngkharte chu a hawng a ni. Phên dangin sawi ila, heng damdawite hian dopamine-in a tih ang chiah hi an ti a ni. Kan cell te hian an pahnih inthlauhna hi an hre lo.

Dopamine hian kan taksa leh he damdawi hmangtu damdawi lam dinhmunte hi eng nge a tih

Dopamine hian taksa peng (muscle movement) chauh a pui lo. Kan taksa chhunga thil pawimawh dang tam tak control nan pawh a mamawh bawk. Entir nan:

• Lung hnathawh dan
• Kidney hnathawh dan
• Pancreas hnathawh dan
• Pituitary gland hnathawh dan
• Kan endocrine system hi a ni
• Chaw ei dan (digestive system) a ni
• Hmeichhia leh mipa chi thlah dan

Chuvangin taksaa dopamine level a tlahniam chuan harsatna engzat nge a awm theih tih i hrethiam mai thei. Dopamine agonists hi dopamine tlakchhamna avanga natna tam tak enkawlna atan hman a ni.

Heng damdawi te hi eng damdawi lam harsatna atana hman ber nge tih chu a hnuaia table hi en la.

Heng damdawi hman hian eng hlawkna nge a neih?

Dopamine agonists hi damdawi chi khat chauh a ni lo. An hman hian hlawkna chiang tak tak engemaw zat a nei a ni.

• Results tangkai tak tak: Research atanga a lan dan chuan heng damdawi te hian a chunga kan sawi tak natna tam tak enkawlna kawngah hian a tangkai hle a ni.
• Thil chi hrang hrang atan hman theih a ni: I hmuh angin hengte hi natna chi hrang hrangah hman theih a ni a, thluak chetna lama harsatna atanga hormone lama harsatna thlengin hman theih a ni.
• Damdawi dang nena inmil: Hei hi a pawimawh hle. Entirnan, Parkinson damdawi ‘Levodopa’ nen dopamine agonist pek dun a nih chuan levodopa dose tihtlem theih a ni. Dose tlem zawk hmang pawhin result tam zawk a awm thei. Hei hian levodopa side effects a tihziaawm bawk.
• Nunna chhanhim: A chunga kan sawi tawh ‘Neuroleptic Malignant Syndrome’ an tih dinhmun hlauhawmah hian dopamine agonist damdawi hian nunna a chhanhim thei a ni.

Risk leh harsatna awm thei (side effects) .

Damdawi dang ang bawkin dopamine agonists hian side effect engemaw zat a nei thei a ni. Mi zawng zawngin an dawng vek lo va, a dose a san chuan a lo awm tam zawk bawk. Hengte hi fimkhur a pawimawh hle.

Side effect awm fo thin

Hengte hi a side effect tam berte chu an ni:

• Ek khal
• Luak chhuak thei
• Lu na
• Pum a na
• Lungphun dik lo (arrhythmia) .
• Nausea leh luak chhuak
• I ding chhuak thut chuan i mit a rawn sen a, i muhil dawn ang maiin i inhria (Orthostatic hypotension) .
• Muscle twitching ang maia chetna thunun loh

Hun rei tak hman a nih chuan rilru leh nungchang lama inthlak danglamna a awm thei

He damdawi hi rei tak kan hman hian rilru leh nungchang lama inthlak danglamna engemaw zat a awm thei.

• Hriatrengna leh ngaihtuahna buai
• Lungngaihna
• Impulse control chungchang a ni
• Thil danglam bik taka active emaw excited emaw (Mania) .
• Psychosis ang chi symptoms, hallucinations hmuh emaw hriat emaw ang chi te
• Nitin mut tam lutuk leh mut attack nghal

Impulse control chungchang a ni

Hei hi a bik takin ngaihtuah tur side effect a ni. Dopamine hi kan hlimna leh lungawina nen a inzawm tlat avangin, he system hi heng damdawi te hian a tihchak hian mi thenkhat chuan mahni inthununna an hloh thei a ni. Chu chu, mahni inthunun theih loh thil ti tura thlemna an tawk mai thei tihna a ni.

Ngaihtuah teh, a tlangpuiin khelh duhna nei lo mi pakhatin he ruihhlo hi a hman ṭan hnuah, thunun theih lohvin khelh ṭan a ni. An sum zawng zawng an hloh thlengin an ti thin. Mi dang chuan thunun theih lohvin thil lei duhin a inhria mai thei. Mi dangte erawh chuan hypersexuality an tawng thei thung.

Damdawi i ei loh thut chuan eng nge thleng ang? - Dopamine Agonist Withdrawal Syndrome (DAWS) a ni a, a rilru a hah lutuk a, a rilru a buai em em bawk a.

