Biribiara a ɛfa ACTH Stimulation Test a ɛsusuw wo nipadua mu nkwaadɔm ho!

Ɛtɔ mmere bi a, sɛ nneɛma bi a ɛwɔ yɛn nipadua mu ntumi nyɛ adwuma yiye a, yebetumi anya akwahosan ho haw ahorow, ɛnte saa? Titiriw sɛ yɛn nipadua mu nkwaadɔm a ɛnkari pɛ a, ebetumi anya nkɛntɛnso kɛse. Wɔ tebea a ɛte saa mu no, ebia wo duruyɛfo bɛkamfo akyerɛ wo sɛ yɛ nhwehwɛmu titiriw bi. Ɛno ne `ACTH Nkannyan Sɔhwɛ`. Momma yɛnka eyi ho asɛm tiawa.

Dɛn ne ACTH sɔhwɛ (ACTH Stimulation Test)?

Sɛ yɛbɛka no tiawa a, eyi yɛ sɔhwɛ titiriw bi a ɛhwɛ sɛnea adrenal glands a ɛwɔ yɛn nipadua mu no yɛ wɔn ade wɔ hormone bi a wɔfrɛ no ACTH ho. Ɛtɔ mmere bi a, wɔsan frɛ eyi sɛ Cosyntropin Stimulation Test (CST). Eyi ne sɔhwɛ titiriw a wɔde hu sɛ ebia tebea bi wɔ hɔ a wɔfrɛ no adrenal insufficiency, a ɛyɛ adrenal ntini no dwumadi a ɛso tew anaa. Eyi betumi ayɛ nea edi kan, nea ɛto so abien anaa nea ɛto so abiɛsa.

Saa sɔhwɛ yi hwehwɛ sɛ wode ACTH hormone a wɔayɛ (Synthetic ACTH - Cosyntropin) bɛhyɛ wo ntini mu. Afei, dɔnhwerew fã biara anaa nea ɛte saa no, wɔfa wo mogya na wɔsɔ sɛnea hormone bi a wɔfrɛ no cortisol dodow te. Eyi yɛ sɛnea ɛbɛyɛ a wubehu sɛnea wo adrenal glands no reyɛ adwuma yiye.

Dɛn ne ACTH ne Cortisol?

`ACTH`, a egyina hɔ ma `Adrenocorticotropic Hormone`, yɛ hormone a `Pituitary Gland` a ɛwɔ yɛn amemene mu no na ɛyɛ. Ɛnya nkɛntɛnso kɛse wɔ sɛnea yɛn nipadua yɛ n’ade wɔ adwennwen ho no so. Sɛ `ACTH` fi adi a, ɛkanyan adrenal ntini no ma ɛyɛ `Cortisol`, a wɔsan frɛ no `adwennwen hormone` . Ɛkame ayɛ sɛ cortisol yɛ hormone a ɛho hia a ɛka yɛn nipadua mu akwaa ne ntini biara.

Adrenal Insufficiency Ahorow Ahorow

Eyi betumi asi wɔ akwan atitiriw abiɛsa so:

1. Adrenal Insufficiency Titiriw: Eyi ba bere a wo adrenal ntini no asɛe na entumi nyɛ cortisol yiye no. Nea ɛde eyi ba titiriw ne Addison yare no. Ɛyɛ yare a nipadua no tumi ko tia nyarewa.

2. Secondary Adrenal Insufficiency: Eyi ba bere a wo pituitary gland no ntumi nyɛ ACTH a ɛdɔɔso no. Afei wɔnkanyan adrenal ntini no sɛnea ɛbɛyɛ a ɛbɛyɛ cortisol.

3. Tertiary Adrenal Insufficiency: Eyi ba bere a hypothalamus a ɛwɔ amemene no mu no ntumi nyɛ hormone `CRH (Corticotropin-Releasing Hormone)` yiye no. `CRH` ne nea ɛka kyerɛ pituitary gland no sɛ ɛnyɛ `ACTH`.

Bere bɛn na ɛho hia sɛ wɔyɛ ACTH nhwehwɛmu?

