So wunim Bosutinib nnuru a wɔde di dwuma? Saa nneɛma yi ho hia yiye wɔ kokoram ayaresa mu!

So wo duruyɛfo akyerɛw wo anaa obi a ɔbɛn wo aduru `Bosutinib`? Anaasɛ w’ani gye ho sɛ wubesua aduru yi ho ade pii? Enti ɛnnɛ, momma yɛnka saa aduru `Bosutinib` yi ho asɛm kɔ akyiri na yɛmfa ɔkwan a ɛyɛ mmerɛw yiye so. Nnuru a ɛtete saa ho ntease a ɛteɛ a obi nya no boa kɛse ma ayaresa no di yiye.

Dɛn ne aduru yi? Dɛn ne Bosutinib?

Sɛ yɛbɛka no tiawa a, Bosutinib yɛ aduru a ɛde n’ani si protein ahorow bi a ɛwɔ kokoram nkwammoaa mu so na esiw wɔn nyin ano . Ne titiriw no, wɔtaa de sa mogya mu kokoram bi a wɔfrɛ no Chronic Myelogenous Leukemia (CML). Ɛka nnuru kuw bi a wɔfrɛ no Targeted Therapy ho. Eyi kyerɛ sɛ saa aduru yi nka nkwammoaa wɔ ɔkwan a ɛkɔ akyiri so nko, na mmom ɛka kokoram nkwammoaa pɔtee.

Ebia wobɛtumi ama oduruyɛfoɔ no akyerɛw saa aduru yi wɔ din ``BOSULIF.'' Ɛno yɛ din a wonim no yie ma saa aduru yi.

Nanso kae sɛ ɛtɔ mmere bi a nnuruyɛfo betumi de saa aduru yi adi dwuma wɔ tebea afoforo nso ho. Enti ɛbɛyɛ papa sɛ wubebisa wo duruyɛfo anaa nnuruyɛfo no nea enti a wɔakyerɛw aduru yi ama wo no pɛpɛɛpɛ.

Dɛn na ɛsɛ sɛ woka kyerɛ wo duruyɛfo ansa na woafi saa aduru yi ase?

Eyi ho hia paa. Ansa na wobɛhyɛ Bosutinib ase no, ɛho hia sɛ wobɔ wo duruyɛfo amanneɛ wɔ akwahosan tebea biara a ebia wowɔ ho. Eyi bɛboa wɔn ma wɔasi gyinae sɛ saa aduru yi fata wo ne ahwɛyiye a ɛsɛ sɛ woyɛ.

Nneɛma bi a ɛsɛ sɛ yɛka no pintinn ni:

• Sɛ wowɔ asikreyare ( asikre dodow a ɛkɔ soro wɔ mogya mu).
• Sɛ wowɔ `Koma Yare` a .
• Sɛ wowɔ `Mogya Nhyɛso a Ɛkɔ soro` a .
• Sɛ wowɔ asaabo mu yare a .
• Sɛ wowɔ mmerɛbo mu yare a .
• Sɛ woanya Bosutinib, nnuru afoforo, nnuan, nnuru a wɔde yɛ nneɛma, anaa nneɛma a wɔde sie ho a ɛyɛ soronko a .
• Sɛ woanyinsɛn anaasɛ worebɔ mmɔden sɛ wubenyinsɛn a . Eyi ho hia paa!
• Sɛ woyɛ ɛna a ɔma nufu a .

Ɛho hia paa ma w’ankasa ahobammɔ sɛ wobɛka akyerɛ oduruyɛfo no a womfa saa nsɛm yi nsie, ɛyɛ?

Ɔkwan bɛn so na ɛsɛ sɛ mede saa aduru yi di dwuma?

Okay, afei momma yɛnhwɛ sɛnea yɛde saa `Bosutinib` nnuru yi bedi dwuma pɛpɛɛpɛ. Nea ɛho hia paa ne sɛ wobɛnom aduru no sɛnea oduruyɛfo no ka kyerɛ wo no pɛpɛɛpɛ.

