Ni i miirila kansɛri furakɛli la, chimiothérapie bɛ na i hakili la o yɔrɔnin bɛɛ, tiɲɛ tɛ? An b’a dɔn ko furakɛli min bɛ taa farikolo fan bɛɛ la, ka kansɛribanakisɛw minɛ ka fara farikolokisɛ kɛnɛmanw kan, wa a kɔlɔlɔ jugu dɔw bɛ a la. Nka miiri k’a filɛ, fɛɛrɛ bɛ yen min bɛ se ka kansɛribanakisɛ yɔrɔ tigitigi dɔn, ka fura di a ma, ka kansɛri tiɲɛ k’a sɔrɔ a ma kojugu kɛ a kɛrɛfɛ banakisɛ kɛnɛmanw na. An bɛna kuma o de kan bi. O bɛ wele ko Anticorps-Drug Conjugates, walima ADCs ni a surunyalen don.
N’an y’a fɔ cogo nɔgɔman na, nin Anticorps-Drug Conjugate (ADC) in ye mun ye?
ADC ye fɛɛrɛ kura ye min bɛ layidu ta kosɛbɛ kansɛri furakɛli diɲɛ kɔnɔ. O la, an bɛ baara kɛ ni furakɛli fɛɛrɛba fila faralen ye ɲɔgɔn kan: Furakɛli laɲinitaw ani Chimiothérapie.
Miiri k’a filɛ i n’a fɔ ‘misile ɲɛminɛlen’ . Misile bɛ se k’a laɲini sɔrɔ k’a dɔrɔn de gosi. O cogo kelen na, ADC furakɛli bɛ kansɛribanakisɛw dɔrɔn de sugandi ani k’u faga farikolokisɛ miliyari caman cɛma. A b’o kɛ ni chimiothérapie fura barikamaba dɔ lase kansɛri banakisɛ ma lafiya la, k’a pikiri kɛ selilɛri dɔrɔn kɔnɔ. O kɔrɔ ye ko chimiothérapie fura tɛ nɔba bila farikolokisɛ kɛnɛmanw na.
A ka c’a la, kansɛri dɔgɔtɔrɔw bɛ nin ADC furakɛli in kɛ ka:
- Ni kansɛri seginna ka kɛ .
- Ni furakɛli wɛrɛw ma ɲɛ (kansɛri min tɛ se ka furakɛ) .
- Ni kansɛri jɛnsɛnna farikolo yɔrɔ wɛrɛw la (a bɛ taa yɔrɔ wɛrɛw la) .
ADC furakɛli bɛ se ka kɛ a tɛ kansɛri furakɛ pewu, nka ɲininiw y’a jira ko banabagatɔ minnu bɛ nin furakɛli in kɛ, olu ka kisi ka jan .
Okey, donc nin ‘magic bullet’ min bɛ wele ko ADC, o bɛ baara kɛ cogo di?
A bɛ se ka kɛ ko nin faamuyali ka gɛlɛn dɔɔnin, nka an k’a faamu ni misali nɔgɔman ye. Miiri k’a filɛ, parsela min komandira ɛntɛrinɛti kan, o bɛ lase i ka so.
Nin ADC foroko in yɔrɔba saba bɛ yen:
1. Banakisɛfagalan kelen : Nin ye an ka jiginnikɛlan ye. Nin ye farikolojɔlan kɛrɛnkɛrɛnnen ye min bɛ dilan laboratuwari kɔnɔ. Se kabakoma b’a la ka taamasiɲɛ kɛrɛnkɛrɛnnen dɔ dɔn kansɛribanakisɛw sanfɛ (an b’o wele ko Tumu Antigènes ). I n’a fɔ kilisi bɛ don dakun na cogo min na, o banakisɛfagalan bɛ taa o taamasiyɛn na kansɛribanakisɛ kan, ka nɔrɔ a la. A tɛ nɔrɔ farikolokisɛ kɛnɛman wɛrɛw la.
2. Simifura kɛrɛnkɛrɛnnen:Nin ye pake ye min bɛ ka lase. Ninnu ye furaw ye minnu fanga ka bon kosɛbɛ ka tɛmɛ chimiothérapie basigilen kan. Nka ni fura in cilen don farikolo la a kelen na, a bɛ se ka tiɲɛniba kɛ farikolokisɛ kɛnɛmanw na. O de y’a to an b’a ci jiginnikɛla ma.
3. "Linker" poroteyini : Nin ye yɔrɔ ye min bɛ i n’a fɔ ‘gum’, min bɛ jiginnikɛlan ni parsela siri ɲɔgɔn na. Baara fla b'a la. A fɔlɔ ye ka parsela (chimiothérapie fura) minɛ ka ɲɛ fo jiginnikɛlan (anticorps) ka kansɛribana sɔrɔ. Fɛn filanan min nafa ka bon kosɛbɛ, o ye ka parsela bila ka taa kansɛribanakisɛ kɔnɔ ni a sera a yɔrɔ bɛnnen na.
