G-CSF (Granulocyte-Colony Stimulating Factor) hi eng nge ni? Cancer enkawlnaah engvangin nge a pawimawh?

I chhungte, i chhungte emaw, i thian emaw cancer natna enkawl lai i hmu tawh mai thei. Chutiang enkawlna i neih lai chuan "Chemotherapy" an tih enkawlna chungchang hi i hre tawh ngei ang. He chemo treatment chhung hian taksaa natna dotu thisen var (white blood cells) a tlahniam tih pawh i hre mai thei. Chutiang dinhmunah chuan he thuziak ah hian kan taksa invenna kawnga Doctor ten an hman thin damdawi bik kan sawi dawn a ni. Chu chu G-CSF a ni.

G-CSF hi eng nge ni tak tak?

A awlsam zawngin, G-CSF hi kan taksain thisen var tam zawk siam turin a puitu damdawi a ni , a bik takin "neutrophils" an tih chi khat.

Kan taksa hi ram ang maiin han ngaihtuah teh. Tichuan heng neutrophils te hi chu ram chhunga sipai te ang mai an ni. Heng sipai neutrophil tia koh te hian pawn lam hrik, chu chu bacteria leh virus ang hmelma te dotu, natna leh hri kai lakah min vengtu te hi an ni. Chuti a nih chuan heng sipaite hi an tlem chuan eng nge thleng ang? Kan ram, chu chu kan taksa hi natna vei awlsam tak a lo ni ta a ni.

G-CSF tih hming hi a buaithlak deuhin lang mah se, a awmzia kan tihchhiat chuan a awlsam hle.

• Granulocyte: Hei hi thisen var chi khat hming an vuah a ni. Neutrophils hi granulocyte chi khat a ni bawk.
• Colony-Stimulating Factor: Hei hi cell "order" emaw "stimulate" emaw thil a ni. Factory manager-in hnathawkte hna a pek ang bawkin he protein hi kan ruhroah a kal a, "Okay, tunah hian neutrophil siam tan rawh," a ti a.

Chuvangin he damdawi G-CSF an tih hian a tih chu kan ruh chhunga sponge ang chi bone marrow -ah a kal a, chuta stem cell-te hnenah, "Nangni ho hi rang takin neutrophil in ni tur a ni a, chutah chuan neutrophil awmte chu inthen darh se, pung zel tur a ni," a ti a ni. Tichuan heng neutrophil sipai lo piang tharte hian thisen chu an zawm a, min humhim turin hna an thawk tan ta a ni.

Eng dinhmunah nge G-CSF hi hman a nih?

G-CSF hi "neutropenia" tih natna enkawlna leh venna atan hman a ni ber. Neutropenia hi thisen chhunga neutrophil awm zat pangngai aia tlem zawk chauh a ni.

Cancer enkawlnaah (Chemotherapy) .

Cancer enkawlna atana hman tur chemotherapy damdawi te hi cancer cell inthen darh chak tak takte tihlum thei tura duan a ni. Mahse, heng damdawi te hian cancer cell chauh ni lovin, kan taksaa inthen darh chak tak cell hrisel tak takte pawh an hre thei lo. Chuvangin, ruhroa siam neutrophils pawh hi cell inthen chak chi khat a nih avangin chemo damdawi pawhin a tichhe bawk.

Hei hi hnim hnah paih chhuahna atana herbicide kah ang a ni a, mahse thlai tha tak takte pawh a tichhe bawk.

Hei vang hian chemotherapy hnuah neutropenia hi a hluar hle a ni. Hetiang dinhmun hi a nasat chuan natna tenau tak pawh hi nunna atana hlauhawm tak a ni thei. Chutiang hunah chuan doctor-te chuan G-CSF hi hri kai theihna tihziaawmna tur leh taksa invenna siam that lehna turin an rawt a ni.

Stem cell thlak danglamnaah

Cancer chi hrang hrang leh thisen lama harsatnaah chuan stem cell transplant a ngai thin. Hetiang tih hma leh a hnuah G-CSF hi hman a ni.

• Transplant hma: Damlo chu G-CSF pek a nih chuan ruhro hian stem cells tam tak a siam chhuak a, thisenah a chhuah tir thin. Chumi hnuah chuan doctor-te chuan chu stem cell hrisel tak takte chu thisen atangin an la khawm thin.
• Transplant lai: A dawtah chuan high-dose chemotherapy emaw radiation therapy emaw chuan taksaa cell pangngai lo la awm zawng zawng chu a tichhia a ni.
• Transplant zawhah: A tawp berah chuan a hmaa stem cell hrisel tak tak an khawnkhawmte chu taksaah an luhtir leh thin. Heng cell te hi a hnuah thisen cell thar, hrisel tak an lo ni ang.

