Momma yensua Hepcidin a ɛhwɛ dade a ɛwɔ nipadua no mu so no ho ade kɛkɛ?

So woate edin Hepcidin no ho asɛm pɛn? Ebia woannyɛ saa. Nanso eyi yɛ biribi a edi dwuma titiriw wɔ yɛn nipadua mu. Sɛ yɛbɛka no pɛpɛɛpɛ a, saa Hepcidin yi ne nea ɛhwɛ dade dodow a ɛwɔ yɛn nipadua mu so. Enti ɛnnɛ, momma yɛnka Hepcidin yi ho asɛm, ne nea ɛyɛ yɛn nipadua, tiawa ne adamfofa kwan so.

Dɛn ne Hepcidin? Sɛ yɛbɛka no tiawa a...

Hepcidin yɛ hormone bi a wɔyɛ wɔ yɛn nipadua mu. Hormone te sɛ ɔbɔfo ketewaa bi a ɔhwɛ yɛn nipadua mu dwumadi biara so na ɔde nsɛm kɔ anim ne akyi. Enti saa hormone a wɔfrɛ no hepcidin yi na ɛkyerɛ sɛnea yɛn nipadua no de iron di dwuma, iron dodow a nipadua no hia, ne dodow a ehia sɛ ɛkora so.

Dade yɛ ade a ɛho hia ma yɛn nipadua. So wunim sɛ dade yɛ ade titiriw a ɛma protein hemoglobin a ɛwɔ yɛn mogya mu nkwammoaa kɔkɔɔ mu no yɛ? Saa hemoglobin yi na ɛkyekyere oxygen na ɛde kɔ yɛn ntini ne yɛn akwaa ahorow mu wɔ nipadua no nyinaa mu. Ɛyɛ adwuma te sɛ oxygen taksi!

Ɛnyɛ ɛno nko, na mmom dade ho hia na ama yɛatumi ayɛ protein myoglobin a ɛma mframa pa kɔ yɛn ntini ne koma mu no.

Enti, ɛtɔ mmere bi a wɔfrɛ saa hepcidin yi "owura a ɔhwɛ dade so." Nea enti a ɛte saa ne sɛ ɛhwɛ dade dodow a yɛn nkwammoaa hia na ama wɔatumi ayɛ nneɛma a ɛho hia te sɛ hemoglobin ne mogya mu nkwammoaa kɔkɔɔ. Wo de susuw ho hwɛ, sɛ dade nni yɛn mu a, dɛn na ɛba? mogya a ɛtɔ kɔ nipadua mu a dade nnim betumi aba. Ɛno kyerɛ sɛ nipadua no ntumi nyɛ mogya mu nkwammoaa kɔkɔɔ a ɛdɔɔso. Ɔkwan foforo so no, sɛ yɛwɔ dade pii nso ɛ? Ɛno nso pira nipadua no kɛse, te sɛ awuduru, na ɛtɔ mmere bi mpo a ɛde nkwa to asiane mu.

Ɛhe na wɔyɛ saa hepcidin yi wɔ yɛn nipadua mu?

Wɔyɛ hepcidin titiriw wɔ yɛn mmerɛbo mu . Sɛ ɛba wie a, ɛhyɛn yɛn mogya mu.

Dɛn na Hepcidin yɛ ankasa?

Yɛadi kan aka sɛ hepcidin ne "dade nhyehyɛe ho ɔbenfo." Ɛne sɛ, ɛboa ma dade homeostasis kɔ so tra yɛn nipadua mu, a ɛkyerɛ sɛ wɔma dade dodow no kɔ so yɛ nea ɛfata, ɛnyɛ kakraa bi dodo anaasɛ ɛnyɛ pii dodo.

Yenya dade fi nnuan a yedi mu. Yenya dade fi nnuan te sɛ nam, mpataa, nhabannuru, ne nnuaba mu. Nanso, nea ɛnte sɛ aboɔden abo afoforo no, yɛn nipadua nni ɔkwan a ɛbɛtra hɔ daa a yɛbɛfa so ayi dade a ɛboro so afi hɔ. Sɛ nhwɛso no, sɛ yɛwɔ sodium pii a, ebeyi afi yɛn nsu mu. Nanso, dade yera kakraa bi pɛ fi yɛn nipadua mu, ɛnam mogya a yɛhwere anaa bere a nkwammoaa wuwu so.

