Momma yɛnhwehwɛ wo AST level no ho nsɛm. (Aspartate Transferase - AST) Dɛn na ɛno kyerɛ?

Ebia woahu botae bi a wɔfrɛ no AST wɔ mogya mu nhwehwɛmu amanneɛbɔ bi so, anaasɛ woate oduruyɛfo bi a ɔreka ho asɛm. Enti, ebia woresusuw ho sɛ, "Dɛn na AST kyerɛ?" Mma ɛnhaw wo, momma yɛnka ho asɛm tiawa. Sɛnea wo ne w’adamfo bi bɛkasa no ara pɛ.

Dɛn ne AST? Sɛ yɛbɛka no tiawa a...

AST yɛ edin tiawa a wɔde frɛ enzyme Aspartate Transferase . Ɛtɔ mmere bi a wɔsan frɛ no Aspartate Aminotransferase . Afei ebia worebisa wo ho sɛ, "Dɛn ne saa enzyme yi?"

Fa no sɛ, adwumayɛfo nketewa dodow bi wɔ yɛn nipadua mu a wɔboa nneɛma ahorow ma ɛyɛ adwuma yiye. Enzymes te sɛ nea ɛte saa. Wɔyɛ protein bi ankasa. Saa enzyme a wɔfrɛ no AST yi wɔ mmeae pii wɔ yɛn nipadua mu. Wohu no titiriw wɔ mmerɛbo mu . Nanso nea ɛka ho no, saa AST enzyme yi wɔ ntini afoforo pii te sɛ koma, amemene, dwensɔtwaa, asaabo, ne ntini mu. Nanso, mpɛn pii no, sɛ yɛka AST ho asɛm a, ɛtaa fa yɛn mmerɛbo akwahosan ho.

Enti dɛn ne AST mogya mu nhwehwɛmu?

AST mogya mu nhwehwɛmu kyerɛ AST dodow a ɛwɔ wo mogya mu. Mpɛn pii no, sɛ yɛn nipadua mu nkwammoaa sɛe a, saa AST enzyme yi betumi ayɛ kɛse wɔ mogya no mu. Enti, AST dodow a ɛkɔ soro wɔ mogya mu no yɛ sɛnkyerɛnne a ɛkyerɛ sɛ ebia biribi asɛe wɔ nipadua no mu. Mpɛn pii (nanso ɛnyɛ bere nyinaa) eyi betumi ayɛ mmerɛbo mu yare.

Nanso, ɛnyɛ mmerɛbo mu nko na wohu AST. Enti, ɛyɛ den ma oduruyɛfo sɛ obegyina AST dodow nkutoo so ahu yare ko a wowɔ no pɛpɛɛpɛ. Mpɛn pii no, wɔyɛ AST sɔhwɛ no de ka sɔhwɛ afoforo pii ho. Sɛ nhwɛso no, wɔyɛ no sɛ mmerɛbo mu enzyme panel (HFP) anaasɛ comprehensive metabolic panel (CMP) fã . Eyi ma wutumi susuw nneɛma pii wɔ mogya biako mu na wunya w’akwahosan ho mfonini a edi mũ.

AST sɔhwɛ no wɔ din afoforo pii:

• Aspartate a wɔde fa nipadua no mu (AST).
• Aspartate aminotransferase (AST) a wɔde hyɛ nipadua mu no.
• Nnuru a Wɔde Glutamic-Oxaloacetic Transaminase (SGOT) di dwuma wɔ mogya mu.
• SGOT na ɛwɔ hɔ.
• Aspartate transaminase a wɔde yɛ aduru a wɔfrɛ no transaminase.

Nsonsonoe bɛn na ɛda AST ne ALT ntam?

Ebia woate botae foforo a wɔfrɛ no ALT a ɛka AST ho. ALT (Alanine Transferase) yɛ enzyme foforo a wɔsusuw wɔ mmerɛbo mu. Eyinom abien nyinaa fi mogya no mu bere a mmerɛbo mu nkwammoaa asɛe no.

