Mina míasrɔ̃ nu tso asrafo sue siwo le wò ŋutilã me ŋu - granulocytes.

Mí katã míedzea agbagba vevie be míate ɖa le dɔlélewo ŋu, alo? Ɣeaɖewoɣi la, dzamezã gɔ̃ hã ate ŋu ana míadze dɔ. Eyata le míaƒe ŋutilã me la, ametakpɔnu wɔnuku aɖe ŋutɔ li be wòawɔ avu kple dɔléle kple dɔlékui mawo tɔgbe. Ametakpɔnu ma ƒe akpa vevi aɖe ŋutɔe nye granulocytes siwo ŋu míele nu ƒom tsoe egbea. Ame siawo wɔa dɔ le míaƒe ŋutilã me abe asrafo siwo kpɔa míaƒe dukɔa ta ene. Enyo, eyata mina míakpɔ amesiwo nye granulocyte siawo, nusi wowɔna, kple nusi adzɔ ne wova le ʋɛ akpa alo wosɔ gbɔ akpa. Nusianu le bɔbɔe.

Ènya nusiwo granulocytes nyea?

Kpuie ko la, granulocyte nye ʋumenugbagbevi ɣi ƒomevi aɖe. Ẽ, èse be ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi ɣiwo le ʋua me. Le ʋumenugbagbevi ɣi mawo dome la, esi bɔ wue nye granulocyte.

Woxɔ ŋkɔa elabena le woƒe lãmenugbagbeviwo me, le cytoplasm (tsi ɣi si le lãmenugbagbevi la me) me la, nu suesuesue siwo le abe nuku ene siwo woyɔna be granules li. Atike vovovowo abe enzymewo ene le kpekui siawo me . Esiawo le abe woƒe aʋawɔnuwo ene.

Bu eŋu kpɔ, ne nane abe dɔlékui alo dɔlékui ene ge ɖe wò ŋutilã me, alo ne abi aɖe le ŋuwò le abi aɖe ta la, granulocyte siawo ƒua du yia teƒea abe dɔnɔdzikpɔʋu si si siren le ene. Wova ɖea atike siwo le woƒe lãmenugbagbeviwo me la ɖe go tsɔ wɔa avu kple dɔlékuia.

Eyata mɔ ɖeka kolia si dzi nàto anya nusi tututu wò granulocyte ƒe agbɔsɔsɔ nyee nye be woado ʋu kpɔ. Woate ŋu awɔ esia kple CBC (Complete Blood Count), si wowɔna zi geɖe.

• Ne wò granulocyte ƒe xexlẽme sɔ gbɔ , ate ŋu afia be dɔlékui aɖe ƒomevi le wò ŋutilã me.
• Azɔ hã, ne granulocyte ƒe xexlẽme le sue la , ate ŋu anye ƒumeŋuɖui ƒe dɔléle, abe ʋumenugbagbeviɣidɔ alo aplastic anemia ene, ƒe dzesi. Gake mègatsi dzi o, menye ɖiɖi ɖesiaɖee nye afɔku o.

Wogayɔa granulocyte siawo be `granular leukocytes`, `polymorphonuclear leukocytes` alo `PMN cells`. Gake mina míayɔ wo ko be `granulocytes`.

Nukae dzɔna ne granulocytes siwo metsi o le ŋuwò?

Zi geɖe la, ne wotsi bliboe le míaƒe ƒumeŋuɖui me ko hafi granulocyte lãmenugbagbevi siawo gena ɖe ʋua me, si fia be ne wotsi vɔ ko. Abe alesi ɖevi siwo le suku srɔ̃a nu nyuie hetoa dodokpɔwo me ene la, wodona.

Gake ɣeaɖewoɣi la, granulocyte , si metsi o siawo, si fia lãmenugbagbevi siwo metsi bliboe o, nɔa ʋua me. Susu geɖe li siwo tae esia ate ŋu adzɔ ɖo:

• Ðekae nye be kuxi aɖe ate ŋu anɔ ƒumeŋuɖui ŋu.
• Alo, ate ŋu anye be ame kukua le nu wɔm ɖe dɔlékui aɖe ŋu le mɔnukpɔkpɔ gbãtɔ me, abe asrafo yeyewo ɖoɖo kabakaba ɖe aʋa me ene.

