ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ ꯈꯪꯍꯧꯗꯅꯥ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯂꯩꯕ꯭ꯔꯥ? ꯍꯦꯔꯤꯇꯦꯖ ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ (HAE)ꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯁꯤ!

ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯒꯤ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯃꯐꯃꯁꯤꯡꯗꯥ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯃꯈꯣꯌꯒꯤ ꯃꯥꯌ, ꯈꯨꯠ ꯑꯃꯁꯨꯡ ꯈꯣꯡꯗꯥ ꯈꯪꯍꯧꯗꯅꯥ ꯁꯣꯀꯄꯥ ꯎꯈꯤꯕ꯭ꯔꯥ? ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯈꯣꯡ ꯍꯥꯝꯕꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯗꯥ ꯑꯋꯥꯕꯥ ꯃꯥꯌꯣꯛꯅꯕꯒꯤ ꯈꯨꯗꯃꯁꯤꯡ ꯎꯕꯥ ꯐꯪꯂꯤꯕ꯭ꯔꯥ? ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯌꯥꯝꯅꯥ ꯇꯣꯏꯅꯥ ꯊꯣꯀꯄꯥ ꯑꯗꯨꯕꯨ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯥ ꯂꯩꯔꯝꯕꯥ ꯌꯥꯏ꯫ ꯉꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯔꯤ, ꯃꯗꯨꯗꯤ `ꯍꯦꯔꯤꯇꯦꯖ ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯦꯃꯥ (HAE)꯫ ꯋꯥꯈꯜ ꯋꯥꯕꯥ ꯂꯩꯔꯣꯏꯗꯕꯅꯤ, ꯑꯩꯈꯣꯌꯅꯥ ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯗꯣꯝꯅꯥ ꯈꯉꯕꯤꯕꯥ ꯌꯥꯕꯥ ꯏꯆꯝ ꯆꯝꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯒꯅꯤ꯫

ꯃꯁꯤ `ꯍꯦꯔꯤꯇꯦꯖ ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ (HAE)` ꯍꯥꯌꯕꯁꯤ ꯀꯔꯤꯅꯣ?

ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, `ꯍꯦꯔꯤꯗꯤꯇꯦꯔꯤ ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ` (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ `HAE` ꯍꯥꯌꯅꯥ ꯈꯪꯅꯕꯥ) ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯊꯣꯀꯄꯥ, ꯖꯦꯅꯦꯇꯤꯛ ꯑꯣꯏꯕꯥ (ꯃꯁꯤꯅꯥ ꯃꯤꯔꯣꯜ ꯀꯌꯥꯒꯤ ꯃꯔꯛꯇꯥ ꯄꯤꯕꯥ ꯌꯥꯏ ꯍꯥꯌꯕꯅꯤ) ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫ ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡꯒꯤ ꯍꯀꯆꯥꯡꯒꯤ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯃꯐꯃꯁꯤꯡꯗꯥ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯊꯣꯀꯍꯜꯂꯤ꯫ ꯃꯁꯤꯒꯤ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯑꯁꯤ ꯃꯄꯥꯟꯗꯥ ꯎꯕꯥ ꯐꯪꯗꯕꯥ ꯃꯐꯃꯁꯤꯡ, ꯍꯥꯌꯕꯗꯤ ꯈꯨꯠ, ꯈꯣꯡ ꯑꯃꯁꯨꯡ ꯃꯥꯌꯗꯥ ꯅꯠꯠꯔꯒꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯑꯩꯈꯣꯌꯅꯥ ꯎꯕꯥ ꯐꯪꯗꯕꯥ ꯃꯐꯃꯁꯤꯡꯗꯥ, ꯍꯥꯌꯕꯗꯤ ꯑꯉꯥꯡꯒꯤ ꯑꯦꯌꯔꯋꯦ (ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯒꯤ ꯁꯤꯁ꯭ꯇꯦꯝ) ꯅꯠꯠꯔꯒꯥ ꯗꯥꯏꯖꯦꯁ꯭ꯇꯤꯚ ꯁꯤꯁ꯭ꯇꯦꯝ (ꯒꯠ)ꯒꯤ ꯇꯤꯁꯨꯁꯤꯡꯗꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫

ꯍꯧꯖꯤꯛꯇꯤ ꯅꯍꯥꯛꯅꯥ ꯀꯔꯤꯒꯤꯗꯃꯛꯇꯥ ꯁꯣꯀꯄꯥ ꯑꯁꯤ ꯊꯣꯛꯂꯤꯕꯅꯣ ꯍꯥꯌꯅꯥ ꯈꯅꯕꯤꯔꯃꯒꯅꯤ꯫ ꯃꯁꯤꯒꯤ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯑꯁꯤ ꯑꯉꯥꯡꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯂꯩꯕꯥ ``ꯀꯦꯄꯤꯂꯦꯔꯤ'' ꯀꯧꯕꯥ ꯑꯄꯤꯀꯄꯥ ꯏꯒꯤ ꯈꯣꯡꯖꯦꯂꯁꯤꯡꯅꯥ ꯃꯈꯣꯌꯗꯒꯤ ꯐ꯭ꯂꯨꯏꯗ ꯂꯤꯛ ꯇꯧꯗꯨꯅꯥ ꯑꯀꯣꯌꯕꯗꯥ ꯂꯩꯕꯥ ꯇꯤꯁꯨꯁꯤꯡꯗꯥ ꯈꯣꯃꯖꯤꯜꯂꯀꯄꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯊꯣꯀꯏ꯫ ꯐ꯭ꯂꯨꯏꯗ ꯑꯁꯤ ꯈꯣꯃꯖꯤꯜꯂꯀꯄꯥ ꯃꯇꯃꯗꯥ, ꯃꯁꯤꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯃꯔꯛꯇꯥ ꯏ ꯅꯠꯠꯔꯒꯥ ꯂꯤꯝꯐ ꯆꯦꯅꯕꯥ ꯊꯤꯡꯕꯥ ꯉꯝꯃꯤ꯫ ꯃꯁꯤꯒꯤ ꯁꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯃꯁꯤꯒꯥ ꯃꯔꯤ ꯂꯩꯅꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ (``HAE ꯑꯦꯇꯦꯀꯁꯤꯡ'' ꯍꯥꯌꯅꯥꯁꯨ ꯀꯧꯕꯥ) ꯑꯁꯤ ꯀꯗꯥꯏꯗꯥ ꯊꯣꯛꯀꯅꯤ ꯍꯥꯌꯕꯁꯤ ꯈꯪꯗꯣꯀꯄꯥ ꯌꯥꯝꯅꯥ ꯂꯨꯏ꯫ ꯃꯁꯤꯗꯁꯨ ꯅꯠꯇꯅꯥ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯃꯁꯤ ꯑꯄꯤꯀꯄꯥ ꯁꯣꯀꯄꯥ ꯑꯃꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯊꯤꯡꯖꯤꯅꯕꯥ ꯌꯥꯏ, ꯑꯗꯨꯕꯨ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯄꯨꯟꯁꯤꯗꯥ ꯈꯨꯗꯣꯡꯊꯤꯕꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯁꯥꯊꯤꯕꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫

ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛꯇꯥ "ꯑꯦꯟꯖꯤꯑꯣ" (`ꯑꯦꯟꯖꯤꯑꯣ-`) ꯍꯥꯌꯕꯥ ꯋꯥꯍꯩ ꯑꯁꯤꯅꯥ ꯏꯒꯤ ꯈꯣꯡꯖꯦꯂꯁꯤꯡꯕꯨ ꯈꯪꯅꯩ꯫ "ꯏꯗꯤꯃꯥ` (`-ꯏꯗꯤꯃꯥ`) ꯍꯥꯌꯕꯁꯤ ꯇꯤꯁ꯭ꯌꯨꯁꯤꯡꯗꯥ ꯐ꯭ꯂꯨꯏꯗ ꯑꯦꯛꯌꯨꯃꯨꯂꯦꯁꯟ ꯇꯧꯕꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯁꯣꯀꯄꯥ ꯍꯥꯌꯕꯁꯤꯕꯨ ꯈꯪꯅꯩ꯫ `ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ` ꯃꯈꯜ ꯀꯌꯥ ꯂꯩ, ꯃꯈꯣꯌ ꯈꯨꯗꯤꯡꯃꯛ ꯑꯁꯤ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯃꯔꯃꯁꯤꯡ ꯂꯩ꯫ `HAE` ꯑꯁꯤ ꯃꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯌꯥꯝꯅꯥ ꯊꯦꯡꯅꯩ꯫ ꯃꯁꯤꯕꯨ `ꯀꯣꯟꯖꯤꯅꯤꯑꯦꯜ` ꯍꯥꯌꯅꯥ ꯀꯧꯏ, ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯁꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯄꯣꯀꯄꯅꯤ꯫"

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ HAE ꯂꯩꯔꯦ ꯍꯥꯌꯅꯥ ꯈꯪꯂꯕꯗꯤ, ꯅꯍꯥꯛꯅꯥ ꯀꯔꯤ ꯊꯣꯛꯀꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯌꯥꯝꯅꯥ ꯁꯣꯌꯗꯅꯥ ꯈꯪꯗꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯕꯨ ꯃꯁꯤ ꯈꯉꯕꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯅꯥ ꯂꯩꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯒꯅꯤ: ꯑꯉꯥꯡꯁꯤꯡ ꯌꯥꯑꯣꯅꯥ HAEꯅꯥ ꯅꯥꯕꯥ ꯆꯍꯤ ꯈꯨꯗꯤꯡꯒꯤ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯤ ꯑꯅꯧꯕꯥ ꯂꯥꯌꯦꯡꯁꯤꯡꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯔꯤꯁꯔꯆ ꯇꯧꯕꯥ ꯆꯠꯊꯔꯤ꯫ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤꯗꯃꯛ ꯀꯔꯤ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯆꯨꯝꯃꯤ ꯑꯃꯁꯨꯡ ꯇꯨꯡꯗꯥ ꯀꯔꯤ ꯇꯧꯒꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯈꯪꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯒꯅꯤ꯫

`HAE`ꯒꯤ ꯃꯈꯂꯁꯤꯡ ꯂꯩꯕ꯭ꯔꯥ?

ꯍꯣꯌ, `HAE` ꯑꯁꯤ `ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ`ꯒꯤ ꯃꯈꯜ ꯑꯃꯅꯤ ꯍꯥꯌꯔꯕꯁꯨ, ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ `HAE` ꯑꯁꯤ ꯑꯇꯩ ꯃꯈꯜ ꯀꯌꯥꯗꯥ ꯈꯥꯌꯗꯣꯀꯏ:

• ꯃꯈꯜ I HAE: ꯃꯁꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯃꯈꯂꯅꯤ . HAE ꯄꯦꯁꯦꯟꯇ ꯄꯨꯝꯅꯃꯛꯀꯤ ꯆꯥꯎꯔꯥꯛꯅꯥ 85%ꯗꯤ ꯃꯁꯤꯒꯤ ꯃꯈꯜ ꯑꯁꯤ ꯂꯩ꯫ ꯃꯁꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯍꯀꯆꯥꯡꯅꯥ C1-inhibitor (C1-INH ꯍꯥꯌꯅꯥ ꯈꯪꯅꯕꯥ) ꯀꯧꯕꯥ ꯑꯈꯟꯅꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯃꯥ ꯃꯇꯤꯛ ꯆꯥꯅꯥ ꯄꯨꯊꯣꯀꯄꯥ ꯉꯃꯗꯕꯅꯥ ꯊꯣꯀꯍꯅꯕꯅꯤ꯫ ꯃꯁꯤꯒꯤ C1-INH ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯅꯦꯝꯅꯥ ꯂꯩꯕꯥ ꯃꯇꯃꯗꯥ, ꯍꯀꯆꯥꯡꯗꯥ ꯏꯅꯐ꯭ꯂꯦꯃꯦꯁꯟ ꯑꯃꯁꯨꯡ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫ ꯃꯁꯤꯕꯨ ꯁꯤ ꯱-ꯑꯥꯏ.ꯑꯦꯟ.ꯑꯩꯆ.
• ꯃꯈꯜ II HAE: ꯃꯁꯤ ꯑꯅꯤꯁꯨꯕꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯃꯈꯂꯅꯤ꯫ ꯃꯁꯤꯒꯤ ꯀꯦꯁ ꯑꯁꯤꯗꯥ, ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯍꯀꯆꯥꯡꯅꯥ C1-INH ꯄ꯭ꯔꯣꯇꯤꯟ ꯄꯨꯊꯣꯀꯏ, ꯑꯗꯨꯕꯨ ꯃꯗꯨ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯗꯦ꯫
• ꯅꯣꯔꯃꯦꯜ C1-INHꯒꯥ ꯂꯣꯌꯅꯅꯥ HAE: ꯃꯁꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯃꯈꯂꯅꯤ . ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ C1-INH ꯄ꯭ꯔꯣꯇꯤꯅꯒꯤ ꯆꯥꯡ ꯑꯃꯁꯨꯡ ꯑꯦꯛꯇꯤꯚꯤꯇꯤ ꯑꯁꯤ ꯅꯣꯔꯃꯦꯜ ꯑꯣꯏ, ꯑꯗꯨꯕꯨ ꯑꯇꯩ ꯃꯔꯃꯁꯤꯡꯅꯥ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯊꯣꯀꯍꯜꯂꯤ꯫

ꯑꯍꯥꯅꯕꯥ ꯃꯈꯜ ꯑꯅꯤ (ꯇꯥꯏꯞ I ꯑꯃꯁꯨꯡ ꯇꯥꯏꯞ II HAE) ꯑꯁꯤ ꯄꯨꯟꯅꯥ, ꯃꯤꯑꯣꯏ 50,000ꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯆꯥꯎꯔꯥꯛꯅꯥ 1ꯗꯥ ꯁꯣꯀꯍꯜꯂꯤ . ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯑꯃꯦꯔꯤꯀꯥꯒꯨꯝꯕꯥ ꯂꯩꯕꯥꯛ ꯑꯃꯗꯥ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯃꯤꯑꯣꯏ ꯶,꯰꯰꯰ꯅꯥ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯃꯈꯂꯒꯤ ꯑꯩꯆ.ꯑꯦ.ꯏ. ꯔꯤꯁꯔꯆꯔꯁꯤꯡꯅꯥ HAEꯅꯥ ꯅꯥꯕꯥ ꯃꯤꯑꯣꯏ ꯀꯌꯥꯗꯥ ꯅꯣꯔꯃꯦꯜ C1-INH ꯂꯦꯚꯦꯜ ꯂꯩꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯆꯨꯝꯅꯥ ꯈꯉꯗꯦ, ꯑꯗꯨꯕꯨ ꯃꯈꯣꯌꯅꯥ ꯍꯥꯌꯔꯤ ꯃꯗꯨꯗꯤ ꯃꯁꯤ ꯌꯥꯝꯅꯥ ꯅꯦꯝꯃꯤ꯫

HAEꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

HAEꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯈꯦꯠꯅꯕꯥ ꯌꯥꯏ꯫ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯂꯥꯏꯑꯣꯡ ꯈꯔꯗꯤ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯁꯤꯡꯁꯤꯅꯤ:

• ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯍꯀꯆꯥꯡꯒꯤ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯃꯐꯃꯁꯤꯡꯗꯥ ꯊꯣꯀꯄꯥ ꯁꯣꯀꯄꯥ, ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ , ꯃꯈꯨꯠ, ꯈꯣꯡ, ꯃꯃꯤꯠ, ꯃꯤꯠ, ꯑꯃꯁꯨꯡ ꯃꯤꯠꯀꯤ ꯃꯐꯃꯁꯤꯡꯗꯥ ꯊꯣꯀꯄꯥ ꯁꯣꯛ-ꯄꯅꯕꯥ .
• ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯗꯥꯏꯖꯦꯁ꯭ꯇꯤꯚ ꯁꯤꯁ꯭ꯇꯦꯝ (Gastrointestinal (GI) tract)ꯗꯥ ꯏꯅꯐ꯭ꯂꯦꯃꯦꯁꯅꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ꯫ ꯃꯁꯤꯗꯥ ꯅꯣꯡꯃꯩ ꯀꯥꯞꯄꯥ, ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯑꯃꯁꯨꯡ ꯗꯥꯏꯔꯤꯌꯥ ꯌꯥꯎꯕꯥ ꯌꯥꯏ꯫
• ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯃꯆꯤꯟꯖꯥꯛ, ꯀꯣꯛ, ꯑꯃꯁꯨꯡ ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯒꯤ ꯂꯝꯕꯤꯗꯥ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ . ꯃꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯂꯧꯅꯒꯅꯕꯥ ꯂꯥꯌꯅꯥ, ꯂꯣꯜ ꯁꯣꯀꯄꯥ, ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯥ ꯃꯇꯃꯗꯥ ꯈꯣꯟꯖꯦꯜ ꯊꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯈꯣꯟꯖꯦꯜ ꯍꯣꯡꯂꯀꯄꯥ ꯑꯁꯤ ꯌꯥꯎꯕꯥ ꯌꯥꯏ .

ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯗꯤ: ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯂꯧꯅꯒꯅꯕꯥ ꯂꯥꯌꯅꯥ ꯂꯩꯔꯕꯗꯤ, ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯅꯀꯄꯥ ꯏꯃꯔꯖꯦꯟꯁꯤ ꯔꯨꯃꯗꯥ ꯀꯣꯜ ꯇꯧꯕꯤꯌꯨ ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨ ꯈꯨꯗꯛꯇꯥ ꯍꯣꯁ꯭ꯄꯤꯇꯥꯂꯗꯥ ꯄꯨꯈꯠꯄꯤꯌꯨ꯫ ꯑꯦꯌꯔꯋꯦ (airways) ꯁꯣꯀꯄꯥ ꯍꯥꯌꯕꯁꯤ HAEꯒꯤ ꯌꯥꯝꯅꯥ ꯁꯥꯊꯤꯕꯥ, ꯄꯨꯟꯁꯤꯗꯥ ꯈꯨꯗꯣꯡꯊꯤꯅꯤꯉꯥꯏ ꯑꯣꯏꯕꯥ ꯀꯃꯞꯂꯤꯀꯦꯁꯟ ꯑꯃꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯊꯨꯅꯥ ꯂꯥꯏꯌꯦꯡꯗ꯭ꯔꯕꯗꯤ ꯁꯤꯍꯅꯕꯥ ꯌꯥꯏ꯫

HAE ꯅꯥ ꯍꯥꯏꯕꯁꯤ ꯊꯣꯀꯍꯟꯗꯦ꯫ ꯃꯁꯤꯅꯥ HAE ꯑꯃꯁꯨꯡ ꯑꯇꯩ ꯃꯈꯂꯒꯤ ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ, ꯍꯥꯌꯕꯗꯤ ꯑꯦꯛꯌꯨꯠ ꯑꯦꯂꯥꯔꯖꯤꯒꯤ ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥꯒꯤ ꯃꯔꯛꯇꯥ ꯂꯩꯕꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯈꯦꯠꯅꯕꯥ ꯑꯗꯨꯅꯤ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, HAEꯅꯥ ꯅꯥꯕꯥ ꯃꯤꯑꯣꯏ ꯈꯔꯗꯗꯤ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯊꯣꯛꯂꯛꯠꯔꯤꯉꯩꯗꯥ ꯅꯟ-ꯏꯆꯤ ꯔꯦꯗ ꯔꯦꯁ ꯑꯃꯥ ꯂꯥꯀꯄꯥ ꯌꯥꯏ, ꯃꯁꯤꯅꯥ ꯂꯥꯛꯀꯗꯧꯔꯤꯕꯥ ꯑꯦꯇꯦꯛ ꯑꯃꯒꯤ ꯈꯨꯗꯝ ꯑꯃꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫

`HAE ꯑꯦꯇꯦꯛ` ꯑꯃꯅꯥ ꯃꯍꯧꯁꯥꯅꯥ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯅꯨꯃꯤꯠ ꯍꯨꯝꯅꯤꯗꯒꯤ ꯃꯉꯥ ꯐꯥꯎꯕꯥ ꯆꯠꯊꯩ . ꯍꯥꯌꯔꯤꯕꯥ `ꯑꯦꯇꯦꯀꯁꯤꯡ` ꯑꯁꯤ ꯈꯉꯍꯧꯗꯅꯥ ꯂꯥꯀꯏ ꯑꯃꯁꯨꯡ ꯆꯠꯂꯤ, ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯃꯈꯣꯌ ꯀꯗꯥꯌꯗꯥ ꯑꯃꯁꯨꯡ ꯀꯔꯝꯅꯥ ꯊꯣꯛꯀꯅꯤ ꯍꯥꯌꯕꯁꯤ ꯇꯁꯦꯡꯅꯥ ꯍꯥꯌꯕꯥ ꯉꯃꯗꯦ꯫

HAEꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯀꯗꯥꯏꯗꯒꯤ ꯍꯧꯔꯀꯄꯒꯦ?

HAEꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯃꯍꯧꯁꯥꯅꯥ ꯑꯉꯥꯡ ꯑꯣꯏꯔꯤꯉꯩ ꯅꯠꯠꯔꯒꯥ ꯏꯅꯈꯠꯂꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯍꯧꯏ . ꯃꯈꯣꯌ ꯑꯁꯤ ꯃꯤꯔꯣꯜꯂꯤꯉꯩ ꯃꯇꯃꯗꯥ ꯍꯦꯟꯅꯥ ꯁꯥꯊꯤꯕꯥ ꯑꯣꯏꯔꯀꯄꯥ ꯌꯥꯏ꯫ ꯑꯉꯥꯡ ꯈꯔꯗꯤ ꯆꯍꯤ 2 ꯁꯨꯔꯀꯄꯗꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯥꯀꯄꯥ ꯍꯧꯔꯀꯄꯥ ꯌꯥꯏ . HAE ꯇꯥꯏꯞ I ꯅꯠꯠꯔꯒꯥ IIꯅꯥ ꯅꯥꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯤ ꯆꯥꯎꯔꯥꯛꯅꯥ 50%ꯗꯤ ꯆꯍꯤ 10 ꯁꯨꯔꯀꯄꯗꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯥꯀꯏ, ꯃꯤꯔꯣꯜꯂꯤꯉꯩ ꯃꯇꯨꯡꯗꯥ, ꯑꯦꯇꯦꯀꯁꯤꯡ ꯑꯁꯤ ꯍꯦꯟꯅꯥ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯑꯃꯁꯨꯡ ꯁꯥꯊꯤꯕꯥ ꯑꯣꯏꯔꯀꯄꯥ ꯌꯥꯏ꯫ HAE ꯇꯥꯏꯞ I ꯅꯠꯠꯔꯒꯥ II ꯂꯩꯕꯥ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯃꯤꯑꯣꯏ ꯈꯨꯗꯤꯡꯃꯛꯇꯥ ꯆꯍꯤ 20 ꯁꯨꯔꯀꯄꯗꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯥꯀꯏ꯫