Nanso, nea ɛnte sɛ AST no, ALT yɛ enzyme a ɛwɔ mmerɛbo mu titiriw. Wohu AST wɔ nipadua no afã afoforo pii. Enti, wobu ALT dodow a ɛkɔ soro sɛ ɛyɛ sɛnkyerɛnne pɔtee bi a ɛkyerɛ sɛ obi anya mmerɛbo mu yare sen AST dodow a ɛkɔ soro . Nanso, sɛ oduruyɛfo rehwɛ mmerɛbo akwahosan a, wɔtaa bom hwɛ AST ne ALT nyinaa.

Dɛn nti na mihia AST sɔhwɛ?

AST nhwehwɛmu atirimpɔw titiriw ne sɛ ɛbɛma nkwammoaa a ɛwɔ yɛn nipadua mu no asɛe. Eyi boa ma wohu mmerɛbo mu haw ahorow, titiriw sɛ nkwammoaa a ɛwɔ mmerɛbo no mu asɛe a, efisɛ AST boaboa ano wɔ mogya no mu. Afei nso, sɛnea yɛadi kan aka no, sɛ nkwammoaa asɛe wɔ nipadua no mmeae afoforo mpo a, wobetumi ama AST dodow akɔ soro.

Ebia oduruyɛfo bi bɛka akyerɛ wo sɛ yɛ AST nhwehwɛmu (mpɛn pii no sɛ kuw bi fã) esiane nneɛma te sɛ:

1. Nhwehwɛmu a wɔbɛyɛ ansa na sɛnkyerɛnne ahorow no ada adi

Nnipa binom wɔ asiane kɛse mu sɛ wobenya mmerɛbo mu yare. Sɛ wowɔ asiane ahorow yi bi a, wubetumi ayɛ nhwehwɛmu yi de ahwɛ wo mmerɛbo akwahosan ansa na sɛnkyerɛnne ahorow no ada adi. Saa asiane ahorow yi bi ne:

• Nsã a wɔnom boro so.
• Berɛbo mu yare a obi wɔ wɔ abusua no mu.
• Asikyireyareɛ.
• Kɛse mmoroso (nipadua mu srade a ɛkɔ soro).
• Nnuru a wɔde twitwiw nneɛma mu a wɔde nnade a afoforo de di dwuma.

Ɛtɔ da bi a, wɔde AST nhwehwɛmu ka Comprehensive Metabolic Panel (CMP) ho sɛ akwahosan mu nhwehwɛmu a wɔyɛ no daa no fã, enti ebia ɛho behia sɛ woyɛ nhwehwɛmu yi sɛ mpo wunnya mmerɛbo mu yare a.

2. Hwɛ tebea no so (Monitoring) .

Sɛ wowɔ mmerɛbo mu yare dedaw a, ebia wo duruyɛfo bɛkra saa AST nhwehwɛmu yi na ama wahwɛ sɛ ɛreyɛ yiye, ɛreyɛ kɛse, anaasɛ ɛreyɛ yiye wɔ ayaresa mu anaa. Afei nso, sɛ worenom nnuru a ebetumi aka mmerɛbo no a, wɔyɛ nhwehwɛmu yi nso de hwɛ sɛ ebia aduru no resɛe mmerɛbo no anaa.

3. Sɛ́ mmoa a wɔde hwehwɛ yare no mu (Diagnosing) .

Sɛ wowɔ mmerɛbo mu yare ho sɛnkyerɛnne a, wobetumi de AST nhwehwɛmu aka nhwehwɛmu ahorow no ho de aboa ma wɔahu. Bere a AST dodow nkutoo ntumi nhu yare bi no, ɛyɛ ade titiriw wɔ ɔkwan a wɔfa so hu yare no mu.

Nsɛnkyerɛnne a ɛkyerɛ sɛ obi nya mmerɛbo mu yare no bi ne:

• Akisikuru ne/anaasɛ ɔfe.
• Yafunu mu yaw (yafunu mu yaw).
• Wora a ɛyɛ wo yaw.
• Jaundice (honam ani yɛ kɔkɔɔ ne aniwa fitaa).
• Ɔbrɛ a wɔtaa te nka (ɔbrɛ).
• Aduan no nyɛ dɛ.