• Ɛsɛ sɛ wɔnom saa aduru yi ne nsu kuruwa biako .
• Di akwankyerɛ a ɛwɔ nnuru a wɔkyerɛw ma no so no akyi pɛpɛɛpɛ.
• Ɛsɛ sɛ wɔde saa aduru yi ka aduan ho. Mfa no bere a wo yafunu da mpan. Sɛ wode ka aduan ho a, ɛboa ma aduru no kɔ nipadua no mu yiye na ebetumi atew nsunsuanso bɔne no bi so.
• Ntwitwa, ntwitwa, anaa nwe aduru no. Mene pill no nyinaa.
• Mfa saa aduru yi nka borɔdɔma nsu ho. Grapefruit yɛ aduaba a ɛte sɛ borɔdɔma kɛse. Nsu a wɔde aduaba yi yɛ no betumi ne aduru yi ayɛ adwuma na aka sɛnea ɛyɛ adwuma. Enti hwɛ yiye titiriw wɔ eyi ho.
• Sɛ worenom nnuru a esiw H2 ano (e.g., cimetidine, famotidine, ranitidine) anaa antacids (e.g., Digene, Gelusil) ma komayare anaa yafunu mu yare a , ɛsɛ sɛ wonom nnɔnhwerew 2 ansa na woanom bosutinib anaa nnɔnhwerew 2 akyi. Eyi kyerɛ sɛ anyɛ yiye koraa no, ɛsɛ sɛ nnɔnhwerew 2 da nnuru abien yi a wɔbɛnom ntam. Bisa wo duruyɛfo anaa nnuruyɛfo ma ɔmma wo nsɛm pii.
• Nom w’aduru no bere ne bere mu. Mma nnnom nsen dodow a wo duruyɛfo akyerɛ wo, anaasɛ nnom no mpɛn pii.
• Mma nnnyae saa aduru yi nom mpofirim a wunnya wo duruyɛfo afotu.

Sɛ wode saa aduru yi rema mmofra a, ɛsɛ sɛ wo ne mmofra oduruyɛfo kasa fa ho na wudi n’afotu akyi. Ebia ɛho behia sɛ wɔhwɛ yiye titiriw.

Sɛ wususuw sɛ woadi mfomso anom aduru yi dodo a, frɛ Poison Control Center anaa Emergency Room a ɛbɛn wo ntɛm ara.

Nea ɛho hia sen biara: Saa aduru yi yɛ ma wo nkutoo. Mfa saa aduru yi mma obi foforo biara esiane biribi nti, sɛ mpo saa onipa no wɔ yare no ho sɛnkyerɛnne koro no ara te sɛ wo a.

Sɛ wopa nnuru dodow bi a, dɛn na ɛsɛ sɛ woyɛ?

Aduru dodow bi a wɔhwere no betumi ato obiara. Sɛ ɛba saa a, mma ɛnhaw wo.

• Fa dodow a woayera no bere a woakae ara pɛ.
• Nanso, sɛ ennu nnɔnhwerew 12 kosi sɛ wobɛnom dodow a edi hɔ no a, nnom dodow a woayera no. Twa so na fa dodow a edi hɔ no ara kwa wɔ bere a wɔahyɛ da ayɛ no mu.
• Mma nnom nnuru mmɔho abien da. Saa a wɔyɛ no ma asiane a ɛwɔ hɔ sɛ wobenya ɔhaw ahorow no yɛ kɛse.

Nneɛma foforo bɛn na ebetumi ne aduru yi adi nkitaho?

Bosutinib betumi ne nnuru afoforo bi, nnuan, ne nhabannuru a wɔde ma a ebia worenom no adi nkitaho. Saa nkitahodi ahorow yi betumi atew Bosutinib a etu mpɔn no so anaasɛ ɛbɛma asiane a ɛwɔ hɔ sɛ ebefi mu aba no ayɛ kɛse.

