Èdi be yeanya nu tso ANCA Dodokpɔa hã ŋua? Mina míaƒo nu tso eŋu tsitotsito!

Èse `(ANCA dodokpɔ)` ŋu nya kpɔa? Ðewohĩ wò ɖɔkta gblɔ na wò be nàwɔ dodokpɔ sia, alo ɖewohĩ ɖeko nèkpɔ ŋkɔa le afi aɖe eye nèdi be yeanya nu tso eŋu. Eyata nukae nye `(ANCA dodokpɔ)` sia? Nuka tututue wòdia? Le nyati sia me la, míakpɔ ŋuɖoɖo na biabia mawo tɔgbe siwo ate ŋu anɔ susu me na wò.

Nukae nye ANCA dodokpɔ? Mina míase egɔme bɔbɔe!

Kpuie ko la, ANCA dodokpɔ nye ʋudodokpɔ si xɔa wò ʋu ƒe kpɔɖeŋu eye wòdia nu tɔxɛ aɖewo siwo woyɔna be Antineutrophil Cytoplasmic Antibodies, alo ANCAs kpuie.

Fifia àte ŋu anɔ eŋu bum be, nukae nye `(ANCA)` siawo? `(ANCAs)` nye `(autoantibodies)` ƒomevi aɖe. `(Autoantibodies)` nye protein ƒomevi aɖe si mía ŋutɔwo míaƒe ŋutilã ƒe dɔlélenutsiŋutete (si nye ɖoɖo si kpɔa mía ta tso dɔlélewo me) wɔna. Ke hã, kuxi si le `(autoantibodies)` siawo ŋue nye be wodzea lãmenugbagbevi kple lãkusi siwo le lãmesẽ me le míaƒe ŋutilã me dzi vodadatɔe. Ele abe mía ŋutɔwo ƒe aʋakɔ si le mía ŋutɔwo míaƒe dukɔ dzi dzem ene.

`(ANCA)` siawo tɔa ŋku protein siwo le ʋumenugbagbevi ɣi siwo woyɔna be `(neutrophils) me koŋ. `(Neutrophils)` le abe asrafo suewo ene le míaƒe ŋutilã me. Woawoe wɔa avu kple dɔlékuiwo eye wokpena ɖe mía ŋu míekpɔa mía ɖokui ta tso dɔlélewo me. Eyata, `(ANCA dodokpɔ)` sia ateŋu anya nenye be `(autoantibodies)` siawo le wò ʋu me, eye ne ele nenema la, ne wosɔ gbɔ.

Dɔléle ka ƒomevie wozãa ANCA dodokpɔ tsɔ dea dzesii?

Ðɔktawo zãa ANCA dodokpɔa koŋ tsɔ kpena ɖe ame ŋu be woanya dɔléle aɖewo siwo dɔlélenutsiŋutete wɔa dɔ le, siwo le dɔlélewo ƒe hatsotso aɖe si woyɔna be vasculitis .

Nukae nye `(vasculitis)` sia?

Bu eŋu kpɔ be nu suesuesue siwo le abe mɔ̃ ene siwo tsɔa ʋu la le míaƒe ŋutilã katã mea? Emae míeyɔna be ʋukawo. Le nɔnɔme sia si woyɔna be ``vasculitis'' me la, nusi dzɔna enye be mía ŋutɔwo ƒe dɔlélenutsiŋutete dzea ʋuka siawo dzi eye wònana wobiãna, si fia be wovuvu . Ele abe abi si le ememe ene.

Vasculitis ƒomevi vovovowo li siwo do ƒome kple ANCA:

• `(Granulomatosis kple polyangiitis)` (si woyɔna tsã be `(Wegener granulomatosis)`).
• `(Nu suesuesuewo ƒe polyangiitis)` .
• Eosinophilic granulomatosis kple polyangiitis (si woyɔna tsã be Churg-Strauss ƒe dɔléle).

Ʋukawoe nye esiwo tsɔa ʋu tso míaƒe dzi me yia ŋutinu kple lãkusi bubuwo katã me. Eyata ne ʋuka siawo xɔ dzo la, ʋu metoa sisi nyuie o. Esia ate ŋu agblẽ nu le míaƒe ŋutinu veviwo ŋu, eye ɣeaɖewoɣi la, ahe nɔnɔme siwo me afɔku le abe ʋukawo ƒe gbagbã (ʋuka siwo me ʋu sina tona) ene gɔ̃ hã vɛ . Esia tae wòle vevie be woade dzesi nɔnɔme mawo kaba ɖo.

Ðe (ANCA) ƒomevi vevi aɖewo lia?

Ẽ, ANCA ƒomevi vevi evee li. ANCA dodokpɔ sia ate ŋu anya ne ɖeka alo evea siaa le ŋuwò.

• `cANCA` : Esia tɔa ŋku protein si woyɔna be `(proteinase 3)` alo `(PR3)` .
• `pANCA` : Esia tɔa ŋku protein si woyɔna be `(myeloperoxidase)` alo `(MPO)` .

`(protein)` ƒomevi siawo evea siaa le ʋumenugbagbevi ɣi siwo woyɔna be `(neutrophils)` siwo míeyɔ va yi la me. `(ANCA)` ƒomevi si le ɖɔkta nyanya kpena ɖe ɖɔkta ŋu le dɔlélea didi kple ɖoɖowɔwɔ ɖe atikewɔwɔ ŋu me.

Amekae wɔa ANCA dodokpɔa? Aleke wodonɛ kpɔ le dodokpɔxɔ me?