ꯅꯣꯔꯃꯦꯜ C1-INH ꯂꯦꯚꯦꯜ ꯂꯩꯕꯥ HAE ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯗꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯈꯔꯥ ꯇꯨꯡꯗꯥ ꯍꯧꯔꯀꯄꯥ ꯌꯥꯏ – ꯃꯍꯧꯁꯥꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯂꯦꯃꯍꯧꯔꯤꯕꯥ ꯇꯤꯅꯁꯤꯡ ꯅꯠꯠꯔꯒꯥ ꯉꯟꯅꯥ ꯏꯅꯈꯠꯂꯀꯄꯥ ꯃꯇꯃꯗꯥ꯫

HAE ꯑꯦꯇꯦꯛ ꯑꯃꯒꯤ ꯇ꯭ꯔꯤꯒꯔꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

HAE ꯑꯦꯇꯦꯛ ꯑꯃꯥ ꯊꯣꯀꯍꯜꯂꯤꯕꯥ ꯑꯀꯛꯅꯕꯥ ``ꯇ꯭ꯔꯤꯒꯔ`` ꯑꯗꯨ ꯀꯔꯤꯅꯣ ꯍꯥꯌꯕꯁꯤ ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯃꯌꯦꯛ ꯁꯦꯡꯗꯦ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯃꯁꯛ ꯈꯪꯗꯣꯛꯂꯕꯥ ``ꯇ꯭ꯔꯤꯒꯔ`` ꯈꯔꯗꯤ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤ:

• ꯍꯀꯆꯥꯡꯒꯤ ꯑꯁꯣꯛ-ꯑꯄꯟ ꯅꯠꯠꯔꯒꯥ ꯑꯄꯤꯀꯄꯥ ꯑꯦꯛꯁꯤꯗꯦꯟꯇ: ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨ ꯅꯨꯃꯤꯠ ꯑꯃꯗꯥ ꯁꯥꯟꯅꯔꯤꯉꯩꯗꯥ ꯁꯣꯀꯄꯥ ꯌꯥꯏ ꯍꯥꯌꯅꯥ ꯈꯅꯕꯤꯌꯨ꯫
• ꯗꯥꯛꯇꯔꯒꯤ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ: ꯍꯥꯀꯆꯥꯡ ꯑꯃꯥ ꯂꯧꯊꯣꯀꯄꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯗꯨ ꯊꯨꯒꯥꯌꯕꯒꯨꯝꯕꯥ ꯄꯣꯠꯁꯀꯁꯤꯡ꯫
• ꯁꯔꯖꯔꯤ: ꯑꯣꯄꯔꯦꯁꯟ ꯑꯃꯥ , ꯃꯥꯏꯅꯣꯔꯤꯇꯤ ꯅꯠꯠꯔꯒꯥ ꯃꯦꯖꯔ ꯑꯣꯏꯔꯕꯁꯨ꯫
• ꯁ꯭ꯠꯔꯦꯁ ꯅꯠꯠꯔꯒꯥ ꯏꯃꯣꯁꯅꯦꯜ ꯄ꯭ꯔꯦꯁꯔ: ꯁ꯭ꯀꯨꯂꯒꯤ ꯄꯔꯤꯈꯥ ꯑꯃꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯔꯨꯞ ꯑꯃꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯑꯄꯤꯀꯄꯥ ꯂꯥꯅꯐꯝ ꯑꯃꯥ ꯐꯥꯎꯕꯅꯥ ꯏꯝꯄꯦꯛꯇ ꯑꯃꯥ ꯄꯤꯕꯥ ꯌꯥꯏ꯫
• ꯚꯥꯏꯔꯁ ꯏꯅꯐꯦꯛꯁꯅꯁꯤꯡ: ꯐ꯭ꯂꯨ ꯑꯃꯁꯨꯡ ꯀꯣꯜꯗꯒꯨꯝꯕꯥ ꯄꯣꯠꯁꯀꯁꯤꯡ꯫
• ꯐꯤꯖꯤꯀꯦꯜ ꯑꯦꯛꯇꯤꯚꯤꯇꯤ ꯈꯔꯗꯤ: ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯂꯦꯞꯇꯅꯥ ꯇꯥꯏꯞ ꯇꯧꯕꯥ, ꯍꯥꯃꯗꯣꯀꯄꯥ, ꯅꯠꯠꯔꯒꯥ ꯈꯣꯡꯎꯞ ꯑꯃꯅꯥ ꯈꯣꯡ ꯍꯥꯝꯕꯥ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯄꯣꯠꯁꯀꯁꯤꯡ꯫

ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ ꯑꯦꯇꯦꯛ ꯑꯃꯥ ꯂꯥꯀꯄꯒꯤ ꯃꯔꯝ ꯀꯔꯤꯅꯣ ꯍꯥꯌꯕꯗꯨ ꯅꯍꯥꯛꯅꯥ ꯈꯨꯗꯛꯇꯥ ꯈꯪꯂꯃꯗꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯑꯦꯇꯦꯛ ꯑꯗꯨ ꯊꯣꯀꯈꯤꯕꯥ ꯃꯇꯝ ꯑꯃꯁꯨꯡ ꯃꯇꯝ ꯑꯗꯨꯗꯥ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯀꯔꯤ ꯇꯧꯔꯤꯕꯒꯦ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯑꯉꯥꯡ ꯑꯗꯨ ꯑꯅꯥꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯁ꯭ꯠꯔꯦꯁ ꯂꯩꯔꯕꯔꯥ)ꯒꯤ ꯖꯔꯅꯦꯜ ꯑꯃꯥ ꯊꯝꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯇꯦꯡ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫

HAEꯒꯤ ꯑꯁꯦꯡꯕꯥ ꯃꯔꯝ ꯀꯔꯤꯅꯣ?

HAE ꯃꯈꯜ I ꯑꯃꯁꯨꯡ II ꯑꯅꯤꯃꯛ ꯑꯁꯤ SERPING1 ꯀꯧꯕꯥ ꯖꯤꯟ ꯑꯃꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ (ꯅꯠꯠꯔꯒꯥ ꯑꯍꯣꯡꯕꯥ) ꯑꯃꯅꯥ ꯊꯣꯀꯍꯅꯕꯅꯤ꯫ ꯖꯤꯟ ꯑꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ C1-INH ꯀꯧꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯃꯥ ꯀꯔꯝꯅꯥ ꯁꯦꯃꯒꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯈꯪꯍꯜꯂꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ HAE ꯇꯥꯏꯞ I ꯂꯩꯔꯕꯗꯤ, ꯖꯤꯟ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯁꯤꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯅꯥ C1-INH ꯃꯇꯤꯛ ꯆꯥꯅꯥ ꯁꯦꯝꯕꯥ ꯉꯃꯗꯦ ꯍꯥꯌꯕꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ HAE ꯇꯥꯏꯞ II ꯂꯩꯔꯕꯗꯤ, ꯃꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯅꯥ C1-INH ꯁꯦꯝꯕꯥ ꯌꯥꯏ, ꯑꯗꯨꯕꯨ ꯖꯤꯟ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯁꯤꯅꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯗꯨ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯗꯦ ꯍꯥꯌꯕꯅꯤ꯫

