So wobɛpɛ sɛ wuhu aduru a wɔfrɛ no SNRI no ho asɛm? (Nnuru a Ɛmma Serotonin ne Norepinephrine a Wɔsan Fa Nneɛma Mu) .

So oduruyɛfo bi akyerɛw wo aduru bi a wɔfrɛ no SNRI ama w’adwenemhaw anaa dadwen a ɛkɔ so daa? Ebia wo nnamfo no mu biako de aduru yi redi dwuma. Ebia wotee ehu nka kakra bere a wotee saa din yi. Ebia wowɔ nsɛmmisa pii wɔ w'adwene mu te sɛ, "Dɛn ne aduru yi? So eyinom ye ma nipadua no?" Enti ɛnnɛ, momma yɛnka aduru a wɔfrɛ no SNRI yi ho asɛm tiawa koraa, te sɛ nea wo ne w’adamfo bi rekasa.

Sɛ yɛbɛka no tiawa a, dɛn ne saa SNRI ahorow yi?

SNRI ntease nyinaa ne Serotonin ne Norepinephrine Reuptake Inhibitors . Okay, edin no te sɛ nea ɛyɛ den kakra, ɛnte saa? Momma yɛnkyekyɛ mu na yɛnte ase kɛkɛ.

Wɔ yɛn amemene mu no, nnuru a wɔde di dwuma titiriw bi wɔ hɔ a ɛhwɛ nneɛma pii so, a yɛn nkate, yɛn nsusuwii, nna, ne yɛn akɔnnɔ ka ho. Yɛfrɛ eyinom ``Neurotransmitters.'' Te sɛ postman no, saa abɔfo yi de nkrasɛm fi amemene no fã biako kɔ foforo.

Saa abɔfo yi mu abien ne serotonin ne norepinephrine .

• Serotonin ho hia yiye ma nneɛma te sɛ yɛn adwene, yɛn nna, ne yɛn aduan a yedi. Sɛ serotonin dodow kɔ soro a, yɛte anigye ne ahomegye nka.
• Norepinephrine boa yɛn ma yɛde yɛn adwene si biribi so, yɛwɔ ahoɔden, na yɛyɛ nnam.

Nea ɛtaa ba ne sɛ, sɛ saa abɔfo yi de wɔn nkrasɛm no kɔ a, amemene mu nkwammoaa no san twetwe wɔn kɔ mu Wɔfrɛ eyi ``Reuptake.'' Te sɛ nea posɔfesefo no san kɔ posɔfese bere a ɔde krataa akɔma awie no.

Nanso, wɔ nnipa a wɔwɔ tebea horow te sɛ adwenemhaw anaa dadwen mu no, ebia serotonin ne norepinephrine abɔfo yi dwumadi so bɛtew kakra wɔ amemene no mu.

Eyi ne baabi a SNRI nnuru ba Nea nnuru yi yɛ ne sɛ esiw saa abɔfo no kwan bio bere tiaa bi. Ɛte sɛ nea woreka akyerɛ posɔfesefo no sɛ "ɔntwɛn kakra na ɔmfa nkrasɛm kakraa bi bio nkɔma." Afei abɔfo pa yi (serotonin ne norepinephrine) tra amemene no mu kyɛ na wɔyɛ wɔn adwuma pa. Eyi fi ase ma yɛn adwene tu mpɔn, ɛtew dadwen so, na ɛma yɛn ahoɔden yɛ kɛse.

Tebea bɛn na wɔde SNRI nnuru di dwuma ma?

Ɛwom sɛ wɔkyerɛw nnuru yi ma adwenemyare ho nsɛm titiriw de, nanso nnuruyɛfo kyerɛw ma nipadua mu tebea afoforo pii nso. Momma yɛnhwɛ nea wɔyɛ.

Ebia woresusuw nea "off-label use" kyerɛ ho. Ɛkyerɛ sɛ oduruyɛfo bi gyina n’aduruyɛ ho nimdeɛ ne osuahu so kamfo aduru bi kyerɛ wɔ tebea foforo ho, de ka tebea titiriw a wɔapene so no ho. Eyi yɛ biribi a wɔtaa yɛ.