Bosutinib betumi ne nea edidi so yi adi nkitaho:

• Nnuru bi a ekum ɔyare mmoawa (sɛ nhwɛso no, ciprofloxacin, clarithromycin, erythromycin) .
• Nnuru bi a ekum fungal (sɛ nhwɛso no, fluconazole, ketoconazole, itraconazole) .
• Nnuru bi a wɔde ko tia akisikuru (sɛ nhwɛso no, carbamazepine, phenobarbital, phenytoin) .
• `Nnuru bi a wɔde sa yafunu mu haw` (e.g. `Proton Pump Inhibitors` ne `H2 blockers` te sɛ `cimetidine`, `famotidine`, `ranitidine`, `omeprazole`, `pantoprazole`)
• Nnuru bi a wɔde sa HIV yareɛ (e.g. amprenavir, atazanavir, ritonavir) .
• Grapefruit nsu (Maka eyi pɛn, nanso mɛsan aka bio!)
• Nnuru a wɔde nhabannuru St. John’s Wort (nnipa binom de eyinom di dwuma ma adwenemyare).
• Nnuru afoforo pii (sɛ nhwɛso no, amiodarone, diltiazem, verapamil, rifampin).

Saa list yi nwie pɛyɛ. Ebia nnuru afoforo nso wɔ hɔ. Enti, ka nnuru a worenom (wɔakyerɛw ama wo, nea wontɔn, nhabannuru, vitamin, anaa aduannuru) nyinaa ho asɛm kyerɛ wo duruyɛfo. Afei nso, sɛ wonom sigaret, wonom nsa, anaa wode nnubɔne foforo di dwuma a, ka kyerɛ wo duruyɛfo. Afei obetumi ayɛ w’ayaresa ho nhyehyɛe sɛnea ɛfata.

Dɛn na ɛsɛ sɛ mehwɛ yiye wɔ ho bere a merenom aduru yi?

Ɛho hia sɛ wohwɛ nsakrae biara a ɛbɛba wo nipadua mu bere a worenom Bosutinib no.

• Ɛho behia sɛ woyɛ wo mogya mu nhwehwɛmu daa . Eyi bɛboa wo duruyɛfo ma wahu sɛnea aduru no renya wo nipadua so nkɛntɛnso, sɛ ebia w’akwaa te sɛ wo mmerɛbo ne w’asaabo reyɛ adwuma yiye, ne sɛ ebia nsakrae bi aba wo mogya mu nneɛma mu anaa.
• Ebia saa aduru yi bɛma wo ho ayɛ wo yaw anaa mogya bɛtɔ wo. Sɛ wuhu sɛ akuru bi a ɛyɛ soronko, mogya retu wo anom, hwene mu mogya, anaa mogya a ɛretu a, ka kyerɛ wo duruyɛfo ntɛm ara.
• Sɛ wowɔ atiridiinini, atiridiinini, menewa mu yaw , anaa ɔyare mmoawa ho sɛnkyerɛnne te sɛ atiridiinini anaa ɔfe a, nnyɛ wo ho aduru. Frɛ wo duruyɛfo ntɛm ara na ɔmma no afotu. Ebia saa aduru yi bɛtew tumi a wo nipadua wɔ sɛ ɛbɛko atia nyarewa no so. Enti, bɔ mmɔden sɛ wobɛtwe wo ho afi nnipa a wɔyare ho.
• Adwene titiriw a ɛfa nyinsɛn ho:
• Nnyinsɛn bere a worenom aduru yi.
• Kwati sɛ wubenyinsɛn anyɛ yiye koraa no adapɛn 2 bere a woagyae aduru no akyi .
• Ɛsɛ sɛ mmea a wɔreyɛ nhyehyɛe anyinsɛn anaa wosusuw sɛ ebia wɔanyinsɛn no ka kyerɛ wɔn duruyɛfo ntɛm ara. Saa aduru yi betumi de ɔhaw ahorow a emu yɛ den aba akokoaa a ɔhyɛ yafunu mu no so. Bisa wo duruyɛfo anaa nnuruyɛfo ma ɔmma wo nsɛm pii.
• Ɛdefa nufu a wɔde ma ho no: Mma wo ba no nufu bere a worenom aduru yi ne anyɛ yiye koraa no adapɛn 2 bere a woagyae aduru no akyi.
• Awo: Ebia aduru yi bɛka sɛnea wubetumi awo mma. Sɛ eyi haw wo a, wo ne wo duruyɛfo nkasa.

Dɛn ne aduru yi mu nsunsuanso bɔne a ebetumi afi mu aba?

Te sɛ aduru biara no, Bosutinib betumi de nsunsuanso bɔne bi aba. Nanso, ɛnyɛ obiara na onya bi. Nneɛma bɔne bi a efi mu ba no yɛ aniberesɛm na sɛ wunya bi a, ɛsɛ sɛ woka kyerɛ wo duruyɛfo ntɛm ara. Ebinom nyɛ aniberesɛm na ebia ebefi hɔ nna kakraa bi akyi.

