ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯀꯦꯟꯁꯔꯒꯥ ꯂꯥꯟꯊꯦꯡꯅꯔꯕꯗꯤ, ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯅꯨꯡꯁꯤꯖꯔꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯃꯁꯤ ꯅꯥꯕꯥ ꯑꯣꯏꯔꯕꯗꯤ, ꯅꯍꯥꯛꯅꯥ "ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ" ꯑꯃꯁꯨꯡ "ꯔꯦꯗꯤꯑꯦꯁꯟ ꯊꯦꯔꯥꯄꯤ"ꯒꯨꯝꯕꯥ ꯋꯥꯍꯩꯁꯤꯡ ꯑꯁꯤ ꯈꯪꯂꯝꯕꯥ ꯌꯥꯏ꯫ ꯂꯥꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯂꯥꯀꯄꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯇꯥꯕꯤꯔꯝꯂꯒꯅꯤ꯫ ꯑꯗꯨꯕꯨ ꯉꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯈꯛꯇꯗꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯑꯃꯁꯨꯡ ꯍꯀꯆꯥꯡ ꯐꯕꯥ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯍꯟꯊꯍꯜꯂꯤꯕꯥ ꯗ꯭ꯔꯒꯁꯤꯡꯒꯤ ꯌꯥꯝꯅꯥ ꯑꯅꯧꯕꯥ ꯀ꯭ꯂꯥꯁ ꯑꯃꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯔꯤ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯕꯨ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ ꯍꯥꯌꯅꯥ ꯀꯧꯏ .
ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯃꯁꯤꯒꯤ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯏꯅꯍꯤꯕꯤꯇꯔ ꯑꯁꯤ ꯀꯔꯤꯅꯣ?
ꯃꯁꯤ ꯈꯉꯅꯕꯒꯤꯗꯃꯛ ꯑꯩꯈꯣꯌꯅꯥ ꯑꯍꯥꯅꯕꯗꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯒꯤ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯊꯣꯀꯄꯥ ꯑꯄꯤꯀꯄꯥ ꯑꯗꯨꯕꯨ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯊꯧꯑꯣꯡ ꯑꯃꯥ ꯈꯉꯕꯥ ꯃꯊꯧ ꯇꯥꯏ꯫ ꯑꯩꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯒꯤ ꯁꯦꯜ ꯈꯨꯗꯤꯡꯃꯛꯀꯤ ꯃꯅꯨꯡꯗꯥ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ. ꯑꯩꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯄꯣꯠ ꯈꯨꯗꯤꯡꯃꯛ ꯀꯔꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯒꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯏꯕꯥ ꯑꯆꯧꯕꯥ ꯕ꯭ꯂꯨꯞꯔꯤꯟꯇ ꯑꯃꯒꯨꯝ ꯈꯅꯕꯤꯌꯨ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ, ꯗꯤ.ꯑꯦꯟ.ꯑꯦ.ꯒꯤ ꯕ꯭ꯂꯨꯞꯔꯤꯟꯇ ꯑꯁꯤꯒꯤ ꯄꯦꯖꯁꯤꯡ ꯑꯁꯤ ꯈꯔꯥ ꯁꯣꯀꯍꯜꯂꯤ꯫