ꯔꯤꯁꯔꯆꯔꯁꯤꯡꯅꯥ ꯍꯧꯖꯤꯀꯁꯨ ꯅꯣꯔꯃꯦꯜ ꯁꯤ ꯱-ꯑꯥꯏ.ꯑꯦꯟ.ꯑꯩꯆ.ꯒꯤ ꯆꯥꯡꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯑꯩꯆ.ꯑꯦ.ꯏ.ꯒꯤ ꯃꯔꯃꯁꯤꯡ ꯊꯤꯖꯤꯜꯂꯤ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯃꯈꯣꯌꯅꯥ ꯈꯪꯏ ꯃꯗꯨꯗꯤ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯖꯤꯅꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃ꯭ꯌꯨꯇꯦꯁꯅꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ:

• `ꯑꯦꯐ꯱꯲`꯫
• `ꯑꯦ.ꯑꯦꯟ.ꯖꯤ.ꯄꯤ.ꯇꯤ.꯱`
• `ꯄꯤ.ꯑꯦꯜ.ꯖꯤ`
• `ꯀꯦ.ꯑꯦꯟ.ꯖꯤ.꯱`

ꯀꯦꯁ ꯈꯔꯗꯗꯤ, HAE ꯑꯁꯤ ꯃꯁꯛ ꯈꯪꯗꯣꯛꯂꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯃꯠꯇꯥ ꯌꯥꯎꯗꯅꯥ ꯂꯩꯕꯥ ꯌꯥꯏ꯫ ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯃꯁꯤꯕꯨ "ꯑꯩꯆ.ꯑꯦ.ꯏ.-ꯑꯅꯅꯣꯟ" ꯍꯥꯌꯅꯥ ꯀꯧꯏ꯫

HAE ꯊꯣꯀꯍꯜꯂꯤꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯃ꯭ꯌꯨꯇꯦꯁꯅꯁꯤꯡꯅꯥ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯑꯀꯛꯅꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯑꯗꯨ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯍꯟꯗꯦ꯫ ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯑꯄꯤꯀꯄꯥ ꯕ꯭ꯂꯗ ꯚꯦꯁꯦꯂꯁꯤꯡ (capillaries)ꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯐ꯭ꯂꯨꯏꯗꯁꯤꯡ ꯑꯗꯨ ꯅꯣꯔꯃꯦꯜ ꯑꯣꯏꯅꯥ ꯆꯠꯄꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ, ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯗꯕꯥ ꯃꯇꯃꯗꯥ, ꯐ꯭ꯂꯨꯏꯗꯁꯤꯡ ꯑꯁꯤ ꯂꯤꯛ ꯑꯣꯏꯔꯀꯏ ꯑꯃꯁꯨꯡ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯕ꯭ꯂꯗ ꯚꯦꯁꯦꯂꯁꯤꯡꯒꯤ ꯑꯀꯣꯌꯕꯗꯥ ꯂꯩꯕꯥ ꯇꯤꯁꯨꯁꯤꯡꯗꯥ ꯊꯨꯃꯖꯤꯜꯂꯤ꯫ ꯃꯗꯨꯅꯥ HAEꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯊꯣꯀꯍꯜꯂꯤ꯫

HAE ꯑꯁꯤ ꯏꯃꯨꯡꯗꯒꯤ ꯂꯥꯀꯄꯔꯥ?

ꯍꯣꯌ, HAE ꯑꯁꯤ ꯑꯣꯇꯣꯁꯣꯃꯜ ꯗꯣꯃꯤꯅꯦꯟꯇ ꯄꯦꯇꯔꯟ ꯑꯃꯗꯥ ꯏꯅꯍꯦꯔꯤ ꯇꯧꯏ꯫ ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯃꯁꯤꯅꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯁꯤ ꯊꯣꯀꯍꯟꯅꯕꯒꯤꯗꯃꯛꯇꯥ ꯑꯦꯕꯅꯣꯔꯃꯦꯜ ꯖꯤꯟ ꯑꯃꯈꯛꯇꯃꯛ ꯃꯊꯧ ꯇꯥꯏ꯫ ꯑꯉꯥꯡ ꯑꯃꯅꯥ ꯃꯁꯤꯒꯤ ꯑꯦꯕꯅꯣꯔꯃꯦꯜ ꯖꯤꯟ ꯑꯁꯤ ꯃꯈꯣꯌꯒꯤ ꯃꯃꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯄꯥꯗꯒꯤ ꯂꯧꯕꯥ ꯌꯥꯏ꯫

HAEꯅꯥ ꯅꯥꯕꯥ ꯃꯤꯑꯣꯏ ꯀꯌꯥꯅꯥ ꯂꯥꯌꯅꯥ ꯑꯁꯤꯒꯤ ꯏꯃꯨꯡ-ꯃꯅꯨꯡꯒꯤ ꯍꯤꯁ꯭ꯇꯔꯤ ꯂꯩ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯏꯃꯨꯡꯒꯤ ꯍꯤꯁ꯭ꯇꯔꯤ ꯑꯃꯠꯇꯥ ꯌꯥꯎꯗꯅꯥ ꯖꯤꯟ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯃꯥ ꯔꯦꯟꯗꯝ ꯑꯣꯏꯅꯥ ("ꯗꯦ ꯅꯣꯚꯣ" ꯅꯠꯠꯔꯒꯥ "ꯑꯅꯧꯕꯥ" ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯃꯥ) ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫

ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯃꯁꯤ ꯀꯔꯝꯅꯥ ꯊꯤꯔꯤꯕꯒꯦ?

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ HAEꯒꯤ ꯂꯥꯏꯑꯣꯡ ꯎꯠꯂꯕꯗꯤ, ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯑꯁꯤ ꯇꯧꯒꯅꯤ:

• ꯐꯤꯖꯤꯀꯦꯜ ꯑꯦꯀꯖꯥꯃꯤꯅꯦꯁꯟ ꯑꯃꯥ ꯇꯧꯏ .
• ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯃꯦꯗꯤꯀꯦꯜ ꯍꯤꯁ꯭ꯇꯔꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯍꯪꯒꯅꯤ꯫
• ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ `C1-INH`ꯒꯤ ꯆꯥꯡ ꯑꯃꯁꯨꯡ ꯑꯦꯛꯇꯤꯚꯤꯇꯤ ꯌꯦꯡꯁꯤꯟꯅꯕꯥ ꯕ꯭ꯂꯗ ꯇꯦꯁ꯭ꯠ ꯇꯧꯏ .
• ꯀꯦꯁ ꯈꯔꯗꯗꯤ, HAE ꯊꯣꯀꯍꯜꯂꯤꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯂꯩꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯅꯕꯒꯤꯗꯃꯛ ꯖꯦꯅꯦꯇꯤꯛ ꯇꯦꯁ꯭ꯠ ꯇꯧꯏ꯫

HAEꯒꯤ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

HAEꯅꯥ ꯅꯥꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯤ ꯑꯣꯏꯅꯥ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯃꯈꯜ ꯑꯅꯤ ꯂꯩ:

