I chhungkuaa mi tu emaw, i pa emaw, i nu emaw, i hriat mi emaw pawh ni se, Parkinson natna vei an nei em? An kut a nghing te, an kal harsat te, an taksa a nghet lo te, an hmaiah hriatna zawng zawng a hloh te i hmuh chuan i lungngai hle ngei ang. He natna nena khawsak hi a awlsam lo tak zet a ni. Mahse a tha ber chu tunlai damdawi lam thiamna changkang tak tak hmang hian, damdawi dik tak hmangin heng natna lanchhuahna te hi nasa takin i thunun thei a, nun tha takin i nung thei a ni. Chuvangin vawiin hian Parkinson natna damdawi pek chungchang hi awlsam tak leh ngilnei takin i sawi dawn nia.
A hmasain, Parkinson natna hi eng nge ni tak tak?
Hei hi awlsam takin i hrethiam ang u. Parkinson’s hi kan nervous system nena inzawm natna a ni. A bik takin kan thluak. Hun kal zelah a zual zel a . Kan thluak chhungah hian `substantia nigra` an tih hmun pakhat a awm a, chu chuan chetna a thunun a ni. He lai hmuna nerve cell te hi a chhe vek a, zawi zawiin an thi thin.
Heng nerve cell te hian kan taksa tana chemical messenger pawimawh tak, `neurotransmitter` an siam chhuak thin. A hming chu dopamine a ni . He dopamine hi kan taksa che vel a mumal a, a thunun theih nan a pawimawh hle. Chuvangin chu nerve cell te chu a chhiat chuan thluaka dopamine level chu a tlahniam ta a ni. Chuvangin Parkinson natnaah hian symptoms, khur, kal harsa, leh stiffness te hi a awm thin.
A pawimawh ber chu Parkinson natna damdawi pek hian heng symptoms te hi a control a ni. Tunah hian he natna hi damdawi a la awm lo. Mahse, heng damdawi te hian natna lan chhuah dan control leh nunphung tihchangtlunna kawngah nasa takin a pui a ni.
Parkinson natna damdawi ber berte
Parkinson natna enkawl hian doctor-te chuan damdawi pakhat chauh ni lovin, damdawi engemaw zat inzawmkhawm an hmang fo thin. Chungte chu mimal natna lan chhuah dan, kum leh natna stage a zirin a inang lo. Damdawi chi hrang hrang hi han thlir ila.
1. Levodopa leh Carbidopa te
Hei hi Parkinson natna damdawi ber leh tangkai ber a ni. Rangkachak tehfung an ti bawk.
- Levodopa: He damdawi hi kan taksaa a luh chuan thluaka a lut a, dopamine-ah a chang ta a ni. Chu chu he damdawi hian thluaka dopamine a tlakchham tawh zat chu a siam tha leh thin tihna a ni.
- Carbidopa: Mahse harsatna a awm. Levodopa ringawt kan ei chuan a tam zawk hi kan taksaa enzyme awmte hian thluak a thlen hmain a tichhia a ni. Hei hi tihtawp nan hian damdawi carbidopa an tih chu levodopa nen an pe dun a. Carbidopa hian levodopa tam zawk chu thluak ah him takin a thleng thei a ni. Tin, carbidopa hian levodopa chauh ei avanga side effects, natna leh riltam te a tihziaawm bawk.
Hetiang damdawi inkawp hian bradykinesia symptoms, stiffness, leh tremor symptoms te tan a thawk tha hle fo thin.
| Damdawi chi hrang hrang | Sri Lanka rama Brand Name hman tlanglawn tak tak te |
|---|---|
| Levodopa leh Carbidopa te hi a inzawm khawm a ni | Sinemet®, Rytary®, Parcopa®, Dhivy® te a awm bawk |
2. Dopamine Agonists te hi a awm a
Hetiang damdawi chi hi actor ang mai a ni. Chu chu, a takah chuan dopamine a ni lo tihna a ni. Mahse thluak lamah a kal a, dopamine angin a thawk a ni. Thluaka dopamine receptor te a tichak a, thluak chu dopamine a awm tih hriatna a pe a ni.
