Nin miyɛlini bɔgɔlan min bɛ an ka nɛrɛmuguma lamini, o ye mun ye? An ka kuma o kan ka ɲɛ!

Yala i delila k’i yɛrɛ ɲininka ciden fitinin minnu bɛ an farikolo kɔnɔ, n’olu ye nɛrɛmuguma ye, olu bɛ baara teliya cogo min na ani u hakili ka di cogo min na wa? Tiɲɛ na, an farikolo bɛɛ, k’a ta an ka miiri cogo la ka taa a bila an bolow ni an senw lamagacogo la, o farikolo-ɲɛnajɛ-minɛn in de bɛ o mara. O la bi an bɛna kuma fɛn nafamaba dɔ kan min bɛ nin nɛrɛmuguma ninnu dɛmɛ ka baara kɛ ka ɲɛ. O ye Myelin Sheath ye .

Myelin Sheath ye mun ye? An k’a faamu cogo nɔgɔman na!

N’an y’a fɔ cogo nɔgɔman na, miyɛlini dawolo ye lakanani datugulan ye min bɛ an ka nɛrɛmuguma kelen-kelen bɛɛ lamini (an b’o fana wele ko `(Neuron)`). A bɛ i n’a fɔ gansan fitinin dɔ. A dilannen don ni tulumafɛnw ye (i n’a fɔ `(Lipids)`) ani farikolojɔli dumuniw. O datugulan in bɛ nɛrɛmuguma yɔrɔba "kɔnɔna" datugu, o min bɛ wele ko axon . Miiri k’a filɛ i n’a fɔ kuran nɛgɛ min bɛ an ka so kɔnɔ. A bɛ ni plastiki bɔgɔlan ye ka nɛgɛberew lamini. O cogo de la nin miyɛlini bɔgɔdaga in bɛ nɛrɛmuguma lakana ani k’u dɛmɛ ka baara kɛ ka ɲɛ.

Senfagabana yɔrɔ jumɛnw ye? A bɛ iko jiri!

Sani an ka kuma caman fɔ miyɛlini bɔgɔlan kan, an k’a faamu farikolojidɛsɛ ye min ye ani a yɔrɔw ye mun ye. farikolo yɔrɔw de bɛ an ka farikoloɲɛnajɛw kɛ . O farikolo-ɲɛnajɛ-yɔrɔ in bɛ i n’a fɔ kunnafoni-falen-falen-yɔrɔba min bɛ an farikolo la. A bɛ kunnafoniw sɔrɔ farikolo fan bɛɛ fɛ, ka jaabi di o ma, ka ladamu fɛn minnu bɛ kɛ farikolo kɔnɔ ani farikolo kɔkan. N’an ye nɛrɛmuguma jateminɛ, a yɔrɔ koloma saba bɛ yen. Miiri k’a filɛ ko nɛrɛmuguma bɛ i n’a fɔ jiri : 1. Soma walima Seli Farikolo : Nin bɛ i n’a fɔ jiri ju. Dendrites , minnu bɛ i n'a fɔ soma ju, olu bɛ "balofɛnw" minɛ ka bɔ dugukolo la. Nka yan, "balofɛnw" ye kemikɛli cikanw ye minnu bɛ Bɔ nɛrɛmuguma wɛrɛw la minnu bɛ u kɛrɛfɛ. O cikanw bɛ Yɛlɛma ka Kɛ kuran-minɛnw ye o kɔ fɛ. Kɔnɔnatumu fana bɛ o soma in kɔnɔ. 2. Axon: Nin bɛ i n’a fɔ jiribolo jan. I n’a fɔ balofɛn minnu bɛ Minɛ jiri ju la, olu bɛ Yɛlɛn a jiribolo la cogo min na, axon fana bɛ kuran-minɛnw Ta minnu bɛ Bɔ soma la a fɛ. 3. Axon Terminal (Axon Terminal): O bɛ i n’a fɔ jiribolo minnu bɛ jiribolo dakunw na. Furu ni mugu bɛ bɔ o jirisunw na. O cogo la, kuran-minɛnw bɛ "bɔ" o axon dakun in na walasa u ka Se ka Taa nɛrɛmuguma nata fɛ. O kɛcogo bɛ taa ɲɛ fo cikan ka se i kunkolo ma, i kɔkolo la , walima i farikolo yɔrɔ wɛrɛw la. O kɔlɔlɔ ye fɛnw ye i n’a fɔ farikolo yɔrɔw minnu bɛ sɔgɔsɔgɔ walasa ka i bolokɔni lamaga, ka i dɛmɛ ka ninakili, walima ka i dusukun tantanni kɛ. Sisan, i bɛ se ka hakilina dɔɔnin sɔrɔ nɛrɛmuguma dɔ jɔcogo jɔnjɔn kan.