Stem cell donor i nih chuan i tih hmain G-CSF injection i lak a ngai thei bawk.

Neutrophils hniam siamtu dinhmun dang

Neutrophil level hi nau piang laia thil awm thenkhat (severe congenital neutropenia) emaw, a chhan hriat loh (idiopathic neutropenia) emaw avang pawhin a hniam thei bawk. Chutiang hunah chuan G-CSF hmangin neutrophil level tihsan a ni.

G-CSF chi hrang hrang leh pek dan

G-CSF hi hming hrang hrangin market-ah a awm a. A hman tlanglawn ber chi hnih chu:

1. Filgrastim: Hei hi short-acting type a ni. Nitin injection anga pek a ngai tlangpui.

2. Pegfilgrastim: Hei hi damdawi hman rei tak a nih avangin chemotherapy round hnih inkara injection vawi khat chauh pek hi a tawk fo thin.

Heng damdawi te hi brand name hrang hrang leh biosimilars hmanga lei theih a ni. Entirnan, i doctor chuan Neupogen®, Neulasta®, Nivestym®, leh Zarxio® tih ang chi hmingte chu a hrilh thei che a ni.

Engtin nge he damdawi hi taksaah pek a nih?

G-CSF hi subcutaneous injection angin pek a ni tlangpui a , mahse a then phei chuan IV infusion angin pek theih a ni bawk .

• Vaccine lak nan nitin clinic-ah i kal a ngai mai thei.
• A nih loh leh, nurse chuan nangmah emaw, chhungte emaw chu in lama vaccine inject dan tur chiang takin a zirtir ang che. Chutiang chuan a harsa lo.

Mi zawng zawng hian G-CSF hi kan mamawh em?

No. G-CSF hi chemotherapy nei zawng zawng emaw, neutrophils hniam nei zawng zawng tan pek a ni lo. Damdawi dang ang bawkin G-CSF hian hlawkna a nei a, chubakah side effect a neih theihna tur hlauhawm thenkhat a nei bawk. I doctor chuan he damdawi hi a pek hmain thil engemaw zat a ngaihtuah hmasa ang.

• i kum zat
• I hriselna dinhmun zawng zawng
• Cancer i neih chi hrang hrang
• Chemotherapy i dawn chi hrang hrang
• Neutropenia symptoms (khawsik ang chi) i nei tawh em tih .

G-CSF hlawkna leh a side effect awm thei te

G-CSF hi rawt a nih chuan a hlawkna chuan a hlauhawmna aiin a tam zawk tih hre reng ang che.

A thatna ber chu:

• Infection na tak, nunna atana hlauhawm thei vei theihna chu nasa takin a tlahniam a ni.
• Neutrophil level hniam chuan chemotherapy tihkhawtlai emaw, a dose tihtlem emaw a veng thei a, cancer enkawlna chu ruahman angin chhunzawm theih a ni.

Side effect awm thei te

Side effect tam zawk hi chu hun eng emaw chen atan a ni a, G-CSF tihtawp hnuah a bo vek.

G-CSF ei huna hriat reng tur thil

• I doctor hnenah i medical history kimchang hrilh rawh. Natna dang i neih leh damdawi dang i ei lai (vitamin te pawh tel) chu hriattir ngei ang che.
• Naupai emaw, naupai tum emaw, naupai lai emaw chuan G-CSF ei hi a tha lo . Hemi chungchang hi i doctor nen sawiho rawh.
• Side effects ngaihtuah buai suh. Side effect i neih chuan doctor emaw nurse emaw hrilh rawh. An enkawl danah an pui ang che.
• I thisen test a hun takah tihsak rawh. I doctor chuan i neutrophil level a enfiah ang a, eng chen nge enkawl a ngai tih a hre ang.

G-CSF hi cancer enkawlna kawngah hian adjunct pawimawh tak a ni. Chemotherapy enkawlna him zawk leh hlawhtling zawka siam turin boost ropui tak a pe a ni. Hemi chungchanga zawhna dang i neih chuan i enkawltu doctor zawt hreh suh.