So wo nipadua no ntumi nyɛ adwuma yiye wɔ Parathyroid Hormone ho? Momma yɛnka tebea a ɛyɛ nwonwa yi (Pseudohypoparathyroidism) ho asɛm!

So ɛtɔ mmere bi a wote nka sɛ biribi a ɛwɔ wo nipadua mu no ntumi nyɛ adwuma yiye? Nyarewa bi wɔ hɔ a ɛyɛ nwonwa, na ne din betumi ayɛ hu kakra. Yare a ɛte saa biako a wɔntaa nte ho asɛm, nanso ɛho hia sɛ wohu ho asɛm ne Pseudohypoparathyroidism (PHP). Ɛwom sɛ ebia edin no bɛyɛ te sɛ nea ɛware kakra de, nanso momma yɛmma ɛnyɛ mmerɛw.

Dɛn ne pseudohypoparathyroidism?

Sɛ yɛbɛka no tiawa a, eyi yɛ awosu mu tebea a ɛntaa nsi . Yɛwɔ ntini nketenkete wɔ yɛn nipadua mu a wɔfrɛ no parathyroid ntini. Eyinom ma wonya nkwaadɔm bi a wɔfrɛ no Parathyroid Hormone (PTH). Saa PTH hormone yi ho hia yɛn nipadua yiye. Efisɛ, saa hormone yi boa ma Calcium, Phosphorus, ne Vitamin D dodow a ɛfata kɔ yɛn mogya mu.

Afei, wunim nea ɛto obi a ɔwɔ pseudohypoparathyroidism (PHP)? Ɛwom mpo sɛ wɔn parathyroid ntini no yɛ PTH hormone sɛnea ɛte biara de, nanso nkwammoaa a ɛwɔ wɔn nipadua mu no nyɛ ho biribi yiye, a ɛkyerɛ sɛ wontumi "nhu" no. Ɛte sɛ nea obi ne wo rekasa nanso wuntumi nte wɔn. Yɛfrɛ eyi Parathyroid Hormone Resistance .

Dɛn na ɛba esiane eyi nti? Calcium dodow a ɛwɔ mogya mu no so tew, bere a phosphorus dodow kɔ soro. Saa kari a ɛnkari pɛ yi betumi ama ntini ahorow no ayɛ mmerɛw, ayɛ mmerɛw, akisikuru, ne ntini mu haw ahorow.

Nea ɛho hia no, saa tebea a wɔfrɛ no PHP yi yɛ soronko wɔ tebea a wɔfrɛ no Hypoparathyroidism ho. Nnipa a wɔwɔ hypoparathyroidism no ntumi nyɛ PTH hormone a ɛdɔɔso a wɔde befi ase. Nanso, wɔ PHP mu no, wɔyɛ hormone no, nanso nipadua no mfa nni dwuma.

PHP ahorow titiriw bɛn na ɛwɔ hɔ?

Saa PHP tebea yi ahorow atitiriw pii wɔ hɔ. Ma yɛnhwɛ nea wɔyɛ.

PHP-1 no su

Eyi ne PHP a wɔtaa de di dwuma . Wɔ PTH hormone a yɛadi kan aka ho asɛm no akyi no, wobetumi ahu nsakrae bi a ɛba nnompe mu nhyehyɛe mu. Nhwɛsoɔ:

• Anim a ɛyɛ kurukuruwa
• Ɔsorokɔ a ɛso atew (ne tenten a ɛyɛ tiaa) .
• Kɔn mu yaw
• Nsa ne anan a abubu

Nnuruyɛfo frɛ sɛnkyerɛnne ahorow a wɔaka abom yi Albright Hereditary Osteodystrophy (AHO) . Nnipa a wɔwɔ PHP-1 no wɔ tebea no esiane awosu mu abɔde bi a wɔfrɛ no `GNAS` a wonya fi wɔn awofo no mu biako hɔ nti.

PPHP (Pseudopseudohypoparathyroidism) a ɛma obi nya ɔyare a ɛma mogya tu .

Eyi yɛ PHP-1 a anohyeto wom. Ebia nnipa a wɔwɔ PPHP (Pseudopseudohypoparathyroidism) no benya nipadua mu nneɛma a wohu wɔ AHO mu (te sɛ wɔn anim kurukuruwa ne wɔn tenten tiaa), nanso wonni PTH hormone a ɛko tia . Eyi kyerɛ sɛ wɔn calcium ne phosphorus dodow yɛ nea ɛfata.