Nneɛma bɔne a ɛsɛ sɛ wobɔ wo duruyɛfo amanneɛ ntɛm ara:

• Nneɛma a ɛma obi ho yɛ no hyew: Honam ani akisikuru, ɛyaw, akisikuru, anim, anofafa, anaa tɛkrɛma a ɛho ahonhon. Sɛ saa sɛnkyerɛnne ahorow yi ba a, kɔ ayaresabea ntɛm ara.
• Akyi yaw ( a emu yɛ den, ɛyɛ soronko).
• Nsu a mogya anaa tuntum ayɛ mu ma . Eyi betumi ayɛ mogya a ɛretu wɔ nipadua no mu ho sɛnkyerɛnne.
• Atiridiinini a emu yɛ den .
• Adwene a ɛyɛ basaa (ɛyɛ den, ɛtaa ba).
• Tiyɛ (ɛyɛ den, wontumi nnyina ano).
• Koma mu yare ho sɛnkyerɛnne: Ɔhome mu haw, ɛyaw anaa ɛyaw a ɛyɛ den wɔ koko, kɔn, akyi, anaa abasa mu.
• Koma a entumi nyɛ adwuma yiye ho sɛnkyerɛnne: Ɔhome a ɛyɛ tiaa, koma a ɛbɔ ntɛmntɛm anaasɛ ɛnyɛ daa, ne mu duru a ɛkɔ soro mpofirim; nansoaa, nan, nsa a ɛho ahonhon.
• `Infection signs`: atiridiinini, atiridiinini, ɔfe, menewam yaw, ɛyaw anaasɛ ɛyɛ den sɛ wobɛtow.
• Nkwaa mu yaw ( a emu yɛ den).
• `Asaabo mu opira ho nsɛnkyerɛnne`: Nsakrae a ɛba nsu dodow a ɛba mu (ɛso tew kɛse anaasɛ ɛkɔ soro).
• `Asɛnka agua a ɛyɛ kɔla a ɛyɛ hann` .
• Mmɛn mu opira ho sɛnkyerɛnne: Nsu a ɛyɛ kɔkɔɔ anaa bruu tuntum, yare a wɔte nka wɔ ɔkwan a ɛkɔ akyiri so anaasɛ sɛnkyerɛnne a ɛte sɛ atiridii, aduan ho akɔnnɔ a ɛyera, yafunu atifi nifa mu yaw, aniwa anaa honam ani yɛ kɔkɔɔ (jaundice).
• `Mogya mu nkwammoaa kɔkɔɔ dodow a ɛba fam (Anemia)`: Ɔhome a ɛyɛ den, totɔ piti, te nka sɛ wo ho ayɛ wo hyew, te nka sɛ wobɛtaa ahwe ase, wo te nka sɛ woabrɛ anaasɛ woayɛ mmerɛw wɔ ɔkwan soronko so.
• Akisikuru (a emu yɛ den, ɛkɔ so tra hɔ).
• `Nsuo kɔkɔɔ anaa bruu tuntum` .
• Yafunu mu yaw ( a emu yɛ den).
• `Mogya a ɛtɔ anaasɛ akuru a ɛyɛ soronko`.
• `Ɔhohoro a ɛyɛ soronko` .
• Ɔfe (a emu yɛ den, ɛkɔ so daa).

Nsunsuanso bɔne a mpɛn pii no enhia aduruyɛ (nanso ɛsɛ sɛ wɔbɔ oduruyɛfo amanneɛ sɛ ɛkɔ so anaasɛ ɛhaw adwene a):

• `Akisikuru` .
• `Ɔbrɛ` .

Kae sɛ, ɛnyɛ nea ebetumi afi mu aba nyinaa nka saa nsɛm a wɔahyehyɛ yi ho. Sɛ wuhu biribi a ɛyɛ soronko anaa ɛsono a, ka ho asɛm kyerɛ wo duruyɛfo.

Ɔkwan bɛn so na ɛsɛ sɛ mede m’aduru sie?

Ɛho hia paa nso sɛ wode w’aduru sie yiye.

