Chii chinonzi Felty Syndrome? Izvi zvakakosha kune avo vane arthritis!

Ungavewo uine kurwadziwa kwemajoini, kuzvimba, uye kuomarara kwemakumbo ako mangwanani, handiti? Kazhinji, izvi zvinogona kukonzerwa nerheumatoid arthritis. Asi waiziva here kuti pane chimwe chinetso chinogona kuuya nechirwere ichi chearthritis, asi hachizivikanwe zvakanyanya, asi zvakakosha kuziva nezvacho? Ndiyo Felty Syndrome. Ngatitaurei nezvazvo zvakadzama nhasi.

Chii chinonzi Felty Syndrome?

Zvichitaurwa zviri nyore, Felty Syndrome musanganiswa wezvirwere zvitatu zvinoitika pamwe chete. Izvi ndeizvi:

• Rheumatoid Arthritis - Kuzvimba kwemajoini kwamunojaira vazhinji venyu.
• Neutropenia - Uku kudzikira kwehuwandu hwema neutrophils, rudzi rwemasero machena eropa muropa.
• Splenomegaly - Izvi zvinoreva kuti spleen, nhengo iri mumuviri, inokura kupfuura zvakajairika.

Kazhinji inotanga ne rheumatoid arthritis (RA). Zvimwe zvirwere zviviri zvinoitika sematambudziko eRA. Vanachiremba vanoti izvi 'extra-articular manifestations'. Kureva kuti, arthritis haingogumiri pamajoini chete, asi inokanganisa majoini ari kunze kwawo. Izvi zvinokonzerwa nekuzvimba kunokonzera arthritis. Kunyange zvazvo zvakajairika kuti mhando idzi dzemigumisiro dziitike kunze kwemajoini ane RA, Felty Syndrome chirwere chisingawanzoitiki.

Izvi zvinokukanganisa sei?

Felty's syndrome inotanga neRheumatoid Arthritis. Wobva wava nekurwadziwa kwakanyanya uye kuzvimba mumajoini ako. Wobva waita seNeutropenia neSplenomegaly, zvinokanganisa immune system yako. Neutropenia kudzikira kwerudzi rwemasero machena eropa anonzi neutrophils. Aya ma neutrophils rudzi rwakakosha kwazvo rwemasero anodzivirira muviri wedu kubva kuzvirwere. Saka kana akadzikira, mikana yekukura kwezvirwere inowedzera. Kukura kwepleen kunogonawo kuva chimwe chikonzero chekudzikira kwemasero aya.

Dambudziko iri rakajairika zvakadii?

Felty's syndrome inowanikwa muvanhu vanosvika 2% vane rheumatoid arthritis. Kufanana neRA, Felty's syndrome inowanikwa kakawanda katatu muvakadzi kupfuura varume. Zvinofadza kuti vanhu vese vane RA vanowana Felty's syndrome 'vane seropositive'. Izvi zvinoreva kuti bvunzo dzinosimbisa kuti vane chimwe chinhu chinonzi rheumatoid factor antibodies muropa ravo. Vanhu 'vane seronegative', zvichireva kuti vanhu vasina ma antibodies iwayo, havawanzowana Felty's syndrome.

Ndezvipi zviratidzo zveizvi?

Kazhinji, zviratidzo zvekutanga zvinoonekwa ndezve rheumatoid arthritis. Izvi zvinosanganisira:

• Kurwadziwa kwemajoini
• Kuzvimba kwemajoini
• Kuomarara kwemajoini, kunyanya mangwanani

Vamwe vanhu vanogona kusangana nezvimwe zviratidzo pamusoro peRA mumajoini avo. Semuenzaniso:

• Mapundu anoumbwa pasi peganda pedyo nemajoini (aya anonzi rheumatoid nodules)
• Ma lymph nodes akazvimba munzvimbo dzakadai semutsipa nehapwa
• Chiropa chinogona kuzvimba uye chinorwadza kana chikabatwa.
• Maziso nemuromo zvakaoma (izvi zvinonzi Sjogren's syndrome)
• Maziso matsvuku, akazvimba (izvi zvinonzi episcleritis)
• Maronda eganda, kunyanya pamakumbo
• Zviratidzo zvekubuda ropa pasi peganda
• Kutadza kufema nekuda kwekuzvimba kwemapapu
• Kurwadziwa pachipfuva nekuda kwekuzvimba kwakakomberedza moyo
• Kupindwa nechando
• Kuneta uye kuneta
• Kurasikirwa nechido chekudya kana kudzikira uremu kusingatsananguriki

Kuwedzera kune izvi, Felty Syndrome ine zvimwe zviratidzo. Dzimwe nguva zviratidzo izvi zvinogona kuonekwa zviratidzo zveRA zvisati zvatanga.

• Zvirwere zvinogara kwenguva refu. Mienzaniso inosanganisira dzihwa, marwadzo emudumbu, uye hutachiona hweganda.
• Kuzvimba kwetsvina. Kunogona kunzwikwa muruoko uye kunorwadza.
• Kuchinja ruvara rweganda (kunge mavara).

