Do you have a condition called `(Porphyria)`? Or does someone you know have this disease? Do you suffer from symptoms such as severe stomach pain, vomiting, and weakness in the body? Then your doctor may have told you about a vaccine called `Givosiran`. The name may sound a little scary at first, but don't worry. Today, we will talk about this medicine in a simple way that you can understand.
What exactly is this medicine called Givosiran?
Simply put, `Givosiran` is a vaccine that is given to treat a disease called `(Porphyria)`. In this disease, a toxic chemical substance called `(Porphyrins)` accumulates in our body. Just like when the garbage bin in our house is full, when these toxic substances accumulate in the body, you experience severe symptoms such as severe stomach pain, vomiting, and loss of limbs. Now, what this `Givosiran` vaccine does is reduce the formation of those toxic `(Porphyrins)` in the body. That is, it works like controlling the formation of waste. When the amount of these toxic substances decreases, the symptoms you feel also decrease to a great extent.
This medicine is usually available under the brand name `GIVLAARI`. Also, doctors may sometimes prescribe it for other diseases. Don't worry about it.
Things you should definitely tell your doctor before taking this medicine
Your doctor will need to know your complete health history before starting this treatment. So, if you have any of the following, be sure to tell your doctor
without hiding anything .
- Kidney disease : If you have any kidney problems.
- Liver disease : If you have any liver disease.
- Allergies : If you have any allergies (allergies) not only to this medicine, but also to any other medicine, food, or dye, please tell us about it.
- Pregnancy : If you are pregnant or expecting a baby.
- If you are a breastfeeding mother: If you are breastfeeding your baby.
Providing this information accurately is very important for your safety.
How do you use this medicine?
This is not a medicine you can take home. `Givosiran` is
an injection that is given under the skin .This is given to you by a doctor or a trained nurse in a hospital or clinic. So you don't have to worry about the dose or how to take it.
Can this medicine be given to children?
Yes, sometimes children are given this medicine too. But it requires special care. If your child needs this treatment, talk to a pediatrician about it and find out the details.
What to do if you overdose?
This is given in a hospital setting, so the chances of this happening are very low. However, if you suspect that you have overdosed, immediately contact
the National Poisons Information Centre at the Colombo National Hospital . Or go
to the Emergency Treatment Unit (ETU) of the nearest hospital.
The most important thing is that this medicine is prescribed for you only. Never share this medicine with anyone else.
What if I miss the vaccination day?
It is very important to get your vaccinations on time for this treatment. So do not miss your clinic dates. If you are unable to attend on your scheduled date due to an emergency, please call your doctor or clinic in advance and let them know.
Other things that may interact with this medicine
Some medications can cause problems when taken with `Givosiran`. Therefore, you should tell your doctor
about all the medications you are taking. This includes medications for other conditions, vitamins, traditional medicines, and herbs.
In particular, do not take `Givosiran` with these medications: Problems can also occur with these:- Caffeine - found in tea and coffee
- Dextromethorphan (contained in some cough syrups)
This list is not complete. So it's best to tell your doctor about all the medications you take. Also, tell them if you smoke, drink alcohol, or use other drugs.
Things to consider during treatment
Your doctor will monitor you closely while you are receiving this vaccine. They may also order
blood tests to see how the medicine is affecting your body.
What are the possible side effects?
Like any medicine, `Givosiran` can cause some side effects. However, not everybody gets them. Some are serious, while others are common. It is important to be aware of these.
Side effects of Givosiran vaccine🚨 If you experience these symptoms, tell your doctor immediately🙂 They are usually not serious, but if they persist, you should tell
your doctor. | Allergic reactions | Skin rash, itching, swelling of the face, lips, tongue or throat. |
| Kidney injury | Decreased urine output, swelling of the ankles, hands, or feet. |
| Liver injury | Pain in the upper right side of the stomach, loss of appetite, nausea, light-colored stools, dark yellow or brown urine, yellowing of the eyes or skin, unusual tiredness. |
| Pancreatitis | Severe stomach pain that feels like it's radiating to the back, pain that gets worse after eating or when the stomach is touched, fever, nausea, and vomiting. |
| Fatigue | Feeling of lifelessness. |
| Nausea | Feeling like vomiting. |
| Pain at the injection site | Redness, soreness, or slight swelling at the injection site. |
If you experience any other unusual symptoms not mentioned in this list, tell your doctor about them as well.
Take-Home Message
- `Givosiran` means ` Porphyria`A special vaccine given in a hospital or clinic to treat a medical condition.
- Before starting treatment, be sure to tell your doctor about any other illnesses you have, medications you are taking, allergies, and whether you are pregnant.
- If you experience any serious side effects such as severe stomach pain , yellowing of the eyes, or decreased urination , seek medical advice immediately without delay.
- Do not miss your scheduled clinic appointments. This is very important for the success of the treatment.
- If you have any questions, concerns, or fears about this medication, talk to your doctor about it openly.
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