Hena na ɔyɛ AST mogya mu nhwehwɛmu no? Wɔyɛ no dɛn?

Mpɛn pii no, obi a wɔatete no titiriw sɛ ɔmfa mogya, a wɔfrɛ no phlebotomist, na ɔfa mogya yi. Nanso, akwahosan ho ɔyaresafo biara a wɔatete no sɛ ɔmfa mogya no betumi ayɛ eyi. Afei wɔde nhwɛsode no kɔ adwumayɛbea bi a wɔyɛ nhwehwɛmu. Ɛhɔ no, aduruyɛdan mu nyansahufo bi hwehwɛ nhwɛsode no mu na ɔde mfiri titiriw (analyzers) susuw AST dodow.

So biribi wɔ hɔ a ɛsɛ sɛ meyɛ ansa na mayɛ sɔhwɛ no?

• Mmuadadi: Sɛ wo AST nhwehwɛmu no yɛ Comprehensive Metabolic Panel (CMP) fã a, wobetumi aka akyerɛ wo sɛ mmuada (nnni anaa nnom biribiara gye nsu) nnɔnhwerew 10-12 ansa na woayɛ wo mogya nhwehwɛmu. Nanso, sɛ woreyɛ AST nhwehwɛmu no ara kwa anaasɛ Hepatic Function Panel (HFP) kɛkɛ a, mpɛn pii no ɛho nhia sɛ wudi mmuada. Mmom,Di wo duruyɛfo akwankyerɛ akyi pɛpɛɛpɛ.
• Nnuru Ho Nsɛm: Ɛsɛ sɛ woka nnuru, vitamin, ne nnuru a wɔde ka ho a worenom nyinaa kyerɛ wo duruyɛfo. Nnuru bi betumi aka AST dodow. Ebia wo duruyɛfo bɛka akyerɛ wo sɛ gyae nom nna kakraa bi ansa na wɔayɛ nhwehwɛmu no, gye sɛ wɔaka akyerɛ wo. Nnyae nnuru biara a wobɛnom da a wunnya wo duruyɛfo afotu.

Sɛ wode mogya ma a, dɛn na ɛba?

Eyi yɛ mmerɛw yiye.

• Wɔbɛtena akongua bi so. Afei wobehu ntini a ɛfata wɔ wo basa mu (mpɛn pii no wɔ wo nsateaa ase, wɔ mu).
• Sɛ wohu ntini no wie a, wɔhohoro baabi a ɛwɔ no na wɔde nnuru a ekum mmoawa gu mu.
• Afei, wɔde ade ketewaa bi hyɛ saa ntini no mu na wogye mogya. Ebia eyi bɛyɛ yaw kakra, te sɛ nea ntɛtea aka wo.
• Bere a wɔde ade no hyɛ mu wie no, wɔboaboa mogya kakraa bi ano wɔ afiri bi a wɔde sɔ hwɛ mu.
• Sɛ woboaboa mogya a ɛdɔɔso ano ma nhwehwɛmu no wie a, yi ade no na fa kotoku anaa gauze bi hyɛ baabi a mogya no retu no na ama mogya no agyae.
• Afei wɔde plaster gu beae no na wɔyɛ adwuma no.

Mpɛn pii no, adeyɛ yi nyinaa gye nea ennu simma anum.

Dɛn na ɛba bere a wɔde mogya ama akyi?

Sɛ wɔde mogya no kɔ aduruyɛdan mu wie a, wobehu nea ebefi mu aba no wɔ bɛyɛ da koro anaa nnanu mu. Ɛtɔ mmere bi a, ebetumi agye bere kakra. Wo duruyɛfo bɛka nea ebefi mu aba no ho asɛm akyerɛ wo bere a wɔaba mu no.

So asiane bi wɔ eyi mu?

Mogya mu nhwehwɛmu yɛ nhwehwɛmu a wɔtaa yɛ na ɛho hia. Asiane ahorow no sua koraa. Ebia akuru ne ɛyaw bi wɔ baabi a wɔtwe mogya no. Nanso ɛno befi hɔ ntɛm.

