Kunzima ukuchaza uloyiko kunye nexhala esilivayo xa sifumanisa ukuba sinomhlaza. Kodwa ngenxa yesayensi yezonyango ephucukileyo esifikileyo namhlanje, kukho unyango olusebenzayo kakhulu lomhlaza. Ubusazi na, kukho iintlobo ezithile zomhlaza ezikhula "ngokondla" iikhemikhali zomzimba wethu ezibizwa ngokuba zii-hormones? Xa unyanga umhlaza onjalo, ukulawula ukuveliswa kwezo hormones kubaluleke kakhulu. Namhlanje siza kuthetha ngonyango olulodwa olukhethekileyo. Igama elithi 'Chemical Castration'. Nangona igama lisenokuvakala lisoyikisa kancinci, olu lonyango oluzisa isiqabu kwizigulane ezininzi zomhlaza.
Ngamafutshane, yintoni iChemical Castration?
Kulungile, masichaze oku ngokulula. 'I-Chemical Castration' kukusetyenziswa kwamayeza okanye iikhemikhali ukuthintela ukuveliswa kweehomoni zesondo emizimbeni yethu. Ezi homoni zikhutshwa egazini zii-glands ezahlukeneyo emizimbeni yethu. Ezi homoni zilawula izinto ezininzi emizimbeni yethu; izinto ezinje ngamandla, ukukhula, kunye neemvakalelo. Iihomoni zesondo zibaluleke kakhulu kwizinto ezinje ngokufikisa kunye nempilo yokuzala.
Nangona kunjalo, ezinye iintlobo zomhlaza, ezifana nomhlaza weprostate kunye nezinye iintlobo zomhlaza webele, zixhomekeke kwezi hormone zesini ukuze zikhule. Kanye njengokuba isityalo sifuna amanzi ukuze sikhule, ezi seli zomhlaza zifuna iihormone ukuze zikhule. Ngoko ke, unyango lweChemical Castration lunciphisa ubungakanani bezi hormone zesini emzimbeni. Emva koko iiseli zomhlaza zilahlekelwa "kukutya" ezikufunayo, kwaye ukukhula kwazo kuyayeka okanye kucothe.
Kukho amanye amagama aliqela asetyenziswayo kolu nyango. Xa uziva, oku kuya kucaca kuwe:
- Ukuthenwa kwezonyango
- Unyango lweHormone
- Unyango lwe-Androgen Depression/Deprivation/Depression
Onke la magama athetha into enye: anciphisa izinga leehomoni zesini emzimbeni.
Zeziphi iimeko olu nyango lusetyenziselwa zona?
Oogqirha basebenzisa olu nyango ikakhulu kwiithumba ezixhomekeke kwiihomoni zesini, ngakumbi:
- Umhlaza weprostate: Lo mhlaza kumadoda udla ngokubangelwa yi-testosterone yehomoni yamadoda.
- Umhlaza Webele: Iihomoni zabasetyhini i-estrogen kunye ne-progesterone zinefuthe ekukhuleni kwezinye iintlobo zomhlaza webele kubafazi.
- Umhlaza Webele Wamadoda: Nangona oku kungaqhelekanga, unyango lweehomoni lukwasetyenziswa koku.
Elinye igama eliqhelekileyo leehomoni zesini yi -androgens.. Wonke umntu uvelisa ii-androgens, kodwa amadoda avelisa ezininzi zazo. I-Testosterone yi-androgen enkulu. Le hormone ibalulekile ekukhuleni nasekusebenzeni kwe-prostate gland. Xa kuvela umhlaza, le hormone yiyo eqhuba umhlaza ukuba ukhule.
Kwenzeka ntoni ngaphambi kokuba unyango luqale?
Ngaphambi kokuba ugqirha wakho akucebise unyango lweehomoni, kufuneka azi kakuhle ukuba uhlobo lomhlaza wakho luya kusabela kakuhle na kulo. Oku kuya kubandakanya iimvavanyo ezininzi. Ezi vavanyo zinokumisela uhlobo lomhlaza kunye nenqanaba osele usasazeka ngalo.
Ezinye zeemvavanyo ezenziweyo ngenxa yale njongo zezi:
- Iskeni ye-CT
- Iskeni yePET
- I-Endoscopy
- I-Biopsy - Ukuthatha isampuli encinci yeeseli zomhlaza ukuze zihlolwe.
- Uvavanyo lwegazi lomhlaza
Kwezinye iimeko, ingakumbi ukuba ufuna ukunciphisa amanqanaba akho e-testosterone ngokusisigxina, ugqirha wakho unokuthetha ngenkqubo yotyando ebizwa ngokuba yi-orchiectomy . Oku kubandakanya ukususwa kwesende elinye okanye omabini ngotyando. Esi sisisombululo esihlala sihleli. Olunye ukhetho kukususwa kwezicubu ezenza i-testosterone kuphela. Nangona kunjalo, esithetha ngako apha kukuthuthwa kwamakhemikhali, hayi utyando. Lunyango lwexeshana ngamayeza.
