Viral infection control tu protease inhibitor chungchang i zir dawn teh ang.

Natna hrang hrang damdawi chi hrang hrang kan hre vek tawh a ni lawm ni? Vawiin hian ruihhlo chi hrang hrang tlem kan sawi dawn a ni. Chungte chu ‘Protease Inhibitors’ an ti a. He hming hi i hre lo mai thei, mahse he damdawi chi hi HIV/AIDS, Hepatitis C, leh COVID-19 ang chi virus infection na tak tak control nan a pawimawh hle. Chuvangin hengte hi eng nge an nih, engtin nge an hnathawh tih leh an chungchanga hriat tur pawimawh ber berte chu i lo thlir ang u.

A awlsam zawngin, heng protease inhibitor te hi engte nge ni?

A awlsam zawngin, protease inhibitor hi damdawi chi khat a ni a, virus infection enkawlna atana hman thin a ni . An hnathawh ber chu virus pakhatin kan taksa a a luh veleh a copy a siam loh nan a titawp a, chu chu a darh zau thei lo tihna a ni. He damdawi hian a bul berah chuan virus hi a darh loh nan a ‘block’ a ni.

He damdawi hi HIV/AIDS enkawlna atana hman thin antiretroviral drug tia hriat lar ber a ni. Hepatitis C leh COVID-19 enkawlna atan pawh hman a ni.

A châng chuan heng protease inhibitor te hi a chauhvin pek a ni (monotherapy). Mahse a tam zawkah chuan antiviral damdawi dang nen pek dun an ni. Hei hi enkawlna thatna tihpun nan tih a ni. Hetiang a nih chuan "booster" an ti bawk.

He damdawi hmanga enkawl dan ber berte chu engte nge ni?

Viral infection bik tlemte enkawlna atan hian damdawi class pakhat protease inhibitors tih chu pawm a ni. Eng nge an nih i han thlir teh ang.

He damdawi hian engtin nge hna a thawh?

Hei hi hrethiam tur chuan entirnan tlem han la ila. Virus chu protein chain sei tak siamna factory a ni tih han ngaihtuah teh. He chain sei tak hi hnathawhna atana hman tur chuan a te te, hnathawk thei tak takah a then a ngai a ni. He cutting atana virus hian a hman bik ‘scissors’ te hi enzyme ‘proteases’ an tih te an ni.

Protease inhibitor chi hrang hrangte chu engte nge ni?

Virus tin hian anmahni protease enzyme an neih avangin HIV, hepatitis C, leh COVID-19 te enkawlna atan hian protease inhibitor chi hrang hrang hman a ni. Anmahni hriat theih dan awlsam tak a awm bawk.

• HIV enkawlna atana hman damdawi hming hi "-navir" tiin a tawp tlangpui.
• Hepatitis C damdawi hman hming hi "-previr" tiin a tawp tlangpui.

HIV tana protease inhibitor a ni

Hengte hian HIV-PR an tih protease enzyme chu an block a, chu chu HIV virus hian a copy siam nan a hmang thin.

• Atazanavir a ni
• Darunavir a ni
• Fosamprenavir hmanga enkawl a ni
• Indinavir a ni
• Lopinavir a ni
• Nelfinavir a ni
• Ritonavir a ni
• Saquinavir a ni
• Tipranavir a ni

Hepatitis C tan hian protease inhibitor a awm a

Hengte hian enzyme pakhat NS3/4A serine protease an block a, chu chu hepatitis C virus hian a copy siam nan a hmang thin.

• Boceprevir hmanga enkawl a ni
• Glecaprevir hmanga enkawl a ni
• Grazoprevir hmanga enkawl a ni
• Paritaprevir hmanga enkawl a ni
• Simeprevir hman a ni
• Telaprevir hmanga enkawl a ni

COVID-19 tan Protease inhibitor a ni

Paxlovid® hi protease inhibitor pahnih, nirmatrelvir leh ritonavir te inzawmkhawm a ni a, COVID-19 enkawlna atana hman a ni.

Engtin nge ka tan damdawi dik tak ka thlan ang?

Tunah chuan heng damdawi te hian ka tan eng nge a tih theih ang tih i ngaihtuah mai thei.I doctor chauhvin a rel thei ang. I tâna damdawi ṭha ber a thlan hunah thil engemaw zat a ngaihtuah ang.

• Eng viral infection bik nge i neih?
• I hriselna zawng zawng leh damdawi lam harsatna dang i neih theih zawng zawng (e.g. zunthlum, thinlung natna).
• Tunah hian eng damdawi dang nge i ei mek (hengte hi inzawmna a awm theih avangin).
• Hetiang dinhmun hi a hmain damdawi dang i ei tawh em?
• Damdawi hlawhtlinna chu i kaihhnawih virus chi hrang hrangah a innghat a ni.
• Damdawi avanga side effect emaw complication awm thei te chungchang.

Heng damdawi te hian eng side effects leh thatna nge a neih?

Damdawi dang ang bawkin protease inhibitor hian hlawkna leh side effect a nei vek a ni.

A thatna ber

• HIV vei tan ART enkawlnaah hian taksaa HIV virus awm zat chu hriat theih loh level-ah a awm theih nan a pui a ni.
• Hepatitis C infection tihdamna atan a pui.
• COVID-19 hri kai a nasat loh nan a pui thin.

Side effect awm thei te

Side effects chu damdawi i ei lai te, damdawi dang i ei lai te, leh i hriselna dinhmun ah a innghat a ni. Hemi chungchangah hian doctor nen inbiakna neih a pawimawh a, hriat reng a pawimawh bawk.

Enkawlna awlsam zawk nan eng nge ka tih theih ang?

Hetiang enkawlna i neih lai hian a side effect thenkhat tih tlem nan leh enkawlna awlsam zawka siam turin thil engemaw zat i tih theih a ni.

• I damdawi chu i doctor-in a tih ang chiah chiah, a hun takah, a dose dik takah ei rawh. Dose khat pawh skip suh.
• Tui tam tak in thin ang che. Hei hian kal (kidney)-a nghawng a neih chu a tiziaawm thei a ni.
• I damdawi nena inzawm thei damdawi dang ei loh tur. Hemi chungchang hi doctor zawt rawh.
• Damdawi thenkhat chu ei tur nena ei chuan a thawk tha zawk . Ṭhenkhat chuan chaw thau tak tak an mamawh a. I doctor hnenah i damdawi ei dan tur zawt la, chu thurawn chu zawm rawh.

Engtikah nge Doctor ka hmuh ang?

Enkawl laiin beisei loh taka nghawng i neih emaw, enkawlna chungchangah ngaihtuahna i neih emaw chuan i doctor hnenah zawh nghal rawh.

A bik takin, a hnuaia side effect na tak tak i neih chuan, tihkhawtlai lohvin doctor lam pan nghal la, a nih loh leh damdawi in hnai ber Emergency Department (ETU)-ah kal nghal rawh.

• Khawsik
• Buaina emaw rilru lam inthlak danglamna emaw
• Vun emaw mit emaw a sen (jaundice) .
• Blistering, na tak, emaw, hmun zau tak atanga lo chhuak
• Pum natna nasa tak
• Luak chhuak nasa tak