Dɛn na nea efii AST sɔhwɛ no mu bae no kyerɛ?

Mpɛn pii no, mogya mu nhwehwɛmu amanneɛbɔ de nsɛm a edidi so yi ka AST aba ho:

• Mogya mu nhwehwɛmu no din (wɔfrɛ no AST).
• AST dodow (bo) a ɛwɔ wo mogya mu.
• Range a ɛfata ma saa sɔhwɛ no.
• Sɛ́ ebia nea efi mu ba no yɛ nea ɛfata anaasɛ ɛnyɛ nea ɛfata (ɛkɔ soro anaasɛ ɛba fam).

Dɛn ne AST dodow a ɛfata?

AST dodow a ɛfata no betumi ayɛ soronko kakra wɔ lab biako mu akɔ foforo mu. Nneɛma a wɔtaa de di dwuma daa ne 8 kosi 33 U/L (units/liter) . Nanso, ɛho hia sɛ wohwɛ range a ɛfata wɔ w’amanneɛbɔ no so.

Afei nso, kae sɛ, AST level biako biara nni hɔ a "ɛyɛ daa" a ɛyɛ adwuma ma obiara. AST dodow a ɛwɔ apɔwmuden betumi ayɛ soronko a egyina nneɛma te sɛ:

• wo mfe a woadi.
• Wo ɔbeayɛ/mmarimayɛ.
• Wo mmirikatu.
• Wo mu duru.

Wo duruyɛfo no besusuw eyinom nyinaa ho na wasi nea ebefi mu aba no ho gyinae.

Sɛ me AST level no kɔ soro a, ɛkyerɛ dɛn?

Sɛ AST dodow kɔ soro a, ebetumi ayɛ mmerɛbo mu yare ho sɛnkyerɛnne.Sɛ mogya mu nhwehwɛmu afoforo, titiriw nea ɛfa mmerɛbo ho no nso nyɛ nea ɛfata a, ɛda adi kɛse sɛ wowɔ mmerɛbo mu yare. Nanso, sɛnea yɛadi kan aka no, sɛ nkwammoaa a ɛwɔ nipadua no afã afoforo sɛe, titiriw wɔ mmerɛbo mu a, AST dodow nso betumi akɔ soro.

AST dodow a ɛkɔ soro no betumi akyerɛ mmerɛbo mu yare tebea horow te sɛ:

• Mmerɛbo a nsa asɛe no.
• Hepatitis a ɛyɛ mmerɛbo mu yare.
• Mmerɛbo mu akuru (Cirrhosis).
• Nnuru a epira (awuduru) ma mmerɛbo no a wɔnom.
• mmerɛbo mu akisikuru anaa mmerɛbo mu kokoram.
• Mogya a ɛkɔ mmerɛbo no mu a ɛso tew (Liver Ischemia) (eyi betumi ama mmerɛbo no mu ntini awuwu).

Bio nso, tebea horow a ɛne mmerɛbo no nni abusuabɔ tẽẽ nso betumi ama AST dodow akɔ soro:

• Iron a ɛboaboa ano dodo wɔ nipadua no mu (Hemochromatosis) (eyi sɛe koma, mmerɛbo, ne dwensɔtwaa).
• Komayare a ɛma obi nya komayare (Myocardial Infarction).
• Mononucleosis yɛ atiridiinini.
• Ntini mu nyarewa.
• Ɔyare a ɛba dwensɔtwaa mu (Pancreatitis).

Wɔ saa nneɛma yi akyi no, AST dodow nso betumi akɔ soro bere tiaa bi wɔ nsɛm a esisi te sɛ:

• Ɔhyew a emu dɔ.
• Nneɛma a ɛma obi ho popo.
• Oprehyɛn anaa ayaresa a ɛfa koma ho.
• Sɛɛgyiri.
• Apɔw-mu-teɛteɛ a emu yɛ den.
• Sɛ woanyinsɛn a.