Kwenzeka ntoni ngexesha lonyango?
Olu asilonyango lwexesha elinye. Olu lunyango oluqhubekayo. Ngokwesiqhelo, ugqirha wakho uya kukunika la mayeza njengenaliti okanye njengesixhobo esincinci esifakwe phantsi kolusu lwakho (i-implant). Nangona kunjalo, amanye amayeza akwafumaneka njengeepilisi.
Ngokuxhomekeke kuhlobo kunye nomthamo wamayeza owanikwayo, kunokufuneka uphinde olu nyango kube kanye ngenyanga, kube kanye kwiinyanga ezintathu, okanye kube kanye ngonyaka.
Xa kunyangwa umhlaza weprostate, kukho iindlela ezininzi ezisebenza ngazo eli yeza:
- Iyanciphisa imveliso yee-androgens (ingakumbi i-testosterone) ezivela kumasende.
- Ithintela amandla e-androgens emzimbeni okubopha nokusebenza neeseli zomhlaza.
- Iyayimisa imveliso yee-androgens ezivela kwezinye iindawo zomzimba (hayi nje kuphela emasendeni).
Ngawaphi amayeza asetyenziswa koku?
Kukho iindidi ezininzi eziphambili zamayeza asetyenziselwa umhlaza weprostate. Makhe sijonge ngokusondeleyo.
| Udidi lweziyobisi | Indlela esebenza ngayo ngokulula | Imizekelo (amagama eempawu zamayeza) |
|---|---|---|
| Ama-GnRH Agonists | Ezi zinto ziqala ngokubangela ukunyuka ngequbuliso kwamanqanaba e-testosterone (ukudumba kwe-testosterone). Emva koko umzimba uqala ukungawunaki umqondiso wokuvelisa i-hormone. Emva kweentsuku ezimbalwa, ukuveliswa kwe-testosterone phantse kuyeke ngokupheleleyo. | IGoserelin (Zoladex®), iLeuprolide (Lupron®), iTriptorelin (Trelstar®) |
| Abachasi be-GnRH | Eli yeza alinyusi ngequbuliso amanqanaba eehomoni njengohlobo lwangaphambili. Liyekisa ngokuthe ngqo ukuveliswa kwe-testosterone. Ngenxa yoko, 'iTestosterone Flare' ayifumaneki. | I-Degarelix (iFirmagon®), iRelugolix (i-Orgovyx®) |
| Unyango lwe-Antiandrogen | Endaweni yokuthintela ukuveliswa kweehomoni, ezi zithintela iihomoni ze-androgen emzimbeni ekubeni zinamathele kwiiseli zomhlaza. Ngamanye amazwi, kukho isitshixo, kodwa isitshixo (i-receptor) esingena kuso sivaliwe. | Bicalutamide (Casodex®), Enzalutamide (Xtandi®), Apalutamide (Erleada®) |
| Izithinteli ze-Androgen Synthesis | Eli yeza lithintela ukuveliswa kwee-androgens naphi na emzimbeni (amasende, ii-adrenal glands, kwaneeseli zomhlaza). | I-Abiraterone (Zytiga®), iKetoconazole (Nizoral®) |
Ingaba le ndlela ikwasetyenziswa kumhlaza webele?
Ewe. Oogqirha bakwacebisa olu nyango lwehomoni kumhlaza wamabele oluxhomekeke kwi-estrogen kunye/okanye kwi-progesterone. Lusebenza ngokuthintela ukuveliswa kweehomoni zabasetyhini okanye ukuziyekisa ukusebenza kwiiseli zomhlaza. Kukho iintlobo ezahlukeneyo zamayeza oku:
- Amayeza afana neTamoxifen asebenza ngokuthintela i-hormone ye-estrogen ekubeni inamathele kwiiseli zomhlaza.
- Ii-Aromatase inhibitors (umz. i-Anastrozole, i-Letrozole) zisebenza ngokuthintela i-enzyme evelisa i-estrogen emzimbeni.
- Amayeza afana neGoserelin kunye neLeuprolide (akwasetyenziswa kumhlaza weprostate) ayamisa okwethutyana ama-ovari ukuba angasebenzi kwaye anciphise ukuveliswa kwe-estrogen. Oku kufana nokuya exesheni okwethutyana.
Yintoni onokuyilindela emva konyango?
La mayeza aqala ukusebenza kwangoko xa uqala ukuwasela. Anefuthe logama nje uwasela.
Isiphumo esiphambili kukuncipha kwenkanuko yesini/i-libido. Impendulo ekukhuthazweni kwengqondo okanye komzimba inokuncipha. Umzekelo, ukuphindaphindwa kweengcinga ngesondo kunokuncipha.
