So obi wɔ w’abusua mu, ebia wo papa, wo maame, anaa obi a wunim no, wɔ Parkinson Yare no? Ɛbɛyɛ sɛ wotee awerɛhow kɛse bere a wuhui sɛ wɔn nsa rewosow, na ɛyɛ den sɛ wɔnantew, wɔn nipadua reyɛ den, na wɔn anim ahwere nkate nyinaa. Ɛnyɛ mmerɛw ankasa sɛ wo ne yare yi bɛtra ase. Nanso nea eye sen biara ne sɛ, ɛdenam nnɛyi aduruyɛ ho nyansahu a ɛkɔ anim so, sɛ wode nnuru a ɛfata di dwuma a, wubetumi adi saa sɛnkyerɛnne ahorow yi so kɛse na woabɔ bra pa. Enti ɛnnɛ, momma yɛnka nnuru a wɔde ma Parkinson yare no ho asɛm tiawa na yɛmfa ayamye nyɛ.
Nea edi kan no, ma yɛnhwɛ, dɛn ankasa ne Parkinson yare?
Momma yɛnte eyi ase yiye. Parkinson yɛ yare a ɛne yɛn ntini ahorow wɔ abusuabɔ. Ne titiriw no, yɛn amemene. Ɛyɛ tebea a ɛkɔ so nkakrankakra a bere kɔ so no ɛyɛ kɛse . Yɛn amemene no fã bi wɔ hɔ a wɔfrɛ no `substantia nigra` a ɛhwɛ kankyee so. Ntini mu nkwammoaa a ɛwɔ beae yi sɛe na nkakrankakra ewu.
Saa ntini mu nkwammoaa yi yɛ nnuru somafo a ɛho hia yiye, `neurotransmitter`, ma yɛn nipadua. Ne din de dopamine . Saa dopamine yi ho hia na ama yɛn nipadua no kankyee ayɛ mmerɛw na yɛadi so. Enti sɛ wɔsɛe saa ntini mu nkwammoaa no a, dopamine dodow a ɛwɔ amemene no mu no so tew. Ɛno nti na sɛnkyerɛnne te sɛ ahopopo, nantew a ɛyɛ den, ne ne ho a ɛyɛ den ba wɔ Parkinson yare no mu no.
Nea ɛho hia sen biara ne sɛ nnuru a wɔde ma Parkinson yare no di saa sɛnkyerɛnne ahorow yi so. Mprempren, yare yi ano aduru biara nni hɔ. Nanso, nnuru yi boa kɛse ma wodi sɛnkyerɛnne ahorow no so na ɛma asetra tu mpɔn.
Nnuru atitiriw a wɔde sa Parkinson yare no
Sɛ nnuruyɛfo resa Parkinson yare no a, wɔtaa de nnuru pii a wɔaka abom di dwuma, sen sɛ wɔde aduru biako bedi dwuma. Eyinom gu ahorow gyina onipa no yare no ho sɛnkyerɛnne, mfe a wadi, ne faako a yare no wɔ so. Momma yɛnhwɛ nnuru ahorow atitiriw no.
1. Levodopa ne Carbidopa a ɛwɔ nipadua no mu
Eyi ne aduru titiriw a etu mpɔn sen biara a wɔde sa Parkinson yare no. Wɔsan frɛ no sika kɔkɔɔ gyinapɛn.
- Levodopa: Sɛ saa aduru yi hyɛn yɛn nipadua mu a, ɛkɔ amemene no mu na ɛdan dopamine. Ɛne sɛ, saa aduru yi san ma dopamine dodow a asɛe wɔ amemene no mu no ba.
- Carbidopa: Nanso ɔhaw bi wɔ hɔ. Sɛ yɛnom levodopa nkutoo a, enzymes a ɛwɔ yɛn nipadua mu sɛe emu dodow no ara ansa na adu amemene no mu. Nea ɛbɛyɛ na wɔagyae eyi no, wɔde aduru bi a wɔfrɛ no carbidopa ka levodopa ho. Carbidopa ma levodopa no pii du amemene no mu dwoodwoo. Afei nso, carbidopa boa ma nea efi levodopa nkutoo a wɔnom mu ba te sɛ akisikuru ne ɔfe so tew.