Dɛn ne SNRI ahorow a abu so wɔ Sri Lanka?

SNRI nnuru ahorow pii wɔ hɔ. Wo duruyɛfo no begyina wo tebea, mfe a woadi, ne w’akwahosan tebea afoforo so apaw aduru a ɛfata wo.

• Venlafaxine (te sɛ edin a wɔde frɛ no Effexor®) .
• Duloxetine (te sɛ edin a wɔde frɛ no Cymbalta®) .
• Desvenlafaxine (aduru a wɔde yɛ adwuma no din Pristiq®) .
• Milnacipran (ahyɛnsode din Savella®) .
• Levomilnacipran (te sɛ edin a wɔde frɛ no Fetzima®) .

Ebia nea yɛaka ho asɛm wɔ atifi hɔ no biako wɔ aduru a wo nsa kaa no mu.

Dɛn ne nsunsuanso bɔne a ebetumi afi aduru yi a wɔde di dwuma mu aba?

Te sɛ nnuru nyinaa no, eyi betumi anya ɔhaw nketenkete. Nanso nnipa dodow no ara fam no, eyinom nyɛ aniberesɛm. Mpɛn pii no, ɛba wɔ adapɛn kakraa a edi kan bere a woanom aduru no mu na afei ɛkɔ bere a wo nipadua no reyɛ nsakrae wɔ aduru no ho no.

Asiane tebea horow titiriw a ɛsɛ sɛ wohwɛ so yiye

Ɛwom sɛ mpɛn pii no SNRI yɛ aduru a ahobammɔ wom de, nanso eye sɛ wubehu asiane ahorow bi a anibere wom, ɛwom sɛ ɛntaa mma de.

1. Serotonin Yare a Ɛyɛ Fɛ

Eyi ne ade a ɛho hia sen biara a ɛsɛ sɛ yɛhwɛ yiye. Sɛ wɔnom SNRI ne nnuru afoforo a ɛka serotonin dodow bom a, serotonin dodow a ɛwɔ amemene no mu betumi akɔ soro a ɛho nhia. Eyi yɛ aduruyɛ mu tebea a egye ntɛmpɛ a anibere wom .

• Nsɛnkyerɛnne: Adwene a ɛyɛ basaa a wontumi nkyerɛkyerɛ mu, koma bɔ ntɛmntɛm, atiridiinini kɛse, ntini a ɛyɛ den anaa ɛbɔ, ne fifiri a ɛboro so.
• Nea ɛsɛ sɛ woyɛ: Sɛ wo anaa obi a wunim no nya saa sɛnkyerɛnne yi mpofirim a, kɔ oduruyɛfo nkyɛn ntɛm ara anaa kɔ ayaresabea a ɛbɛn wo no Emergency Department (ETU).

2. Nsɛnkyerɛnne a ɛba bere a wɔagyae aduru no (Antidepressant Discontinuation Syndrome) .

Sɛ wonom saa aduru yi kyɛ na wugyae mpofirim a, ebia wo nipadua no bɛhaw sɛ nea ɛyɛ n’ade wɔ ho.

• Esu:Adwene a ɛyɛ yaw, tiyɛ, akisikuru, nipadua mu yaw (te sɛ bere a wowɔ atiridii), ne dadwen a emu yɛ den.
• Siw ano: Nnyae nnuru nom da a wonkɔ wo duruyɛfo nkyɛn. Sɛ ɛho hia sɛ wugyae a, wo duruyɛfo no bɛtew dodow no so nkakrankakra wɔ ɔsram biako anaa abien mu, ama wo nipadua no ayɛ nsakrae, na afei wakyerɛ wo sɛnea wubegyae dwoodwoo.

