Yala aw bɛ FAP (Familial Adenomatous Polyposis) dɔn, bana min na polipu kɛmɛ caman bɛ sɔrɔ kɔnɔbara la wa?

Yala mɔgɔ dɔ ye kansɛri sɔrɔ aw ka denbaya kɔnɔ, kɛrɛnkɛrɛnnenya la a denmisɛnman wa? Walima dɔgɔtɔrɔ dɔ y’a fɔ aw ye ko polipu caman bɛ aw kɔnɔbara la wa? Laala o bɛ bɔ jamu dɔ la min bɛ boli denbayaw kɔnɔ. Bi an bɛna kuma o cogoya kelen kan min man ca, nka a nafa ka bon kosɛbɛ. O ye FAP ye, walima Familial Adenomatous Polyposis. Hali n’a tɔgɔ ka gɛlɛn dɔɔnin, an k’a Faamu nɔgɔya la.

N’an y’a fɔ cogo nɔgɔman na, FAP ye mun ye?

FAP ye jamu bana ye min bɛ se ka bɔ mɔgɔw la ka taa mɔgɔw la. Nin bana in bɛ mɔgɔ minnu na, olu bɛ kuru caman sɔrɔ minnu bɛ wele ko adenomas , olu bɛ se ka kɛ kansɛri ye, u ka kolotuguda ni u kɔnɔbara la.

Sisan, aw bɛ se ka miiri ko: “Yala a bɛnnen don ni kuru bɛ ​​aw kɔnɔbara la wa?” Ɔwɔ, a ka ca a la mɔgɔ dɔw ka nin kurukuru kelen walima fila sɔrɔ ni u kɔrɔla. Nka FAP bɛ mɔgɔ min na, o tigi bɛ se ka nin kurukuru kɛmɛ caman sɔrɔ, laala hali ba caman . Wa a bɛ daminɛ a denmisɛnman kosɛbɛ , n’a sɔrɔ a si bɛ san 15 walima san 16 la.

Nin polipu ninnu tɛ kansɛri ye a daminɛ na. Nka u bɛ Weele ko ‘kansɛri ɲɛfɛ’. O kɔrɔ ye ko ni a ma furakɛ, faratiba bɛ a la kosɛbɛ ko nin polipu kelen walima caman bɛ laban ka kɛ kolotuguda kansɛri ye .

Ni nin opereli in ma kɛ, FAP bɛ mɔgɔ minnu na, a ka c’a la, kansɛri bɛna sɔrɔ u cɛmancɛ la. Ani fana, FAP bɛ mɔgɔ minnu na, farati bɛ olu la ka kurukuruw sɔrɔ kolotuguda dɔrɔn na, nka farikolo yɔrɔ wɛrɛw fana na (misali la, kɔnɔbara, banakɔtaa fitini, fari ani kolo). O la, hali kɔnɔbara bɔlen kɔfɛ, u mago bɛna kɛ dɔgɔtɔrɔso la tuma bɛɛ u ka ɲɛnamaya bɛɛ kɔnɔ.

Kansɛri farati ye mun ye ni FAP ye?

Ni a ma furakɛ, FAP bɛ se ka kɔnɔbara kansɛri sɔrɔ 100% ɲɔgɔn . Nin ye bana juguba ye. FAP bɛ mɔgɔ minnu na, olu bɛ kansɛri sɔrɔ u si ka kɔn kosɛbɛ ani u bɛ teliya ka tɛmɛ mɔgɔ gansan kan. O la, ni aw b’a dɔn ko FAP bɛ denbaya kɔnɔ, aw den ka kan ka kolotuguda lajɛ san o san k’a daminɛ a si san 10 la.

Ka fara kɔnɔbara kansɛri kan, FAP bɛ mɔgɔ minnu na, olu fana ka kan ka kansɛri suguya wɛrɛw sɔrɔ.

Yala FAP suguya wɛrɛw bɛ yen wa?

Ɔwɔ, FAP suguya kunba dɔ bɛ yen ani suguya fitinin damadɔ minnu tɛ kelen ye dɔɔni ani minnu man jugu. An k’a lajɛ u ye min ye.

Danfara jumɛn bɛ FAP ni Lynch Syndrome cɛ?