PHP-2 no su

Nnipa a wɔwɔ PHP-2 no wɔ PTH hormone a ɛko tia, a ɛkyerɛ sɛ wɔn calcium sua na phosphorus dɔɔso. Nanso wonni nipadua mu nneɛma (te sɛ wɔn anim kurukuruwa ne wɔn tenten tiaa) a wohu wɔ AHO mu no. Nhwehwɛmufo nnya nhuu awosu mu sintɔ pɔtee a ɛde PHP-2 a ɛte sɛɛ ba.

Dɛn ne PHP ho sɛnkyerɛnne ahorow?

PHP ho sɛnkyerɛnne betumi ayɛ soronko wɔ onipa biara ho . Eyi kyerɛ sɛ ɛnyɛ obiara na obenya yare no ho sɛnkyerɛnne koro. Nsɛnkyerɛnne a ɛtaa ba no bi ne:

• Ntini a ɛyɛ mmerɛw
• Ntini a ɛtaa yɛ mmerɛw : Nkate a ɛte sɛ nea wɔretwe nan bi.
• Akwaa a ɛyɛ mmerɛw anaasɛ ɛyɛ mmerɛw wɔ akwaa no mu
• Akisikuru a ɛma obi ho kyere no
• Nsõ a ɛkyɛ
• Nsõ mu ntini a ɛyɛ mmerɛw
• Mogya mmoroso a ɛba fam
• Nwi ne nnadewa a ɛyɛ mmerɛw
• Brɛ
• Hahaahayɔ

Nnipa a wɔwɔ PHP-1 betumi anya sɛnkyerɛnne afoforo a ɛka Albright awosu mu nnompe mu yare (AHO) tebea a yɛadi kan aka ho asɛm no ho. Nnipa binom a wɔwɔ PHP nso betumi anya saa sɛnkyerɛnne ahorow yi:

• Anim a ɛyɛ kurukuruwa
• Short stature (ɔtenten a ɛyɛ tiaa) .
• Kɔn mu yaw
• Nnompe a ɛwɔ nsa ne anan mu : Ebia ɛbɛyɛ te sɛ nea wɔadan nsateaa a ɛto so anan ne anum de no akɔ mu.
• Kɛse mmoroso : Ɛkyerɛ sɛ obi bɛyɛ kɛse mmoroso.
• Aniwa a ɛyɛ mmerɛw : nneɛma te sɛ ani a ɛyɛ mmerɛw, aniwa a ɛyɛ mmerɛw, ne hann a wɔte nka.
• Nnompe a ɛyɛ kurukuruwa wɔ wo honam ani
• Nkɔso a ɛkyɛ : Mmofra binom betumi anya nkɔso bi a ɛkyɛ.

Dɛn ne nneɛma a ɛde PHP ba?

Nea ɛde saa yare yi ba titiriw ne nsakrae a ɛba yɛn awosu mu nkwaadɔm mu, titiriw wɔ awosu mu abɔde a wɔfrɛ no `GNAS` mu . Nnipa binom nya fi wɔn awofo hɔ . Ɛno kyerɛ sɛ ɛyɛ awosu. Nanso ɛtɔ da bi a saa tebea yi betumi aba a abusua abakɔsɛm biara nni mu na wontumi nhu nea ɛde ba biara.

Wɔtaa hu PHP wɔ nkokoaa anaa mmofraase , nanso ɛtɔ mmere bi a ebetumi ada adi wɔ mpanyin afe so.

Nsɛnnennen bɛn na ebetumi aba esiane PHP nti?

Sɛ wowɔ PHP a, ɛda adi sɛ wubenya endocrine system mu nyarewa afoforo . Saa ɔhaw ahorow a ɛfa hormone ho yi betumi de sɛnkyerɛnne ahorow te sɛ ahoɔden a ɛba fam ne nna ho akɔnnɔ a ɛba fam aba.

Nnipa binom a wɔwɔ PHP wɔ asiane kɛse mu sɛ wobenya tebea horow te sɛ:

• Parkinson ho yare a ɛma obi ho kyere no: Ɛda sɛnkyerɛnne ahorow a ɛte sɛ Parkinson yare no adi.
• Difficulty with fine motor skills : Eyi kyerɛ sɛ ɛyɛ den wɔ nnwuma pa te sɛ buttoning anaa akyerɛw mu.
• Carpal Tunnel Syndrome : Titiriw ma wɔn a wɔwɔ PHP-1. Eyi yɛ tebea a ɛma ntini bi a ɛwɔ nsateaa mu no mia, na ɛma nsa no yɛ mmerɛw na ɛyɛ yaw.
• Akyi berɛmo mu akisikuru
• Sleep apnea : Titiriw wɔ mmofra mu.