Ade a ɛho hia ne sɛ AST dodow a ɛkɔ soro no nkyerɛ ankasa sɛ wowɔ yare a emu yɛ den. Nneɛma afoforo pii betumi aka eyi. Wo duruyɛfo no bɛhwɛ mogya mu nhwehwɛmu afoforo, w’ayaresa ho abakɔsɛm, ne biribiara de awie.

So ɛsɛ sɛ mehaw me ho sɛ me AST aba no dɔɔso a?

Sɛ wo AST dodow boro dodow a ɛfata a wɔde ama wɔ wo AST nhwehwɛmu amanneɛbɔ so a, ɛnkyerɛ ankasa sɛ wowɔ yare bi a ɛsɛ sɛ wɔsa. Obi a ne mmerɛbo yɛ adwuma yiye mpo betumi anya AST dodow a ɛboro nea ɛfata so. Eyi betumi aba esiane nneɛma pii nti, sɛ nhwɛso no:

• wo mfe a woadi.
• Wo ɔbeayɛ/mmarimayɛ.
• Wo mmirikatu.
• W’aduan a wudi.
• Dwumadie.
• Nnuru a ɛka AST dodow a wɔnom.
• Woanyinsɛn.

Wo duruyɛfo no besusuw saa nneɛma yi nyinaa ho, ne nea efii wo mogya mu nhwehwɛmu afoforo mu, na wasi gyinae sɛ ebia ɛsɛ sɛ wɔyɛ nhwehwɛmu foforo anaa.

Sɛ me AST aba no nyɛ nea ɛfata a, so ebehia sɛ meyɛ nhwehwɛmu foforo?

Yiw, sɛ wo AST dodow no nyɛ nea ɛfata a, wo duruyɛfo betumi ahyɛ sɛ wɔnyɛ nhwehwɛmu kakraa bi bio. Saa sɔhwɛ ahorow yi bi ne:

• San yɛ AST mogya mu nhwehwɛmu bio.
• Mogya mu nhwehwɛmu afoforo (e.g. ALT, Bilirubin).
• Mfoniniyɛ mu sɔhwɛ ahorow (e.g. Ultrasound scan).
• Biopsy a wɔde hwehwɛ nipadua mu.

Bere bɛn na ɛsɛ sɛ mefrɛ oduruyɛfo no?

• Sɛ wowɔ mmerɛbo a asɛe ho sɛnkyerɛnne (e.g. jaundice, yafunu mu yaw) a, frɛ wo duruyɛfo ntɛm ara.
• Sɛ wunim dedaw sɛ wowɔ mmerɛbo mu yare a, sɛ wunya sɛnkyerɛnne foforo anaa ɛhaw adwene a, ka kyerɛ wo duruyɛfo.
• Sɛ wowɔ nsɛmmisa bi fa wo AST aba ho a, nsuro sɛ wubebisa wo duruyɛfo.

Ade a ɛho hia sen biara a ɛsɛ sɛ wode sie w’adwenem (Take-Home Message) .

Ɛyɛ ade a ɛfata sɛ wobɛte nka sɛ wohaw wo ho kakra bere a wuhu bo a ɛnteɛ wɔ mogya mu nhwehwɛmu amanneɛbɔ bi so no. Nanso kae sɛ, esiane sɛ wo AST dodow kɔ soro nti, ɛnkyerɛ sɛ wowɔ yare bi anaasɛ wuhia ayaresa. Nneɛma pii betumi aka AST dodow. Ebia nnipa a wɔwɔ apɔwmuden bɛyɛ 20 biara mu biako benya nea efi mu ba a ɛnyɛ nea ɛfata.

Wo duruyɛfo besi gyinae sɛ ebia ɛsɛ sɛ woyɛ nhwehwɛmu foforo biara na ama woahu nea ɛde saa bo a ɛnteɛ yi ba anaasɛ ɛnsɛ sɛ woyɛ. Enti, nsuro sɛ wo ne wo duruyɛfo bɛkasa afa eyi ho. Wɔwɔ hɔ sɛ wɔbɛboa wo. Ate aseɛ?

` AST, mmerɛbo, enzymes, mogya mu nhwehwɛmu, SGOT, mmerɛbo mu yare, akwahosan ho nhwehwɛmu