I taksa hian natna laka vengtu "sipai" lian tak a nei tih i hria em? Hei hi immune system kan ti a. He sipai hna hi pawn lam atanga lo chhuak hrik, virus, cancer cell ang chi hmelma te do a, kan hriselna kan vawn that hi a ni. Mahse a chang chuan, he sipai hian tanpuina tlem a mamawh a ni. Sipai chakna a tawk lo emaw, sipaite chuan thunun theih lohvin hna an thawk tan emaw a ni thei. Chutih lai chuan damdawi chi hrang hrang `(Immunomodulators)` tih hian min pui thei a ni.
A awlsam zawngin, heng Immunomodulators te hi engte nge ni?
Immunomodulators hi damdawi chi khat a ni a, i immune system hnathawh "tidanglam" emaw "tidanglam" emaw a ni. I immune system chu radio-a volume control ang maiin ngaihtuah rawh. Natna thenkhatah chuan he volume hi a hniam lutuk a, chu chu immune system a chak lo tihna a ni. Natna dang ah chuan he volume hi a sang lutuk a, chu chu immune system a overactive tihna a ni.
Chuvangin `(Immunomodulators)` tih dan chu a tul angin he volume hi adjust hi a ni. Chu chu, immunity a hniam chuan heng damdawi te hian a tipung thei a, a tul lo taka immunity a san chuan an tihtlem thei a, an control thei bawk . Hei hi function bik tak a ni.
Heng damdawi te hian kawng hnih in hna an thawk ber a:
Kan sawi tawh ang khan heng damdawi te hian hna an thawh dan tlangpui pahnih a awm a. Hei hi i hriatthiam chuan he damdawi hi i hrethiam zawk ang.
| Thiltih | Hei hian eng nge a tih? (Eng nge a tih) . |
|---|---|
| Immune Response tihchak | In some disease states, especially cancer, cancer cells are very good at hiding from our immune system. Heng ruihhlo te hian an tih chu kan "sipai" te hian heng hmêlma thup te hi zawng chhuakin tihchhiat tumin chakna leh training an mamawh a ni. |
| Immune Response tihtawp (suppress) a ni | Heng damdawi te hi a bik takin Immunosuppressants kan ti a.Hengte hi autoimmune natna nei tan a mamawh a ni. Heng natnaah hian keimahni taksa hriselna (immune system) hian kan cell hrisel tak takte hi a rawn bei sual a ni. Tin, organ transplant an tih hian heng damdawi te hian taksain organ thar a hnawl loh nan a pui bawk. |
Immunomodulators hmanna tur condition lian ber berte chu engte nge ni?
Hetiang damdawi chi hi natna chi hrang hrang enkawlna atan hman a ni. Chung zinga ṭhenkhat chu:
- Joint leh connective tissue natna: Hengte hi autoimmune natna chi khat ber an ni. Entirnan, natna chi hrang hrang `(Rheumatoid Arthritis)` (joint inflammation), `(Lupus)`, `(Psoriatic Arthritis)`, `(Ankylosing Spondylitis)` ang chi natnaah te hian heng damdawi te hian taksain a ruh, vun, etc. a beih dan tur a thunun thei a ni.
- Digestive system natna: ``Crohn's Disease'' leh ``Ulcerative Colitis'' ang natnaah chuan hengte hi intestine-a lo awm thin immune process duh loh tak control nan an hmang thin.
- Vun natna: Psoriasis ang natnaah hian immune system hian vun cell te rang taka thang chakna a control thin.
- Nervous system natna: Heng damdawi te hian ``Multiple Sclerosis`` ang chi natnaah nervous system chhiatna control nan a pui thin.
- Cancer: Cancer chi thenkhatah chuan hengte hi cancer cell tihchhiat nan immune system tichak turin an hmang thin. Hei hi ``Immunotherapy'' tih enkawlna pakhat a ni.
Immunomodulator chi hrang hrangte chu engte nge ni?
Heng damdawi te hi chi khat vek an ni lo. Doctor te chuan natna chi hrang hrang ``Immunomodulators`` chi hrang hrang an pe thin.
Corticosteroid hmanga tihdam theih a ni
Hengte hi mi tam takin an hriat angin immunosuppressant damdawi hman tlanglawn ber an ni. Entirna pakhat chu `(Prednisone) hi a ni.` Hengte hian immune system hnathawh chak taka tihtlem a, taksaa hring leh inflammation control-na hmangin hna an thawk a ni.
DMARDs (Natna tidanglam thei damdawi damdawi) .