3. Adwene a ɛne sɛ obekum ne ho

Eyi yɛ asɛmti a ɛyɛ nkate kɛse, nanso ɛyɛ biribi a ɛsɛ sɛ wɔka ho asɛm. Nhwehwɛmu ahorow ada no adi sɛ asiane kakraa bi pɛ na ɛwɔ hɔ sɛ wobesusuw sɛ wobekum wɔn ho kɛse, titiriw wɔ mmerante ne mmabaa a wonnii mfe 25 mu , wɔ adapɛn kakraa a edi kan a wɔde aduru yi di dwuma no mu.

• Nea ɛho hia: Sɛ wowɔ saa nsusuwii yi a, yɛsrɛ wo, mma wo nkutoo nhu amane. Eyi nyɛ wo mfomso, ebetumi ayɛ aduru no mu nsunsuanso bɔne. Ka kyerɛ wo duruyɛfo ntɛm ara. Ka kyerɛ w’abusua muni anaa w’adamfo bi a wowɔ ne mu ahotoso. Mmoa a wobɛsrɛ no ma wonya tumi.

Nneɛma afoforo a ɛsɛ sɛ wususuw ho bere a worenom SNRI ahorow no

Nsã a wɔnom

Ɛyɛ papa sɛ wobɛkwati nsa a wobɛnom bere a worenom nnuru a ekum adwenemhaw te sɛ SNRI no. Nsã nso yɛ ade a ɛma nipadua no ntini yɛ adwuma yiye. Enti, ebetumi asiw aduru no a etu mpɔn no kwan. Ɛtɔ mmere bi a, nsa betumi ama adwenemhaw ho sɛnkyerɛnne no asɛe kɛse.

Nnuru afoforo

Sɛ worenom SNRI a, ka nnuru afoforo a worenom nyinaa ho asɛm kyerɛ wo duruyɛfo (nnuru a wɔde kum ɛyaw, nnuru a wɔde kum ɔfe, vitamin, nnuru a wɔde yɛ nhabannuru mpo). Nnuru bi betumi ne SNRI ahorow adi nkitaho.

• Nnuru a wɔde kum ɛyaw te sɛ NSAID (e.g. Ibuprofen, Diclofenac) .
• Nnuru a ɛmma mogya ntumi nkɔ (e.g. Aspirin, Clopidogrel) .
• Triptans yɛ nnuru a wɔde sa atiridiinini.
• Nneɛma a wɔde nhabannuru yɛ te sɛ St. John’s Wort

Nyinsɛn ne nufu a wɔde ma

Sɛ woreyɛ nhyehyɛe sɛ wubenyinsɛn, woanyinsɛn dedaw, anaasɛ worenom nufu a, akyinnye biara nni ho sɛ ɛsɛ sɛ wo ne wo duruyɛfo kasa fa aduru yi a wode bedi dwuma ho. SNRI ahorow bi betumi aka akokoaa a ɔwɔ awotwaa mu no. Afei nso, sɛ wogyae aduru no mpofirim a, ebetumi apira ɛna no. Wo duruyɛfo betumi aboa wo ma woasi nea ahobammɔ wom sen biara ma wo ne wo ba no ho gyinae.

Bere tenten ahe na egye ansa na aduru no ayɛ adwuma?

Eyi yɛ asɛm a nnipa pii bisa. SNRIs nyɛ aduru a ɛyɛ adwuma ntɛm ara te sɛ Panadol. Egye bere kakra ansa na amemene no mu nnuru a ɛkari pɛ.

• Nnipa dodow no ara behu nkɔso bi (nkɔso) wɔ sɛnkyerɛnne ahorow mu wɔ adapɛn 4 kosi 6 ntam .
• Ebia ebegye adapɛn 9 kosi 12 (asram 2-3) ansa na nnipa binom anya aduru no so mfaso nyinaa.

Enti, nnyae aduru no nom esiane sɛ wonte nsonsonoe kɛse nka wɔ adapɛn kakraa a edi kan no mu nti.Nya abotare. Sɛ woda so ara nte nsonsonoe biara nka wɔ saa bere no akyi a, wo ne wo duruyɛfo nkasa bio. Ebia obetumi ayɛ nsakrae wɔ dodow a wɔde ma no mu anaasɛ ɔbɛsakra wo akɔ aduru foforo so.