Hei pawh hi a pawimawh hle. He damdawi hi i doctor thurawn tel lo chuan i ei nghal vat ngai lo va, a dose pawh tihtlem ngai suh. Chutianga tih chuan Dopamine Agonist Withdrawal Syndrome (DAWS) tih natna a thlen thei a ni. Hei hi damdawi addiction a ni lo va, taksain damdawi a lo thiam tawh a, a ei tawh loh thut atanga lo awm thin reaction a ni.

Hetiang dinhmunah hian a hnuaia symptoms te hi a lo lang thei a ni:

• Lungkhamna leh panic attack te
• Thaw chhuak lutuk (diaphoresis) .
• Restlessness a awm
• Chauh lutuk
• Taksa natna
• Luhai
• Ding chunga luak chhuak (Orthostatic hypotension) .

He DAWS natna vei theihna tipungtu thil engemaw zat a awm. A hnuaia table hi en rawh.

Heng damdawi te hi ei loh tur a awm em?

Ni e, heng damdawi te hi hman a rem loh lai pawh a awm. I doctor chuan damdawi a pek hmain heng zawng zawng hi a ngaihtuah hmasa ang. Mahse hei pawh hi i tan a tha khawp mai.

• Naupai lai leh nau hnute pek lai: Heng damdawi te hian hnute hnute siamchhuah (lactation) a tikhawlo thei a ni. Chuvangin heng hun chhung hian an tha lo.
• Thisen sang (hypertension) i neih chuan: Dopamine agonist thenkhat chuan thisen sang a tisang thei.
• Fibrosis-type condition thenkhat lo awm theihna: Pulmonary fibrosis ang chi natna vei theihna a awm a, a bik takin dopamine agonists upa zawk (ergot-based) te nen chuan a awm thei.
• Kidney emaw liver natna: Damdawi te hi kal leh thin hmanga taksa atanga lakchhuah a ni. Heng taksa peng hrang hranga natna nei te hian he damdawi hi an taksaah a lo pungkhawm thei a, chu chuan side effect a thlen theihna a tipung thei a ni.
• Damdawi dang thenkhat i ei a nih chuan: Hengte hi ‘monoamine oxidase inhibitors’ (MAOIs) an tih, a bik takin rilru natna atana hman thin damdawi i ei a nih chuan ei theih a ni lo.
• Tun hmaa psychosis i neih tawh chuan: Heng mite hian heng damdawi te hmang hian heng symptoms te hi an lo lang leh thei a ni.

Dopamine leh Dopamine Agonists te hi eng nge an danglamna?

Mi pakhat chuan, dopamine a tlem a nih chuan engvangin nge dopamine ngei pawh hi damdawi atan direct-a pek theih a nih loh a, engvangin nge hetiang thil ti thei damdawi hi pek a nih? Chutiang a nih chhan hi eng emaw zat a awm.

1. Blood-Brain Barrier: Kan thluak hi a fimkhur hle. Thisen chhunga awm zawng zawng chu thluaka a luh tir vek lo. ‘Blood-brain barrier’ an tih, venhimna filter a nei a. Thluak tan chuan 'security guard' ang mai a ni. Pawn lam atanga dopamine pek hian he security guard hi a paltlang thei lo va, thluak chhungah a lut thei lo. Mahse, dopamine agonists te hian he barrier hi an paltlang thei a, thluak chhungah an lut nghal thei a ni.

2. Side effects: Dopamine hi injection anga direct-a pek a nih chuan taksa pum a nghawng avangin duh loh zawng tam tak a thlen thei a ni. Dopamine agonists hi targeted zawka hnathawk thei tura siam a ni.

3. Hun rei tak chhunga hman tur:Parkinson natnaah chuan ‘Levodopa’ an tih damdawi an pe thin. Thluak chhungah a lut a, dopamine ah a chang ta a ni. Mahse hun kal zelah chu damdawi dose chu tihpun a ngai a, chutah chuan a side effects chu a pung zel a ni. Chuvangin, natna hmasa berah dopamine agonists hman hian levodopa tan hun sawn hlat theih a ni. Hei hian damlo chu rei zawk dam turin a pui thin.

Nangmah emaw, i hriat mi emaw hnenah heng damdawi te hi i lo pe tawh a nih chuan lungngai suh. Hengte hi damdawi hlu tak tak an ni a, dik taka hman chuan i nunphung nasa takin a tichangtlung thei a ni. A pawimawh ber chu i doctor nena inbiak reng reng tur leh harsatna emaw, side effect emaw awm apiang zalen taka sawi dun hi a ni.