Mmom no, yɛn nipadua no sie dade, na yɛde adi dwuma bere a ɛho hia. Yɛwɔ dade a wɔde asie mmeae te sɛ yɛn nnompe mu ntini, yɛn akyi berɛmo, ne yɛn mmerɛbo . Iron a ɛwɔ nipadua no mu nyinaa mu bɛyɛ 70% wɔ hemoglobin a ɛwɔ saa mogya mu nkwammoaa kɔkɔɔ a yɛadi kan aka ho asɛm no mu.

Enti, saa hepcidin yi ne nea ɛboa akwan horow a ɛboa ma wɔkora dade so, de fi baabi kɔ baabi foforo, na wɔde di dwuma bio no kɛse. Ɛyɛ eyi denam dade a ɛwɔ yɛn nkwammoaa mu a ɛhwɛ so sɛnea ɛbɛyɛ a obenya bere a ɛho hia, ne sɛnea ɛbɛyɛ a dade a ɛboro so nso renyɛ ɔhaw mma nipadua no so.

Hepcidin ka ho titiriw wɔ:

• Dade a ɛtwetwe no a yɛbɛhwɛ so: Dade a wɔtwe ne ɔkwan a wɔfa so twe dade a efi nnuan a yedi mu fi yɛn dwensɔtwaa ketewa no mu kɔ yɛn mogya mu. Bere a adu mogya no mu akyi nkutoo na nipadua no betumi de dade no adi dwuma. Enti, hepcidin na ɛhwɛ dade dodow a ɛkɔ mogya no mu ne dodow a wɔkora so no so.
• Dade a Wɔsan De Di Dwuma Wɔ Macrophages Mu: Macrophages yɛ mogya mu nkwammoaa fitaa bi a ɛte sɛ asraafo a wɔtew yɛn nipadua ho. Wɔn na wɔsɛe mogya mu nkwammoaa kɔkɔɔ dedaw a ɛrewuwu na wɔma mogya mu nkwammoaa kɔkɔɔ foforo kwan. Yɛn nnompe mu ntini no ma mogya mu nkwammoaa kɔkɔɔ foforo ba bɛyɛ nnafua 120 biara. Enti, sɛ macrophages sɛe mogya mu nkwammoaa kɔkɔɔ dedaw yi a, ɛgye dade no fi hemoglobin a ɛwɔ mu no mu. Hepcidin na esi gyinae sɛ ebia wɔde saa dade no sie macrophages no mu anaasɛ wɔsan gyae kɔ nipadua no mu.
• Dade a wɔakora so a woyi fi hɔ: Dade sie yɛn mmerɛbo mu nkwammoaa (a wɔfrɛ no hepatocytes) ne yɛn dwensɔtwaa ketewaa (a wɔfrɛ no enterocytes ) nkwammoaa mu. Hepcidin na ɛhwɛ sɛ ebia saa dade no bɛtra saa nkwammoaa no mu anaasɛ ɛbɛkɔ so de adi dwuma.

Ɔkwan bɛn so na hepcidin di dade a ɛkɔ nipadua no mu no so?

Nea ɛyɛ anigye ankasa ne sɛ hepcidin nhwɛ dade a wɔtwe no so denam adeyɛ biara a efi ase no so. Mmom no, ɛyɛ saa denam nneɛma a ɛboa ma dade twetwe no a egyae so.

Hepcidin ne protein bi a wɔfrɛ no ferroportin yɛ adwuma . Saa ferroportin yi te sɛ "iron transporter" a ɛwɔ yɛn nipadua mu. N’adwuma ne sɛ ɛbɛma dade afi mmeae a wɔkora so (macrophages, hepatocytes, enterocytes) na ɛde dade akɔ anim ne akyi wɔ nipadua no nkwammoaa ntam. Ferroportin ne nea ɛde dade fi dwensɔtwaa ketewa no mu kɔ mogya no mu sɛnea ɛbɛyɛ a nipadua no betumi de adi dwuma.

Hepcidin kyekyere saa ferroportin yi. Afei ferroportin no sɛe. Sɛ ɛba saa a, dade a anka wobetumi de ferroportin akɔ mogya no mu no kɔhyɛ mmeae koro no ara a wɔde siee no.

Susuw ho saa kwan yi so:

* Sɛ hepcidin kɔ soro a , ɛbɛyɛ den ma ferroportin sɛ ɛde dade bɛkɔ mogya no mu. Eyi kyerɛ sɛ dade a wɔtwe no so tew.

* Bere a hepcidin sua noƐnyɛ den sɛ Ferroportin betumi de dade akɔ mogya no mu. Eyi kyerɛ sɛ dade a wɔtwe kɔ nipadua no mu no kɔ soro.