Zi geɖe la, ɖɔktawo tsia dzi vie ne ʋumenugbagbevi ɣiwo katã ƒe xexlẽme wu 2% le asiwò abe granulocytes siwo metsi o ene.

Gake ɖo ŋku esia hã dzi be:

• Le dzɔdzɔme nu la, granulocytes siwo metsi o aɖewo ate ŋu anɔ vidada funɔwo kple vidzĩ siwo wodzi yeyee ƒe ʋu me. Esia sɔ, si nye dzesi be ƒumeŋuɖui le dɔ wɔm nyuie. Eyata naneke meli si ŋu woatsi dzi ɖo o.

Dɔ vevitɔ kae granulocytes wɔna?

Granulocytes ɖeɖe mewɔa dɔ o. Wowɔa dɔ ɖekae abe ƒuƒoƒo ene tsɔ wɔa avu kple mía ta tso nuwo abe dɔlékuiwo, dɔlékuiwo, kple nulɔdɔ siwo gena ɖe míaƒe ŋutilã me ene me.

Granulocyte ƒomevi vevi enee li. Atike kple enzyme siwo le ƒomevi ɖesiaɖe me to vovo vie le ƒuƒu mawo me, eye le esia ta woƒe dɔwɔwɔ to vovo vie.

1. Neutrophils ƒe dɔwɔwɔ

• Esiae nye granulocyte ƒomevi si bɔ wu , abe asrafoha gãtɔ kekeake si le asrafoha me ene.
• Woƒe futɔ vevitɔe nye dɔlékuiwo . Neutrophil cell ɖeka ate ŋu aɖu dɔlékui siwo ade 20 ahatsrɔ̃ wo le eƒe agbenɔɣi!
• Neutrophils nye granulocytes siwo katã le míaƒe ŋutilã me ƒe 40% va ɖo 60%, si fia be ʋumenugbagbevi ɣiwo ƒe akpa eve le etɔ̃ me lɔƒo.

2. Eosinophils ƒe lãwo

• Esiawo hã le vevie ŋutɔ. Wokpɔa wo le dɔlélenutsiŋutete ƒe dɔwɔwɔwo katã kloe me .
• Woƒe dɔwɔwɔ sɔ gbɔ ŋutɔ le nusiwo ŋu nulɔdɔ le me .
• Azɔ hã, eosinophils siawoe wɔa avu kple dɔlékuiwo , si fia be nugbagbevi siwo hea dɔlélewo abe nudzodzoewo ene vɛ.

3. Basophils ƒe lãwo

• Ame siawo wɔa avu kple nulɔdɔwo koŋ .
• Woɖea atike aɖe si woyɔna be histamine , si kpena ɖe ŋutilãa ŋu wòɖea nusiwo nana ŋutilãa mewɔa nuvevi ame o ɖa (bu eŋu be enye aɖuɖɔɖɔɖɔ kple ŋɔti me tsi si le dodom).
• Eɖea heparin , si xea mɔ na ʋu ƒe sisi hã.

4. Lãmenugbagbevi siwo woyɔna be mast cells

• Mast cells hã nye granulocyte ƒomevi aɖe. Gake womezɔna le ʋua me abe bubuawo ene o. Wonɔa míaƒe lãkusiwo me.
• Abe basophils ene la, woɖea histamine kple heparin hã ɖe go.
• Basophils kple mast cells ƒe dzedzeme sɔ. Vovototo vevitɔe nye be basophils ƒe agbenɔƒe nɔa kpuie wu eye ne edzɔ ko la, woƒua du yia afisi dɔdzẽa dze le.

Afikae granulocytes le?

Wowɔa asrafo sue siawo siwo woyɔna be granulocytes le míaƒe...Le ƒumeŋuɖui me . Abe boot camp ene. Emegbe ne ŋutilãa hiã woƒe subɔsubɔdɔwo la, wowɔa ɖeka kple ʋua eye woyia teƒe siwo sɔ.

