So wunim MUTYH-Associated Polyposis (MAP) ho asɛm? Momma yɛnka ho asɛm!

So woate saa din yi `(MUTYH-Associated Polyposis)` pɛn? Ebia ɛnte saa. Ɛyɛ awosu mu tebea a ɛntaa nsi, nanso ebetumi ayɛ nea ɛho hia kɛse. Esiane eyi nti, nyini nketenkete, a wɔfrɛ no `(polyps),` tumi nyin wɔ nipadua no afã horow bi. Ɛno nti na ɛho hia sɛ wohu eyi no.

Dɛn ne MUTYH awosu mu nkwaadɔm a ɛne polyposis (MAP) wɔ abusuabɔ?

Sɛ yɛbɛka no tiawa a, `(MUTYH-Associated Polyposis)` anaa `(MAP)` yɛ tebea a ɛnam yɛn awosu mu nkwaadɔm so fi awo ntoatoaso so kɔ awo ntoatoaso so. Nea ɛkɔ so wɔ eyi mu ne sɛ ntini nketenkete a yɛmpɛ a wɔfrɛ no `(polyps)` nyin wɔ yɛn nipadua mu, titiriw wɔ akyi berɛmo ne akyi berɛmo mu. Saa `(polyps)` yi nyɛ kokoram. Nanso, sɛ wɔannyi emu bi mfi hɔ a, bere kɔ so no, wobetumi anya kokoram kɛse. Saa `(polyps)` yi ntumi nkɔ so wɔ dwensɔtwaa mu nko, na mmom ɛtɔ da bi a ɛwɔ dwensɔtwaa ketewa ne yafunu mu nso.

So MAP tebea yi de kokoram ho asiane ba?

Yiw, koraa. Sɛ wowɔ (MAP) a, asiane a ɛwɔ hɔ sɛ wubenya kokoram a ɛwɔ akyi berɛmo mu no dɔɔso kɛse sen obi a onni tebea no. Susuw ho hwɛ, nnipa a wɔwɔ (MAP) no mu bɛyɛ fã wɔ kokoram a ɛwɔ wɔn akyi berɛmo mu dedaw bere a wohu sɛ wɔwɔ (MAP) no! Mpɛn pii no, saa kokoram ahorow yi ba bere a wɔadi mfe 40 kosi 60. Nanso ɛtɔ mmere bi a ebetumi ada adi ntɛm. Ɛnyɛ ɛno nko, na mmom ebia wobɛkɔ asiane mu nso sɛ wubenya kokoram a ɛwɔ akyi berɛmo mu ne kokoram ahorow afoforo a ɛwɔ aduan mu (yafunu mu (GI) kwan) akyi.

Obi a ɔwɔ MAP nkwa nna yɛ dɛn?

Nsuro sɛ wobɛte eyi. Nnipa dodow no ara a wɔwɔ `(MAP)` betumi atra ase sɛnea ɛte daa, nanso tebea biako wɔ hɔ. Ɛne sɛ, sɛ wubefi ase ayɛ kokoram ho nhwehwɛmu ntɛm na woayɛ no daa . Adeɛ a ɛho hia paa ne sɛ wobɛhwehwɛ na woayi saa `(polyps)` yi afiri hɔ ansa na wɔadan kokoram. Ɛno ansa na yebetumi akɔ so anya apɔwmuden.

Dɛn ne MUTYH gene-associated polyposis (MAP) ho sɛnkyerɛnne ahorow?

Ɔhaw no ni. Wontaa nhu anaasɛ wonte MAP ho sɛnkyerɛnne biara nka. Sɛ wowɔ polyps wɔ wo aduan mu mpo a, mpɛn pii no ɛmma wonhu sɛnkyerɛnne biara. Enti, polyps a ɛwɔ hɔ nkutoo nyɛ sɛnkyerɛnne a wotumi de ho to so a ɛkyerɛ sɛ wowɔ MAP. Ɛfiri:

• Ɛwom mpo sɛ nnipa pii wɔ polyps de, nanso ebia wonni MAP.
• Awosu mu tebea afoforo te sɛ Familial Adenomatous Polyposis (FAP) nso betumi ama polyps aba wɔ akyi berɛmo no mu. Awosu mu nhwehwɛmu nkutoo na ebetumi ahu sɛ wowɔ FAP, MAP, anaa awosu mu tebea foforo bi anaa.
• Ɛtɔ mmere bi a, sɛ wohu sɛ wɔwɔ MAP mpo a, ebia nnipa binom nni polyps biara.