So wote ase? Ɛyɛ mmerɛw yiye, ɛnte saa?

Nneɛma bɛn na ɛka Hepcidin dodow a ɛwɔ yɛn nipadua mu?

Hepcidin dodow a wowɔ wɔ wo nipadua mu no gyina nsɛnkyerɛnne a wo nipadua no de mena so. Esiane nneɛma ahorow nti, wo nipadua no nya nsɛnkyerɛnne a ɛbɛma ayɛ hepcidin pii anaa kakraa bi.

Nneɛma a ɛtete saa bi ni:

• Dade a ɛwɔ nipadua no mu nyinaa: Sɛ nipadua no mu dade sua a, ɛkyerɛ sɛ nipadua no nyɛ hepcidin kakraa bi. Sɛ nipadua no mu dade dɔɔso a, ɛkyerɛ nipadua no sɛ ɛnyɛ hepcidin pii.
• Mogya mu nkwammoaa kɔkɔɔ a wɔyɛ: Sɛ nipadua no hia hemoglobin pii na ama ayɛ mogya mu nkwammoaa kɔkɔɔ a, hepcidin dodow so tew. Eyi ne bere a ferroportin tumi yi dade fi mu na ɛboa ma wɔyɛ nkwammoaa foforo.
• Oxygen dodow a ɛba fam (Hypoxia): Hypoxia yɛ bere a wo ntini ahorow no nnya oxygen a ɛdɔɔso. Sɛ oxygen dodow sua a, nipadua no ma nipadua no kyerɛ sɛ ɛbɛtew Hepcidin so. Eyi ma Ferroportin a ɛma dade fi mu ma ɛyɛ hemoglobin no fi adi. Hemoglobin ne nea ɛde mframa pa fa mogya mu nkwammoaa kɔkɔɔ mu.
• Ɔfe a opira anaa ɔyare mmoawa de ba: Wɔ mmere te sɛ eyinom mu no, hepcidin dodow kɔ soro. Nea enti a ɛte saa ne sɛ ɛbɛma dade a ɛkɔ nipadua no mu no agyae. Mmoawa pii a epira te sɛ mmoawa de dade na enyin. Enti ɛdenam hepcidin a woma kɔ soro, dade a wobɛtew so so no, wusiw saa mmoawa no kwan sɛ dade nnya. Smart, ɛnte saa?

Sɛ hepcidin dodow no nyɛ nea ɛfata a, tebea horow bɛn na ɛba?

Seesei wunim sɛnea hepcidin ho hia. Enti, sɛ ɛkɔ soro dodo anaa ɛba fam dodo a, ebetumi de ɔhaw aba.

Sɛ hepcidin dɔɔso dodo a , ebia nipadua no rentumi nnye dade a ɛdɔɔso, na ɛde tebea horow te sɛ dade a enni nipadua no mu aba.

Sɛ hepcidin sua , nipadua no betumi atwe dade pii, na ama dade a ɛboro so.

Nyarewa a ɛbata hepcidin a ɛba fam ho

Sɛ hepcidin dodow sua a, wobetumi ahu tebea horow a edidi so yi:

• mogya a ɛtɔ kɔ nipadua mu a dade nnim: Eyi ne mogya a ɛtaa ba a ɛne hepcidin a ɛso tew wɔ abusuabɔ. Ɛtɔ mmere bi a, hepcidin dodow betumi ayɛ nea wontumi nhu. Eyi kyerɛ sɛ nipadua no rebɔ mmɔden sɛ ɛde dade bɛkɔ mogya no mu denam ferroportin a ebeyi afi mu no so.
• Hemochromatosis a wonya fi awosu mu:Eyi yɛ awosu mu yare. Esiane nkwaadɔm mu nsakrae a ɛba nkwammoaa no mu nti, mmerɛbo no ma hepcidin kakraa bi pɛ na ɛba. Ne saa nti, nipadua no twe dade pii dodo. Dade a ɛboro so yi kɔ koma, mmerɛbo, ne dwensɔtwaa mu titiriw.
• mogya a ɛtɔ kɔ nipadua mu a dade wom: Eyinom yɛ mogya a ɛtɔ kɔ nipadua mu no bi. Nanso, wɔ eyi mu no, ɛnyɛ dade a enni hɔ, na mmom dade a ɛboro so. Ɔhaw ahorow a ɛba mogya mu nkwammoaa kɔkɔɔ a wɔyɛ mu no ma hepcidin a wɔyɛ no so tew. Ne saa nti, ferroportin ma dade pii fi mu.
• Hepatitis C: Eyi yɛ mmerɛbo mu yare a mmoawa (HCV) de ba. Saa mmoawa yi brɛ nipadua no tumi a ɛde yɛ hepcidin no ase.
• Asikreyare a ɛto so abien: Nhwehwɛmu ahorow bi ada no adi sɛ nnipa a wɔwɔ asikreyare a ɛto so abien no so tew hepcidin dodow so, na ɛde dade a ɛboro so ba. Ebia insulin a wɔtaa de sa asikreyare no na ɛde ba.