Saa nnuru a wɔaka abom yi taa yɛ adwuma yiye wɔ bradykinesia, akisikuru, ne wosow ho sɛnkyerɛnne ahorow ho.
| Aduru ko a wɔde yɛ | Edin a Wɔtaa De Di Dwuma wɔ Sri Lanka |
|---|---|
| Levodopa-Carbidopa a wɔde afrafra | Sinemet®, Rytary®, Parcopa®, Dhivy®, na wɔde wɔn ho ahyɛ mu |
2. Nnuru a Ɛma Dopamine Agonists
Saa aduru yi te sɛ odiyifo. Ɛne sɛ, ɛnyɛ dopamine ankasa. Nanso ɛkɔ amemene no mu na ɛyɛ adwuma te sɛ dopamine. Ɛkanyan dopamine a ɛwɔ amemene no mu, na ɛma amemene no te nka sɛ dopamine wɔ hɔ.
Wɔtaa kyerɛw nnuru yi ma wɔ yare no mfiase, titiriw wɔ ayarefo nkumaa mu. Ɛtɔ mmere bi a wobetumi aboa ma levodopa a etu mpɔn no akyɛ.
- Pramipexole (Mirapex®) a wɔde di dwuma wɔ ɔkwan a ɛfata so.
- Ropinirole (Ahwehwɛde®) .
- Rotigotine (Neupro®) a wɔde yɛ aduru a wɔfrɛ no Rotigotine (Neupro®) .
3. Nneɛma a Wɔde Siw Enzyme Ano
Mma wo ho nnsuro sɛ wote saa din yi a. Ɛyɛ mmerɛw yiye. Yɛadi kan aka sɛ enzyme ahorow bi wɔ yɛn nipadua mu a ɛpaapae dopamine. Nea nnuru yi yɛ ne sɛ egyae saa enzyme ahorow no dwumadi. Afei dopamine a ɛwɔ amemene no mu no nsɛe bere tenten.
Eyinom ahorow atitiriw abien na ɛwɔ hɔ:
- MAO-B Inhibitors: Eyinom siw `MAO-B`, enzyme titiriw bi a ɛpaapae dopamine a ɛwɔ amemene no mu no dwumadi ano. Nhwɛsoɔ: `Selegiline`, `Rasagiline`.
- COMT Inhibitors: Eyinom siw enzyme `COMT` a ɛpaapae dopamine a efi levodopa mu ba no ano. Esiane eyi nti, nkɛntɛnso a levodopa nya no kyɛ. Nhwɛsoɔ: `Entacapone`, `Opicapone`.
4. Amantadine a wɔde di dwuma
Ayarefo binom a wɔnom nnuru te sɛ levodopa bere tenten no betumi anya wɔn ho a wɔmpɛ, na wɔyɛ basaa (dyskinesia). Wɔde amantadine di dwuma titiriw de sa tebea horow yi. Nea ɛyɛ nwonwa no, mfiase no wɔyɛɛ no sɛ aduru a ekum ɔyare mmoawa. Nanso akyiri yi wohui sɛ ɛboa nso wɔ Parkinson yare no ho sɛnkyerɛnne ahorow mu.
5. Nnuru a Ɛko Tia Cholinergic
Saa aduru yi boa titiriw ma obi ho popo na ne ho yɛ den.Kyerɛ kwan. Sɛ dopamine a ɛwɔ yɛn amemene mu so tew a, `neurotransmitter` foforo a wɔfrɛ no acetylcholine nkɛntɛnso kɔ soro. Saa nnuru yi siw saa acetylcholine no tumi ano. Nhwɛsoɔ: `Benztropine`, `Trihexyphenidyl`.