• ꯑꯣꯟ-ꯗꯤꯃꯥꯟꯗ ꯍꯤꯗꯥꯀꯁꯤꯡ: ꯃꯁꯤ HAE ꯑꯦꯇꯦꯛ ꯑꯃꯥ ꯂꯥꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯄꯤꯕꯥ ꯍꯤꯗꯥꯀꯁꯤꯡꯅꯤ꯫ ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯕꯦꯔꯤꯅꯦꯔꯠ® ꯅꯠꯠꯔꯒꯥ ꯀꯥꯂꯕꯤꯇꯔ®ꯒꯨꯝꯕꯥ ꯍꯤꯗꯥꯀꯁꯤꯡ꯫ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯍꯧꯔꯀꯄꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯌꯥꯔꯤꯕꯃꯈꯩ ꯊꯨꯅꯥ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯑꯁꯤ ꯂꯧꯕꯅꯥ ꯑꯦꯇꯦꯛ ꯑꯗꯨꯒꯤ ꯃꯑꯣꯡ-ꯃꯇꯧ ꯑꯗꯨ ꯍꯟꯊꯍꯅꯕꯥ ꯉꯝꯃꯤ ꯑꯃꯁꯨꯡ ꯄꯨꯟꯁꯤ ꯃꯥꯡꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯀꯃꯞꯂꯤꯀꯦꯁꯅꯁꯤꯡ ꯊꯤꯡꯕꯥ ꯉꯝꯃꯤ꯫
• ꯄ꯭ꯔꯣꯐꯥꯏꯂꯦꯛꯇꯤꯛ ꯍꯤꯗꯥꯀꯁꯤꯡ: ꯃꯁꯤ ꯑꯦꯇꯦꯛ ꯑꯃꯥ ꯂꯥꯀꯄꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯟꯊꯍꯜꯂꯤꯕꯥ ꯍꯤꯗꯥꯀꯁꯤꯡꯅꯤ꯫ ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, Cinryze®, Haegarda®, ꯅꯠꯠꯔꯒꯥ Takhzyro® ꯑꯁꯤ ꯌꯥꯎꯏ꯫ ꯗꯣꯛꯇꯔ ꯑꯃꯅꯥ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯑꯁꯤ ꯈꯪꯂꯕꯥ ꯇ꯭ꯔꯤꯒꯔ ꯑꯃꯒꯤ ꯃꯅꯨꯡꯗꯥ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯗꯦꯟꯇꯤꯁ꯭ꯇꯇꯥ ꯆꯠꯄꯥ) ꯁꯤꯖꯤꯟꯅꯅꯕꯥ, ꯅꯠꯠꯔꯒꯥ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯁꯤꯖꯤꯟꯅꯅꯕꯥ, ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯃꯊꯧ ꯇꯥꯕꯁꯤꯡꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ ꯄꯤꯕꯥ ꯌꯥꯏ꯫

ꯃꯦꯗꯤꯀꯦꯂꯒꯤ ꯑꯈꯉ-ꯑꯍꯩꯁꯤꯡꯒꯤ ꯃꯇꯨꯡ ꯏꯟꯅꯥ ꯑꯣꯟ-ꯗꯤꯃꯥꯟꯗ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯑꯁꯤ ꯇꯉꯥꯏꯐꯗꯕꯥ ꯑꯃꯗꯤ ꯄꯨꯟꯁꯤ ꯀꯅꯕꯥ ꯉꯝꯃꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯄ꯭ꯔꯣꯐꯥꯏꯂꯦꯛꯇꯤꯛ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯂꯧꯔꯕꯁꯨ, ꯑꯣꯟ-ꯗꯤꯃꯥꯟꯗ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯑꯁꯤ ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ, ꯃꯐꯝ ꯈꯨꯗꯤꯡꯃꯛꯇꯥ (ꯌꯨꯃꯗꯥ ꯑꯃꯁꯨꯡ ꯁ꯭ꯀꯨꯂꯗꯥ) ꯐꯪꯍꯅꯒꯗꯕꯅꯤ꯫

ꯗꯣꯛꯇꯔ ꯑꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯀꯔꯤ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯃꯊꯧ ꯇꯥꯕꯒꯦ, ꯃꯈꯣꯌꯗꯨ ꯀꯔꯝꯅꯥ ꯄꯤꯒꯗꯒꯦ ꯑꯃꯁꯨꯡ ꯀꯗꯥꯏꯗꯥ ꯄꯤꯒꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯆꯨꯝꯅꯥ ꯈꯪꯍꯜꯂꯛꯀꯅꯤ꯫ ꯃꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ ꯃꯈꯣꯌꯒꯤ ꯆꯍꯤꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ ꯀꯔꯤ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯄꯤꯕꯥ ꯌꯥꯕꯒꯦ ꯍꯥꯌꯕꯗꯨꯁꯨ ꯈꯪꯍꯜꯂꯛꯀꯅꯤ꯫ ꯏꯅꯁ꯭ꯠꯔꯛꯁꯅꯁꯤꯡ ꯑꯗꯨ ꯁꯣꯌꯗꯅꯥ ꯏꯅꯒꯗꯕꯅꯤ, ꯑꯃꯁꯨꯡ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯁꯣꯌꯗꯅꯥ ꯈꯪꯗꯕꯥ ꯋꯥꯐꯝ ꯑꯃꯥ ꯂꯩꯔꯕꯗꯤ ꯋꯥꯍꯪꯁꯤꯡ ꯁꯣꯌꯗꯅꯥ ꯍꯪꯕꯤꯌꯨ꯫

ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯑꯩꯍꯥꯛ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯐꯒꯠꯂꯛꯀꯅꯤ?

ꯑꯣꯟ-ꯗꯤꯃꯥꯟꯗ ꯃꯦꯗꯤꯀꯦꯁꯅꯒꯥ ꯂꯣꯌꯅꯅꯥ, ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ HAE ꯑꯦꯇꯦꯛ ꯑꯃꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯐꯒꯠꯂꯀꯄꯥ ꯍꯧꯔꯒꯅꯤ꯫ ꯂꯥꯏꯌꯦꯡ ꯍꯧꯔꯀꯄꯗꯒꯤ ꯃꯤꯅꯠ 30ꯗꯒꯤ ꯄꯨꯡ ꯑꯅꯤ ꯐꯥꯎꯕꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯃꯍꯥꯛꯀꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯐꯒꯠꯍꯅꯒꯗꯕꯅꯤ꯫ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯌꯨꯃꯗꯥ ꯂꯥꯏꯌꯦꯡ ꯑꯗꯨ ꯀꯔꯝꯅꯥ ꯃꯦꯅꯦꯖ ꯇꯧꯒꯗꯒꯦ ꯑꯃꯁꯨꯡ ꯀꯔꯤ ꯇꯧꯒꯗꯒꯦ ꯍꯥꯌꯕꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯍꯦꯟꯅꯥ ꯏꯅꯐꯣꯔꯃꯦꯁꯟ ꯄꯤꯒꯅꯤ꯫

HAE ꯂꯩꯕꯥ ꯑꯉꯥꯡ ꯑꯃꯕꯨ ꯀꯔꯝꯅꯥ ꯌꯦꯡꯁꯤꯅꯒꯅꯤ?

ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ HAE ꯑꯦꯇꯦꯛ ꯑꯃꯅꯥ ꯁꯣꯀꯍꯜꯂꯕꯥ ꯎꯕꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯗꯕꯥ ꯐꯥꯎꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤꯗꯃꯛ ꯑꯦꯇꯦꯛ ꯑꯃꯒꯤ ꯃꯃꯥꯡ, ꯃꯅꯨꯡꯗꯥ ꯑꯃꯁꯨꯡ ꯃꯇꯨꯡꯗꯥ ꯇꯧꯕꯥ ꯌꯥꯕꯥ ꯊꯕꯛ ꯀꯌꯥ ꯂꯩ:

• ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯑꯣꯟ-ꯗꯤꯃꯥꯟꯗ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯈꯨꯠꯇꯥ ꯊꯝꯃꯨ: ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯄꯨꯟꯁꯤ ꯀꯅꯕꯥ ꯉꯃꯒꯅꯤ꯫ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯑꯁꯤ ꯀꯗꯥꯏꯗꯥ ꯃꯊꯧ ꯇꯥꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯅꯍꯥꯛꯅꯥ ꯈꯪꯕꯥ ꯉꯃꯒꯗꯕꯅꯤ꯫ ꯃꯈꯣꯌꯁꯤꯡ ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯄꯤꯒꯗꯒꯦ ꯍꯥꯌꯕꯗꯨꯁꯨ ꯈꯉꯒꯗꯕꯅꯤ꯫ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯍꯦꯟꯅꯥ ꯈꯪꯍꯜꯂꯛꯀꯅꯤ꯫
• HAE ꯑꯦꯇꯦꯛ ꯑꯃꯕꯨ ꯑꯦꯂꯥꯔꯖꯤ ꯑꯃꯥ ꯑꯣꯏꯅꯥ ꯂꯧꯒꯅꯨ: ꯑꯦꯂꯥꯔꯖꯤꯒꯤꯗꯃꯛꯇꯥ ꯃꯍꯧꯁꯥꯅꯥ ꯄꯤꯕꯥ ꯑꯦꯟꯇꯤꯍꯤꯁ꯭ꯇꯥꯃꯤꯟ ꯑꯃꯁꯨꯡ ꯑꯦꯄꯤꯅꯦꯐ꯭ꯔꯤꯅꯒꯨꯝꯕꯥ ꯍꯤꯗꯥꯀꯁꯤꯡꯅꯥ HAE ꯑꯦꯇꯦꯛ ꯑꯃꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯣꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ ꯄꯤꯕꯤꯒꯅꯨ꯫
• ꯑꯦꯇꯦꯛ ꯑꯃꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯇ꯭ꯔꯤꯒꯔꯁꯤꯡ ꯑꯗꯨ ꯈꯪꯖꯤꯅꯕꯤꯌꯨ: ꯇ꯭ꯔꯤꯒꯔꯁꯤꯡ ꯑꯁꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯈꯦꯠꯅꯩ꯫ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ ꯑꯦꯇꯦꯛ ꯑꯃꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯄꯣꯠꯁꯀꯁꯤꯡꯒꯤ ꯂꯤꯁ꯭ꯠ ꯑꯃꯥ ꯁꯦꯝꯃꯨ ꯑꯃꯁꯨꯡ ꯃꯗꯨ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯁꯦꯌꯔ ꯇꯧ꯫ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨ ꯌꯥꯔꯤꯕꯃꯈꯩ ꯇ꯭ꯔꯤꯒꯔꯁꯤꯡ ꯑꯗꯨꯗꯒꯤ ꯂꯥꯞꯅꯥ ꯊꯝꯅꯕꯥ ꯍꯣꯠꯅꯧ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯈꯣꯌꯗꯒꯤ ꯂꯥꯄꯊꯣꯀꯄꯥ ꯉꯃꯗ꯭ꯔꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯄ꯭ꯔꯣꯐꯥꯏꯂꯦꯛꯇꯤꯛ ꯍꯤꯗꯥꯀꯁꯤꯡꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯍꯪꯕꯤꯌꯨ꯫

ꯀꯗꯥꯏꯗꯥ ꯗꯣꯛꯇꯔꯒꯥ ꯇꯥꯟꯅꯒꯗꯒꯦ?

ꯀꯦꯁꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯗꯣꯛꯇꯔ ꯑꯃꯒꯥ ꯇꯥꯟꯅꯧ:

• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ `ꯍꯦꯔꯤꯇꯦꯖ ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ`ꯒꯤ ꯂꯥꯏꯑꯣꯡ ꯂꯩꯔꯦ ꯍꯥꯌꯅꯥ ꯈꯜꯂꯕꯗꯤ꯫
• ꯀꯔꯤꯒꯨꯝꯕꯥ HAE ꯑꯦꯇꯦꯛ ꯑꯃꯒꯥ ꯃꯔꯤ ꯂꯩꯅꯕꯥ ꯑꯅꯧꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯥꯀꯄꯥ ꯇꯥꯔꯕꯗꯤ, ꯅꯠꯠꯔꯒꯥ ꯍꯧꯖꯤꯛ ꯂꯩꯔꯤꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯗꯨ ꯍꯣꯡꯂꯛꯂꯕꯗꯤ꯫
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛ ꯑꯗꯨ ꯊꯥꯖꯕꯥ ꯌꯥꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯊꯕꯛ ꯇꯧꯕꯥ ꯉꯃꯗ꯭ꯔꯕꯗꯤ꯫

ꯀꯗꯥꯏꯗꯥ ꯏꯃꯔꯖꯦꯟꯁꯤ ꯔꯨꯃꯗꯥ ꯆꯠꯄꯥ ꯃꯊꯧ ꯇꯥꯕꯒꯦ?

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯍꯦꯛꯇꯕꯨ ꯊꯦꯡꯅꯔꯕꯗꯤ , ꯈꯨꯗꯛꯇꯥ ꯏꯃꯔꯖꯦꯟꯁꯤ ꯔꯨꯃꯗꯥ ꯆꯠꯂꯨ:

• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯂꯧꯅꯒꯅꯕꯥ ꯂꯥꯌꯅꯥ ꯑꯣꯏꯔꯕꯗꯤ꯫
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯗꯥ ꯑꯋꯥꯕꯥ ꯂꯩꯔꯕꯗꯤ꯫
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯖꯤꯕ ꯅꯠꯠꯔꯒꯥ ꯀꯣꯛ ꯆꯤꯀꯄꯒꯤ ꯈꯨꯗꯝ ꯑꯃꯠꯇꯥ ꯎꯔꯕꯗꯤ (ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯦꯇꯦꯛ ꯑꯃꯒꯤ ꯑꯍꯥꯅꯕꯥ ꯈꯨꯗꯃꯁꯤꯡꯗꯥ ꯍꯤꯗꯥꯛ ꯂꯥꯡꯊꯛ ꯄꯤꯔꯕꯁꯨ)꯫

ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡꯒꯤ ꯑꯦꯌꯔꯋꯦ (airway)ꯗꯥ ꯁꯣꯀꯍꯜꯂꯤꯕꯥ ꯈꯨꯗꯣꯡꯊꯤꯅꯤꯉꯥꯏ ꯑꯣꯏꯕꯥ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯑꯃꯒꯤ ꯈꯨꯗꯃꯁꯤꯡ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯂꯥꯏꯌꯦꯡ ꯂꯧꯕꯗꯥ ꯊꯦꯡꯊꯒꯅꯨ꯫ ꯃꯁꯤꯒꯤ ꯁꯣꯛ-ꯄꯅꯕꯥ ꯑꯁꯤꯅꯥ ꯄꯨꯟꯁꯤ ꯃꯥꯡꯍꯅꯕꯥ ꯌꯥꯏ꯫

ꯗꯣꯛꯇꯔꯗꯥ ꯀꯔꯤ ꯋꯥꯍꯪ ꯍꯪꯒꯗꯒꯦ?

ꯅꯍꯥꯛꯅꯥ ꯗꯣꯛꯇꯔꯗꯥ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯋꯥꯍꯪꯁꯤꯡ ꯑꯁꯤ ꯍꯪꯕꯤꯔꯀꯄꯥ ꯌꯥꯏ:

• ꯑꯩꯒꯤ ꯑꯉꯥꯡꯗꯥ ꯀꯔꯤ ꯃꯈꯂꯒꯤ HAE ꯂꯩꯕꯒꯦ?
• ꯀꯔꯤ ꯂꯥꯏꯌꯦꯡꯒꯤ ꯔꯤꯀꯃꯦꯟꯗ ꯇꯧꯔꯤꯕꯒꯦ?
• ꯑꯩꯒꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯑꯣꯟ-ꯗꯤꯃꯥꯟꯗ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛ ꯃꯊꯧ ꯇꯥꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯑꯩꯅꯥ ꯀꯔꯝꯅꯥ ꯈꯪꯒꯅꯤ?
• ꯑꯩꯒꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯄ꯭ꯔꯤꯚꯦꯟꯇꯤꯚ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯃꯊꯧ ꯇꯥꯕ꯭ꯔꯥ? ꯀꯔꯤꯒꯨꯝꯕꯥ ꯑꯣꯏꯔꯒꯗꯤ ꯀꯗꯥꯌꯗꯥ?
• ꯑꯩꯒꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯊꯤꯡꯒꯗꯕꯥ ꯊꯕꯛ-ꯊꯧꯔꯃꯁꯤꯡ ꯅꯠꯠꯔꯒꯥ ꯐꯤꯚꯃꯁꯤꯡ ꯂꯩꯕ꯭ꯔꯥ?
• ꯑꯩꯒꯤ ꯑꯉꯥꯡꯒꯤ ꯇꯨꯡꯒꯤ ꯄꯨꯟꯁꯤ (ꯑꯥꯎꯠꯂꯨꯛ)ꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯀꯔꯤ ꯍꯥꯌꯕꯥ ꯌꯥꯕꯒꯦ?

