Kurwadziwa nemusoro kunonzwa sekunge musoro wako uchaputika, mwenje inoonekwa pamberi pemaziso ako, uye unonzwa sekunge wava kuda kurutsa... Unoziva here nezvechiitiko ichi? Dzimwe nguva unofanira kugara muimba ine rima, yakanyarara zuva rese, handiti? Kurwadziwa nemusoro hakusi kungorwadziwa nemusoro chete, chinhu chinongozivikanwa nemunhu ane musoro wacho. Saka nhasi tichataura nezvemhando yemushonga unoshandiswa kurapa migraine. Ndiyo Triptans.
Chii chinonzi Triptans?
Muchidimbu, Triptans imhando yemishonga inopihwa kumisa kurwiswa kwemigraine kana yatanga . Inoonekwa senzira yekutanga yekurapa migraine. Kazhinji, mishonga iyi haidziviriri kurwiswa kwemigraine, asi inogona kubatsira kudzora marwadzo nezvimwe zviratidzo kana yatanga .
Kurwadziwa nemusoro hakusi kungorwadziwa nemusoro chete. Idambudziko retsinga rinokanganisa pfungwa dzedu. Ndokusaka, pamusoro pemusoro, kune zvimwe zvinhu zvakaita sekuchinja kwekuona, kuona mwenje pamberi pemaziso edu (aura), kuda kurutsa, kurutsa, uye kunzwa chiedza neruzha. Kune vamwe, zviratidzo izvi zvakanyanya zvekuti havagone kuita chero chinhu kunze kwekurara pasi munzvimbo ine rima, yakanyarara kusvika migraine yapera.
Triptans, yakawanikwa kuma1980, yakachinja zvakanyanya kurapwa kwemusoro. Triptan yekutanga, `(Sumatriptan)` yakaunzwa kuma1990. Mamwe matriptan akati wandei akazounzwa gare gare.
Ndeapi marudzi ematriptan aripo?
Parizvino kune mhando nomwe dzematriptan. Dzese dzinorapa migraine, asi dzimwe dzinotenderwa kushandiswa pamhando dzakasiyana dzemigraine uye kuvana nevechidiki. Nzira iri nyore yekuziva mishonga iyi ndeyekutsvaga chivakashure "-triptan" mumazita avo.
Tafura iri pazasi inoratidza mhando dzematriptan uye kuti angawanikwa sei.
| Zita reMushonga weTriptan | Maitiro ekuwana (Fomu) |
|---|---|
| Almotriptan | Mapiritsi emuromo |
| Eletriptan | Mapiritsi emuromo |
| Frovatriptan | Mapiritsi emuromo |
| Naratriptan | Mapiritsi emuromo |
| Rizatriptan | Mapiritsi emuromo |
| Sumatriptan | Muromo, Pupurai yemhino/upfu, Jekiseni repasi peganda |
| Zolmitriptan | Mapiritsi emuromo, pfapfaidzo yemhino |
Mishonga iyi inonzi Triptans inoshanda sei chaizvo?
Kuti tinzwisise mashandiro anoita mushonga uyu, tinofanira kunzwisisa zvishoma nezvekuti tinonzwa sei kurwadziwa uye kuti migraines inoitika sei.
Ngationei kuti tinonzwa sei kurwadziwa.
Fungidzira kuti warova chigunwe chako pane imwe nzvimbo. Marwadzo acho haanzwikwe nemunwe. Tsinga dziri mumunwe dzinotumira chiratidzo kuuropi dzichiti, "Pane chakuvara pano." Uropi hunoshandura chiratidzo ichocho kuita "kurwadziwa" uye hunokuita kuti unzwe.
Uropi hwedu hahuna magumo etsinga anonzwa kurwadziwa, ndosaka masayendisiti asati anyatsonzwisisa kuti migraine inoitika sei. Asi ikozvino vawana nzira dzakasiyana-siyana dzinogona kukonzera izvi.