Dɛn na ɛde MAP tebea yi ba?

MAP fi nsakrae a ɛba yɛn MUTYH awosu mu abɔde (a wɔsan frɛ no MYH) mu. Wonya fi awo mu wɔ autosomal recessive kwan so. Eyi kyerɛ sɛ, sɛ wubenya tebea no a, ɛsɛ sɛ wunya nkwaadɔm mu nsakrae no fi w’awofo baanu no nyinaa hɔ. Sɛ wunya nkwaadɔm mu nsakrae no fi w’awofo no mu biako pɛ hɔ a, worennya MAP. Nanso, woyɛ MAP soafo . Sɛ́ wobɛyɛ obi a ɔsoa nneɛma no kyerɛ sɛ sɛ wo wofo foforo a ɔwoo wo no nso yɛ obi a ɔsoa a, wubetumi de akɔma wo ba no.

Mprempren wɔbu akontaa sɛ nnipa dodoɔ no mu 1% kɔsi 2% na wɔkura `(MAP)`. Wɔn a wɔde kokoram kɔ ​​no nso wɔ asiane a ɛkɔ soro kakra sɛ wobenya kokoram wɔ wɔn akyi berɛmo mu, nanso ɛnyɛ kɛse te sɛ wɔn a wɔwɔ `(MAP)`.

Ɔkwan bɛn so na wonya saa (MAP) tebea yi fi awo ntoatoaso so kɔ awo ntoatoaso so?

Fa no sɛ awofo baanu no nyinaa yɛ `(MAP)` soafo. Sɛ saa a, hokwan a ɛwɔ hɔ sɛ wɔn mma benya tebea no fi awo mu no te sɛ nea edidi so yi:

• Hokwan wɔ baanan biara mu biako (25%) sɛ wɔrennya `(MUTYH)` awosu mu nkwaadɔm mu nsakrae no. Eyi kyerɛ sɛ abofra no rennya yare no, na saa abofra no rentumi mfa nkwaadɔm mu nsakrae no mma wɔn mma.
• Hokwan a ɛwɔ anan biara mu abien (50%) wɔ hɔ sɛ wobɛyɛ obi a ɔde nneɛma kɔ. Eyi kyerɛ sɛ abofra no rennyin (MAP), nanso obetumi de awosu mu nsakrae no akɔma wɔn mma.
• Hokwan wɔ baanan biara mu biako (25%) sɛ awofo baanu no nyinaa benya saa nkwaadɔm mu nsakrae yi afi awo mu. Afei abofra no benya `(MAP)` tebea no. Afei nso, anyɛ yiye koraa no, abofra no de `(MUTYH)` awosu mu nkwaadɔm mu nsakrae biako bɛma wɔn mma.

Ɔkwan bɛn so na wobehu tebea no (MAP)?

Mpɛn pii no, sɛ wubehu sɛ wowɔ MAP anaa a, ɛhwehwɛ sɛ wutu anammɔn kakraa bi. Wo duruyɛfo bedi kan abisa wo w’abusua abakɔsɛm ho asɛm akɔ akyiri. Obebisa kokoram anaa akwahosan tebea foforo biara a w’awofo, wo nananom, ne wo nuanom anya ho asɛm.

Sɛ wo duruyɛfo susuw sɛ ebia wowɔ awosu mu yare bi a, ebia ɔbɛkamfo akyerɛ sɛ wɔnyɛ awosu mu nhwehwɛmu. Saa nhwehwɛmu ahorow yi betumi ahu (MUTYH) awosu mu nkwaadɔm mu nsakrae ne awosu mu tebea afoforo a ɛma asiane a ɛwɔ hɔ sɛ wubenya kokoram no yɛ kɛse.