Mun bɛ kɛ ni Myelin Sheath ye?

Miyɛlini bɔgɔlan bɛ baara kunbaba saba kɛ:

• Lakanali: I n’a fɔ n y’a fɔ cogo min na ka tɛmɛ, nin lipid-protéine fini in bɛ farikolo tangalan di farikolojidɛsɛ ma, i n’a fɔ plastiki bɔgɔlan min bɛ kuran kabɔri nɛgɛw lamini.
• Kumaɲɔgɔnya teliya: O de y’a to kuran wulicogo bɛ bɔ nɛrɛmuguma kelen na ka taa dɔ wɛrɛ la joona kosɛbɛ ani ka ɲɛ . Ni miyɛlini tun tɛ, o taama in tun bɛna kɛ dɔɔnin dɔɔnin.
• Dusukunnata fanga marali : Nin miyɛlini bɔgɔlan in bɛ dɛmɛ ka cikan fanga mara ni a bɛ taama axon fɛ.

Miyɛlini bɛ dilan ni farikolokisɛw ye minnu bɛ wele ko oligodendrocytes an ka hakili ni kɔkolo la (an b’o wele ko CNS farikolo yɔrɔ tɔ.

Miyɛlini bɔgɔdaga kɔnɔ yɔrɔw bɛ wele cogo di?

Aw kana miiri ko miyɛlini dawolo ye datugulan ye min bɛ to senna, min ka bon. Ayi, a bɛ iko tɛrɛn jan min bɛ kɛsu kɔnɔ. Box kelen bɛ ban yɔrɔ min na, kɛsu nata bɛ daminɛ yɔrɔ min na, yɔrɔ fitinin dɔ bɛ yen. O cogo kelen na, miyɛlini dawolo bɛ kɛ ni miyɛlini jiribolo dɔw ye minnu bɛ fara ɲɔgɔn kan. o miyɛlini jirisun kelen-kelen bɛɛ bɛ wele ko internode . o yɔrɔ misɛnnin minnu bɛ miyɛlini jirisun fila ni ɲɔgɔn cɛ , olu bɛ wele ko Ranvier ka node . Ranvier ka o node ninnu na, sodium ion positif caman bɛ sɔrɔ. Ni kuran taamasiyɛn walima wulikan dɔ bɛ taama axon fɛ, o bɛ pan ka bɔ Ranvier ka node kelen na ka taa node wɛrɛ la. Ni a ye o yɔrɔ in Tɛmɛ, soja ionw bɛ kuran taamaʃyɛn Lasegin. O kɔfɛ, taamasiyɛn bɛ se ka taa a fɛ ka taa k’a sɔrɔ a ma bɔnɛ a ka charge la walima a fanga ma bɔ a la. O ye fɛɛrɛ ye min bɛ mɔgɔ kabakoya kosɛbɛ, tiɲɛ tɛ?

Mun bɛ kɛ ni miyɛlini dawolo tiɲɛna?

A fɔra ko nɛrɛmuguma miliyari 100 ɲɔgɔn bɛ an fari la. Olu kelen-kelen bɛɛ bɛ baara kɛ tuma bɛɛ, u bɛ cikanw ci ani ka u sɔrɔ, ka baara bɛɛ kɔlɔsi an farikolo la. Miiri k’a filɛ min bɛna kɛ ni miyɛlini bɔgɔlan min bɛ o farikolojidɛsɛbanakisɛw lamini, o tiɲɛna. O kɔfɛ, kuran taamasiyɛn teliya tun bɛna dɔgɔya, walima a tun bɛ se ka jɔ pewu. Miyɛlini tiɲɛni kunba dɔ ye farikolo tangacogo ye an farikolo la.Kɔnɔnatumuw bɛ fili k’a miiri ko miyɛlini ye dunan fɛn ye min bɛ bɔ kɛnɛma. O kɔ, an farikolo tangalanw bɛ daminɛ ka bin miyɛlini kan. O bɛ kɛ sababu ye ka funufɛnw bɔ, minnu bɛ miyɛlini tiɲɛ. A laban na, farikolokisɛ minnu bɛ miyɛlini dilan (oligodendrocytes ani Schwann cellules) olu fana bɛ sa. o miyɛlini bɔgɔdaga tiɲɛni in bɛ wele ko demyelination . Ka kɛɲɛ ni miyɛlini binna yɔrɔ min na, aw ka bana taamasiɲɛw bɛna ɲɔgɔn ta.

Bana jumɛnw bɛ miyɛlini tiɲɛ?

Bana damadɔ bɛ yen minnu bɛ miyɛlini tiɲɛ. N’a sɔrɔ aw ye nin bana ninnu dɔw mɛn.