Heng damdawi te hi natna tan tirh lamah an pe tlangpui a, a bik takin damlo naupang zawkte tan an pe thin. A chang chuan levodopa hnathawh rei zawk nan an pui thei bawk.
- Pramipexole (Mirapex®) hmanga siam a ni.
- Ropinirole (Requip®) hman a ni.
- Rotigotine (Neupro®) hmanga siam a ni.
3. Enzyme tihkhawtlai thei thil
He hming i hriat hian hlau suh. A awlsam khawp mai. Kan taksaah hian dopamine tichhe thei enzyme a awm tih kan sawi tawh a. Heng damdawi te hian an tih chu chu enzyme te hnathawh chu a titawp a ni. Tichuan thluaka dopamine awm chu rei tak a chhe lo.
Hengte hi chi hnih a awm a, chungte chu:
- MAO-B Inhibitors: Hengte hian thluaka dopamine tichhe thei enzyme lian tak `MAO-B` hnathawh a tikhawlo a ni. Entirnan: `Selegiline`, `Rasagiline` tih te hi a ni.
- COMT Inhibitors: Hengte hian levodopa atanga lo chhuak dopamine tichhe thei enzyme `COMT` chu a titawp a ni. Hei vang hian levodopa hian nghawng a nei rei zawk. Entirnan: `Entacapone`, `Opicapone` tih te hi a ni.
4. Amantadine a ni
Damlo thenkhat chuan levodopa ang damdawi rei tak an ei chuan an duh loh zawng, jerky movement (dyskinesia) an nei thei. Heng natnate enkawlna atan hian Amantadine hi hman a ni ber. Mak tak maiin a tir chuan antiviral drug anga siam a ni. Mahse a hnuah Parkinson natna lan chhuahnaah pawh a puih thu hmuhchhuah a ni.
5. Anticholinergic Damdawi hman tur
He damdawi hian tremor leh rigidity a pui ber.Thunun. Kan thluaka dopamine a tlahniam chuan `neurotransmitter` dang acetylcholine an tih hian nghawng a nei nasa hle. Heng damdawi te hian chu acetylcholine hnathawh chu a tikhawlo thin. Entirnan: `Benztropine`, `Trihexyphenidyl` tih te hi a ni.
Incheina nena inzawm lo symptom dang damdawi
Parkinson natna hian che vel chauh a nghawng lo. Harsatna dang a thlen thei bawk a, chu chu chaw ei kham, mut harsatna, lungngaihna, leh mipat hmeichhiatna lama harsatna te a thlen thei bawk. Heng zinga pakhat zel atan hian i doctor chuan damdawi a pe ang.
| Symptom a ni | Damdawi chi hrang hrang pek theih |
|---|---|
| Erectile dysfunction a awm thin | Damdawi Sildenafil (Viagra®) ang chi te hi a ni. |
| Nitin mutthilh lutuk (Hypersomnia) . | Modafinil (Provigil®) tih a ni. |
| Ek khal | Stool ti nemtu, polyethylene glycol (MiraLax®) ang chi te hi a ni. |
| Chau | Methylphenidate (Ritalin®) hmanga siam a ni. |
| Dementia natna (dementia) a awm | Cholinesterase tihkhawtlai a ni |
| Lungngaihna/Lungkhamna | SSRIs (Selective Serotonin Reuptake Inhibitors) te hi a tha ber pawl a ni. |
| Psychosis/Hallucinations te a awm thei | Antipsychotic damdawi pimavanserin ang chi te |
Heng damdawi te hian side effect a neih dan te pawh i zir dawn bawk ang.