Asi chinoshamisa ndechekuti, dzimwe nguva unogona kuonekwa uine Felty Syndrome pasina zviratidzo. Kuongororwa kweropa uye kuskena kunogona kuratidza kuti une zvirwere zvese zvitatu usati watombonzwa zviratidzo.

Izvi zvinowanzotanga pazera ripi?

Felty Syndrome inowanzoonekwa nevanhu vakuru, vane makore ari pakati pe50 ne70. Kune vanhu vazhinji, Felty Syndrome inoonekwa mushure mekunge vaine zviratidzo zverheumatoid arthritis kwemakore angangoita gumi kusvika gumi nemashanu.

Sei Felty Syndrome ichiitika?

Rheumatoid arthritis 'chirwere che autoimmune'. Izvi zvinoreva kuti masoja edu emuviri anorwisa zvikamu zvemuviri wedu sekunge muvengi. Masayendisiti mazhinji anotenda kuti Felty Syndrome idambudziko guru reRA. Muzvirwere izvi zve autoimmune, miviri yedu inogadzira 'antibodies' kurwisa mamwe mapuroteni. Ma antibodies aya anoenda onobata mapuroteni iwayo oaratidza kuti aparadzwa. Izvi ndizvo zvinoita kuti kuzvimba kuwedzere.

Ma antibodies aya anogona kunge asiripo nguva dzose muRA. Zvisinei, muvanhu vane Felty Syndrome, ma antibodies aya aripo zvechokwadi. Kuvapo kwema antibodies aya ndicho chikonzero chinoita kuti RA iwedzere kuipa uye mimwe migumisiro iri kunze kwemajoini (extra-articular manifestations) iwedzere. RA ine ma antibodies inonzi 'seropositive RA'. Tsvagiridzo inoratidza kuti ese ari maviri seropositive RA neFelty Syndrome zvine chekuita nezvimwe 'genetic factors'. Izvi zvinoreva kuti anogona kupfuudzwa kuburikidza nezvizvarwa kusvika pamwero wakati.

Rheumatoid arthritis (RA) inokonzera sei neutropenia uye splenomegaly?

Maitiro eNeutropenia

Neutropenia kudzikira kwehuwandu hwemasero machena eropa anonzi ma neutrophils. Pane zvikonzero zviviri zvikuru zveizvi. Chimwe ndechekuti mapfupa ako emupfupa haasi kugadzira ma neutrophils akakwana. Kana kuti, ma neutrophils ari mumuviri wako ari kuparadzwa. MuFelty Syndrome, zvese izvi zvinogona kuitika. Maitiro e autoimmune ataurwa kare anogona kukanganisa kugadzirwa kwema neutrophils mumapfupa emupfupa, uye ma neutrophils akatogadzirwa anogona kuparadzwa. Uyewo, kukura kwepleen chimwe chikonzero chekuderera kwema neutrophils.

Maitiro eSplenomegaly

Basa retsvina yako nderekusefa masero eropa ekare, asina basa kubva muropa rako. Asi kana tsandanyama yako yakura zvakanyanya (splenomegaly), inotanga kushanda zvakanyanya uye inotanga kubvisa masero eropa akawanda akanaka. Rheumatoid arthritis dzimwe nguva inogona kukonzera tsandanyama yakakura. Chikonzero chaicho hachisati chajeka. Tsandanyama inogonawo kukura pasina neutropenia. Uyewo, kashoma, Felty Syndrome inogona kuitika pasina tsandanyama yakakura.

Ndezvipi zvinetso zvine njodzi zveFelty Syndrome?

Nekuti Felty Syndrome inoshayisa simba masoja emuviri wako simba, uri panjodzi huru yekubatwa nezvirwere zvakakomba kakawanda . Kunyangwe kana uchiwanzova nechirwere chidiki chinorapwa zviri nyore, chirwere ichi chinogona kukura zvakanyanya zvekuti chinoramba chiripo uye dzimwe nguva chinotyisidzira hupenyu. Zvirwere zvebhakitiriya zvisingadzoreki zvinogona kutungamira kuchirwere chine njodzi chinonzi sepsis. Vanhu vane Felty Syndrome vari panjodzi huru yekubatwa nezvirwere zvakasiyana-siyana, zvakaita se lymphoma.

Asi musatya kana mukanzwa zvinhu izvi. Njodzi idzi dziripo, asi dzinogona kudzorwa nekurapwa nekutarisirwa kwakakodzera.

Ungaziva sei izvi?

Vanachiremba vanoongorora chirwere cheFelty Syndrome kana vakaona kuti chirwere cherheumatoid arthritis, neutropenia, uye splenomegaly zvese zviripo. (Kashoma kuti chirwere ichi chiongororwe pasina kukura kwepleen.)

Miedzo inowanzoitwa ndeiyi:

• Kuongororwa kweropa: Kuongororwa kweropa rose, kunyanya kutarisa huwandu hwema neutrophils.
• Kuongororwa kwemajoini eX: Tarisa kana paine arthritis.
• Kuskena kwetsvina: Semuenzaniso, kuskena kweultrasound kana CT.
• Kuongororwa kwemwongo wemapfupa:Izvi zvinobatsira kuona kuti hapana zvimwe zvirwere.