Nyaya iri shure kwemigraines
Zvinotendwa kuti zvinhu zvitatu zvikuru zvinobatsira pakuonekwa kwemigraines:
1. Kushanda kwetsinga dzeuropi: Uropi hwedu, musana, uye tsinga zvinoumbwa nemasero anonzi ma neuron. Kana migraine ikaitika, mamwe ma neuron ari muuropi anorova neimwe nzira. Kushanda kwetsinga idzi ndiko kunoita kuti tinzwe kurwadziwa nezvimwe zviratidzo zvemigraine.
2. Kuchinja kwekufamba kweropa: Panguva yekurwadziwa kwemusoro, tsinga dzeropa muuropi dzinovharika uye dzinokura. Izvi zvinoshandura kufamba kweropa. Sezvo ma triptan achikanganisa tsinga idzi dzeropa, izvi zvinofungidzirwawo kuti ndizvo zvinokonzera kurwadziwa kwemusoro.
3. Kuzvimba:Kuzvimba inzira inoshandiswa nemuviri wedu kuzvidzivirira nekuzvirapa. Zvakaonekwawo kuti makemikari anokonzera kuzvimba anoburitswa panguva yekutemwa nemusoro.
Matriptan anokanganisa sei maitiro aya?
Iye zvino ngationei kuti maTriptans anopindira sei mune izvi. Masero etsinga dzedu akabatana kuburikidza nemakemikari anonzi neurotransmitters. Aya akafanana nemakiyi. Masero etsinga ane zvikamu zvinonzi mareceptor. Aya akafanana nemakiyi. Kana kiyi yekurudyi (neurotransmitter) yakabatana nekiyi yekurudyi (receptor), sero rinotanga kushanda.
MaTriptans anoshanda nekutevedzera serotonin ye neurotransmitter iri muuropi. Izvi zvinoreva kuti mishonga iyi inosunga uye inomutsa mareceptor e serotonin. Anonyanya kukanganisa mhando nhatu dzemareceptor:
- Ma 5HT1B receptors: Aya anowanikwa mutsinga dzeropa dzeuropi. Kana ma triptan avhura ma receptor aya, tsinga dzeropa dzakakura zvisina kufanira nekuda kwemigraines dzinodzikira. Izvi zvinoderedza marwadzo.
- Ma 5HT1D receptors: Aya ari mu "Trigeminal" nervous system, iyo inobatanidzwa mukunzwisisa kwedu kurwadziwa. Kana ma triptan akashanda, anomisa kuburitswa kwemakemikari anokonzera kurwadziwa.
- Ma 5HT1F receptors: Izvi zvinobatsirawo kuderedza kutapurirana kwezviratidzo zvekurwadziwa kuuropi.
Zvichitaurwa zviri nyore, matriptan anoshanda nekuzorodza mitsipa yeropa muuropi, achidzivirira kuburitswa kwemakemikari anokonzera kurwadziwa, uye achideredza kutapurirana kwezviratidzo zvekurwadziwa kuuropi. Zvese izvi zvitatu zvinobatsira kudzora zviratidzo zvemigraine.
Ndezvipi zvakanakira kushandisa Triptans?
Triptans dzine zvakanakira zvakawanda zvichienzaniswa nemishonga yekare yemigraine.
- Migumisiro mishoma: MaTriptans ane migumisiro mishoma pane mishonga yekare, uye haana kunyanyisa.
- Hazvina kujairika: Mimwe mishonga inoderedza marwadzo emusoro, kunyanya opioid, inogona kukanganisa pfungwa. Zvisinei, triptans hadzina kujairika.
- Yakachengeteka zvikuru: MaTriptans kazhinji imhando yemishonga yakachengeteka zvikuru. Mishonga yakaita se`(Sumatriptan)` yakachengeteka zvekuti mune dzimwe nyika inogona kutengwa muchitoro chemishonga pasina kunyorerwa nachiremba.