Oduruyɛfo no betumi akamfo akyerɛ sɛ wɔnyɛ awosu mu nhwehwɛmu wɔ nsɛm a edidi so yi mu:

• Sɛ obi wɔ w'abusua mu wɔ `(FAP)`, `(MAP)` anaa awosu mu tebea afoforo a.
• Sɛ w’abusua wɔ abakɔsɛm a emu yɛ den a wɔanya kokoram wɔ akyi berɛmo mu a.
• Sɛ wo nuanom mu biako anaa nea ɛboro saa wɔ polyps pii wɔ wɔn akyi berɛmo mu, nanso w’awofo nni bi (eyi kyerɛ sɛ ebia w’awofo yɛ wɔn a wɔsoa nneɛma).

Sɛ w’awosu mu nhwehwɛmu si so dua sɛ wowɔ (MAP) anaasɛ woyɛ obi a ɔwɔ ɔyare mmoawa a, wo duruyɛfo no ne wo bɛkasa afa anammɔn a edi hɔ a wobɛfa so ayɛ kokoram nhwehwɛmu ho.Ɛho hia paa nso sɛ wobɛbɔ w’abusua mufo a aka no amanneɛ wɔ eyi ho sɛnea ɛbɛyɛ a sɛ wɔpɛ a, wɔn nso betumi ayɛ awosu mu nhwehwɛmu.

Ɔkwan bɛn so na wɔyɛ MAP?

Sɛ yɛbɛka nokware a, aduru biara nni hɔ a wɔde sa tebea `(MAP).` Nanso, nhwehwɛmu ne ayaresa pii wɔ hɔ a ebetumi aboa ma wɔasiw kokoram ano na sɛ kokoram ba a, hu na wɔasa no ntɛm.

Sɛ wowɔ (MAP) a, ebia ɛho behia sɛ woyɛ kokoram ho nhwehwɛmu ntɛm na mpɛn pii sen sɛnea wotaa yɛ no. Eyinom bi ne:

• Colonoscopy: Bere a wo duruyɛfo reyɛ colonoscopy no, ɔde afiri titiriw bi a kanea wom a mfoninitwa afiri bi abata ho di dwuma de hwɛ wo dwensɔtwaa ne wo akyi berɛmo mu. Colonoscopy ne ɔkwan a eye sen biara a wobɛfa so ahu polyps a ɛwɔ wo dwensɔtwaa mu na woayi afi hɔ. Ɛsɛ sɛ wufi ase yɛ wo colonoscopy no bɛyɛ mfe 20, anaasɛ sɛ obi a ɔwɔ w’abusua mu anya kokoram wɔ akyi berɛmo mu a, mfe 10 ansa na mfe a onyaa kokoram no (nea edi kan biara).
• Upper endoscopy: Endoscopy a ɛwɔ soro no ma wo duruyɛfo tumi hu na oyi polyps a ɛwɔ wo yafunu ne wo dwensɔtwaa ketewa (duodenum) no atifi fã. Sɛ wɔahu sɛ wowɔ polyps wɔ wo dwensɔtwaa mu a, ɛsɛ sɛ wufi ase yɛ upper endoscopies ansa na woadi mfe 25, anaasɛ ansa na ɛno mpo.

So wobetumi asiw tebea no ano?

Ɔkwan biara nni hɔ a wɔbɛfa so asiw `(MUTYH)` awosu mu nkwaadɔm mu nsakrae no ano. Ɛne sɛ, ɛyɛ biribi a yenya fi awo mu. Nanso, akwan bi wɔ hɔ a wɔfa so boa awo a ebetumi atew asiane a ɛwɔ hɔ sɛ daakye abofra benya `(MAP) agyapade no so. Sɛ nhwɛso no, ` (Preimplantation Genetic Diagnosis - PGD)`, a wɔde di dwuma ne ` (In Vitro Fertilization - IVF) , betumi ama hokwan a ɛwɔ hɔ sɛ wobenya abofra a onni saa awosu mu tebea yi ayɛ kɛse. Wɔ saa kwan yi so no, wɔsɔ awotwaa no awosu mu tebea hwɛ ansa na wɔde ahyɛ awotwaa no mu.

Nanso, sɛ wode ``IVF'' reyɛ ``PGD'' a, ɛgye sika kɛseɛ na adwene mu nneɛma pii wɔ hɔ a ɛsɛ sɛ wosusu ho. Ɛyɛ papa sɛ wo ne awo mu ntini ho ɔbenfo a ɔfata behyia na woasua eyi ho ade pii.