Nyarewa a ɛbata hepcidin dodow a ɛkɔ soro ho

Hepcidin dodow a ɛkɔ soro no ne mogya a ɛtɔ kɔ nipadua mu a ɛnyɛ dade a enni nipadua mu no wɔ abusuabɔ. Ɛne sɛ, mogya a ɛtɔ kɔ nipadua mu a ɛnyɛ nea dade nnim. Ebia eyinom fi awosu mu tebea horow a ɛma hepcidin yɛ kɛse boro so no.

Hepcidin dodow nso kɔ soro wɔ tebea horow a wɔfrɛ no anemias of inflammation anaa anemia of chronic disease (ACD) mu . Wɔ ACD mu no, ɔfe ma nipadua no yi protein bi a wɔfrɛ no cytokine . Saa protein yi ma hepcidin dodow kɔ soro.

Nyarewa bi a ebia ɛne ACD wɔ abusuabɔ no bi ne:

• Nyarewa a enni sabea
• Crohn yare no
• Kokoram
• Asaabo mu yare a enni sabea

Enti wubetumi ahu, Hepcidin yɛ ade a ɛho hia yiye a ɛhwɛ dade a yɛde di dwuma wɔ yɛn nipadua mu no so. Ɛdenam hepcidin a egyae dade a ɛba no so no, ɛhwɛ sɛnea yɛn nipadua no tumi yɛ hemoglobin ne mogya mu nkwammoaa kɔkɔɔ no so. Wɔ saa kwan yi so no, Hepcidin nya oxygen dodow a ɛwɔ nipadua no nyinaa mu no so nkɛntɛnso wɔ ɔkwan a ɛnteɛ so. Hepcidin nso mma nipadua no ntumi nnye dade pii. Efisɛ dade pii betumi de nsɛnnennen a emu yɛ den aba bere tenten mu.

Nneɛma a ɛsɛ sɛ yɛkae fi saa asɛm yi mu (Take-Home Message) .

Okay, enti yɛaka Hepcidin ho asɛm pii nnɛ, ɛnte saa? Sɛ yɛbɛbɔ no mua a:

• Hepcidin yɛ hormone bi a wɔyɛ wɔ mmerɛbo mu.
• Eyi ne ade titiriw a ɛhwɛ dade dodow a ɛwɔ yɛn nipadua mu so. Ɛte sɛ "Dade Awurade."
• Yehia dade na ama yɛatumi ayɛ hemoglobin, a ɛno ne nea ɛde mframa pa kɔ nipadua no mu nyinaa.
• Hepcidin dodow, .Wɔnam protein bi a wɔfrɛ no ferroportin so na ɛhwɛ sɛnea dade twetwe, ɛkora so, ne nea ɛkɔ no so.
• Sɛ hepcidin sua a dade a ɛboro so betumi atwe , na ama dade a ɛboro so aba . Eyi betumi de tebea horow te sɛ hemochromatosis a wonya fi awo mu aba.
• Sɛ hepcidin kɔ soro a , ebia dade a ɛtwetwe no so bɛtew, na ɛde mogya a ɛtɔ kɔ nipadua mu a dade nni mu (ɛtɔ mmere bi a ɛyɛ ɔfe na ɛde ba).
• Sɛ nipadua no bɛkɔ so anya apɔwmuden a, ɛsɛ sɛ nipadua no mu dade dodow ne Hepcidin dodow kari pɛ.

Enti, sɛ wowɔ ɔhaw biara wɔ iron ho, anaasɛ wowɔ sɛnkyerɛnne te sɛ mogya a ɛtɔ kɔ nipadua mu a, ɛbɛyɛ papa sɛ wobɛkɔ oduruyɛfo nkyɛn na woanya afotu. Ɛho hia paa nso sɛ wobɛma w’ani aku nneɛma a ɛte sɛɛ ho.

` Hepcidin, dade, mogya a ɛtɔ kɔ nipadua mu, nkwaadɔm, hemoglobin, mmerɛbo, ferroportin