I taksa hian nunna nei loin a inhria em? Chu chu Myasthenia Gravis (MG) a ni em? Kan sawi dawn nia!

Ni a lo kal zel a, a chang chuan chau tak leh nunna nei lo angin i inhria em? A bik takin i mit chu a khar ang maia i hriat laiin, thusawi, ei leh in, kut emaw, ke emaw pawh chawi a harsat lai hian? Heng thilte hi hahna mai ni lovin a tam thei hle. Vawiin hian Myasthenia Gravis , emaw (MG) a tawi zawngin, a buaithlak deuh a, mahse uluk taka enkawl a nih chuan enkawl tha theih a nih thu kan sawi dawn a ni

Myasthenia Gravis chu eng nge ni? A awlsam zawngin...

Myasthenia gravis hi autoimmune natna a ni a. Eng nge ni? A awlsam khawp mai. Kan taksaah hian immune system kan nei a. Kan taksaah sipai awm ang mai a ni. A hna chu pawn lam atanga hrik leh natna lo chhuakte do a, min venhim hi a ni. Mahse, a chang chuan he sipai hian tlem a tisual thin. Kan taksaa cell hrisel tak takte pawh hi hmelma niin a ngai a. Tichuan, chu cell hrisel tak takte chu a bei tan ta a ni. Chu chu myasthenia gravis-ah pawh a thleng thin.

Hei hian ruh ruh (skeletal muscles) a nghawng ber a ni . Chu chu kan ruh nena inzawm tlat, kan chetna tura min puitu ruh (muscles) te hi a ni. Ngaihtuah teh, i kut i phar a, i mit i chhing a, i tawng a, i nui a, i ei a, i kal... Heng taksa peng hrang hrangte hian heng zawng zawngah hian a pui a ni. Myasthenia gravis veiah chuan heng ruhte hi a chak lo va, nunna nei lovin a awm ta a ni.

A pawimawh ber chu he taksa chak lohna hi hnathawh leh active lai hian a pung a, tlem i chawlh hian a tlahniam bawk . Zingkar i thawh chuan i dam tha a nih pawhin, ni a lo kal zel a, i hna i thawh chuan zawi zawiin i chau zual a, i taksa ruhte pawh a chak lo zual sauh sauh thin.

Hei hi natna khirh tak a ni a, hun rei lote chhungin a bo lo tihna a ni. Mahse, lungngai suh, i symptoms control theihna tur leh nun pangngaia nunpui thei tur enkawlna tha tak tak a awm .

Engvangin nge hetiang hi a lo awm? Kan taksa chhungah eng thil nge thleng?

Hei hi hrethiam tur chuan entirnan tlem han la ila. Cricket match en lai kha han mitthla teh.

Kan nerve te hi pitcher a ni. Muscle-ah message thawn chhuaktu an ni.

Kan taksa ruhte hi a mantu a ni. Thuchah mantu an ni.

Heng pahnih thuchah inthlengna hmun hi neuromuscular junction an ti a . Chu chu khelhna hmun a ni.

Tunah chuan nerve pakhatin taksa ruh pakhat hnena thuchah a thawn a ngaih chuan chu nerve chuan acetylcholine (hei hi ball a ni) an tih chemical a tichhuak thin. Muscle te hian he acetylcholine hi man theihna hmun bik an nei a, chu chu acetylcholine receptors an ti a (hei hi keeper’s glove a ni).

Ball-in glove a tawk ang bawkin, taksa ruh chu a inzawm khawm a, chu chu a thawk chhuak a, chu chu acetylcholine chu a kal a, chu receptor-te nena a inzawm chuan a ni. Hei hi mi hrisel taksaah chuan a thleng rang hle a, tihbuai lohvin a thleng thin.

Mahse, myasthenia gravis vei chunga thil thleng chu a hmaa kan sawi tawh immune system hian heng acetylcholine receptor (catcher’s glove) te hi a tichhia emaw, a block emaw tihsual hi a ni. Tichuan nerve atanga message (ball) lo chhuak chu muscle (keeper) chuan a man tha thei lo. Thuchah inthlengna hi a thleng zawi hle a, a thleng lo tak zet a ni. Chuvang chuan taksa ruhte chu a chak lo ta a ni. I hrethiam em?

Myasthenia gravis hi chi hrang hrang a awm em?