Sɛ mewɔ (MAP) a, dɛn na ɛsɛ sɛ mehwɛ kwan?

Sɛ wowɔ `(MAP)` a, ebia ɛho behia sɛ wɔhwehwɛ kokoram mu ntɛm na wɔtaa yɛ sen afoforo. Ɛno yɛ nokware. Nanso, sɛ wonya ayaresa a ɛfata na wɔhwɛ wo so a, wubetumi atra ase a ahoɔden wom. Enti, ɛho hia sɛ wokɔ wo duruyɛfo nkyɛn daa na wosusuw akwan pa a wobɛfa so asiw kokoram ano ho.

Mɛyɛ dɛn ahwɛ me ho sɛ obi a ɔwɔ (MAP)?

Sɛ wuhu sɛ asiane kɛse wom sɛ wubenya kokoram a, ebetumi ama woanya adwenemyare te sɛ dadwen anaa adwenemhaw. Eyi yɛ ade a ɛfata. Sɛ wowɔ adwenemhaw a ɛte saa a, yɛsrɛ sɛ mmɔ mmɔden sɛ wo nkutoo wubegyina ano. Ayaresa ne akwan horow a wɔfa so boa wɔ hɔ, efi kasa mu ayaresa so kosi nnuru so.

Wubetumi nso ahwehwɛ mpɔtam hɔ nneɛma a ebetumi ama woanya awerɛkyekye ne akwankyerɛ. Wubetumi nso akɔka mmoa akuw a wubetumi ne afoforo akasa ho. Wɔ mmeae te sɛ eyinom no, ebetumi ayɛ ahoɔden fibea kɛse efisɛ wubetumi ne nnipa a wɔafa nneɛma koro no ara mu akasa.

Sɛ wunya awosu mu tebea bi a ɛma asiane a ɛwɔ hɔ sɛ wubenya kokoram no yɛ kɛse a, ebetumi ayɛ adwennwen ankasa. Nanso ɛnyɛ wo nkutoo na wowɔ. W’akwahosan kuw no wɔ ha sɛ wɔbɛboa wo. Ɛnnɛ akwan a ɛkɔ akyiri a wɔfa so hwehwɛ kokoram no betumi atew asiane a ɛwɔ hɔ sɛ wubenya kokoram no so kɛse na aboa wo ma woahu ntɛm.

Nea etwa to no, nneɛma a ɛsɛ sɛ yɛkae

Okay, enti seesei woanya nteaseɛ pa wɔ deɛ yɛaka ho asɛm (MUTYH-Associated Polyposis - MAP) no ho. Nneɛma a ɛho hia a ɛsɛ sɛ wokae ni:

• MAP yɛ awosu mu tebea a wonya fi awo mu. Ɛma polyps ba dwensɔtwaa no mu na ɛma asiane a ɛwɔ hɔ sɛ obi benya kokoram wɔ dwensɔtwaa mu no yɛ kɛse.
• Ɛmfa sɛnkyerɛnne atitiriw mma. Enti, sɛ abusua bi wɔ hɔ a kokoram wɔ hɔ a, ɛho hia sɛ wɔyɛ awosu mu nhwehwɛmu wɔ aduruyɛ mu afotu so.
• Sɛ wohu sɛ wowɔ `(MAP) a, mma wo ho nnyɛ wo hu. Ɛdenam nhwehwɛmu te sɛ `(Colonoscopy)` ne `(Upper endoscopy)` a wɔbɛyɛ wɔ bere a ɛfata mu so no, wobetumi asiw kokoram ano anaasɛ wɔahu no ntɛm.
• Adwene mu akwahosan nso ho hia paa. Sɛ wuhia a, ntwentwɛn wo nan ase sɛ wubenya mmoa.
• Kɔ so ne w’aduruyɛfo kuw no nni nkitaho na hwɛ w’akwahosan so.

Yɛwɔ anidaso sɛ saa nsɛm yi so bɛba wo mfaso. Yɛpɛ sɛ wo ne w’abusua nya akwahosan pa!

` MUTYH-Associated Polyposis, MAP, polyposis, awosu mu nyarewa, kokoram a ɛwɔ akyi berɛmo mu, colonoscopy, awosu mu nhwehwɛmu