- Inowanikwa mumhando dzakasiyana: Sezvatakaona patafura yapfuura, izvi zvinogona kuwanikwa mumhando dzakasiyana dzakadai semapiritsi, maspray emumhino, uye majekiseni. Spray yemumhino iri nyore kune munhu anonetseka nekumedza piritsi kana kuti ari kurutsa.
Pane zvazvakaipira, migumisiro, uye matambudziko here?
Kufanana nemishonga chero ipi zvayo, Triptans ine zvimwe zvinokanganisa uye zvinhu zvekuziva.
Zvakaipa zveTriptans
Dambudziko guru nderekuti hadzidziviriri migraine . Dzinoshandiswa semushonga wekudzivirira migraine mushure mekunge yatanga. Zvisinei, pane imwe nyaya yakakosha, iyo ndeyekuenda kumwedzi. Mamwe ma triptan anogona kubatsira kudzivirira migraine kana akatorwa mazuva maviri usati waenda kumwedzi. Chiremba wako achakupa mazano panyaya iyi.
Chimwe chinhu ndechekuti hazvina kunaka kuzvishandisa zvakawandisa . Vamwe vanhu vanoda mushonga unopfuura mumwe chete kuti vaderedze migraine. Zvisinei, kana ukatora Triptans kakawanda, kushanda kwayo kunogona kudzikira. Kwete izvozvo chete, asi unogona zvakare kuwana "musoro wemusoro unonyanya kushandiswa nemishonga" nekuda kwekushandisa mushonga zvakanyanya. Saka, zvakakosha kushandisa izvi chete muhuwandu hwakatarwa uye kakawanda, sezvinotaurwa nachiremba .
Migumisiro yakajairika
Kunyange hazvo vasiri vese vanowana migumisiro iyi kana vachitora mapiritsi etriptan, vamwe vanhu vanogona kuiwana.
| Mhedzisiro Yepadivi | Tsananguro |
|---|---|
| Dzungu | Dzungu |
| Kurara kana kuneta | Kurara kana kuneta |
| Kusvotwa | Kusvotwa |
| Kurira kwemaoko nemakumbo | Kunzwa kurwadza kana kusanzwa simba mumaoko/tsoka `(Paresthesia)` |
| Kurwadziwa kwemutsipa | Kurwadziwa kwemutsipa |
| Kurwadziwa pachipfuva (kashoma) | Kurwadziwa pachipfuva (zvisingawanzoitiki) |
Ndirini pausingafaniri kutora triptan?
Triptans hadzina kukodzera vanhu vane mamwe matambudziko ehutano (Contraindications).
- Kudyidzana nemimwe mishonga: Kana uri kutora mimwe mishonga ine "Ergotamine" yekurwadziwa kwemusoro kana zvimwe zvirwere, inogona kudyidzana neTriptans. Saka, zvakakosha kuudza chiremba wako nezvemishonga yese, mavhitamini, nezvimwe zvinovaka muviri zvauri kutora .
- Zvirwere zvemwoyo kana matambudziko eropa: MaTriptans haana kukodzera kana uine chirwere chemwoyo, BP isingadzoreki (BP), kana chirwere chetsinga dzeropa. Vanachiremba havakurudziriwo mishonga iyi kana wakambova kana kuti uri panjodzi yezvirwere zvemwoyo, kurwiswa nemwoyo, sitiroko, kana TIA.
- Kubata pamuviri nekuyamwisa: Kana uine pamuviri, uchiedza kuva nepamuviri, kana kuti uchiyamwisa, unofanira kutaura nachiremba wako nezvekushandisa matriptan.
Unofanira kutsvaga mazano ekurapa rini?
Nguva yekufonera chiremba
Kana uine migumisiro yakaipa kubva kumishonga inonzi triptans, kana ikakanganisa mabasa ako ezuva nezuva, kana kuti uchinzwa sekuti mushonga wawagara uchitora kwenguva yakareba hauchashandi, taura nachiremba wako. Anogona kukupa imwe triptan kana imwe nzira yekurapa.