Saa sɔhwɛ yi betumi ahu sɛ ebia wo adrenal glands ne pituitary gland reyɛ adwuma yiye wɔ cortisol a wɔyɛ no mu anaa. Wo duruyɛfo betumi ahyɛ nhwehwɛmu yi esiane nneɛma a edidi so yi nti:

• Sɛ nhwehwɛmu foforo hu sɛ wo cortisol dodow sua a.
• Sɛ wowɔ sɛnkyerɛnne ahorow a ɛkyerɛ sɛ adrenal insufficiency (e.g., ɔbrɛ a ɛtaa ba, wo mu duru so tew, yafunu mu yaw, akisikuru, adwenemhaw, honam ani tuntum ).
• Sɛ wugyae glucocorticoid nnuru te sɛ prednisone a wode di dwuma bere bi akyi a, hwɛ sɛ wo pituitary ne adrenal ntini no asan ayɛ sɛnea na ɛte kan anaa.

Hena na ɔreyɛ sɔhwɛ yi?

Mpɛn pii no, ɔyarehwɛfo na ɔyɛ ACTH aduru no. Mogya a wɔtwe, kyerɛ sɛ, mogya a wɔtwe no, obi a ɔyɛ ntini a ɛma mogya tu, kyerɛ sɛ obi a wanya ntetee titiriw ama atirimpɔw no na ɔyɛ. Afei wɔde saa nhwɛsode ahorow yi kɔ adwumayɛbea bi a wɔyɛ nhwehwɛmu. Ɛhɔ no, nyansahufo bi a ɔwɔ aduruyɛ mu nhwehwɛmu dan mu sɔ saa nhwɛsode ahorow yi hwɛ.

Wɔtaa yɛ nhwehwɛmu yi wɔ ayaresabea anaa endocrinologist, oduruyɛfo a ne ho akokwaw wɔ nyarewa a ɛfa hormone mu ho adwumayɛbea. Nea ɛka eyi ho ne nnuru a wɔde twitwiw nipadua mu na wɔfa mogya. Endocrinologist yɛ oduruyɛfo a ne ho akokwaw wɔ nyarewa a ɛfa hormone ho.

So ɛsɛ sɛ misiesie biribi ansa na mayɛ sɔhwɛ no?

Yiw, nneɛma bi wɔ hɔ.

• Ebia wɔbɛka akyerɛ wo sɛ to wo dwumadi ano hye na di aduan a carbohydrate pii wom nnɔnhwerew 12-24 ansa na wɔayɛ sɔhwɛ no.
• Wubetumi nso aka sɛ wubedi mmuada bɛyɛ nnɔnhwerew asia. Ɛno kyerɛ sɛ wuntumi nnidi anaa nnom biribiara gye nsu.
• Sɛ worenom nnuru bi a ebetumi aka cortisol nhwehwɛmu no a, wobetumi aka akyerɛ wo sɛ gyae nom bere tiaa bi.
• Esiane sɛ ɛsono sɛnea cortisol dodow wɔ da mũ no nyinaa (ɛdɔɔso sen biara anɔpa) nti, eye sɛ wɔyɛ nhwehwɛmu yi anɔpa na ama asiane a ɛwɔ hɔ sɛ wobenya atoro a ɛyɛ papa no so atew.

Nanso, wo duruyɛfo bɛma wo akwankyerɛ pɔtee a ɛfa sɛnea wubesiesie wo ho ama nhwehwɛmu yi ho. Ɛsɛ sɛ wudi saa akwankyerɛ ahorow no akyi pɛpɛɛpɛ.

Ɔkwan bɛn so na wɔyɛ ACTH sɔhwɛ no?

Eyinom ne anammɔn atitiriw a ɛsɛ sɛ woyɛ:

1. Nea edi kan no, wogye mogya fi ntini bi a ɛwɔ wo nsa mu mu. Eyi bɛhwɛ wo cortisol dodow a ɛwɔ wo mfiase no mu. Wobetumi ayɛ sɔhwɛ afoforo nso.

2. Afei, ɔyarehwɛfo bi de hormone bi a wɔayɛ a wɔfrɛ no `ACTH (Cosyntropin)` bɛhyɛ wo ntini mu. Saa `ACTH` a wɔayɛ no yɛ adwuma te sɛ `ACTH` a yɛn nipadua no yɛ no ara pɛ, ɛkanyan adrenal ntini no ma ɛyɛ cortisol.