Nnuru a wɔde sa sɛnkyerɛnne afoforo a ɛne kankyee nni abusuabɔ
Parkinson yare no nka sɛnea obi keka ne ho kɛkɛ. Ebetumi de ɔhaw afoforo nso aba, te sɛ akisikuru, nna ho haw, adwenemhaw, ne nna mu ɔhaw ahorow. Wo duruyɛfo bɛkyerɛw nnuru ama eyinom mu biara.
| Nsɛnkyerɛnne a ɛkyerɛ | Nnuru ahorow a wobetumi akyerɛw ama obi |
|---|---|
| Ɔbarima ne ɔbea nna a ɛnyɛ adwuma yiye | Nnuru te sɛ Sildenafil (Viagra®) . |
| Da a obi da dodo awiabere (Hypersomnia) . | Modafinil (Provigil®) a wɔde yɛ aduru a wɔfrɛ no Modafinil . |
| Ayamtim | Nneɛma a ɛma nsu mu yɛ mmerɛw, te sɛ polyethylene glycol (MiraLax®) . |
| Ɔbrɛ | Methylphenidate (Ritalin®) a wɔde yɛ aduru a wɔfrɛ no methylphenidate (Ritalin®) . |
| Adwene mu yare | Nnuru a esiw cholinesterase ano |
| Adwenemhaw/Adwennwen | SSRIs (Nnuru a Wɔde Siw Serotonin a Wɔsan Fa Ano a Wɔpaw) . |
| Adwene mu Nneyɛe/Nneɛma a Ɛyɛ Fɛ | Nnuru a wɔde kum adwene mu yare te sɛ pimavanserin |
Momma yensua nsunsuanso bɔne a nnuru yi de ba nso ho ade.
Te sɛ nnuru biara no, Parkinson nnuru betumi anya nkɛntɛnso bɔne. Ɛho hia sɛ wudi kan hu eyinom. Nanso, ɛnyɛ obiara na onya saa nneɛma bɔne yi. Afei nso, eyinom bi kɔ bere a wɔkɔ so de nnuru no di dwuma no.
| Aduru ko a wɔde yɛ | Nneɛma bɔne a ɛtaa ba |
|---|---|
| Levodopa a wɔfrɛ no Levodopa | Akisikuru, ɔfe, adwenemhaw, tiyɛ, awiabere, mogya mmoroso a ɛba fam bere a obi gyina hɔ. Adwene mu basaayɛ ne nsusuwii hunu betumi aba wɔn a wɔn mfe akɔ anim mu. |
| Dopamine Nnuru a Ɛma Nnipa Yɛ Adwuma | Nsusuwii hunu, adwene mu basaayɛ, nna a ɛyɛ den, akisikuru, ano a ɛyɛ mmerɛw, adwenemhaw. Eyinom betumi aba mpɛn pii wɔ nna kakraa a edi kan a wɔde afi aduru no ase no mu na afei ɛso atew. |
| Nneɛma a Wɔde Siw Enzyme Ano | (COMT inhibitors): atiridiinini, kankyee a wontumi nni so (dyskinesia). (MAO-B inhibitors): Koko mu yaw, akisikuru, ano a ɛyɛ mmerɛw, adwenemhaw. |
| Amantadine a wɔde di dwuma | Ɛyɛ den sɛ wode w’adwene besi biribi so, adwene mu basaa, nna a wontumi nna, dae bɔne, nan a ahonhon. |
| Nnuru a ɛko tia cholinergic | Ano a ɛyɛ mmerɛw, aniwa a ɛyɛ kusuu, nna a ɛyɛ den, akisikuru, ɛyɛ den sɛ wobɛtow nsu, ɔhaw a ɛma ɔkae ade. |
Nea ɛho hia yiye: Nnyae Levodopa nom anaasɛ ntew dodow no so mpofirim a wunnya wo duruyɛfo afotu esiane biribiara nti. Saa a wɔbɛyɛ no betumi de tebea bi a emu yɛ den a ɛde nkwa to asiane mu a wɔfrɛ no `parkinsonism hyperpyrexia syndrome` aba.
So nnuru nnɔɔso? Dɛn bio na wobetumi ayɛ?