Damdawi dang ang bawkin Parkinson damdawi hian side effect a nei thei a ni. Hengte hi hriat lawk a pawimawh. Mahse, mi zawng zawng hian heng side effects te hi kan nei vek lo. Tin, damdawi hman chhunzawm zel a nih chuan heng zinga thenkhat hi a bo vek bawk.
| Damdawi chi hrang hrang | Side effect awm fo thin |
|---|---|
| Levodopa a ni | Nausea, luak chhuak, luak chhuak, lu na, nitin mutthilh, postural hypotension. Tarte zingah rilru buai leh hallucination a awm thei. |
| Dopamine Agonist te hi an ni | Hallucinations, rilru buai, mutthilh, luak chhuak, hmui vawt, luak chhuak. Hengte hi damdawi ei tan tirh ni engemaw zat chhungin a thleng tam zawk thei a, chutah chuan a tlahniam thei bawk. |
| Enzyme tihkhawtlai thei te | (COMT inhibitors): ril\am, chetna thunun theih loh (dyskinesia). (MAO-B inhibitors): Chhung na, luak chhuak, hmui a vawt, luak chhuak. |
| Amantadine a ni | Thil ngaihtuah harsa, rilru buai, mut theih lohna, mumang chhia, ke hring. |
| Anticholinergics hmanga siam a ni | Kawng a vawt, mit a fiah lo, mutthilh, chaw ei kham, zun harsa, hriatrengna lama harsatna. |
Pawimawh tak: Levodopa ei kha bansan suh emaw, a dose hi tihhniam nghal mai suh, eng thil vang pawh nise doctor thurawn tel lo chuan. Chutianga tih chuan natna khirh tak, nunna atana hlauhawm tak, `parkinsonism hyperpyrexia syndrome` tih chu a thlen thei a ni.
Damdawi hi a tawk lo em ni? Eng dang nge tih theih ang?
Damdawi hi indona hmun khat chauh a ni tak zet a ni. Damdawi nena thil dang tlemte i tih chuan i natna lan chhuah dan chu i thunun tha zawk thei a, hlim takin i awm thei bawk.
Taksa lam enkawlna
Hei hi tih tur a ni ngei ang. Parkinson vei tan bik physical therapy programme a awm a. Chûngte chuan a ṭanpui ang che, .
- I taksa balance leh gait i titha thei a ni.
- Taksa stability a tipung thei a ni.
- Nun chak tak neih theihna turin nasa takin a pui a ni.
Exercise tih hi a ni
Exercise hi Parkinson natna enkawl dan tha ber a ni. Exercise hi scientifically-in natna a zual zel dan a tikhawtlai tih finfiah a ni. Kar khatah minute 150 tal cardiovascular exercise neih a tha ber. Cycle khalh, boxing, leh music-a exercise tih ang chi thilte hian a pui hle.
Rilru hriselna enkawl
Parkinson’s ang natna rei tak nena kan nun hian lungngaihna, lungkhamna leh lungkhamna te hi a awm fo thin. Chuvângin, hetiang hian i awm a nih chuan, chu chu zah lo tûr leh rilru lam hrisêlna lama mithiam, psychologist ang chi hnêna ṭanpuina dîl a pawimawh a ni.
Engtikah nge doctor i hmuh leh tur?
Parkinson damdawi i hman hian doctor pan fo a pawimawh a, damdawi hian hna a thawk em tih leh symptom thar a lo awm em tih enfiah a pawimawh hle. A bik takin hengte hi doctor pan ngei ngei tur a ni.
- I tuar theih loh side effect i neih chuan .
- I symptoms a lo tha lo emaw a nasat loh emaw chuan .
- I damdawi ei kha tihtawp i duh chuan . (He thutlukna hi nangmah chauhin siam ngai suh!)
Take-Home Thuchah a ni
- Parkinson natna damdawi hian natna hi a tidam kim thei lo a, mahse a natna lan chhuah dan a thunun thei a, nunphung a titha thei bawk.
- Chumi atan chuan Levodopa hi damdawi ber leh tangkai ber a ni.
- Damdawi zawng zawng ang bawkin side effect a awm thei. An chungchang hi i doctor nen zalen takin sawipui rawh.
- Damdawi ei kha bansan suh la, doctor thurawn tel lo chuan eng thil vang pawh nise a dose thlak suh. A hlauhawm thei hle.
- Damdawi bakah hian physical therapy leh exercise neih fo hi natna control nan a pawimawh hle.
- He zinkawngah hian i rilru hriselna kha uluk takin enkawl ang che. A tul chuan professional tanpuina zawng rawh.
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