3. Afei, simma 30 ne simma 60 (mpɛn pii) akyi no , wɔsan gye mogya fi wo ntini mu na wɔhwɛ sɛnea cortisol dodow te.

4. Wɔde mogya yi kɔ aduruyɛdan mu.

Osuahu bɛn na wunya wɔ sɔhwɛ no mu?

Nneɛma bi a wubetumi ahwɛ kwan bere a wɔretwe wo mogya no ni:

• Wɔbɛtena akongua bi so na wɔahu ntini bi a ɛnyɛ den wɔ wo basa mu. Mpɛn pii no, ɛbɛyɛ wo basa no mu, wɔ wo nsateaa akyi pɛɛ.
• Sɛ wohu ntini bi pɛ a, wɔhohoro baabi a ɛwɔ no na wɔde nnuru a ekum mmoawa gu mu.
• Afei wɔde ade ketewaa bi hyɛ ntini no mu na wogye mogya. Ebia eyi bɛyɛ te sɛ nea wɔabɔ no kakra.
• Sɛ wɔde ade no hyɛ mu wie a, mogya kakra bɛboaboa ano wɔ afiri bi a wɔde yɛ nhwehwɛmu mu.
• Sɛ wɔboaboa mogya a ɛdɔɔso ano ma nhwehwɛmu no wie a, woyi ade no na wɔde kotoku anaa gauze asinasin bi gu beae no na wɔde mia so na ama mogya no agyae.
• Afei wɔde plaster gu beae no.

Sɛ wunya Cosyntropin a, wɔtaa de gu wo nsa a ɛwɔ soro no mu, wɔ wo mmati atifi pɛɛ. Ebia wobɛte yaw kakra anaasɛ wobɛhyew bere a wode aduru no ahyɛ wo mu no, nanso ɛyɛ bere tiaa mu de.

Dɛn na ɛba wɔ sɔhwɛ no akyi?

Sɛ wɔfa mogya no wie a, wɔde kɔ lab. Sɛ nea efi mu ba no ba a, wo duruyɛfo bɛka ho asɛm akyerɛ wo.

So asiane ahorow bi wɔ sɔhwɛ yi mu?

Mogya mu nhwehwɛmu yɛ ade a abu so kɛse wɔ nnuruyɛ mu. Asiane ahorow no sua koraa. Ebia wobɛte nka sɛ woapirapira kakra anaasɛ woayɛ wo yaw wɔ baabi a wɔtwee mogya no, nanso ɛno befi hɔ ntɛm. Biribiara nni hɔ a ɛsɛ sɛ wohaw wo ho wɔ ho.

Bere tenten ahe na egye ansa na wɔahu nea efi mu ba?

Ebetumi agye dapɛn biako ansa na ACTH sɔhwɛ no mu aba asan aba, efisɛ sɛ lab mu aba no san ba pɛ a, ɛsɛ sɛ oduruyɛfo no sua ho ade yiye na ɔde ba awiei.

Dɛn na efi mu ba?

Mogya mu nhwehwɛmu amanneɛbɔ ahorow, a cortisol amanneɛbɔ ahorow a efi ACTH nhwehwɛmu no mu ka ho, taa kura nsɛm te sɛ eyi:

• Mogya mu nhwehwɛmu no din, anaa nea wɔsusuw wɔ mogya no mu.
• Wo mogya mu nhwehwɛmu aba no dodow anaa susuw.
• Ɛno ne susuw a wɔtaa de yɛ sɔhwɛ no.
• Nsɛm a ɛfa sɛ ebia nea efi mu ba no yɛ nea ɛfata, ɛnyɛ nea ɛfata, ɛkorɔn, anaasɛ ɛba fam ho.

Sɛ wɔkyekyem pɛpɛɛpɛ a, ɛsɛ sɛ nea efi mu ba no yɛ dɛn?

Wɔ tebea horow a ɛfata mu no, ɛsɛ sɛ wo cortisol dodow kɔ soro bere a woakanyan ACTH a wɔde nsa ayɛ akyi. Wɔ nea efi mu ba a ɛfata mu no, ɛsɛ sɛ wo cortisol dodow boro 12.6 mcg/dL (micrograms per deciliter) wɔ ACTH nkanyan akyi.