A hming ang bawkin hengte hi natna chi hrang hrang siam danglam thei damdawi an ni. A bik takin arthritis ang natnaah chuan heng damdawi te hian natna avanga ruhkawr chhiatna tur venna emaw control emaw a pui a, natna tihziaawmna mai ni lovin. `(Methotrexate)` hi he class-ah hian damdawi hriat hlawh tak a ni.
Biologics lam thil a ni
Hengte hi DMARD aiin damdawi class thar zawk, hmasawn zawk an ni. Laboratory-a cell nung atanga protein lakchhuah atanga siam an ni.
A awlsam zawngin, damdawi hlui zawkte hian ‘carpet bomb’ angin hna an thawk a, immune system zawng zawng a nghawng laiin, biologics erawh chu ‘smart bomb’ ang a ni thung. Chu chu, natna thlentu cell emaw chemical bik (`(TNF)`, `(Interleukin)` ang chi) chauh direct-in an kal a, an target tihna a ni.
Hei hian side effect a tihziaawm thei a, result hlawhtling zawk a thlen thei bawk.
Cancer natna vei tan Immunotherapy a ni
Hei hi enkawlna chi khat bik tak a ni. Heta thil thleng hi immune system a tlahniam tihna a ni lo va, a pung zawk tihna a ni. ``Checkpoint Inhibitors`` ang damdawi hian cancer cell-te'n kan immune cells (``(T-cells)``) atanga an thup nan an hman "signal" te chu a titawp a, T-cells te chu cancer cells te hriatchhuah leh tihchhiat nan a pui bawk.
Engtin nge he damdawi hi taksaah pek a nih?
He damdawi pek dan che hi i damdawi lam dinhmun leh damdawi chi hrang hrang a zirin a inang lo thei.
- Through a vein (By IV): Saline ang bawkin cannula hmangin thisenah direct-in a lut a.
- By Injection: Vun hnuaiah emaw, taksa ruh chhungah emaw inject a ni.
- Oral: Ka hmanga tablet emaw capsule emaw angin ei tur a ni.
- Vun chunga cream angin (Topically): Vun natna tan cream angin vun chung lamah hnawih a ni.
Side effect leh risk te pawh i hrechiang ang u.
Hengte hi damdawi \angkai tak tak ni mah se, immune system a nghawng avangin side effect leh risk engemaw zat a nei thei a ni. I doctor chuan hengte hi a zirtir ang che.
| Risk chi hrang hrang | Thil fimkhur tur |
|---|---|
| Side effect awm fo thin | Chauhna, mutthilh, rilru hahna, pum na, vun natna te i nei thei. Chungte chu hun kal zelah a reh tlangpui. |
| Risk bik (immunosuppressed a nih chuan) . | I taksa "defense force" a chak lo a, chuvang chuan natna hrik i kai tam zawk.. Khawsik emaw, flu emaw pawh nise a na thei hle. Chuvangin, mipui tamna hmuna inthiarfihlim leh kut sil fo ang chi thilte hi i fimkhur tur a ni. Khawsik, khuh, thawk harsa tih ang chi symptom i neih chuan doctor pan nghal tur a ni. |
| Risk bik (immunity tihchak hunah) . | A châng chuan immune system chu a overstimulated thei a, tissue hrisel tak takte chu a bei tan thei bawk. Hei hian hormone lama harsatna, vun lama harsatna, leh riltam ang chi thil a thlen thei a ni. |
Eng pawh ni se, i doctor chuan heng hlauhawmnate hi a hre chiang hle. Chuvang chuan a enfiah fo ang che a, a tul angin thisen test a ti ang che a, i damdawi ei tur zat pawh a siamrem ang che a, a enkawl tha ang che. I tih tur chu i doctor hnenah i danglamna emaw, i rilru hahna emaw i neih apiang hrilh mai tur a ni.
Take-Home Thuchah a ni
- Immunomodulators hi damdawi chak tak leh specialized class a ni a, a tul angin i immune system hnathawh a tidanglam thin.
- Hengte hi immunity tihchak nan (cancer ang natnaah) emaw, tihtlem nan (autoimmune natnaah) hman theih a ni.
- Hengte hi natna tidamtu pangngai ang a ni lo. Hengte hi natna bulpui tichhe thei damdawi te an ni.
- Heng damdawi ei lai hian natna hrik laka inven nan a bik takin fimkhur hle ang che .
- Side effect emaw, symptom thar emaw i neih chuan doctor hnenah hriattir hreh suh .
- Heng damdawi te avang hian tun hmaa enkawl harsa nia ngaih natna tam tak chu tunah chuan hlawhtling taka thunun theih a ni ta. Chuvangin damdawi lam thurawn dik taka zawm a pawimawh hle.
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