ꯃꯁꯤꯗꯥ PARP ꯀꯧꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯃꯥ ꯌꯥꯑꯣꯏ꯫ "PARP" ꯍꯥꯌꯕꯁꯤ ꯄꯣꯂꯤ (ADP-ꯔꯥꯏꯕꯣꯖ) ꯄꯣꯂꯤꯃꯔꯦꯖꯒꯤ ꯑꯦꯕꯕ꯭ꯔꯤꯕꯤꯌꯦꯁꯟ ꯑꯃꯅꯤ꯫ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯅꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯃꯅꯨꯡꯗꯥ "ꯔꯤꯄꯦꯌꯥꯔ ꯃꯦꯀꯥꯅꯤꯛ" ꯑꯃꯒꯨꯝꯅꯥ ꯂꯩ꯫ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ.ꯗꯥ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯊꯣꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯆꯪꯗꯨꯅꯥ ꯁꯦꯃꯖꯤꯜꯂꯤ꯫ ꯃꯁꯤ ꯍꯀꯆꯥꯡ ꯐꯕꯥ ꯁꯦꯂꯁꯤꯡ ꯍꯤꯡꯅꯕꯒꯤꯗꯃꯛ ꯇꯉꯥꯏꯐꯗꯕꯥ ꯑꯃꯅꯤ꯫
ꯑꯗꯨꯕꯨ ꯁꯃꯁ꯭ꯌꯥ ꯑꯁꯤꯗꯤ, ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯅꯁꯨ ꯃꯁꯤꯒꯤ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯃꯦꯀꯥꯅꯤꯖꯝ ꯑꯁꯤ ꯃꯈꯣꯌꯒꯤ ꯀꯥꯟꯅꯕꯥ ꯑꯣꯏꯅꯥ ꯁꯤꯖꯤꯟꯅꯩ꯫ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ.ꯗꯥ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯊꯣꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯃꯈꯣꯌꯅꯥ ꯃꯁꯤꯒꯤ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ. ꯃꯁꯤꯒꯤ ꯃꯍꯩ ꯑꯣꯏꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯁꯤꯕꯥ ꯉꯃꯗꯦ, ꯑꯗꯨꯕꯨ ꯃꯈꯥ ꯇꯥꯅꯥ ꯍꯦꯅꯒꯠꯂꯀꯏ ꯑꯃꯁꯨꯡ ꯍꯀꯆꯥꯡ ꯄꯨꯝꯕꯗꯥ ꯁꯟꯗꯣꯀꯏ꯫
ꯃꯁꯤꯒꯤ ꯁꯣꯂꯨꯁꯟ ꯑꯃꯥ ꯑꯣꯏꯅꯥ ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ PARP Inhibitor ꯀꯧꯕꯥ ꯗ꯭ꯔꯒ ꯑꯃꯥ ꯁꯤꯖꯤꯟꯅꯩ꯫ "ꯏꯅꯍꯤꯕꯤꯇꯔ" ꯍꯥꯌꯕꯁꯤ "ꯕ꯭ꯂꯣꯀꯔ" ꯍꯥꯌꯕꯅꯤ꯫ ꯗ꯭ꯔꯒ ꯑꯁꯤꯅꯥ ꯇꯧꯔꯤꯕꯥ ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯤꯕꯥ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯃꯦꯀꯥꯅꯤꯖꯝ ꯑꯁꯤ "ꯕ꯭ꯂꯣꯛ" ꯇꯧꯕꯅꯤ꯫ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯃꯇꯦꯡ ꯌꯥꯑꯣꯗꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯑꯁꯤ ꯇꯞꯅꯥ ꯇꯞꯅꯥ ꯁꯣꯟꯊꯔꯀꯏ, ꯁꯣꯀꯍꯜꯂꯕꯥ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ.
ꯃꯁꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯒꯤ "ꯁꯔꯚꯥꯏꯚꯜ ꯁꯤꯁ꯭ꯇꯦꯝ" ꯊꯤꯡꯕꯒꯥ ꯃꯥꯟꯅꯩ꯫ ꯃꯔꯝ ꯑꯁꯤꯅꯥ ꯂꯥꯌꯦꯡꯕꯒꯤ ꯃꯑꯣꯡ ꯑꯁꯤꯕꯨ ꯇꯥꯔꯒꯦꯠ ꯊꯦꯔꯥꯄꯤ ꯍꯥꯌꯅꯥꯁꯨ ꯀꯧꯏ . ꯍꯥꯌꯕꯗꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯋꯥꯠꯄꯥ ꯑꯃꯥ ꯍꯀꯊꯦꯡꯅꯅꯥ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯏ꯫
ꯃꯥꯂꯦꯃꯗꯥ ꯁꯤꯖꯤꯟꯅꯔꯤꯕꯥ PARP ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯃꯈꯂꯁꯤꯡ꯫
ꯍꯧꯖꯤꯛ ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯅꯕꯥ ꯑꯌꯥꯕꯥ ꯄꯤꯔꯕꯥ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ. ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯃꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯕꯨ ꯄ꯭ꯔꯦꯁ꯭ꯛꯔꯥꯏꯕ ꯇꯧꯔꯕꯗꯤ, ꯃꯗꯨ ꯂꯤꯁ꯭ꯠ ꯑꯁꯤꯗꯥ ꯌꯥꯎꯕꯥ ꯌꯥꯏ꯫
| ꯃꯦꯗꯤꯁꯤꯅꯒꯤ ꯖꯦꯅꯦꯔꯦꯜ ꯃꯃꯤꯡ꯫ | ꯕ꯭ꯔꯥꯟꯗ ꯅꯦꯝ꯫ |
|---|---|
| ꯑꯣꯂꯥꯄꯥꯔꯤꯕ꯫ | ꯂꯤꯅꯄꯥꯔꯖꯥ® |
| ꯅꯤꯔꯥꯄꯥꯔꯤꯕ꯫ | ꯖꯦꯖꯨꯂꯥ® |
| ꯔꯨꯀꯥꯄꯥꯔꯤꯕ꯫ | ꯔꯨꯕ꯭ꯔꯥꯀꯥ® |
| ꯇꯥꯂꯥꯖꯣꯄꯥꯔꯤꯕ꯫ | ꯇꯥꯂꯖꯦꯟꯅꯥ® |
ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯀꯔꯤ ꯃꯈꯂꯒꯤ ꯀꯦꯟꯁꯔꯗꯥ ꯁꯤꯖꯤꯟꯅꯕꯒꯦ?
PARP ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ ꯑꯁꯤ ꯃꯍꯧꯁꯥꯅꯥ ꯍꯦꯟꯅꯥ ꯆꯥꯎꯈꯠꯄꯥ ꯅꯠꯠꯔꯒꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯑꯇꯩ ꯃꯐꯃꯁꯤꯡꯗꯥ ꯁꯟꯗꯣꯔꯀꯄꯥ (ꯃꯦꯇꯥꯁ꯭ꯇꯦꯇꯤꯛ) ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤꯗꯃꯛꯇꯥ ꯁꯤꯖꯤꯟꯅꯩ꯫ ꯃꯈꯣꯌ ꯑꯁꯤ ꯃꯔꯨꯑꯣꯏꯅꯥ ꯏꯐꯦꯛꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯀꯌꯥ ꯂꯩ꯫
- ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ꯫
- ꯑꯣꯕꯦꯔꯤꯌꯟ ꯀꯦꯟꯁꯔ꯫
- ꯐꯦꯂꯣꯄꯤꯌꯥꯟ ꯇꯤꯎꯕ ꯀꯦꯟꯁꯔ꯫
- ꯄ꯭ꯔꯣꯁ꯭ꯇꯦꯠ ꯀꯦꯟꯁꯔ꯫
- ꯄ꯭ꯔꯥꯏꯃꯥꯔꯤ ꯄꯦꯔꯤꯇꯣꯅꯤꯑꯦꯜ ꯀꯦꯟꯁꯔ꯫
- ꯄꯦꯅꯛꯔꯤꯑꯦꯇꯤꯛ ꯀꯦꯟꯁꯔ꯫
ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯒꯤ ꯖꯤꯟ ꯃ꯭ꯌꯨꯇꯦꯁꯅꯒꯥ ꯑꯈꯟꯅꯕꯥ ꯃꯔꯤ꯫
ꯃꯐꯝ ꯑꯁꯤꯗꯥ ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯒꯤ ꯖꯤꯅꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯗꯣꯝꯅꯥ ꯁꯣꯏꯗꯅꯥ ꯈꯉꯒꯗꯕꯥ ꯋꯥꯐꯝ ꯑꯃꯥ ꯌꯥꯑꯣꯔꯤ . ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯅꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ.ꯕꯨ ꯁꯦꯃꯖꯤꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯕꯥ ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔ ꯉꯥꯀꯊꯣꯀꯄꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯤꯕꯥ ꯑꯇꯣꯞꯄꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯖꯤꯟ ꯑꯃꯅꯤ꯫ ꯑꯗꯨꯕꯨ ꯃꯤꯑꯣꯏ ꯈꯔꯗꯤ ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯒꯤ ꯖꯤꯟ ꯑꯁꯤꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯂꯩꯕꯥ ꯌꯥꯏ꯫ ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯃꯈꯣꯌꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ.ꯒꯤ ꯔꯤꯄꯦꯌꯔ ꯁꯤꯁ꯭ꯇꯦꯝ ꯑꯃꯅꯥ ꯃꯑꯣꯡ ꯆꯨꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯗꯦ꯫ ꯃꯁꯤꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯃꯈꯣꯌꯗꯥ ꯀꯦꯟꯁꯔ ꯂꯥꯀꯄꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯟꯅꯥ ꯂꯩ꯫
ꯒꯥꯔꯤ ꯑꯃꯕꯨ ꯕ꯭ꯔꯦꯛ ꯁꯤꯁ꯭ꯇꯦꯝ ꯑꯅꯤ ꯂꯩꯕꯥ ꯍꯥꯌꯅꯥ ꯈꯜꯂꯨ꯫ ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯅꯥ ꯑꯃꯅꯤ, ꯑꯃꯁꯨꯡ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯅꯥ ꯑꯇꯣꯞꯄꯥ ꯑꯃꯅꯤ꯫ ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯒꯤ ꯖꯤꯟ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯂꯩꯕꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯑꯃꯗꯥ, ꯕ꯭ꯔꯦꯛ ꯁꯤꯁ꯭ꯇꯦꯝ ꯑꯃꯥ (ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.) ꯍꯥꯟꯅꯅꯥ ꯁꯣꯀꯈ꯭ꯔꯦ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯑꯁꯤ ꯍꯤꯡꯅꯕꯒꯤꯗꯃꯛ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯃꯄꯨꯡ ꯐꯥꯅꯥ ꯑꯇꯣꯞꯄꯥ ꯕ꯭ꯔꯦꯛ ꯁꯤꯁ꯭ꯇꯦꯝ (ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.)ꯗꯥ ꯊꯥꯖꯕꯥ ꯊꯝꯂꯤ꯫
ꯍꯧꯖꯤꯛ ꯑꯩꯈꯣꯌꯅꯥ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯏꯅꯍꯤꯕꯤꯇꯔ ꯗ꯭ꯔꯒꯁꯤꯡ ꯄꯤꯕꯥ ꯃꯇꯃꯗꯥ ꯑꯩꯈꯣꯌꯅꯥ ꯑꯗꯨꯒꯨꯝꯕꯥ ꯑꯅꯤꯁꯨꯕꯥ ꯕ꯭ꯔꯦꯛ ꯁꯤꯁ꯭ꯇꯦꯝ ꯑꯗꯨꯁꯨ ꯑꯣꯐ ꯇꯧꯏ꯫ ꯑꯗꯨꯗꯒꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯑꯗꯨꯅꯥ ꯃꯁꯥꯒꯤ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ. ꯃꯁꯤꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ ꯑꯁꯤ ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯒꯤ ꯖꯤꯟ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯂꯩꯕꯥ ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤꯗꯃꯛꯇꯥ ꯑꯁꯨꯛ ꯌꯥꯝꯅꯥ ꯏꯐꯦꯛꯇꯤꯕ ꯑꯣꯏ꯫
ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯐꯪꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯃꯇꯝ ꯀꯌꯥ ꯂꯧꯒꯅꯤ?