Lynch syndrome ye bana wɛrɛ ye min bɛ sɔrɔ jamu fɛ, min bɛ se ka tɛmɛ mɔgɔw fɛ mɔgɔw fɛ, ka dɔ fara kɔnɔbara kansɛri farati kan. Nka danfaraba bɛ o fila ni ɲɔgɔn cɛ. Lynch ka bana bɛ mɔgɔ minnu na, olu tɛ polipu kɛmɛ caman sɔrɔ, i n’a fɔ a bɛ kɛ cogo min na FAP la. Tuma dɔw la, polipu kelen walima fila bɛ bɔ, wa u bɛ se ka kɛ kansɛri ye joona. O de kama tuma dɔw la, Lynch ka bana bɛ wele ko "non polypose" bana. O bana fila bɛɛ bɛ sɔrɔ farikolojɔlifɛnw na minnu tɛ kelen ye.

FAP taamasiɲɛw ye jumɛnw ye?

FAP la, kolotugudaw bɛ daminɛ ka daminɛ joona ka tɛmɛ jamanaden bɛɛ kan, a ka ca a la u si hakɛ ka dɔgɔn. A ka ca a la, o kurukuru ninnu tɛ taamasiɲɛ foyi lase mɔgɔ ma fo n’u ka bon farati la. O de y’a to sɛgɛsɛgɛli nafa ka bon kosɛbɛ.

Nka, barisa kuru hakɛ ka ca kosɛbɛ wa u bɛ bonya joona, tuma dɔw la a taamasiɲɛw bɛ se ka bɔ kɛnɛ kan. O taamasiɲɛ suguw ye:

• Joli bɛ bɔ ɲɛgɛnɛsira la
• Kɔnɔboli basigilen
• Kɔnɔdimi basigilen

Ka fara o kan, FAP bɛ mɔgɔ minnu na, olu fana bɛ se ka kɛ ni kɛnɛya taamasiɲɛw ye, dɔgɔtɔrɔ bɛ se ka minnu kɔlɔsi nɔgɔya la.

• Dermatofibromes : Kuru gɛlɛnw, minnu bɛ i n’a fɔ kurukuruw, minnu bɛ kɛ fari jukɔrɔ.
• Farikolola kurukuruw : Kurukuru kurulenw minnu falen don keratini na minnu bɛ kɛ fari jukɔrɔ.
• Kolotugudaw:Tumu minnu tɛ kansɛri ye, olu bɛ sɔrɔ kolotugudaw la. Olu bɛ ye tuma caman na kungolo walima kɔkolo la.
• Ɲɛ wɛrɛw walima ɲinw minnu bɛ sɔgɔsɔgɔ: Olu bɛ se ka dɔn ni ɲinw ka rezow ye.
• Ɲɛkisɛ ɲɛgɛnɛsira ɲɛkisɛw (CHRPE): Olu bɛ se ka ye ɲɛkisɛ sɛgɛsɛgɛli senfɛ. Nka, a ka c’a la, u tɛ nɔ bila yeli la.

FAP sababuba ye mun ye?

I n’a fɔ an y’a fɔ cogo min na ka tɛmɛ, FAP bɛ sɔrɔ jamu caman cili fɛ. Jɛnkulu min bɛ o nɔ bila, o bɛ wele ko APC (Adenomatous Polyposis Coli) jamu.

FAP bɛ mɔgɔ min na, APC jamu caman b’a la, o kɔrɔ ye ko a nafa tɛ. O kɔfɛ, i n’a fɔ mobili min ka freinw karilen don, selilɛriw bɛ tila k’a sɔrɔ u tɛ se ka u yɛrɛ minɛ, ka kuru kɛmɛ caman kɛ.

O jamu nafama in bɛ sɔrɔ ciyɛn fɛ. Ni nin APC jamu jiginni in bɛ bangebaga dɔ la, den bɛ se ka a ciyɛn sɔrɔ 50% . O kɔrɔ ye ko den kelen-kelen bɛɛ bɛ se ka a sɔrɔ walima a tɛ se ka kɛ a la. Nka, FAP bɛ mɔgɔ minnu na, olu 30% ɲɔgɔn tɛ ni denbaya kɔnɔko ye. O kɔrɔ ye ko nin jamu nafama in wulila u farikolo la kɔsa in na (mutation originale).

Gɛlɛya jumɛnw bɛ se ka sɔrɔ FAP fɛ?

gɛlɛya min nafa ka bon kosɛbɛ ani min farati ka bon ni FAP ye , o ye kɔnɔbara kansɛri ye . O farati bɛ dɔgɔya kosɛbɛ ni kolotuguda bɔra opereli fɛ. Nka, gɛlɛya dɔw bɛ ɲɛnamaya la ni kolotuguda tɛ. Banakɔtaa taabolo bɛ Changé. O kama, ileostomi foroko walima ileal foroko bɛ se ka kɛ.

