Triple-Negative Breast Cancer chungchanga hriat tur awmte

Tu pawhin hnute cancer tih thumal an hriat hian an hlauthawng deuh hi thil pangngai a ni. Mahse kan hriat tur pawimawh tak chu hnute cancer zawng zawng hi a inang vek lo tih hi a ni. A chi hrang hrang a awm a. Vawiin hian chi khat, tlem a tlem zawk, enkawl laiin ngaihven bik ngai chi kan sawi dawn a ni. Hei hi ‘Triple-Negative Breast Cancer’ (TNBC a tawi zawngin) kan ti a. He hming hriat hi i tan chuan a buaithlak deuhin a lang thei a, mahse hlau suh. Hemi chungchang hi awlsam takin, in hriatthiam theih angin kan sawi dawn a ni.

Engvangin nge hei hi ‘Triple-Negative’ an tih?

Awle, he hming awmzia atang hian tan ila. Hei hi hrethiam tur chuan hnute cancer cell pangngai hnathawh dan tur ngaihtuahna tlem kan neih a ngai a ni.

Kan taksaa cell awmte hi kawngkhar ang maiin han ngaihtuah teh. Chu kawngkhar chuan chabi dahna tur lock a nei a. Damdawi lamah chuan heng keyholes te hi ‘receptors’ kan ti thin. Heng receptor nena inmil key te an lo kal a, an inzawm chuan chu cell te chuan message thenkhat an dawng thin.

Receptor chi thum a awm a, chu chu hnute cancer-ah hian a pawimawh ber a ni.

1. Estrogen Receptors (ER): Hengte hi hmeichhe hormone estrogen nena inzawm a ni.

2. Progesterone Receptors (PR): Hengte hi hmeichhe hormone dang progesterone an tih nen a inzawm tlat a ni.

3. HER2 Receptors: Hei hi HER2 an tih protein nena inzawm receptor a ni. He protein hian hnute cell te than dan a control a.

Breast cancer chi tam takah chuan heng receptor pakhat, pahnih emaw, pathum emaw hi a overexpressed vek a ni. Chumi awmzia chu heng hormone leh protein te hian cancer cell te chu an ti thang lian thin tihna a ni. Meikhuah fuel dah ang mai a ni. Chuvangin doctor ten heng cancer te hi an enkawl hian heng receptor te hi an target a, anmahni block thei damdawi (targeted therapy) an pe thin. Heng damdawi te hian chu ‘keyhole’ te chu an khar thin. Tichuan cancer cell te hian an thanlenna atana an mamawh thuchah an dawng lo.

Tunah chuan buaina chu khawiah nge a awm tih i hrethiam mai thei em? Receptor target tu damdawi hmanlai te hian he cancer chi hi a thawk thei lo. A chhan chu target tur receptor a awm lo. Hei hi TNBC cancer-a harsatna lian ber a ni. Mahse chu chu enkawl theih a ni lo tihna erawh a ni lo. Hei hi enkawlna tha dang a awm a, chu chu a hnuah kan sawi leh ang.

He cancer natna lan chhuah dan hi engte nge ni?

Triple-negative breast cancer symptoms hi hnute cancer dang nen a inang hle. I hnuteah thil danglam bik i hmuh chuan ngaihven a pawimawh.

A hnuaia symptoms pakhat emaw a aia tam emaw i neih chuan hlauthawng suh la, a rang thei ang bera doctor pan rawh. Heng symptoms neih hian cancer a ni tihna a ni hauh lo va, mahse check a finthlak hle.

Mammogram pangngai hian cancer chu a lan chhuah hmain a hmuchhuak thei tih hre reng ang che. Chuvangin, a hun taka kum nena inmil screening neih a pawimawh hle.

He cancer vei theihna chhan leh a hlauhawmna te chu engte nge ni?

Zirchiangtute chuan he cancer thlen chhan chiang tak an la hmu lo a, mahse gene leh genes inzawmna nghet tak a awm tih an hmuchhuak a ni.

A bik takin, gene BRCA1 leh BRCA2 leh TNBC-a mutations te hi inzawmna nghet tak a awm a ni. A tlangpuiin heng BRCA genes te hian kan taksaa cancer lo thang lian zel tur control hna an thawk a ni. Car brake system ang maiin. Heng genes-ah hian defect emaw mutation emaw a awm chuan cancer control theihna a bo ta a ni. Heng gene mutations te hi kan nu leh pate hnen atangin kan rochun thei a ni.

Hei bakah hian TNBC cancer vei theihna tipungtu thil dang engemaw zat a awm bawk.

Engtin nge doctor hian hei hi a hriat chian?