Mamiriro ezvinhu anoda kurapwa nekukasika
Triptans inokonzera migumisiro yakaipa isingawanzoitiki (isingasviki 1%), asi kana ukaona chimwe chezviratidzo zvinotevera zvechirwere chemwoyo kana sitiroko, unofanira kuenda kuchipatara nekukurumidza .
Zviratidzo zvine chekuita nechirwere chemwoyo:
- Kurwadziwa pachipfuva kana kusagadzikana
- Kurova kwemoyo nekukurumidza (Tachycardia) kana kurova kwemoyo zvishoma nezvishoma (Bradycardia)
- Kutadza kufema zvakanaka (Dyspnea)
Zviratidzo zvine chekuita nesitiroko:
Chimwe chezviratidzo zvikuru zvestroke kuoma mitezo, kusanzwa kana kushaya simba kune rumwe rutivi rwemuviri (hemiplegia). Zviratidzo izvi zvinogonawo kuitika mune dzimwe nguva dzakakomba dzemigraine.
Hazvigoneki kuziva kumba kana chiratidzo ichi chiri kukonzerwa nemigraine kana sitiroko. Saka, kana uchinzwa kuti rumwe rutivi rwemuviri wako ruri kurasikirwa nesimba, enda kuEmergency Department (ETU) nekukasika pasina kunonoka . Kana wabatwa nestroke, sekondi yega yega kurapwa kunonoka kunogona kukonzera kukuvara kwehuropi zvachose.
Kana usati wambobatwa nemigraine uye uchinzwa musoro wakanyanya une zviratidzo zvakaita sestroke zvakaita seizvi, funga kuti idambudziko.
Ndeipi Triptan yakanakira ini?
Uyu mubvunzo unobvunzwa nevanhu vazhinji. Hakuna chinhu chinonzi "triptan yakanakisa." Mushonga unoshanda zvakanaka kune mumwe munhu ungasashanda zvakanaka kune mumwe. Chiremba wako achasarudza kuti ndeipi triptan yakakunakira uye kuti ungaitora sei (mapiritsi kana spray) zvichienderana nezvinhu zvakawanda, kusanganisira rudzi rwemusoro wako, mamwe matambudziko ehutano hwako, nemimwe mishonga yaunotora .
Vasati vawana mishonga ye triptan, vanhu vane migraine vairarama hupenyu hwakaoma zvikuru. Nhasi uno, nekuda kwemishonga iyi, mamiriyoni evanhu haacharwadziwi nemigraine uye vanogona kurarama hupenyu hwakajairika. Kana uchitambura nemigraine, usangoshivirira marwadzo chete. Taura nachiremba wako uone kana mishonga ye triptan ichigona kukubatsira. Mishonga iyi inogona kukubatsira kurarama zuva rako sezvariri, pane kuti uremerwe nemigraine.
Mharidzo Yekuenda Nayo Kumba
- Triptans rudzi rwemushonga unopihwa kudzora marwadzo nezviratidzo zvemigraine kana yatanga.
- Izvi hazvidziviriri migraine (kunze kwekunge uri panguva yekuenda kumwedzi). Zvinoshanda semishonga yekununura.
- Triptans inoshanda nekuzorodza mitsipa yeropa muuropi, kudzivirira zviratidzo zvekurwadziwa, uye kudzora migraine.
- Mushonga uyu wakachengeteka zvikuru, haupindi muropa, uye une migumisiro mishoma.
- Izvi hazvina kukodzera vanhu vane zvirwere zvakaita sechirwere chemwoyo kana BP yakakwira isingadzoreki. Udza chiremba wako nezvemishonga yese yauri kutora.
- Shandisa izvi chete muchiyero uye kakawanda zvakakurudzirwa nachiremba wako. Kushandisa zvakanyanya kunogona kuwedzera misoro.
- Kana ukaona zviratidzo zvakakomba zvakaita sekurwadziwa pachipfuva kana kushaya simba kune rumwe rutivi rwemuviri, enda kuchipatara chekukurumidzira (ETU) nekukasika.
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