Bana minnu bɛ miyɛlini minɛ farikolo yɔrɔw la (CNS):

Bana min ka ca ni tɔw bɛɛ ye, mɔgɔ fanba ye min mɛn, n’o bɛ bin farikolo cɛmancɛ la (o kɔrɔ ye ko kunsɛmɛ ni kɔkolo) miyɛlini kan, o ye sklerose multiple ye . Ka fara o kan, bana damadɔ wɛrɛw bɛ yen minnu bɛ farikolo yɔrɔw ka miyɛlini minɛ:

• Kunsɛmɛnasumaya jugumanba : Nin ye farikolo tangacogo ye min man teli ka kɛ, a ka jugu, a ka jugu, a bɛ kɛ farikolo cɛmancɛ la.
• Schilder ka sɔgɔsɔgɔninjɛ : A bɛ fɔ fana ko ``Diffuse Myelinoclastic Sclerosis'', o ye farikolojidɛsɛbana ye min man teli ka sɔrɔ, a bɛ sɔrɔ denmisɛnw na.
• Transverse Myelitis : Nin ye bana ye min bɛ sɔrɔ farikolo tangalanw fɛ, a bɛ kɛ sababu ye ka kɔkolo funu.
• Neuromyelitis Optica: O la, farikolo tangalanw bɛ bin ɲɛ ni kɔkolo nɛrɛw kan farikolo tangalanw fɛ .
• Ɲɛkisɛw : O fana bɛ ɲɛkisɛw funu.
• Tumefactive Demyelination : Nin ye joginda kelen ye min bɛ miyɛlini tiɲɛ min ka bon ni santimɛtɛrɛ 2 ye.

Bana minnu bɛ miyɛlini minɛ farikolo yɔrɔw la:

• Guillain-Barre Syndrome : Nin taamasiɲɛ ninnu bɛ se ka kɛ banakisɛ sɔrɔlen kɔfɛ walima, a man teli kosɛbɛ, boloci kɔfɛ.
• Chronic Inflammatory Demyelinating Polyradiculoneuropathy ( CIDP ): Nin ye bana ye min bɛ taa ɲɛ farikolo tangalanw fɛ, a bɛ bin miyɛlini kan.
• Paraprotéinemic Demyelinating Neuropathy : Nin ye farikolojidɛsɛ suguya dɔ ye min bɛ tali kɛ farikolo tangalan dɔ sɔrɔli la min ni kansɛri bɛ tali kɛ ɲɔgɔn na.
• Charcot Marie Denw ka bana suguya fɔlɔ ani suguya X : Nin ye hakilibana ye min bɛ sɔrɔ ciyɛn fɛ.
• Kupu dɛsɛ : Ni kuran hakɛ dɔgɔyara, miyɛlini tɛ a tangacogo ban, wa a ka teli ka tiɲɛni kɛ.

Bana wɛrɛ jumɛnw bɛ se ka miyɛlini tiɲɛ?

Kun wɛrɛw bɛ yen minnu b’a to miyɛlini dawolo bɛ se ka tiɲɛ walima ka tiɲɛ balikuw la:

• AVC (AVC) bɛ sɔrɔ
• Banakisɛw, farikolo tangalanw ani farikolojɔli banaw (`(Fɛɛrɛbɔbaliya)`)
• Poyi suguyaw
• Witamini B12 dɛsɛ
• Fura dɔw, misali la `(Ethambutol)`
• Dɔlɔmin kojugu

Ka fara o kan, bana damadɔ minnu bɛ sɔrɔ cɛya la minnu man ca kosɛbɛ, miyɛlini dawolo tɛ dilan ka ɲɛ. Misaliw ye Tay-Sachs bana , Gaucher bana , Hurler ka bana ani Niemann-Pick bana ye .

Miiri k’a filɛ an farikolo baara tun bɛna tiɲɛ cogo min na ni o sira teliyalenw minnu bɛ cikanw ta an farikolo kɔnɔ, olu tun datugulen don, i n’a fɔ an sirilen bɛ siraba kan. O de kama miyɛlini dawolo kɛnɛya nafa ka bon kosɛbɛ.

Yala miyɛlini tiɲɛni bɛ se ka dilan wa?