Hnute lump chungchanga doctor i pan chuan i hnute chu a enfiah hmasa ang. Tichuan, i symptoms te an zawt ang che. Hei bakah hian an natna hriat chian nan test eng emaw zat an ti dawn bawk.

• Mammogram: Hnute X-ray hmanga enfiah a ni.
• Breast Ultrasound: Chu chu sound wave hmanga hnute chhunga tissue awmte thlalak lakna a ni.
• Breast MRI: Magnetic field leh radio wave hmanga thlalak chiang zawk, chipchiar zawk siam chhuah dan a ni .

Heng scan-te hian cancer a nih thu a hriat chuan, test pawimawh ber dawttu chu biopsy . Hei hian rinhlelh awm tak atanga tissue te tak te tak te chu needle te tak te hmanga lak a, microscope hmanga enfiah a huam a ni.

Chu bâkah, i doctor chuan BRCA ang chi genetic mutations a awm leh awm loh enfiah nân genetic testing neihpui tûrin a refer thei bawk che a ni. Heng zawng zawng hi i cancer stage hriat nan leh i tana enkawlna tur ruahmanna felfai ber siam nan hman a ni.

Hei hi eng enkawlna nge ni?

TNBC cancer enkawlna kawngah harsatna awm mahse, tunah chuan enkawlna tha tak tak tam tak a awm tawh a ni. I oncologist chuan i dinhmun a zirin enkawlna tur tha ber a rawn rawt ang che.

Enkawlna ber chu cancer tumor chu operation hmanga lakchhuah a ni. Tin, a hnuaia enkawlna pakhat emaw a aia tam emaw pawh hman dun theih a ni bawk.

• Chemotherapy: Hei hi TNBC enkawlna ber leh tangkai ber pakhat a ni. Chemotherapy hi operation hmaa tumor tihtlem nan pek thin a ni (neoadjuvant chemotherapy) leh operation hnuah cancer cell la awm zawng zawng tihhlum nan leh natna lo let leh tur venna atan (adjuvant chemotherapy) pek thin a ni.
• Radiation Therapy: Operation hnuah high-energy rays chu cancer awmna hmunah an kal a, chu chuan cancer cell la awm zawng zawng chu a tichhe vek a ni.
• Immunotherapy: Hei hi enkawlna thar tak a ni. Kan taksa ngeia kan taksa hriselna (immune system) te chu cancer cells te hriatchhuah leh beih theihna tura tichaktu hmangin hna a thawk a ni. TNBC vei thenkhat tan chuan he enkawlna hi chemotherapy nen pek dun theih a ni a, result tha tak tak a awm thei a ni.
• Targeted Therapy: TNBC vei BRCA gene mutations nei tan chuan damdawi bik, PARP inhibitor te hman thin a ni. Chûngte chuan cancer cell-te insiam ṭhat theihna tibuai chungin hna an thawk a ni.

Tunah hian khawvel hmun hrang hrangah TNBC tan hian clinical trial tam tak kalpui mek a ni. Damdawi thar leh enkawlna thar hmuhchhuah a ni reng a. Chuvangin he natna hmalam hun atan hian beiseina tha tak kan nei thei a ni.

Enkawlna hnua ngaihtuah tur thil

Surgery emaw, enkawlna dang emaw hnuah pawh harsatna a awm thei. Entirnan, surgery hliam chu natna hrik a lo awm thei a, thisen zam a lo awm thei bawk. Chuvangin, a hnuaia symptoms te hi i neih chuan doctor rawn nghal tur a ni.

Enkawlna hun chhunga hrisel taka awm theihna tura i tih theih tur

Cancer enkawlna hi taksa leh rilru lamah pawh a buaithlak hle. Hetih hun chhung hian tlem tal i rilru hahdamna tur thil tlemte a awm.

• Exercise light: Kea kal leh yoga ang chi thil tenawm tak takte hian stress a tihziaawm bakah i taksa chu chakna tha tak a pe bawk.
• Ei leh in tha: Ei tur tha tak tak ei la, chutah chuan protein tha lo (nga, vawk), thei, thlai, legumes, leh whole grains (brown rice, oatmeal) te a tel. Tui tam tak in thin ang che.
• I taksa rihna hrisel vawn reng: Research atanga a lan dan chuan i taksa rihna hrisel tak vawn reng hi i duh ang anga enkawl hi enkawlna atana puihna tha tak a ni.
• Rilru lam atanga tanpuina:I chhungte leh i thiante hnai tak takte hnenah i rilru put hmang te, hlauhthawnna te, leh lungkhamna te chu sawipui rawh. A tul chuan mental health counselor tanpuina la rawh.