ꯂꯥꯌꯦꯡ ꯑꯁꯤꯒꯤ ꯈꯨꯗꯣꯡꯆꯥꯕꯥ ꯑꯃꯗꯤ ꯃꯁꯤ ꯄꯨꯝꯅꯃꯛ ꯑꯁꯤ ꯄꯤꯂꯒꯤ ꯃꯑꯣꯡꯗꯥ (ꯀꯦꯄꯁꯨꯜ ꯅꯠꯠꯔꯒꯥ ꯇꯦꯕꯜ) ꯂꯥꯀꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯅꯍꯥꯛꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯅꯣꯡꯃꯗꯥ ꯑꯃꯨꯛ ꯅꯠꯠꯔꯒꯥ ꯑꯅꯤꯔꯛ ꯈꯛꯇꯃꯛ ꯂꯧꯒꯗꯕꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯈꯛꯇꯅꯥ ꯃꯇꯤꯛ ꯆꯥꯕꯥ ꯑꯣꯏꯔꯀꯄꯥ ꯌꯥꯏ꯫ ꯑꯇꯣꯞꯄꯥ ꯃꯇꯃꯗꯥ, ꯅꯍꯥꯛꯅꯥ ꯃꯁꯤ ꯑꯇꯣꯞꯄꯥ ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯌꯦꯡꯁꯤꯡꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯂꯧꯕꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯌꯥꯏ꯫
ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ ꯅꯠꯠꯔꯒꯥ ꯔꯦꯗꯤꯑꯦꯁꯟ ꯊꯦꯔꯥꯄꯤꯒꯨꯝꯕꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ.ꯗꯥ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯂꯥꯌꯦꯡꯁꯤꯡꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ. ꯑꯗꯨꯗꯒꯤ ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯅꯥ ꯁꯣꯀꯍꯜꯂꯕꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯗꯨ ꯃꯁꯥꯅꯥ ꯁꯦꯃꯖꯕꯥ ꯉꯃꯗꯕꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯁꯦꯂꯁꯤꯡ ꯑꯗꯨ ꯁꯤꯕꯒꯤ ꯒ꯭ꯌꯥꯔꯦꯟꯇꯤ ꯂꯩ꯫
ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯝ꯫
ꯃꯁꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯈꯦꯠꯅꯩ꯫
- ꯃꯤꯑꯣꯏ ꯈꯔꯗꯗꯤ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ ꯂꯥꯌꯦꯡ ꯂꯣꯏꯔꯕꯥ ꯃꯇꯨꯡꯗꯥ ꯑꯀꯛꯅꯕꯥ ꯃꯇꯃꯒꯤ ꯑꯣꯏꯅꯥ, ꯍꯥꯌꯕꯗꯤ ꯆꯍꯤ ꯑꯅꯤ ꯅꯠꯠꯔꯒꯥ ꯑꯍꯨꯃꯒꯤ ꯑꯣꯏꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯄꯤꯔꯤ꯫
- ꯃꯤꯑꯣꯏ ꯈꯔꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯃꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯊꯕꯛ ꯇꯧꯕꯥ ꯃꯇꯃꯗꯥ ꯃꯈꯥ ꯇꯥꯅꯥ ꯂꯧꯏ꯫
- ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯑꯗꯨꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯗꯨꯒꯤ ꯀꯥꯟꯅꯕꯁꯤꯡꯗꯒꯤ ꯍꯦꯜꯂꯕꯗꯤ, ꯅꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯗꯨꯅꯥ ꯂꯥꯏꯌꯦꯡ ꯑꯗꯨ ꯊꯤꯡꯖꯤꯅꯕꯥ ꯌꯥꯏ꯫
ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯅꯍꯥꯛꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯗꯨ ꯀꯌꯥꯝ ꯁꯥꯡꯅꯥ ꯂꯧꯒꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯈꯟꯅ-ꯅꯩꯅꯗꯨꯅꯥ ꯋꯥꯔꯦꯞ ꯑꯃꯥ ꯂꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫
ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤꯒꯤ ꯀꯥꯟꯅꯕꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯀꯥꯟꯅꯕꯁꯤꯡ ꯀꯔꯤꯅꯣ?