Kodwa eyona nto ibalulekileyo apha yinzuzo ephambili yoku. Ukususwa kweekhemikhali akuhlali ixesha elide. Kungabuyiselwa kwimeko yesiqhelo.
Emva kokuba uyekile unyango, umzimba wakho uqala ukuvelisa iihomoni kwakhona. Kunye noku, inkanuko yakho yokwabelana ngesondo ibuyela kwinqanaba layo langaphambili. Le yeyona nzuzo inkulu yoku ngaphezu kokususwa kwamasende okanye ama-ovari ngotyando.
Ngaba kukho naziphi na iingozi kunye nemiphumo emibi kolu nyango?
Njengayo nayiphi na imithi, unyango lweehomoni lunokuba nemiphumo emibi. Asinguye wonke umntu oyifumana yonke. Kwaye ubukhali bezi miphumo buyahluka kumntu nomntu. Ugqirha wakho uza kuthetha nawe ngemiphumo emibi yamayeza owaselayo.
Ngokubanzi, ezi zezinye zeziphumo ebezingalindelekanga eziqhelekileyo ezinokubakho xa uthatha olu nyango ixesha elide:
- Umnqweno ophantsi wesondo
- Ukuziva ubushushu ngequbuliso emzimbeni (Ubushushu obugqithisileyo)
- I-Osteoporosis
- Ukunciphisa ubunzima bemisipha
- Ukwanda kokugcinwa kwamafutha emzimbeni
- Umngcipheko okhulayo wesifo sentliziyo
- Ukudakumba okanye ukutshintsha kweemvakalelo
- I-anemia
- Ukuncipha kweenwele zomzimba
- Amabele amancinci kumadoda
Musa ukoyika ngezi ziphumo ebezingalindelekanga. Uninzi lwazo lunokulawulwa. Umzekelo, ugqirha wakho unokucebisa izongezo ze-calcium kunye ne-vitamin D kunye nokuzilolonga ukunceda ubuthathaka bamathambo. Ngoko ke kubalulekile ukuba ukhululeke kugqirha wakho malunga nokungonwabi onokuba nako.
Eminye imibuzo ebuzwa rhoqo
Ingaba olu lunyango olubuhlungu?
Ukuba usela iyeza njengepilisi, akukho ntlungu. Ukuba ulisebenzisa njengenaliti, ungaziva intlungu okanye ukutshisa kancinci xa unikwa inaliti. Kodwa ayihlali ixesha elide.
Ngaba kunokwenzeka ukuba kubekho ukuqina komzimba emva konyango?
Ewe, ukuvuseleleka kunokubakho. Kodwa ngenxa yokungabi namnqweno wesondo, kusenokungenzeki rhoqo njengangaphambili. Kwaye uhlobo lokuvuseleleka lunokutshintsha.
- Ayinamandla njengangaphambili
- Ukungakwazi ukugcina ixesha elide
- Ukwehla kwezihlandlo zokwenzeka
Ingaba i-vasectomy ikwaluhlobo lokuthena?
Hayi. Akunjalo konke konke. I-vasectomy luhlobo lolawulo lokuzalwa. Ithintela kuphela isidoda ukuba singaphumi kwilungu lobudoda kunye nesidoda. Ayinampembelelo kumanqanaba eehomoni zakho, umnqweno wesondo, okanye ukusebenza kwesondo.
Eyona nto ibalulekileyo kukuba unyango lomhlaza luhambo. Kuqhelekile ukuba nemibuzo, iinkxalabo, kunye noloyiko ngeli xesha lohambo. Thetha ngazo zonke ezi zinto nogqirha wakho. Ukuba kuyimfuneko, ungafuna iinkonzo ezifana neengcebiso. Awuwedwa.
Umyalezo Wokuya Ekhaya
- Ukuthena ngamachiza akuyondlela yotyando. Lunyango lomhlaza olusebenzisa amayeza okuthintela ukuveliswa kweehomoni zesini emzimbeni okwethutyana.
- Oku kusetyenziswa kakhulu kumhlaza weprostate kunye nezinye iintlobo zomhlaza webele.
- Enye yezona nzuzo zinkulu zolu nyango kukuba luyakwazi ukutshintshwa . Nje ukuba iyeza liyeke, amanqanaba eehomoni abuyela esiqhelweni.
- Iziphumo ezinje ngokuncipha komnqweno wesondo, ukurhawuzelelwa sisisu, kunye nobuthathaka bamathambo zinokubakho, kodwa ugqirha wakho unokukunceda uzilawule.
- Thetha ngokukhululekileyo nogqirha wakho malunga nemibuzo, iinkxalabo, okanye uloyiko onalo. Ulwazi oluchanekileyo kunye nenkxaso zibaluleke kakhulu ngeli xesha lohambo.
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