Aleke wòle be granulocytes ƒe agbɔsɔsɔ si sɔ nanɔ?

Zi geɖe la, ele be granulocytes siwo ade 1,500 va ɖo 8,500 nanɔ ame si le lãmesẽ me si le ʋu microlitre ɖeka (ʋu sue aɖe ŋutɔ) me. Anɔ eme be wò ʋudodokpɔ ƒe nyatakaka aɖe esia afia be `1.5 – 8.5 x 10^9/L`. Asixɔxɔ siawo ate ŋu ato vovo vie tso dodokpɔxɔ ɖeka me yi bubu gbɔ.

Ne míetsɔ granulocyte ƒomevi vovovo siwo ŋu míeƒo nu tsoe va yi abe alafa memamã ene la, esiae nye nusi wòle be woanɔ le dzɔdzɔme nu:

• Neutrophils: Ʋumenugbagbevi ɣiwo katã ƒe 50% va ɖo 70%.
• Eosinophils: Wole 1% va ɖo 3% dome.
• Basophils: Le 0.4% kple 1% dome.

Dɔléle kawoe bɔ siwo gblẽa nu le granulocytes ŋu?

Atikewɔwɔ me nɔnɔme vovovowo ate ŋu ado mo ɖa le granulocytes ƒe dzidziɖedzi alo edzi ɖeɖe kpɔtɔ ta. Na míalé ŋku ɖe wo dometɔ ʋɛ aɖewo ŋu:

• Basophilia: Esia nye basophils ƒe dzidziɖedzi. Esia ate ŋu anye dɔlékui aɖe ƒe dzesi, dɔléle si tsoa dɔlélenutsiŋutete gbɔ (dɔléle si me ŋutilãa ŋutɔ ƒe lãmenugbagbeviwo dzea eɖokui dzi le), alo nɔnɔme aɖe abe ʋumenugbagbeviɣidɔ ene.
• Cyclic neutropenia: Esiae nye esime neutrophils ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna eye emegbe wògatrɔna yia nɔnɔme si sɔ me. Esia dzɔna le tsatsam me. Nɔnɔme sia nana dɔlékuiwo xɔxɔ ƒe afɔkua dzina ɖe edzi.
• Eosinophilia: Eosinophils ƒe xexlẽme ƒe dzidziɖedzi. Wokpɔa esia zi geɖe le nɔnɔmewo abe asrã kple ɣeyiɣi aɖe ƒe nulɔdɔwo ene me . Ate ŋu anye dɔlékui siwo tsoa dɔlékuiwo gbɔ alo dɔléle siwo dɔlélenutsiŋutete hena vɛ abe sarcoidosis kple dɔgbo ƒe dɔléle si naa dɔdzẽ ene hã ƒe dzesi .
• Granulocytosis: Esia nye granulocytes ƒe xexlẽme bliboa ƒe dzidziɖedzi. Esia ate ŋu atso nu vovovowo gbɔ. Dɔlékuiwo, ʋumenugbagbeviɣidɔ, dɔléle aɖewo siwo dɔlélenutsiŋutete hena vɛ, kple ƒumeŋuɖui ƒe dɔlélewoe nye esiwo koŋ.
• Neutropenia (si woyɔna hã be granulocytopenia): Esia nye granulocytes, vevietɔ neutrophils, ƒe xexlẽme dzi ɖeɖe kpɔtɔ. Zi geɖe la, ʋu alo ƒumeŋuɖui ƒe dɔléle abe aplastic anemia alo ʋumenugbagbeviɣidɔ ene gbɔe esia tsona . Agranulocytosis ye nye ʋumenugbagbeviɣidɔ si nu sẽ wu.

Nukawoe nye dɔléle siwo do ƒome kple granulocyte ƒe dzesi siwo bɔ?