Ni e, a bik takin chi hrang hrang a awm a:

• Autoimmune myasthenia: Hei hi a tam ber a ni. Kan sawi tawh ang khan immune system a malfunction vang a ni. Hei hi a chhan dik tak hriat ni lo mah se, antibody chi hrang hrang siam chhuah avanga lo awm niin an ngai .
• Neonatal myasthenia: Hei hi naute hian naupai laiin myasthenia gravis vei nu hnen atanga antibody thenkhat a dawn hian a thleng thin. Nausen a pian hnuah a tap nêm deuh a, a hnute pawh a harsat phah thei bawk. Mahse, hei hi hun eng emaw chen atan a ni a, a tlangpuiin thla thum vel hnuah a tha leh thin.
• Congenital myasthenia: Hei hi autoimmune condition a ni lo. Genetic change avanga lo awm chi rare tak a ni .

Autoimmune myasthenia gravis hi subtype lian pahnih a awm bawk a:

1. Ocular myasthenia: Hemiah hian mit tikehsawmtu leh mitmeng tisangtu ruh te chu a chak lo hle. Mitmeng a tla (ptosis) , a nih loh leh mit khap reng a harsa thei bawk. Mi thenkhat chuan thil pahnih (double vision) an hmu thei bawk. Vawi tam tak chu myasthenia chhinchhiahna hmasa ber chu mit chak lohna a ni . Hetiang ocular myasthenia vei zinga a chanve vel chuan a hnuah chi dang hi an nei leh ang.

2. Generalized myasthenia: Hemiah hian mit ruh bakah hian hmai, kawng, kut, ke, leh kawr ruh te pawh a chak lo hle. Thusawi te, chaw ei te, kut phar te, thutthleng atanga tho te, hla taka kal te, stairs chho te chu a harsa thei hle.

Myasthenia gravis natna lan chhuah dan chu engte nge ni?

Symptoms hi a inang lo thei hle nachungin, a langsar zualte chu:

• Kut, kut zungtang, ke leh kawr chhunga thau chak lohna .
• Chau lutuk (chau lutuk) .
• Mitmeng tla (ptosis) .
• Blurry emaw double vision emaw .
• Hmêl lantîr harsat (nui ṭha thei lo, hmel siam ang chi).
• Thusawi harsa, ei harsa, emaw, ei harsa . Entîr nân, i thusawi chuan i aw chu a danglam zauh zauh thei a, chu chuan aw râpthlâk tak anga i sawi ang maiin a ri thei a ni.
• Kal harsat .

Myasthenia gravis natna lan chhuah hmasak ber chu a lo lang nghal mai thei. Kan sawi tawh ang khan i taksa ruhte chu i thawhrim laiin a chak lo va, i chawlh laiin chakna an nei leh bawk . He taksa chak lohna nasat dan hi nitin a inang lo thei. Mi tam tak chuan ni tir lamah an rilru a hahdam a, a tawpah chuan an chak lohna lai ber an ni.

A tlem hle a, myasthenia gravis hian thawkna kawng ruhte pawh a nghawng thei bawk . Hei hian thawk harsa emaw, thawk lama harsatna lian zawk emaw a thlen thei a ni. Thâwk lama harsatna nei anga i inhriat chuan emergency a ni. Damdawi in hnai ber pan nghal tur a ni. Hei hi vawi khatah a thleng vek lo tlangpui.

Hemi atan hian tute nge hlauhawm ber?

Myasthenia gravis hi kum eng pawhah a lo awm thei a, mahse hmeichhia kum 40 hnuai lam leh mipa kum 60 chunglam ah a tam zawk tlangpui .

A hnuaia thilte avang hian he natna hi i vei theihna chance a sang zawk thei a ni:

• Autoimmune condition dang (e.g. rheumatoid arthritis, lupus) i neih chuan.
• Thyroid natna i neih chuan .

Myasthenia gravis i vei tawh a nih chuan thil thenkhat chuan i symptoms a ti na zual thei a ni:

• Malaria leh heart rhythm disorder damdawi thenkhat.
• Operation neih mek a ni .
• An natna hrik .

Thymus gland leh myasthenia gravis te hi eng inzawmna nge ni?

Myasthenia gravis vei tam tak chuan an thymus gland ah harsatna an nei thin . Thymus gland hi kan rilru chunglam, hnute ruh hnuai chiaha awm, taksa peng te tak te a ni. Kan lymphatic system-a tel a ni. Thisen var siamtu organ a ni a, natna hrik dotu a ni.

Myasthenia gravis vei hmun thuma ṭhena hmun hnih vel chuan thymic hyperplasia , thymus gland chu a thawk nasa lutuk tihna a ni. Chu bâkah, mi sâwm zînga pakhat vêl chuan thymus gland-ah tumor an nei a, chu chu thymomas . Chungte chu cancer emaw, benign emaw pawh a ni thei. Thymus gland-a heng thil dik lo awmte hian immune system a thawk tha lo hle niin an ngai.