Nnuruyɛ yɛ ɔko no fã biako pɛ ankasa. Sɛ woyɛ nneɛma afoforo kakraa bi ka nnuru ho a, wubetumi adi wo sɛnkyerɛnne ahorow no so yiye na w’ani agye.
Nipadua mu Ayaresa
Akyinnye biara nni ho sɛ eyi yɛ biribi a ɛsɛ sɛ wɔyɛ. Apɔw-mu-teɛteɛ nhyehyɛe ahorow wɔ hɔ a wɔde ma ayarefo a wɔwɔ Parkinson titiriw. Eyinom bɛboa wo, .
- Wubetumi ama wo nipadua kari pɛ na ama wo nantew atu mpɔn.
- Ebetumi ama nipadua no agyina pintinn.
- Ɛboa kɛse ma wokura asetra a ɛyɛ nnam mu.
Apɔw-mu-teɛteɛ
Apɔw-mu-teɛteɛ ne ɔkwan a eye sen biara a wɔfa so di Parkinson yare no ho dwuma. Apɔw-mu-teɛteɛ nkutoo ne ade a nyansahu ada no adi sɛ ɛma yare no kɔ so brɛoo. Ɛyɛ papa sɛ anyɛ yiye koraa no wobɛyɛ koma ne ntini mu apɔw-mu-teɛteɛ simma 150 dapɛn biara. Nneɛma te sɛ sakre so a wɔde tu mmirika, akuturukubɔ, ne apɔw-mu-teɛteɛ a wɔde bɔ nnwom no boa paa.
Adwene mu akwahosan a wɔbɛhwɛ so
Sɛ wo ne yare a ɛtra hɔ kyɛ te sɛ Parkinson te ase a, ɛtaa ba sɛ wobɛte adwenemhaw, dadwen, ne dadwen nka. Enti, sɛ wote nka saa a, ɛho hia sɛ w’ani nwu ho na wohwehwɛ mmoa fi adwenemyare ho ɔbenfo te sɛ adwene ne nneyɛe ho ɔbenfo hɔ .
Bere bɛn na ɛsɛ sɛ wosan kɔ wo duruyɛfo nkyɛn bio?
Sɛ wode Parkinson aduru redi dwuma a, ɛho hia sɛ wokɔ wo duruyɛfo nkyɛn daa kɔhwɛ sɛ ebia aduru no reyɛ adwuma anaa na sɛnkyerɛnne foforo aba anaa. Hwɛ hu sɛ wobɛkɔ wo duruyɛfo nkyɛn titiriw wɔ nsɛm yi mu.
- Sɛ wunya nsunsuanso bɔne a wuntumi nnyina ano a .
- Sɛ wo yare no ho sɛnkyerɛnne no ankɔ yiye anaasɛ ankɔ so ansɛe a .
- Sɛ wote nka sɛ wopɛ sɛ wugyae w’aduru no a . (Mma wo nkutoo nsi gyinae yi da!)
Nkrasɛm a Wɔde Kɔ Fie
- Nnuru a wɔde sa Parkinson yare no ntumi nsa yare no koraa, nanso ebetumi adi sɛnkyerɛnne ahorow no so na ama asetra atu mpɔn.
- Levodopa ne aduru titiriw a etu mpɔn sen biara a wɔde sa eyi.
- Te sɛ nnuru nyinaa no, nsunsuanso bɔne betumi aba. Wo ne wo duruyɛfo nka wɔn ho asɛm pefee.
- Nnyae nnuru nom anaasɛ nsakra dodow a wode ma no a wunnya wo duruyɛfo afotu esiane biribiara nti. Ebetumi ayɛ nea asiane wom.
- Wɔ nnuru akyi no, apɔw-mu-teɛteɛ ne apɔw-mu-teɛteɛ daa ho hia yiye wɔ yare no ano aduru mu.
- Hwɛ w’adwene mu akwahosan so wɔ akwantu yi mu. Sɛ ɛho hia a, hwehwɛ mmoa a efi animdefo mu.
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