Ikomi APC jamu nafama bɛ farikolo kɔnɔ farikolokisɛ kelen-kelen bɛɛ la, tumuw bɛ se ka kɛ banakɔtaa kɔkan fana. Farati bɛ o dɔw la ka kɛ kansɛri ye.

• Duodenal polyps : Ninnu bɛ sɔrɔ FAP bɛ mɔgɔ bɛɛ la. Olu hakɛ dɔɔni bɛ se ka kɛ kansɛri ye ɲɛgɛnɛsira la, ɲɛgɛnɛsira la, walima kɔnɔbara basigilen na.
• Kɔnɔbara basigilen : A bɛ kɛ mɔgɔ 90% ɲɔgɔn na, nka a hakɛ fitinin dɔrɔn, 1% ɲɔgɔn, bɛ kɛ kansɛri ye.
• Desmoid tumors: Ninnu tɛ kansɛri ye. Nka u bɛ se ka farigan kosɛbɛ, wa u bɛ se ka jɛnsɛn farikolo yɔrɔw ni joli siraw la minnu bɛ u kɛrɛfɛ, ka u tiɲɛ. U bɔli ka gɛlɛn, wa u bɛ se ka segin ka na.
• Kansɛri sɔgɔsɔgɔninjɛ : O bɛ se ka kɛ FAP bɛ mɔgɔ minnu na, olu 2% ɲɔgɔn na. A ka ca a la, ninnu bɛ se ka furakɛ pewu.
• Sugunɛ kansɛri : sugunɛbilenni, kɛrɛnkɛrɛnnenya la FAP bɛ denmisɛn minnu naFarati fitinin bɛ sugunɛ kansɛri suguya dɔ sɔrɔli la min man teli ka sɔrɔ a bɛ wele ko.

A furakɛcogo n’a ɲɛnabɔcogo bɛ kɛ cogo di?

FAP furakɛli bolodacogo bɛ se ka tila tilayɔrɔ fila ye: opereli ani a si bɛɛ sɛgɛsɛgɛli.

1. Opereli kɛli

FAP klasiki bɛ mɔgɔ minnu na, olu fanba bɛna a ɲini ka kolotuguda bɛɛ lajɛlen kɛ, o min bɛ kɛ ni kɔnɔbara bɛɛ bɔli ye, u si bɛ san 20 walima san 30 daminɛ na. Aw ka dɔgɔtɔrɔ bɛna a latigɛ opereli in bɛ kɛ waati min na ani cogo min na, ka kɛɲɛ ni aw ka bana ye.

2. Sɛgɛsɛgɛli kɛli tuma bɛɛ

Aw bɛna sɛgɛsɛgɛli suguya caman kɛ sani opereli ka kɛ ani opereli kɔfɛ, ani aw ka ɲɛnamaya bɛɛ kɔnɔ. O de ye fɛɛrɛ ɲuman ye min bɛ se ka i ka ɲɛnamaya lakana.

Ɲɛnamaya bɛ cogo di ni FAP ye?

A bɛnnen don ka dusukasi ni ka kabakoya ni i y’a dɔn ko bana dɔ bɛ i la i n’a fɔ nin jamu. Nka, ka nin bana in dɔn joona, o ye fɛɛrɛ ɲuman ye min bɛ se ka aw ka kansɛri farati kunbɛn.

Ni dɔgɔtɔrɔso ladonni ka ɲi ani ni a bɛ to ka sɛgɛsɛgɛli kɛ, FAP bɛ mɔgɔ min na, o bɛ se ka ɲɛnamaya kɛ cogo la min bɛ bɛn, ka mɛn, ka kɛnɛya . Kɔnɔbara bɔlen kɔfɛ, faratiba bɛ bɔ kɔnɔbara basigilen kansɛri wɛrɛw la walima desmoïde kuruw la. Nka ninnu ka dɔgɔn kosɛbɛ ka tɛmɛ kɔnɔbara kansɛri kan.

Hali ni opereli ye ɲɛnamaya caman yeli ye, ni bi fɛɛrɛ kɔrɔw bɛ yen, opereli min bɛ kɛ ni laparoskopi ye, o bɛ se k’aw dɛmɛ ka kɛnɛya joona.