Myasthenia gravis natna avanga harsatna awm thei te chu engte nge ni?

A bulpui ber chu myasthenic crisis an tih condition a ni . Chutah chuan thawk tura puitu ruhte chu a chak lo hle a ni. Tichuan, thawk chhuahna tur machine (respirator/mechanical ventilation) ang chi thil i mamawh mai thei. Hei hi medical emergency a ni a, nunna atana hlauhawm thei a ni.Myasthenia gravis vei mi panga zinga pakhat vel chuan an dam chhungin vawi khat tal he natna hi an tawk dawn niin an sawi.

Chu bâkah, he taksa chak lohna leh hahna hian i thil tih nuam tihnaah i tel thei lo thei bawk. Stress leh depression a thlen thei bawk . Mahse, zirchianna atanga a lan dan chuan myasthenia gravis vei tam tak chuan light activity an ti thei a, nitin exercise an ti thei bawk.

Doctor-te hian engtin nge myasthenia gravis hi an hriat theih?

I doctor-in i natna lan chhuah dan a ngaihthlak hnu leh taksa enfiahna a neih hnua a rinhlelh chuan test eng emaw zat an ti ang a, chu chu finfiah turin an ti ang:

• Thisen antibody test: Myasthenia gravis vei zinga 85% vel chuan an thisenah acetylcholine receptor antibodies a tam lo hle. 6% dang chuan muscle-specific kinase (MuSK) laka antibodies an nei bawk.
• Imaging scan: MRI (Magnetic Resonance Imaging) emaw CT scan (Computed Tomography scan) emaw hmangin thymus gland-a tumor awm ang chi harsatna a awm leh awm loh enfiah thin a ni.
• Electromyography (EMG): He test hian taksa peng leh nerve te electrical activity a teh thin. Nerve leh muscle inkara inbiakpawhna lama harsatna awmte a hmuchhuak thei a ni.

Doctor-te chuan myasthenia gravis hi natna nasat dan azirin an thliar hrang a. A tlangpuiin class panga (Class I - V) a awm a. Class I hi mit chauh tichhe thei natna na lo tak a ni a, Class V erawh chu thawkna tichhe thei natna khirh tak a ni a, a chang chuan intubation emaw mechanical ventilation emaw a ngai thin

Myasthenia gravis hi eng enkawlna nge ni?

Myasthenia gravis hi damdawi a awm lo a , mahse i natna lan chhuah dan tur enkawl thei tur leh nun tha tak nei thei tur enkawlna tha tak tak a awm a ni.

• Damdawi hman tur: 1.1.
• Cholinesterase inhibitors / anticholinesterase: Heng damdawi te hian nerve leh muscle inkara inbiakpawhna a tichak a, taksa chakna a tipung a ni.
• Immunosuppressants: Corticosteroid ang damdawi te hian immune system overactivity tihziaawmna leh chutiang antibody dik lo siam chhuahna tihtlem hmangin hna a thawk a ni.
• Monoclonal antibodies: Hengte hi bioengineered protein an ni. Intravenous (IV) injection emaw, subcutaneous (SQ) injection emaw angin pek an ni. Immune system hnathawh tam lutuk chu an control a ni.
• Plasma exchange / plasmapheresis: Machine hian thisen atanga plasma, antibody tha lo tak tak awmna chu a la chhuak a, chu chu plasma emaw, donor atanga plasma solution emaw hmangin a thlak thin.
• Intravenous emaw subcutaneous immunoglobulin (IV emaw SQ Immunoglobulin - IVIG emaw SCIG): Donor atanga antibody te hi ni hnih atanga ni nga chhunga intravenous (IV) injection hmanga pek thin a ni. Hei hi myasthenic crisis bakah generalized myasthenia gravis enkawlna a ni.
• Surgery: Thymectomy tih hi thymus gland surgery hmanga lakchhuahna a ni. He surgery hi thymoma vei tan a tha a, chutiang bawkin thymus tumor nei lo tan pawh a tha hle.

Heng enkawlna zawng zawng hian side effect engemaw zat a nei thei a, chuvangin damdawi thar i ei tan hmain i doctor nen inbia ang che.

In lamah eng nge ka tih theih ang, symptoms tihziaawm nan?