Dzesi siawo ate ŋu ato vovo le wò nɔnɔme tɔxɛa nu. Gake dzesi siwo bɔ wu dometɔ aɖewoe nye:

• Ðeɖiteameŋu ƒe seselelãme ɣesiaɣi (Ðɖiteameŋu) .
• Asrã
• Dɔlékuiwo xɔxɔ enuenu (e.g. dzamezã, ŋɔti me dɔlékuiwo, aɖuɖɔtoemedɔlélewo) .
• Aɖuɖɔtoedɔléle
• Ƒunukpeƒewo ƒe vevesese
• Nu me ƒe abiwo
• Aɖuɖɔtoe kple ʋuʋudedi
• Ŋutilã me ʋuʋudedi, abe ʋuʋudedi ene
• Vemexɔabi
• Lãmetsiŋusẽ ƒe ʋuka siwo vuvu (le teƒewo abe kɔ kple akɔta ene) .

Ne dzesi siawo dometɔ ɖeka alo esi wu nenema yi edzi le fu ɖem na wò la, anyo wu be nàyi ɖɔkta gbɔ aɖaɖo aɖaŋu na wò.

Dodokpɔ kawoe wowɔna tsɔ léa ŋku ɖe granulocyte ƒe agbɔsɔsɔ ŋu?

Wò ɖɔkta ate ŋu akpɔ wò granulocyte ƒe xexlẽme to ʋudodo blibo (CBC) wɔwɔ me . Esia nye ʋudodokpɔ bɔbɔe ŋutɔ si wowɔna zi geɖe.

Be nàkpɔ granulocyte ƒe agbɔsɔsɔ le wò CBC nyatakakaa me la, di nya siawo:

• Neutrophil alo “neut.”
• Eosinophil alo “eosin.”
• Basophil alo “baso.”

Zi geɖe la, wotsɔa nya “abs” kplɔa nya siawo ɖo. Esia tsi tre ɖi na “nu blibo.” Efia lãmenugbagbevi ƒomevi ɖesiaɖe ƒe xexlẽme bliboa (xexlẽme si tututu le ʋu ƒe agbɔsɔsɔme aɖe me).

Nukawoe nye dɔléle siwo dona tso granulocyte gbɔ ƒe atikewo?

Atikewɔwɔ ƒe tiatia ato vovo le wò nɔnɔmea nu, gake atikewɔmɔnu siwo bɔ dometɔ aɖewoe nye:

• Dɔlékuiwutikewo: Ne dɔlékui aɖe le ame ŋu.
• Ƒumeŋuɖui dodo: Le nɔnɔme sesẽ aɖewo me.
• Corticosteroids: Ðea dɔdzẽ dzi kpɔtɔna.
• G-CSF (granulocyte colony-stimulating factor) dodo: Dzia granulocyte ƒe wɔwɔ ɖe edzi.
• Dɔlélenutsiŋutete ƒe dɔlékuiwutikewo: Le dɔléle siwo dɔlélenutsiŋutete hena vɛ me.

Ne kansa la gblẽ nu le granulocytes ŋu la, atikewɔwɔ ƒe mɔnuwo ate ŋu anye:

• Atikewo zazã
• Dɔlélenutsiŋutete ƒe atikewɔwɔ
• Kekeli ƒe atikewɔwɔ
• Atikewɔwɔ si ŋu woɖo taɖodzinu ɖo
• Amekoko

Atikewɔwɔ na granulocytes siwo metsi o

Ne wò ʋudodokpɔ me tsonu ɖee fia be granulocytes siwo metsi o le ŋuwò la, wò ɖɔkta ate ŋu awɔ dodokpɔ bubuwo atsɔ adi nusi gbɔ wòtso.

• Ne dɔlékui aɖe gbɔe wòtso la, woaŋlɔ atike si sɔ na ame.
• Ne nusi gbɔ wòtsoe nye nane abe kansa ene la, woaƒo nu tso atikewɔmɔnu siwo woate ŋu azã abe amekoko, atikewɔmɔnu, alo keklẽŋusẽdɔdamɔnu ene ŋu na wò.

Aleke malé be na ɖokuinye? Ke ne ehiã be matsi dzi ɖe nye granulocyte ƒe agbɔsɔsɔ ŋu ya ɖe?