• Fa sie baabi a mmofra ne afieboa ntumi nkɔ hɔ.
• Fa sie wɔ dan mu hyew mu. Ɛne sɛ, ɛyɛ digrii Celsius 20 kosi 25 (digrii Fahrenheit 68 kosi 77). Mfa wo ho nhyɛ ɔhyew, awɔw, anaa nwini a ano yɛ den mu.
• Mfa nnuru a ne bere atwam atwam nni dwuma. Tow wɔn gu.

Ɔkwan bɛn so na wotow nnuru a wɔmfa nni dwuma ne nea ne bere atwam gu?

Ɛnyɛ bere nyinaa na ɛfata sɛ wobɛtow nnuru a ne bere atwam a wɔmfa nni dwuma agu nwura mu kɛkɛ anaasɛ wobɛhohoro akɔ tiafi mu. Wobetumi apira nneɛma a atwa yɛn ho ahyia.

• Adeɛ a ɛyɛ papa sɛ wobɛyɛ ne sɛ wode saa nnuru yi bɛma ``nnuru a wɔde bɛsan agye ho nhyehyɛeɛ.'' Wubetumi abisa wo nnurutɔnbea anaa mpɔtam hɔ akwahosan mpaninfoɔ sɛ wɔwɔ nhyehyɛeɛ a ɛte saa anaa.
• Sɛ wuntumi nhu nhyehyɛe a ɛte saa a, hwɛ nnuru a wɔde ahyɛ mu anaa krataa a ɛwɔ mu no mu hwɛ sɛ ɛwɔ akwankyerɛ a ɛfa sɛnea wɔbɛtow agu nwura anaa tiafi mu ho anaa. Sɛ wunnim a, bisa wo duruyɛfo anaa nnuruyɛfo.
• Sɛ wugye di sɛ asiane biara nni ho sɛ wobɛtow agu nwura mu a, yi nnuru no fi toa anaa kotoku a ɛbaa mu no mu, fa biribi te sɛ kɔfe a wɔde adi dwuma, mpataa nwura, anaa dɔte fra mu, na fa gu kotoku anaa ade a wɔatoto mu denneennen mu na tow gu nwura mu.

Saa kratawa yi yɛ nsɛm a wɔaboaboa ano nkutoo. Sɛ wowɔ nsɛmmisa foforo biara fa Bosutinib ho a, yɛsrɛ wo ne wo duruyɛfo, nnuruyɛfo, anaa akwahosan ho ɔyaresafo foforo nkasa.

Nneɛma a ɛho hia sen biara a ɛsɛ sɛ wokae (Take-Home Message) .

Okay, enti momma yɛnkae wo nneɛma a yɛkaa ho asɛm no bi a ɛsɛ sɛ wokae bio.

• Bosutinib yɛ aduru titiriw a wɔde ma kokoram te sɛ chronic myelogenous leukemia (CML).
• Ɛsɛ sɛ wɔde saa aduru yi ka aduan ho . Ɛnsɛ sɛ wotwitwa, wobubu, anaa wɔwe. Mfa bobe nsu nka ho.
• Ɛsɛ sɛ woka nnuru afoforo a wonom nyinaa, nyarewa foforo biara a wowɔ, ne sɛ ebia woanyinsɛn anaa worema nufu ho asɛm kyerɛ wo duruyɛfo .
• Nnyinsɛn bere a worenom aduru no. Hwɛ yie adapɛn 2 wɔ bere a woagyae no akyi.
• Sɛ mogya tu wo soronko, atiridiinini, wo honam ani akisikuru, ɛyɛ den sɛ wobɛhome, anaa wohu sɛ wo ho yɛ wo yaw a, ka kyerɛ wo duruyɛfo ntɛm ara.
• Ma wɔnyɛ mogya mu nhwehwɛmu wɔ bere ano.
• Nnyae nnuru no nom a wunnyaa wo duruyɛfo afotu.

Yɛpɛ sɛ wo ho tɔ wo ntɛm! Mewɔ anidaso sɛ saa nsɛm yi bɛboa wo.

` Bosutinib, Bosulif, CML, Chronic Myelogenous Leukemia, Kokoram Ayaresa, Kokoram Nnuru, Nsunsuanso bɔne