O la, nin saba ninnu bɛ baara kɛ ɲɔgɔn fɛ nin ye:
- Ni ADC fura pikirila fari la, jiginnikɛlan (anticorps) bɛ yaala farikolo fan bɛɛ la ka kansɛribanakisɛw ɲini.
- Ni kansɛribana dɔ sɔrɔla, a bɛ taa a sanfɛla la ka nɔrɔ a la.
- O kɔ, kansɛribana bɛ nin ADC in sama ka don a kɔnɔ.
- Ni a donna seli kɔnɔ, o jɛgɛnsira bɛ kari ani a foroko (chimio fura) bɛ bɔ.
- Nin fura barikama in bɛ kansɛribanakisɛw tiɲɛ u kɔnɔ.
N’an y’a fɔ cogo nɔgɔman na, nin furakɛli fɛɛrɛ in kɛrɛnkɛrɛnnen don kosɛbɛ bawo a bɛ furaw laɲini ani k’u lase kansɛribanakisɛw dɔrɔn ma, k’a sɔrɔ a ma kojugu kɛ farikolokisɛ kɛnɛmanw na.
Kansɛri suguya jumɛnw bɛ furakɛ ni ADC ye?
Sisan, ADC furakɛli tɛ kɛ kansɛri suguya bɛɛ la. Nka, o furakɛli in dabɔra kansɛri suguya damadɔw kama. A ka c’a la, o lisi bɛna bonya don nataw la.
| Kansɛri suguya | Misaliw |
|---|---|
| Joli Kansɛriw |
|
| Tumu minnu bɛ sɔrɔ kansɛri fɛ |
ADC fura caman bɛ baara la sisan
Sisan, ADC fura tan ni fila ni kɔ bɛ yen minnu dabɔra Ameriki FDA fɛ. Misali dɔw ye ninnu ye:
- Brentuximab vedotin (Adcetris®): ADC fɔlɔw dɔ don min ye FDA ka sɔn sɔrɔ. A bɛ kɛ ka joli kansɛriw furakɛ i n’a fɔ Hodgkin lymphoma ani anaplastic large cell lymphoma.
- Trastuzumab emtansine (Kadcyla®): A bɛ kɛ ka sinji kansɛri furakɛ min bɛ sɔrɔ HER2 fɛ, o min jɛnsɛnna farikolo fan bɛɛ la.
- Sacituzumab govitecan (Trodelvy®): O ye sinji kansɛri furakɛli ye min tɛ se ka furakɛ, min bɛ taa ɲɛ siɲɛ saba. A bɛ kɛ fana sugunɛbaralabana kansɛri jugumanba la.
Sɛgɛsɛgɛlikɛlaw bɛ ka sɛgɛsɛgɛli kɛ sisan ni nin fura ninnu bɛ se ka kɛ kansɛri suguya wɛrɛw la ani bana minnu tɛ kansɛri ye. Kɛnɛyaso sɛgɛsɛgɛli 100 ni kɔ bɛ sen na diɲɛ fan bɛɛ.
ADC furakɛli nafa kunbabaw ye jumɛnw ye?
Nin furakɛli in nafa belebeleba ni a nafa ka bon kosɛbɛ, o ye ko a bɛ se ka chimiothérapie furaw lase kansɛribanakisɛw ma k’a sɔrɔ a ma tiɲɛni kɛ farikolokisɛ kɛnɛmanw na. O b’a to dɔgɔtɔrɔw bɛ se ka chimiothérapie fura barikamabaw kɛ k’a sɔrɔ u ma siran ka tiɲɛni kɛ farikolokisɛ kɛnɛmanw na.
Laadalata la, fura in bɛ lase joli sira fɛ farikolo fan bɛɛ la. O bɛ wele ko chimiothérapie systémique. Ni fura in taara farikolo fan bɛɛ la nin cogo la, a tɛ kansɛribanakisɛw dɔrɔn tiɲɛ minnu bɛ tila teliya la, nka a bɛ farikolokisɛ kɛnɛmanw fana tiɲɛ i n’a fɔ an kunsigikisɛw, farikolokisɛ minnu bɛ joginda kɛnɛya an da la, ani farikolokisɛ minnu bɛ joli dilan. O de ye kɔlɔlɔw caya sababuba ye.
Nka o gɛlɛya in ka dɔgɔn kosɛbɛ ADC furakɛli la. O de kama kansɛri dɔgɔtɔrɔ dɔw yɛrɛ bɛ tɔgɔw fɔ i n'a fɔ "magic bullet" ani "precision treatment" o furakɛli in na.