Ɔkwan bɛn so na nnuruyɛfo hu PHP?

Sɛ wususuw sɛ wowɔ PHP a, wo duruyɛfo bedi kan ayɛ wo nipadua mu nhwehwɛmu . Wobebisa w'abusua abakɔsɛm nso . Afei ebia wɔbɛyɛ nhwehwɛmu afoforo pii de akyerɛ sɛ wɔahu yare no. Eyinom bi ne:

• Mogya mu nhwehwɛmu : Susuw hormone dodow, titiriw calcium, phosphorus, ne PTH dodow.
• Nsu mu nhwehwɛmu : Hwɛ sɛnea calcium ne phosphorus dodow wɔ nsu mu.
• Awosu mu nhwehwɛmu : Hwɛ sɛ nsakrae aba `GNAS` awosu mu abɔde mu.
• Electrocardiogram (EKG) : Ɛhwɛ sɛ ebia koma no bɔ a ɛnteɛ anaa.
• Nsa X-ray : Hwɛ sɛ nnompe abubu ne nsakrae afoforo anaa.
• CT Scan (CT - Computed Tomography scan) : Sɛnea ɛbɛyɛ a wobɛhwɛ sɛ nsakrae bi aba amemene no mu anaa.

Egyina nsɛm a wonya fi nhwehwɛmu ahorow yi mu so na oduruyɛfo no betumi asi PHP tebea no so dua pɛpɛɛpɛ.

Ɔkwan bɛn so na wɔyɛ PHP?

Wɔnnyaa saa tebea yi ano aduru biara . Nanso mma ɛnhaw wo. Sɛ wosa yare no yiye na wodi ho dwuma yiye a, wubetumi adi wo yare no ho sɛnkyerɛnne so na woabɔ bra sɛnea ɛsɛ.

Botae titiriw a ɛwɔ ayaresa mu ne sɛ ɛbɛma calcium ne phosphorus dodow a ɛfata akɔ so ayɛ wo mogya mu . Sɛ wokura saa dodow yi mu a, ebetumi atew sɛnkyerɛnne ahorow no so kɛse. Eyi yɛ nkwa nna nyinaa ayaresa .

Ebia ayaresa a wobetumi apaw bi ne:

• Calcium ne vitamin D a wɔde ma : wɔ ​​aduru anaa nsu mu.
• Calcitriol capsules : Eyi yɛ aduru a ɛma calcium dodow a ɛwɔ nipadua no mu no yɛ kɛse.
• Calcitriol a wɔde twitwiw nipadua no mu
• Onyin hormone anaa thyroid hormone a wɔde si ananmu ayaresa : sɛ ɛho hia a.
• Aduan a calcium pii wom, a phosphorus kakraa bi na ɛwom : Sɛnea aduan ho ɔbenfo de afotu ma no.

Ade a ɛho hia sen biara ne sɛ wubedi aduruyɛ mu afotu akyi yiye na woayɛ nhwehwɛmu wɔ bere ano.

Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn?

Sɛ wowɔ PHP a, ɛho hia sɛ wokɔ wo duruyɛfo nkyɛn daa na wɔahwɛ wo calcium ne phosphorus dodow . Saa nhwehwɛmu a wɔbɛyɛ no daa yi bɛboa ma wɔadi biribiara so.

Sɛ wuhu sɛnkyerɛnne ahorow a emu yɛ den te sɛ ahome a ɛyɛ den mpofirim, ntini a ɛtwetwe kɛse, anaasɛ akisikuru , kɔ ayaresabea dan a ɛbɛn wo a wɔhwɛ ntɛmpɛ so ntɛm ara anaa frɛ 1990.

Dɛn na wubetumi ahwɛ kwan bere a wo ne PHP tebea no te?