Kurapwa kweizvi ndekupi?

Pane zvinangwa zvikuru zvitatu pakurapa Felty Syndrome:

• Kudzora mamiriro echirwere cheRheumatoid Arthritis.
• Kana neutropenia yakanyanya, irape zvakananga.
• Kudzivirira hutachiona uye kurapa kana hukaitika.

Felty Syndrome inogona kukonzerwa nerheumatoid arthritis (RA) isingarapwe kana kuti isingadzoreki zvakanaka. Kune vanhu vazhinji, neutropenia inovandudzikawo sezvo RA yavo ichivandudzika. Nokudaro, vanachiremba vanotanga vachitsvaga mishonga inoshanda yekurwisa rheumatoid arthritis (DMARDs) yeRA. Vanoedzawo kudzivirira mishonga inodzvinyirira immune system zvakanyanya sezvinobvira.

Kune mhando dzakasiyana dzeDMARD dzinogona kushandiswa pakurapa Felty Syndrome:

• Methotrexate ne folic acid (zvinoderedza migumisiro ye methotrexate)
• Abatacept
• Rituximab
• Leflunomide

Asi kana neutropenia yako isingavandudzike neDMARD idzi, kana kana neutropenia yako yakanyanya kuipa, kana kana watova nehutachiona, chiremba wako achaedza mamwe marapirwo kuti awedzere huwandu hwema neutrophil ako. Izvi zvinogona kusanganisira:

• Mushonga unonzi G-CSF (granulocyte colony-stimulating factor).
• Mishonga ye corticosteroid yenguva pfupi.
• 'Splenectomy' - Izvi zvinoreva kubviswa chirwatata chinoshanda zvakanyanya.

Uyewo, vanachiremba vachatora matanho akakosha ekudzivirira kubva kuzvirwere, kunyanya kana kurapwa kwako kuchikanganisa masoja emuviri wako. Vanogona kukurudzira zvinhu zvakaita se:

• Kutora mishonga inorwisa mabhakitiriya ine mativi akasiyana-siyana.
• Kuwana majekiseni anodiwa.
• Nyatsocherechedza hutano hwemuromo wako nemazino.

Kana munhu ane Felty Syndrome akawana hutachiona, vanachiremba vanozvitora zvakakomba. Kana izvi zvikaitika kwauri , unofanira kurapwa nekukasika . Chiremba wako achakupa mishonga yakasimba.

Ndeipi nguva yekurarama neFelty Syndrome?

Hapana nhamba dziripo pari zvino pamusoro pehupenyu hwevanhu vane Felty Syndrome. Zvisinei, kazhinji, kurapwa kwakavandudzika zvikuru mumakore achangopfuura. Saka pane mukana mukuru wekuti chero kurapwa kuchabudirira kwauri. Njodzi huru yekufa muFelty Syndrome ichiri kubva kuzvirwere zvakakomba . Nokudaro, kutora matanho ekuzvidzivirira kubva kuzvirwere kunogona kuita mutsauko mukuru kuhutano hwako hwenguva refu.

Felty Syndrome idambudziko risingawanzoonekwi uye rinowanzo furatirwa re rheumatoid arthritis (RA). Kana uine RA isingadzoreki kwenguva yakareba, kana mishonga yako ikarega kushanda sezvayaimboita, unogona kutanga Felty Syndrome. Vamwe vanhu vanoiwana vasina zviratidzo. Zvinogona kushungurudza zvishoma kuziva kuti chirwere chinokanganisa majoini ako chinogonawo kukanganisa masero ako eropa.

Kana wava kutorwara neRA, pamwe nezvimwe zviratidzo, zvinogona kunetsa kuwana chirwere chitsva. Asi Felty Syndrome haikonzeri zviratidzo zvitsva zvakawanda, uye ingasada imwe mishonga. Chinhu chakakosha kuziva njodzi. Nekushanda nachiremba wako kurapa RA yako uye kudzivirira hutachiona, unogona kudzora Felty Syndrome.

Pakupedzisira, zvinhu zvekurangarira

Felty Syndrome chirwere chinogona kuitika kune vamwe vanhu vane rheumatoid arthritis (RA). Chinoratidzwa nekuderera kwehuwandu hwemasero machena eropa anonzi neutrophils muropa rako (neutropenia) uye kukura kwepleen (spleen).

• Njodzi huru ndeyekutapukirwa nezvirwere kakawanda, saka zvakakosha zvikuru kuzvidzivirira kubva kuzvirwere.
• Kunyangwe izvi zvingaita sezvinotyisa zvishoma, chirwere ichi chinogona kudzorwa zvakanaka nekurapwa kwakakodzera uye mazano ekurapa .
• Kana uine RA, chenjerera zvimwe zviratidzo izvi. Kana uine zvinokunetsa , iva nechokwadi chekutaura nachiremba wako. Vachakwanisa kukubatsira.

Felty Syndrome, Rheumatoid Arthritis, Neutropenia, Splenomegaly, Arthritis, Kuzvimba kwemajoini, Neutrophils, Spleen, Kudzivirira Kurwara