Myasthenia gravis i vei chuan i hahna tihziaawmna tur leh taksa ruh chakna tihpun nan heng thilte hi han ti ve teh:

• Exercise neih fo: Mahse, i doctor i zawh hnuah chauh i duh ang exercise program him tak i tan ang. Exercise hian taksa ruh a tichak a, mood a ti tha a, i taksa chakna a pe bawk.
• Khua lum lutuk karah chhuah loh tur: Khua lum hian symptoms a ti na zual thei. I lum hle tih i hriat chuan i kawr leh i hmaiah puan tui lum a hnim hrual chu dah la.
• I chaw eiah protein leh carbohydrates tam tak telh la: Taksa tan chakna sang zawk an pe a ni.
• Ni hmasa berah hna i hah ber nia i hriatte chu ti rawh: chutih lai chuan chakna i nei tam ber a ni.
• Nitin mut rei emaw chawlh hahdam emaw: Hei hian i taksa chu chawlh hahdam tlem a pe ang.

Myasthenia gravis hmalam hun chu eng nge ni? (Hmuh dan tur) .

Myasthenia gravis hi enkawl theih a ni a . A lan chhuah dan chu a na lo atanga a nasat thlengin a awm thei. A natna lan chhuah dan hi a tir atanga kum khat atanga kum thum chhungin a sang ber a thleng tlangpui.

Mi tam tak chu enkawlna nen nun famkim, active takin an hmang thin.

A chang chuan natna hi remission ah a kal thei bawk . Chumi awmzia chu a natna lan chhuah dan chu rei lo te chhung a bo tihna a ni. Hei hi hun eng emaw chen atan emaw, chatuan atan emaw pawh a ni thei. Chutiang a nih chuan i doctor chuan i enkawl dan tur a thlak danglam ang.

Myasthenia gravis vei tam tak chu nun pangngaiin an hmang thin . Nunna atana hlauhawm tak chu thawk a nghawng chauhvin a thleng a, chu chu kan sawi tawh myasthenic crisis ang kha a ni.

Myasthenia gravis leh naupai lai

A tlem berah chuan naupai hian myasthenia gravis symptoms a rawn lang hmasa ber thei. He natna hi i neih tawh chuan naupai thla thum hmasa berah emaw, naute i neih hnuah emaw i natna lan chhuahna chu a zual thei hle. Mahse, a then phei chuan naupai laiin i natna lan chhuah dan a tha thei hle.

Enkawlna thenkhat chu naupai lai leh nau hnute pek lai hian a him lo . Chuvangin naupai hrisel tak neih theih nan he hun chhung hian doctor kaihhruaina lak a pawimawh.

Engtikah nge Doctor ka hmuh ang?

Heng symptoms te hi i neih chuan doctor pan rawh:

• Blurred vision emaw double vision emaw a awm thei.
• Kea kal, thusawi, ei leh in lama harsatna.
• Muscle hahna nasa tak emaw chak lohna emaw.
• Thâwk harsa.

Thâwk harsa i neih chuan emergency a ni tih hre reng ang che! 911 (i awmna hmuna emergency number) call nghal la, damdawi in hnai ber pan rawh.

Doctor hnenah eng zawhna nge ka zawh ang?

Doctor hnenah hetiang zawhna hi i zawt thei ang:

• Eng thilin nge heng symptoms te hi a thlen?
• Ka tan chuan eng enkawlna tha ber nge ni ang?
• Enkawlnate hian eng side effect nge a neih?
• Eng nunphung tihdanglamna nge ka neih?
• Complication chungchangah eng symptom nge ka fimkhur tur?
• Exercise program hi him takin ka tan thei ang em?
• Patient support group ka zawm theih tur a awm em?

A tawp berah chuan hriat reng tur (Take-Home Message) .

Myasthenia Gravis hi natna khirh tak a ni thei. Active taka awm duh mah la, a châng chuan i chau hle thei a, i chak lo hle bawk. Hei hian hun kal zelah i rilru leh taksa hriselna a nghawng thei a ni.

Mahse, damdawi awm lo mah se, enkawlna nen chuan mi tam tak chu nun famkim, active takin an nung thei tih hre reng ang che. Myasthenia gravis avanga rualbanlo na tak hi a awm lo. I doctor chuan i natna lan chhuah dan tur a rawn rawt thei a, chutiang chuan i dam thei ang. Hlauthawng suh la, hei chauh hi hmachhawn tum suh. I doctor thurawn zawm la, i mamawh tanpuina dawng rawh. Dam leh thuai turin duhsakna ka hlan e!

` Myasthenia Gravis, Myasthenia Gravis, Taksa chak lohna, Autoimmune natna, Acetylcholine, Thymus gland, Neuromuscular junction