Kae sɛ, saa dodow a ɛfata yi betumi ayɛ soronko wɔ lab biara mu, sɔhwɛ biara mu, ne onipa biara. Hwɛ range a ɛfata a wɔde ama wɔ w’amanneɛbɔ no so bere nyinaa.

Wɔ ACTH nhwehwɛmu ho no, ɛho behia sɛ wo duruyɛfo anaa endocrinologist te nea efi mu ba no ase yiye ansa na woahu. Sɛ wowɔ nsɛmmisa bi fa nea ebefi mu aba ho a, hwɛ hu sɛ wubebisa wo duruyɛfo.

Dɛn na nea efi mu ba a ɛnteɛ kyerɛ?

Wo duruyɛfo anaa endocrinologist bɛhwehwɛ wo ACTH nhwehwɛmu aba no mu yiye. Nneɛma pii wɔ hɔ a ebetumi aka sɛnea sɔhwɛ no yɛ pɛpɛɛpɛ. Nea ɛtaa de atoro a ɛyɛ papa ba ne corticosteroids a wɔde dii dwuma nnansa yi.

Mpɛn pii no, nea efi ACTH nhwehwɛmu mu ba a ɛnteɛ kyerɛ sɛ adrenal a entumi nyɛ adwuma yiye titiriw ne nea ɛto so abien.

Adrenal Insufficiency a Ɛho Hia

Sɛ wowɔ saa tebea yi a, wo adrenal glands ntumi nyɛ cortisol anaasɛ ɛnyɛ adwuma yiye wɔ ACTH ho. Enti, ebia worenhu nkɔanim kɛse anaasɛ nkɔanim biara wɔ wo cortisol dodow mu wɔ ACTH nhwehwɛmu akyi. Eyi te saa efisɛ ACTH a wɔde ayɛ no nnya wo adrenal glands no so nkɛntɛnso.

Adrenal Insufficiency a Ɛto so Abien

Sɛ pituitary gland no nyɛ adwuma yiye bere tenten (hypopituitarism), na ACTH a wɔyɛ no sɛe a, eyi ma adrenal a ɛto so abien no ntumi nyɛ adwuma yiye. Ne saa nti, nkwammoaa a ɛtaa yɛ ACTH no nkannyan, na adrenal ntini no fi ase sɛe, kyerɛ sɛ, efi ase yɛ mmerɛw .

Enti, sɛ woanya hypopituitarism ne secondary adrenal insufficiency bere tenten a, ebia wubehu nkɔanim kakraa bi anaasɛ wunhu koraa wɔ wo cortisol dodow mu wɔ ACTH nhwehwɛmu no akyi.

Nanso, sɛ hypopituitarism no yɛ fã bi (a ɛkyerɛ sɛ pituitary gland no da so ara reyɛ ACTH bi), anaasɛ sɛ tebea no yɛ nnansa yi ara a, wobetumi ahu cortisol dodow a ɛkɔ soro, a ɛkyerɛ sɛ ɛyɛ "nea ɛfata" wɔ ACTH sɔhwɛ no akyi.

Nkrasɛm a Etwa To a Wɔde Kɔ Fie

ACTH Stimulation Test yɛ sɔhwɛ a ɛho hia na wotumi de ho to so sen biara a wɔde hu adrenal insufficiency. Sɛ́ wobɛtwɛn nea ebefi nhwehwɛmu a wɔde hu yare no mu aba no betumi ayɛ nea ɛyɛ wo yaw kakra. Nanso kae sɛ, ɛmfa ho nea ebefi mu aba biara no, w’aduruyɛfo kuw no wɔ hɔ sɛ wɔbɛboa wo. Nsuro sɛ wubebisa wo duruyɛfo no wo nhwehwɛmu anaa nea ebefi mu aba no ho asɛm. Ɛho hia sɛ wɔbɔ wo amanneɛ wɔ w’akwahosan ho.

` ACTH sɔhwɛ, cortisol, adrenal ntini, pituitary ntini, hormone, adrenal a entumi nyɛ adwuma yiye, aduruyɛ mu nhwehwɛmu