ꯑꯩꯈꯣꯌꯅꯥ ꯃꯇꯧ ꯀꯔꯝꯅꯥ HAE ꯂꯩꯕꯥ ꯑꯉꯥꯡ ꯑꯃꯒꯤꯗꯃꯛ ꯑꯥꯁꯥ ꯂꯩꯒꯅꯤ?

HAE ꯑꯁꯤ ꯄꯨꯟꯁꯤ ꯆꯨꯞꯄꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯂꯥꯏꯌꯦꯡꯕꯅꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯗꯨꯅꯥ ꯑꯉꯥꯡ ꯑꯃꯒꯤ ꯄꯨꯟꯁꯤꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯁꯥꯐꯨ ꯑꯗꯨ ꯍꯟꯊꯍꯅꯕꯥ ꯉꯝꯃꯤ꯫ ꯃꯁꯤꯅꯥ ꯑꯉꯥꯡ ꯑꯗꯨꯒꯤ ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯥ ꯋꯥꯕꯥ (swelling) ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯄꯨꯟꯁꯤ ꯃꯥꯡꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡꯒꯤ ꯔꯤꯁ꯭ꯀꯁꯨ ꯍꯟꯊꯍꯅꯕꯥ ꯉꯝꯃꯤ꯫

HAE ꯑꯁꯤ ꯊꯤꯡꯕꯥ ꯉꯃꯒꯗ꯭ꯔꯥ?

ꯍꯧꯖꯤꯛꯀꯤ ꯑꯣꯏꯅꯥ ꯑꯩꯆ.ꯑꯦ.ꯏ. ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛ ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯄꯥꯔꯇꯅꯔ ꯑꯗꯨꯗꯥ HAE ꯂꯩꯔꯕꯗꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯅꯥ ꯑꯉꯥꯡ ꯑꯃꯥ ꯄꯣꯛꯅꯕꯥ ꯍꯣꯠꯅꯔꯕꯗꯤ,ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯁꯤ ꯏꯅꯍꯦꯔꯤ ꯇꯧꯕꯒꯤ ꯆꯥꯡ ꯑꯗꯨ ꯈꯪꯖꯤꯅꯕꯥ ꯉꯝꯅꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯀꯥꯎꯟꯁꯦꯂꯔ ꯑꯃꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯑꯐꯕꯥ ꯋꯥꯈꯜꯂꯣꯟ ꯑꯃꯅꯤ꯫

ꯑꯗꯣꯃꯒꯤꯗꯃꯛ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯄꯥꯎꯖꯦꯜ ꯑꯃꯥ꯫

ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯗꯥ HAEꯒꯨꯝꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯥ ꯂꯩ ꯍꯥꯌꯕꯥ ꯈꯪꯂꯕꯥ ꯃꯇꯃꯗꯥ, ꯅꯍꯥꯛꯅꯥ ꯃꯈꯜ ꯀꯌꯥꯒꯤ ꯏꯃꯣꯁꯅꯁꯤꯡ ꯐꯥꯎꯕꯥ ꯌꯥꯏ: ꯑꯀꯤꯕꯥ, ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ, ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ꯫ ꯅꯍꯥꯛꯅꯥ ꯅꯁꯥꯕꯨ ꯗꯣꯁ ꯇꯧꯕꯁꯨ ꯌꯥꯏ꯫ ꯑꯗꯨꯕꯨ ꯅꯍꯥꯛꯅꯥ ꯈꯪꯖꯤꯅꯒꯗꯕꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯋꯥꯐꯃꯗꯤ ꯃꯁꯤꯒꯤ ꯗꯥꯏꯑꯦꯒ꯭ꯅꯣꯁꯤꯁ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯑꯁꯣꯌꯕꯥ ꯅꯠꯇꯦ꯫

ꯖꯦꯅꯦꯇꯤꯛ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯁꯤ ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯊꯣꯀꯏ, ꯑꯌꯥꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯃꯔꯝ ꯑꯃꯠꯇꯥ ꯂꯩꯇꯅꯥ ꯊꯣꯀꯏ꯫ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯅꯥ ꯏꯅꯍꯦꯔꯤ ꯇꯧꯔꯤꯕꯥ ꯖꯤꯅꯁꯤꯡ ꯑꯗꯨ ꯅꯍꯥꯛꯅꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯥ ꯉꯃꯗꯦ꯫ ꯑꯗꯨꯕꯨ ꯅꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯉꯥꯡ ꯑꯗꯨꯕꯨ ꯌꯦꯡꯁꯤꯅꯕꯗꯥ ꯑꯦꯛꯇꯤꯕ ꯑꯣꯏꯕꯥ ꯊꯧꯗꯥꯡ ꯂꯧꯕꯥ ꯌꯥꯏ – ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯃꯁꯤ ꯃꯈꯣꯌꯗꯥ "ꯅꯍꯥꯛ ꯐꯅꯥ ꯂꯩꯒꯅꯤ" ꯍꯥꯌꯅꯥ ꯊꯥꯖꯕꯥ ꯄꯤꯕꯈꯛꯇꯅꯤ꯫

ꯄꯦꯁꯦꯟꯇ ꯁꯄꯣꯔꯠ ꯒ꯭ꯔꯨꯄꯁꯤꯡꯗꯥ ꯌꯥꯎꯍꯅꯕꯗꯁꯨ ꯃꯇꯦꯡ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ HAEꯅꯥ ꯅꯥꯕꯥ ꯑꯉꯥꯡꯁꯤꯡꯒꯤ ꯃꯃꯥ-ꯃꯄꯥꯁꯤꯡꯒꯥ ꯂꯣꯌꯅꯅꯥ, ꯀꯟꯗꯤꯁꯟ ꯂꯩꯕꯥ ꯑꯍꯂꯁꯤꯡꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯕꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯄꯥꯎꯇꯥꯛ ꯄꯤꯕꯥ ꯉꯃꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯇꯥꯕꯥ ꯌꯥꯕꯥ ꯀꯥꯡꯕꯨ ꯑꯃꯥ ꯄꯤꯕꯥ ꯉꯃꯒꯅꯤ꯫ ꯃꯁꯤꯅꯥ ꯅꯍꯥꯀꯄꯨ HAE ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯅꯦꯝꯂꯕꯁꯨ, ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡ-ꯃꯅꯨꯡꯗꯤ ꯃꯁꯥ ꯃꯊꯟꯇꯥ ꯂꯩꯖꯗꯦ ꯍꯥꯌꯕꯁꯤꯁꯨ ꯅꯤꯡꯁꯤꯡꯍꯅꯕꯥ ꯌꯥꯏ꯫

` ꯍꯦꯔꯤꯇꯦꯖ ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ, HAE, ꯁꯣꯀꯄꯥ, C1 ꯏꯅꯍꯤꯕꯤꯇꯔ, ꯖꯦꯅꯦꯇꯤꯛ ꯂꯥꯌꯅꯥ, ꯑꯉꯥꯡꯁꯤꯡꯗꯥ ꯁꯣꯀꯄꯥ, ꯑꯦꯟꯖꯤꯑꯣꯏꯗꯤꯃꯥ꯫