Ne dɔléle aɖe le ŋuwò si gblẽa nu le wò granulocyte ƒe agbɔsɔsɔ ŋu la, ele vevie be nàkpɔ ɖokuiwò ta tso dɔlékuiwo me. Nu siwo nàte ŋu awɔ dometɔ aɖewoe nye esi:

• Ƒo asa na asikaka wò ŋkuwo, ŋɔti, alo mo ŋu evɔ màklɔ asi o. Dɔlékui makpɔmakpɔ nenie le míaƒe asiwo dzi?
• Na atikewɔmɔnu siwo wokafu na wò ɖe game dzi. Esiawo ate ŋu akpɔ ame ta tso dɔlékui geɖe xɔxɔ me.
• Kpɔ aɖudɔdala gbɔ edziedzi, eye nàlé nu me dzadzɛnyenye me ɖe asi le aƒeme. Klɔ aɖuwo nyuie eye nàtsɔ aɖuɖɔ atutu woe nyuie.
• Klɔ asi enuenu eye nàklɔe nyuie, vevietɔ hafi nàɖu nu, ne èzã tsileƒe vɔ, kple ne èdo go.
• Ƒo asa na teƒe siwo amewo sɔ gbɔ ɖo kple teƒe siwo dɔnɔwo le alesi nàte ŋui.
• Ƒo nuɖuɖu si da sɔ nyuie. Ƒo atikutsetse kple amagbe geɖe wu. Esiawo doa ŋusẽ wò dɔlélenutsiŋutete.
• Dɔ alɔ̃ nyuie.
• Ƒo asa na atamanono.

Nu vevitɔe nye be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo ne dzesi aɖewo siwo mebɔ o le ŋuwò, evɔ màŋe aɖaba aƒu wo dzi o.

Vovototo kae le Granulocytes kple Agranulocytes dome?

Esiawo evea siaa nye ʋumenugbagbevi ɣi ƒomeviwo. Gake agranulocytes mekpɔa granules siwo míeyɔ va yi la le woƒe cytoplasm me o. Zi geɖe la, ŋɔŋlɔdzesi "A" gɔmee nye "ao." Eyata "agranulocyte" gɔmee nye nane abe "lãmenugbagbevi siwo me granules mele o."

Monocytes kple lymphocytes nye agranulocyte siawo ƒe kpɔɖeŋu eve. Wowɔa akpa vevi aɖe ŋutɔ le dɔlélenutsiŋutete hã me.

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Granulocytes nye míaƒe dɔlélenutsiŋutete ƒe asrafo siwo meƒoa nu o siwo wɔa avu kple dɔlékuiwo, nusiwo nana ŋutilãa melɔ̃a nu o, kple nu bubu siwo doa dziku na ame siwo gena ɖe míaƒe ŋutilã me. Ne ʋumenugbagbevi ɣi siawo le dɔ wɔm nyuie la, míaƒe ŋutilã ate ŋu akpɔ eɖokui ta nyuie wu.

Gake ne wò ŋutilã mewɔa granulocytes wòsɔ gbɔ o, alo ne granulocytes ƒe xexlẽme le sue akpa alo sɔ gbɔ akpa la, ate ŋu afia be nɔnɔme sesẽ aɖe si le eme.

Ne èle dɔ lém enuenu, dɔlékuiwo xɔxɔ le ŋuwò bɔbɔe, alo dzesi siwo míeyɔ ɖe etame dometɔ aɖe le ŋuwò la, taflatse yi ɖɔkta gbɔ. Woate ŋu awɔ dodokpɔ siwo hiã, anya nusi gbɔ wòtso, eye woawɔ ɖoɖo ɖe atikewɔwɔ nyuitɔ kekeake ŋu na wò. Wò lãmesẽ dzi kpɔkpɔe nye nu vevitɔ kekeake!

` Granulocytes, ʋumenugbagbevi ɣiwo, dɔlélenutsiŋutete, dɔlékuiwo, ʋudodokpɔ, dzesiwo, lãmesẽ ŋuti aɖaŋuɖoɖowo, CBC, neutrophils, eosinophils, basophils