I n’a fɔ fɛn tɔw bɛɛ, yala kɔlɔlɔ dɔw bɛ nin ko in na wa?
Awɔ. ADC furakɛli bɛ se ka kɔlɔlɔw lase mɔgɔ ma. Nka a ka ca a la, olu ka dɔgɔn ka tɛmɛ tubabufura kan. Kɔnɔnatumu minnu bɛ sɔrɔ, olu bɛ se ka ɲɔgɔn ta banabagatɔ ni banabagatɔ cɛ. O bɛ bɔ fɛnw na i n’a fɔ kansɛri suguya min bɛ aw la, kansɛri taabolo, ani aw ka kɛnɛya bɛɛ.
Ni aw bɛ ADC furakɛli kɛ, aw ka dɔgɔtɔrɔso jɛkulu bɛna aw kɔlɔsi kosɛbɛ. Ni kɔlɔlɔ dɔw bɔra a la, u bɛna baara kɛ walasa k’u furakɛ joona.
| Kɔnɔnatumuw kɔlɔlɔ minnu bɛ se ka sɔrɔ tuma caman |
|---|
|
| Waati min na aw ka kan ka aw ka dɔgɔtɔrɔ ladɔnniya |
Ni kɔlɔlɔw ka jugu ka tɛmɛ aw tun bɛ miiri min na, misali la, ni kɔnɔboli ni fɔɔnɔ tɛ se ka kunbɛn, aw bɛ o fɔ aw ka dɔgɔtɔrɔ ye joona. |
ADC furakɛli bɛ ɲɛ cogo di?
A ka ca a la, ɲininiw y’a jira ko banabagatɔ minnu bɛ ADC furakɛ, olu si bɛ mɛn ka tɛmɛ banabagatɔw kan minnu bɛ laadala chimiothérapie ta kansɛri suguya kelen na. Nka, a nɔ bɛ se ka kɛ fɛn wɛrɛ ye mɔgɔ ni mɔgɔ cɛ. Fɛn damadɔ bɛ yen minnu bɛ se ka nɔ bila o la:
- Kansɛri suguya : ADC furakɛli nafa ka bon kosɛbɛ kansɛri suguya dɔw la. A bɛ se ka kɛ ko a tɛna nɔ bɔ mɔgɔ wɛrɛw la ten.
- Kansɛri taabolo : Kansɛri min jɛnsɛnna farikolo fan bɛɛ la, o furakɛli ye gɛlɛya ye tuma bɛɛ.
- Aw ka kɛnɛya bɛɛ lajɛlen : Nin furakɛli in bɛ se ka kɔlɔlɔ jugumanw lase aw ma, o la aw farikolo ka kan ka se ka a muɲu. Aw ka kansɛri dɔgɔtɔrɔ bɛna o ɲɛfɔ aw ye ka ɲɛ sani a ka fura in di aw ma.
Daɲɛ "jigiya" nafa ka bon kosɛbɛ mɔgɔ ma min bɛ kansɛri kɛlɛ. ADC furakɛli ye o jigiya kura sugu ye. Nin furakɛli in bɛ se ka banabagatɔw dɛmɛ minnu ma se ka furakɛli wɛrɛw kɛ, ani minnu ka kansɛri seginna ka na, ka mɛn ani ka ɲɛnamaya kɛcogo ɲuman sɔrɔ.
Take-Home cikan
- Banakisɛfagalanw ni furaw faralen ɲɔgɔn kan (ADC) ye kansɛri furakɛli fɛɛrɛ kɔrɔlen ye min bɛ furakɛli laɲinitaw ni chimiothérapie fara ɲɔgɔn kan.
- Min bɛ kɛ o la, o ye ko kansɛribanakisɛw dɔrɔn de bɛ sɔrɔ, ka chimio fura barikama dɔ pikiri u la walasa k’u tiɲɛ. A bɛ i n’a fɔ ‘misile ɲɛminɛlen’.
- O bɛ na ni tiɲɛni dɔgɔyali ye farikolokisɛ kɛnɛmanw ni kɔlɔlɔw la ka tɛmɛ tubabufura kan.
- Nin furakɛli in bɛ kɛ sisan joli kansɛri suguya caman na ani kansɛri gɛlɛnw i n’a fɔ barajuru, fogonfogon ani kɔnɔbara basigilen.
- Aw ka kansɛri dɔgɔtɔrɔ bɛna a latigɛ ni nin furakɛli in bɛnnen don aw ma. Aw ka baro kɛ aw ka ɲininkaliw n’aw haminankow bɛɛ kan n’a ye.
💬 Comments (0)
Ko foyi ma bila fɔlɔ. Aw ka kuma fɔlen fara a kan yan a siɲɛ fɔlɔ la.
Aw ka kuma fɔlen fara a kan