Nin ye ɲininkali ye min bɛ mɔgɔ caman kan. Ɔwɔ, miyɛlini tiɲɛnen bɛ se ka dilan , farikolo cɛmancɛ la ani farikolo yɔrɔw la. Nka a nafa ka bon ka fɛnw kɔlɔsi minnu bɛ miyɛlini tiɲɛni bila mɔgɔ la, i n’a fɔ funu, ani ka farikolo tangalan/modulation (misali la , stéroïdes , intravenous immune globuline (IVIG) , ani fura wɛrɛw kɛ). Dɔnniyakɛlaw ye ɲɛtaa caman sɔrɔ fɛɛrɛ minnu bɛ se ka kɛ walasa ka miyɛlini dilancogo sabati, olu faamuyali la. Hali ni kalan dɔw bɛ yen minnu bɛ layidu ta, a ma jɛya fɔlɔ u ye nafa hakɛ min lase banabagatɔw ma tiɲɛ na. Sisan, fura minnu dabɔra ka ɲɛsin miyɛlini dilancogo ma, olu tɛ yen. Nin ye misali damadɔw ye minnu bɔra kalanw na:

• Fase II kɛnɛyaso sɛgɛsɛgɛli fitinin dɔ y’a jira ko histamine clemastine min bɛ ta da la, o bɛ ni miyɛlini dilancogo ye. Clemastine ye kuran taamasiɲɛw cicogo ɲɛ ka ɲɛ sklerose multiple banabagatɔw la minnu ɲɛkisɛw tiɲɛna. Hadamadenw ka sɛgɛsɛgɛli fɔlɔ wɛrɛ y’a jira ko sukarodunbana fura mɛtiformini ni klemastini faralen ɲɔgɔn kan, o ye dɛmɛ don ka miyɛlini lasegin a cogo kɔrɔ la.
• Stem Cells (Sɔgɔsɔgɔninjɛw).Ni u ye mɔlikulu dɔ bali oligodendrocyte selilɛriw kɔnɔ, minnu bɛ miyɛlini dilan farikolo cɛmancɛ la (o ye selilu suguya bɛɛ “jɔlanw” ye), soso minnu taamasiɲɛw bɛ i n’a fɔ sklerose multiple, olu sera k’u ka miyɛlini dilan ani ka kɛnɛya fo ka se hakɛ dɔ ma.
• Sɛgɛsɛgɛli bɛ senna ka ɲɛsin jirisunw ka se ka miyɛlini tiɲɛni dilan ani ka bana in taabolo sumaya.
• Fura wɛrɛw bɛ layidu jira farikolo yɔrɔw lakanani na ka bɔ tiɲɛni wɛrɛw la. Fura min bɛ funu kɛlɛ, n’o ye ibudilast ye, o ye dɔ bɔ kosɛbɛ kunsɛmɛnasumaya banakisɛw ka saya hakɛ la (atrophie) Fase II sɛgɛsɛgɛli dɔ la. A jirala ko sɔgɔsɔgɔninjɛ fura fenitoyini tɛ farati la, a bɛ dɔ bɔ miyɛlini tiɲɛni na ni 30% ye ni i ye a suma ni furakisɛ ye. Asidi lipoiki min bɛ farikolo tanga bana ma, o bɛ se ka dɛmɛ don ka farikolojidɛsɛ wɛrɛw bali.

Take-Home cikan

O la, aw bɛ se k’a ye sisan ko nin miyɛlini bɔgɔlan in nafa ka bon cogo min na an ka farikoloɲɛnajɛ kɛnɛya la. Miyɛlini nafa ka bon walasa o farikolo yɔrɔ miliyari caman ka baara kɛ ka ɲɛ, minnu bɛ kumaɲɔgɔnya kɛ ni an farikolo yɔrɔ bɛɛ ye ani ka fɛn bɛɛ mara.

• Miyɛlini ye lakananifɛn ye min dilannen don ni tulumafɛnw ni farikolojɔlifɛnw ye minnu bɛ farikolo yɔrɔw lamini.
• A bɛ farikoloɲɛnajɛw dɛmɛ u ka taa teliya la ani ka ɲɛ.
• Ni miyɛlini tiɲɛna, o bɛ se ka kɛ sababu ye ka bana juguw lase mɔgɔ ma i n’a fɔ sklerose multiple.
• Sɛgɛsɛgɛli bɛ senna fɛɛrɛw kan minnu bɛ kɛ ka banaw kunbɛn ani k’u dilan, bana minnu bɛ kɛ sababu ye ka miyɛlini tiɲɛ.

Bana ni cogoya caman bɛ se ka bin miyɛlini kan. Sklerose multiple (sklerose multiple) de ye o banaw la dɔnni ye ka tɛmɛ tɔw bɛɛ kan. Nka kibaru duman ye ko ɲininikɛlaw bɛ fɛɛrɛw ɲini tuma bɛɛ walasa ka miyɛlini lakana, k’a dilan ani k’a lasegin a cogo kɔrɔ la. Wa, u bɛ ka ɲɛtaa dɔw kɛ o kɛli la. O la sa, jigiya bɛ yen!

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Miyɛlini, miyɛlini bɔgɔdaga, farikolojidɛsɛbanakisɛw, farikolojidɛsɛbanakisɛw, farikolojidɛsɛbanakisɛw, cɛmancɛlafasalanw, farikolojɔli yɔrɔw, demyelination, sklerose multiple