Sɛ wowɔ PHP a, ɛsɛ sɛ wokɔ so ne wo Primary Care Physician yɛ adwuma . Esiane sɛ PHP betumi aka nipadua no afã horow pii nti, ebia ebehia sɛ wuhu nnuruyɛfo atitiriw pii na wɔadi wo sɛnkyerɛnne pɔtee no ho dwuma. Ebia w’aduruyɛfo kuw no bi ne:

• Endocrinologists : Wɔn a wɔyɛ hormone ho abenfo.
• Nnompe ho oprehyɛn ho animdefo : Wɔ ɔhaw ahorow a ɛfa nnompe ho ho.
• Mmofra nnuruyɛfo : Sɛ ɛyɛ abofra a.
• Ntini mu ayaresa ho animdefo : Wɔ ɔhaw ahorow a ɛfa ntini ahorow ho ho.
• Apɔw-mu-teɛteɛ ho animdefo
• Adwuma mu ayaresa ho animdefo
• Aduandi ho abenfo
• Nsõ ho aduruyɛfo
• Awosu ho animdefo
• Ɛyaw ano aduru ho abenfo

Ɛda adi kɛse sɛ ɛsɛ sɛ wonom saa nnuru a wɔde ka aduan ho no wo nkwa nna nyinaa .

Nkɔso ne adwene mu tumi betumi ayɛ soronko kɛse a egyina yare no su ne sɛnea emu yɛ den so. Nanso , mpɛn pii no, nnipa a wɔwɔ PHP no nkwa nna yɛ nea ɛfata sɛ wɔde toto nnipa a wonni PHP ho a . Wo duruyɛfo betumi agyina wo tebea no so akyerɛ wo nea ɛsɛ sɛ wohwɛ kwan.

Esiane sɛ PHP yɛ tebea a ɛntaa nsi nti, ebetumi ayɛ den sɛ wubenya afoforo a wɔwɔ tebea koro no ara te sɛ wo . Ɛtɔ mmere bi nso a ebetumi ate nka sɛ wayɛ ankonam. Sɛ wo anaa wo ba no wɔ PHP a, wo ne wo duruyɛfoɔ nkasa mfa mmoa akuo ne nkyerɛkyerɛ nneɛma ho . Eyinom betumi aboa wo ma woanya akwan a wobɛfa so ama wo yare no ho sɛnkyerɛnne ne w’asetra nyinaa atu mpɔn.

Nkrasɛm a Wɔde Kɔ Fie

Okay, enti momma yɛnhwɛ nneɛma bi a ɛsɛ sɛ yɛkae fa pseudohypoparathyroidism (PHP) a yɛaka ho asɛm no ho.

• PHP yɛ awosu mu tebea a ɛntaa nsi a nipadua no ntumi nyɛ adwuma yiye wɔ parathyroid hormone (PTH) ho.
• Eyi ma calcium a ɛwɔ mogya no mu so tew na phosphorus nso dɔɔso.
• Ɛwɔ ahodoɔ titire : PHP-1, PHP-2, ne PHP-3.Aane. PHP-1 betumi ama nsakrae aba nnompe a wɔfrɛ no AHO no mu.
• Nsɛnkyerɛnne ahorow betumi aba, te sɛ ntini a ɛtwetwe, akisikuru, akisikuru, sẽ mu haw, ne tenten tiaa, ne anim a ɛyɛ kurukuruwa .
• Nea ɛde ba titiriw ne nkwaadɔm mu nsakrae a ɛba `GNAS` awosu mu abɔde mu .
• Ɛwom sɛ wonnya ayaresa koraa de, nanso wobetumi de nkwa nna nyinaa ayaresa (calcium, vitamin D, aduan titiriw bi) adi sɛnkyerɛnne ahorow no so.
• Aduruyɛ mu nhwehwɛmu a wɔyɛ no daa ne nnuruyɛfo a wɔn ho akokwaw mmoa ho hia.
• Nnipa dodow no ara betumi atra ase sɛnea ɛsɛ .
• Mmoa a efi mmoa akuw hɔ no ho hia yiye na ama obi akɔ so ayɛ den wɔ adwene mu.

Mma wo werɛ mmfi sɛ, ɛnyɛ wo nko ara. Ɛwom sɛ eyi yɛ tebea a ɛntaa nsi de, nanso wobetumi adi ho dwuma yiye denam aduruyɛ mu afotu ne mmoa a ɛfata so. Kae sɛ nnuruyɛfo, abusuafo, ne nnamfo wɔ hɔ ma wo bere a wuhia ahoɔden no.

` Pseudohypoparathyroidism, PHP, parathyroid hormone, calcium, phosphorus, awosu mu nyarewa, AHO