PARP ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡꯅꯥ ꯀꯦꯟꯁꯔ ꯃꯄꯨꯡꯐꯥꯅꯥ ꯐꯍꯅꯕꯥ ꯉꯃꯗꯦ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ ꯃꯈꯣꯌꯅꯥ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯈꯔꯒꯤ ꯑꯅꯥꯕꯁꯤꯡꯕꯨ ꯍꯦꯟꯅꯥ ꯍꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯕꯥ ꯉꯃꯒꯅꯤ . ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯏ꯫ ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯃꯁꯤ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ ꯑꯁꯤ “ꯄ꯭ꯔꯣꯒ꯭ꯔꯦꯁꯟ-ꯐ꯭ꯔꯤ ꯁꯔꯚꯥꯏꯚꯜ ꯔꯦꯠ” ꯍꯥꯌꯅꯥ ꯀꯧꯏ꯫ ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯃꯈꯣꯌꯅꯥ ꯀꯦꯟꯁꯔ ꯑꯗꯨ ꯍꯦꯟꯅꯥ ꯐꯠꯆꯤꯜꯂꯛꯇꯨꯅꯥ ꯐꯖꯅꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯥ ꯃꯇꯝ ꯍꯦꯅꯒꯠꯍꯜꯂꯤ꯫ ꯀꯦꯁ ꯈꯔꯗꯗꯤ, ꯃꯈꯣꯌ ꯑꯁꯤ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯏꯐꯦꯛꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫
ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯃꯇꯃꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ, ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯈꯔꯗꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯒꯤ "ꯔꯦꯁꯤꯁ꯭ꯇꯦꯟꯁ" ꯁꯦꯝꯕꯥ ꯍꯧꯏ꯫ ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯥ ꯍꯧꯔꯔꯣꯏ꯫ ꯃꯁꯤ ꯄꯦꯁꯦꯟꯇꯁꯤꯡꯒꯤ 40% ꯑꯃꯁꯨꯡ 70%ꯒꯤ ꯃꯔꯛꯇꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫ ꯁꯥꯏꯟꯇꯤꯁ꯭ꯇꯁꯤꯡꯅꯥ ꯀꯔꯤꯒꯤꯗꯃꯛꯇꯥ ꯃꯁꯤ ꯊꯣꯛꯂꯤꯕꯅꯣ ꯍꯥꯌꯕꯗꯨ ꯈꯉꯅꯕꯥ ꯍꯣꯠꯅꯔꯤ ꯑꯃꯁꯨꯡ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯑꯁꯤ ꯍꯦꯟꯅꯥ ꯏꯐꯦꯛꯇꯤꯕ ꯑꯣꯏꯍꯟꯅꯕꯥ ꯑꯅꯧꯕꯥ ꯄꯥꯝꯕꯩꯁꯤꯡ ꯊꯤꯖꯤꯜꯂꯤ꯫
ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯀꯤ ꯃꯇꯥꯡꯗꯁꯨ ꯈꯪꯖꯤꯅꯁꯤ꯫
ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡ ꯑꯃꯍꯦꯛꯇꯒꯨꯝꯅꯥ, PARP ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡꯅꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯈꯔꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯕꯨ ꯃꯤꯄꯨꯝ ꯈꯨꯗꯤꯡꯃꯛꯅꯥ ꯃꯈꯣꯌꯁꯤꯡ ꯑꯁꯤ ꯐꯪꯗꯦ꯫ ꯑꯃꯁꯨꯡ ꯃꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯀꯌꯥ ꯑꯃꯗꯤ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯥ ꯌꯥꯏ꯫
| ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ꯫ | ꯃꯗꯨꯒꯤ ꯃꯔꯝ ꯅꯠꯔꯒꯥ ꯍꯦꯟꯅꯥ ꯑꯀꯨꯞꯄꯥ ꯃꯔꯣꯂꯁꯤꯡ꯫ |
|---|---|
| ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ꯫ | ꯃꯁꯤ ꯑꯌꯥꯝꯕꯗꯤ ꯑꯦꯅꯤꯃꯤꯌꯥꯅꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ, ꯃꯁꯤꯅꯥ ꯏꯗꯥ ꯔꯦꯗ ꯕ꯭ꯂꯗ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯃꯁꯤꯡ ꯍꯟꯊꯍꯅꯕꯅꯤ꯫ |
| ꯏ ꯊꯣꯀꯄꯥ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯁꯣꯛ-ꯄꯅꯕꯥ, ꯅꯥꯀꯣꯡꯗꯥ ꯏ ꯊꯣꯀꯄꯥ) | ꯃꯁꯤ ꯕ꯭ꯂꯗ ꯄ꯭ꯂꯦꯇꯂꯦꯇꯁꯤꯡꯒꯤ ꯃꯁꯤꯡ ꯍꯟꯊꯔꯀꯄꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ |
| ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯏꯅꯐꯦꯛꯁꯟ ꯂꯩꯕꯥ꯫ | ꯋꯥꯏꯠ ꯕ꯭ꯂꯗ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯃꯁꯤꯡ ꯍꯟꯊꯔꯀꯄꯅꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯏꯝꯝꯌꯨꯟ ꯁꯤꯁ꯭ꯇꯦꯝ ꯁꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫ |
| ꯅꯣꯡꯃꯩ ꯀꯥꯞꯄꯥ ꯑꯃꯁꯨꯡ ꯈꯣꯡ ꯍꯥꯝꯕꯥ꯫ | ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯅꯕꯥ ꯑꯇꯣꯞꯄꯥ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯂꯧꯕꯥ ꯌꯥꯏ꯫ |
| ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯈꯣꯡ ꯍꯥꯝꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯈꯣꯡ ꯍꯥꯝꯕꯥ (constipation)꯫ | ꯃꯁꯤ ꯗꯥꯏꯑꯦꯇꯔꯤ ꯍꯣꯡꯗꯣꯛ-ꯍꯣꯡꯖꯤꯟ ꯇꯧꯗꯨꯅꯥ ꯑꯃꯁꯨꯡ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯊꯧ ꯇꯥꯔꯕꯗꯤ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡꯅꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯥ ꯌꯥꯏ꯫ |
| ꯃꯤꯠꯀꯤ ꯃꯆꯤꯟꯖꯥꯛ ꯍꯣꯡꯂꯀꯄꯥ (dysgeusia) . | ꯆꯤꯟꯖꯥꯛ ꯑꯁꯤ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯃꯈꯂꯒꯤ ꯃꯆꯤ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ |
| ꯑꯔꯨꯝꯕꯥ ꯍꯟꯊꯕꯥ, ꯃꯃꯤꯠ ꯇꯥꯡꯕꯥ, ꯃꯀꯣꯛ ꯁꯣꯀꯄꯥ꯫ | ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯁꯨ ꯃꯤꯑꯣꯏ ꯈꯔꯗꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯕꯥ ꯐꯤꯚꯃꯁꯤꯡꯅꯤ꯫ |
ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ, ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯏꯅꯍꯤꯕꯤꯇꯔ ꯈꯔꯅꯥ ꯑꯦꯛꯌꯨꯠ ꯃꯥꯏꯂꯣꯏꯗ ꯂꯤꯎꯀꯦꯃꯤꯌꯥ ꯀꯧꯕꯥ ꯕ꯭ꯂꯗ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯑꯃꯥ ꯂꯥꯀꯄꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯃꯁꯤ ꯌꯥꯝꯅꯥ ꯇꯣꯏꯅꯥ ꯊꯣꯀꯄꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ꯫
ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯈꯨꯗꯛꯇꯥ ꯀꯗꯥꯏꯗꯥ ꯈꯪꯍꯅꯒꯗꯒꯦ꯫
ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ PARP ꯏꯅꯍꯤꯕꯤꯇꯔ ꯑꯃꯥ ꯂꯧꯔꯕꯗꯤ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯅꯧꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯍꯦꯟꯅꯥ ꯐꯒꯠꯂꯛꯂꯤꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯑꯃꯠꯇꯥ ꯂꯩꯔꯕꯗꯤ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯈꯪꯍꯅꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ . ꯃꯍꯥꯛꯅꯥ ꯗꯣꯖ ꯑꯗꯨ ꯍꯣꯡꯗꯣꯛ-ꯍꯣꯡꯖꯤꯟ ꯇꯧꯕꯥ ꯌꯥꯏ ꯅꯠꯠꯔꯒꯥ ꯑꯇꯩ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯄꯤꯕꯥ ꯌꯥꯏ, ꯃꯗꯨꯅꯥ ꯋꯥꯈꯜ ꯃꯥꯡꯕꯅꯆꯤꯡꯕꯥ ꯄꯣꯠꯁꯀꯁꯤꯡꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫
ꯃꯔꯨꯑꯣꯏꯅꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯊꯦꯡꯅꯔꯕꯗꯤ:ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔ ꯅꯠꯠꯔꯒꯥ ꯂꯥꯏꯌꯦꯡꯂꯤꯕꯥ ꯍꯣꯁ꯭ꯄꯤꯇꯥꯂꯗꯥ ꯈꯨꯗꯛꯇꯥ ꯈꯪꯍꯅꯕꯤꯌꯨ:
- ꯏꯅꯐꯦꯛꯁꯟ ꯑꯃꯒꯤ ꯈꯨꯗꯃꯁꯤꯡ: ꯂꯥꯏꯍꯧ, ꯆꯤꯀꯄꯥ, ꯑꯃꯁꯨꯡ ꯏꯪꯊꯕꯥ꯫
- ꯅ꯭ꯌꯨꯃꯣꯅꯤꯇꯤꯁꯀꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ: ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯥ ꯋꯥꯕꯥ, ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯥ ꯋꯥꯕꯥ, ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯑꯁꯤꯅꯆꯤꯡꯕꯥ (ꯃꯁꯤ ꯂꯪꯁꯀꯤ ꯏꯅꯐ꯭ꯂꯦꯃꯦꯇꯔꯤ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯅꯤ)꯫
- ꯏ ꯁꯣꯀꯄꯒꯤ ꯈꯨꯗꯃꯁꯤꯡ: ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯑꯅꯥꯕꯥ, ꯂꯥꯎꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯈꯣꯡꯗꯥ ꯁꯣꯀꯄꯥ, ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯥ ꯋꯥꯕꯥ꯫
ꯇꯦꯛ-ꯍꯣꯝ ꯃꯦꯁꯦꯖ ꯇꯧꯕꯥ꯫
- ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯗꯤ.ꯑꯦꯟ.ꯑꯦ.
- ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯃꯔꯨꯑꯣꯏꯅꯥ ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯒꯤ ꯖꯤꯟ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯂꯩꯕꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ, ꯑꯣꯕꯦꯔꯤꯌꯟ, ꯑꯃꯁꯨꯡ ꯄ꯭ꯔꯣꯁ꯭ꯇꯦꯠ ꯀꯦꯟꯁꯔꯒꯨꯝꯕꯥ ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤꯗꯃꯛꯇꯥ ꯏꯐꯦꯛꯇꯤꯕ ꯑꯣꯏ꯫
- ꯃꯁꯤꯒꯤ ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯏꯅꯖꯦꯀꯁꯅꯒꯤ ꯈꯨꯠꯊꯥꯡꯗꯥ ꯄꯤꯗꯦ, ꯑꯗꯨꯕꯨ ꯅꯨꯃꯤꯠ ꯈꯨꯗꯤꯡꯒꯤ ꯊꯀꯄꯥ ꯇꯦꯕ꯭ꯂꯦꯠ/ꯀꯦꯄꯁꯨꯜ ꯑꯣꯏꯅꯥ ꯄꯤ꯫
- ꯃꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯃꯄꯨꯡ ꯐꯥꯅꯥ ꯐꯍꯅꯕꯥ ꯉꯃꯗ꯭ꯔꯕꯁꯨ, ꯃꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯗꯨꯅꯥ ꯑꯅꯥꯕꯁꯤꯡꯕꯨ ꯍꯦꯟꯅꯥ ꯍꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫
- ꯑꯇꯣꯞꯄꯥ ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯕꯒꯨꯝꯅꯥ, ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯂꯩ꯫ ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ, ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ, ꯑꯃꯁꯨꯡ ꯕ꯭ꯂꯗ ꯁꯦꯜ ꯃꯁꯤꯡ ꯍꯟꯊꯕꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫
- ꯅꯍꯥꯛꯀꯤ ꯂꯥꯏꯌꯦꯡ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯅꯛꯅꯅꯥ ꯀꯟꯇꯦꯛꯇ ꯇꯧꯕꯥ ꯑꯃꯁꯨꯡ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯑꯃꯍꯦꯛꯇꯕꯨ ꯈꯨꯗꯛꯇꯥ ꯔꯤꯄꯣꯔꯠ ꯇꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫
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