Zi geɖe la, dɔnɔdzikpɔla, ɖɔkta, alo nudokpɔƒe ŋuti nunyala aɖe xɔa wò ʋu, eye emegbe woɖonɛ ɖe nudokpɔƒe be woadoe kpɔ.

Nukae dzɔna le nudokpɔƒe (`lab`)?

Woɖea wò ʋu ƒe kpɔɖeŋu eye wotsakanɛ kple ʋumenugbagbevi dzĩwo le slide dzi. Fifia, ne ANCAwo le wò ʋu me la, woalé ɖe ʋumenugbagbevi dzĩwo ŋu. Emegbe wotsɔa amadede tɔxɛ aɖe (aɖi) dea slide la ŋu. Emegbe ne ètsɔ nusuekpɔmɔ̃ lé ŋku ɖe eŋu la, àte ŋu akpɔ ANCA siwo wotsɔ bla ɖe slide la ŋu ƒe nɔnɔme nyuie.

Nudokpɔƒea dea dzesi lãmenugbagbevi siawo be wonye cANCA (cytoplasmic pattern) alo pANCA (perinuclear pattern) le keklẽŋusẽ ƒe nɔnɔme tɔxɛ si wokpɔ le lãmenugbagbevi siawo me nu.

Nudokpɔƒe ate ŋu azã ANCA dodokpɔ ƒomevi ɖeka alo eve:

• `(Indirect immunofluorescence) (IIF)` : Ðeko dodokpɔ sia gblɔna na wò nenye be `(autoantibodies)` mawo le asiwò alo mele asiwò o. Eyae nye be, emetsonua nye `(positive)` alo `(negative)`.
• Enzyme-linked immunosorbent assay (ELISA) : Wozãa dodokpɔmɔnu sia tsɔ dea dzesi nusi tututu protein si woɖo taɖodzinu na (i.e. PR3 alo MPO) nye le neutrophils me.

Ðe dzadzraɖo tɔxɛ aɖe li si hiã hafi woawɔ ANCA dodokpɔa?

Zi geɖe la , dzadzraɖo tɔxɛ aɖeke mehiã na ANCA dodokpɔ o . Gake ɣeaɖewoɣi la, woate ŋu atsɔ ʋu ɖeka ado nu geɖe kpɔ. Le nɔnɔme mawo me la, dodokpɔ aɖewo ate ŋu abia be nàtsi nu adɔ gaƒoƒo 8 va ɖo 12, si fia be mele be nàɖu nu alo ano naneke o negbe tsi ko. Gake wò ɖɔkta ana mɔfiame tɔxɛwo wò le esia ŋu. Eyata mègatsi dzi ɖe eŋu o.

Nukae wòle be nàkpɔ mɔ na ne èle ANCA dodokpɔa wɔm?

Aɖabaƒoƒo ʋɛ aɖewo koe wòxɔna hafi woɖea wò ʋu. Zi geɖe la, wowɔa esia le ɔfis, atikewɔƒe, alo nudokpɔƒe. Alesi woɖea ʋuae nye esi:

• Gbã la, wotsɔa tourniquet alo ka blaa wò abɔta (le wò dɔgbo tame) sesĩe.
• Emegbe, wotsɔa dɔlékuiwutike kɔ ŋutigbalẽ si me woaɖe ʋua le la ŋu.
• Eyome wotsɔa aŋe dea ʋuka aɖe si te ɖe abɔta ŋu me. Le ɣeyiɣi sia me la , àte ŋu ase le ɖokuiwò me be yeƒe lãme le ʋuʋum alo yeƒe lãme le ʋuʋum vie . Esia sɔ.
• Wotsɔa mɔ̃ sue aɖe dea aŋea ŋu eye woƒoa ʋu agbɔsɔsɔme si hiã la nu ƒu.
• Emegbe, woɖea kaƒomɔ̃a kple aŋea, eye wotsɔa kotoku kakɛ aɖe léa teƒe si wotsɔ aŋea de la be ʋua natɔ te.
• Mlɔeba la, wotsɔa aŋetu sue aɖe (plaster) ƒoa teƒea.

Nukae dzɔna le ANCA dodokpɔa megbe?

Anɔ eme be wò ɖɔkta agblɔ na wò be nàna aŋea nanɔ eŋu gaƒoƒo ʋɛ aɖewo. Woate ŋu agblɔ na wò hã be nàƒo asa na kamedede sesẽ gaƒoƒo ʋɛ aɖewo le ʋudodo vɔ megbe. Ne menye ema o la, naneke mele etɔxɛ o.

Ðe afɔku aɖewo le esia (ANCA dodokpɔ) ŋua?

Ʋudodokpɔ le dedie ŋutɔ eye afɔku siwo le eme hã le sue ŋutɔ .

Àte ŋu akpɔ abi sue aɖe le afisi wotsɔ aŋea de. Zi geɖe la, esia nu ayi le eɖokui si le ŋkeke eve alo etɔ̃ megbe. Ƒã ŋutɔ la, ʋukaa ate ŋu avuvu vie. Ne edzɔ alea la, nutete siwo me dzo le ate ŋu akpe ɖe ŋuwò. Esia menye nusi ŋu woatsi dzi ɖo o.

Ɣeyiɣi didi kae wòxɔna hafi woxɔa ANCA dodokpɔa me tsonu?

ANCA dodokpɔa nye dodokpɔ tɔxɛ aɖe, eyata wowɔa esia le nudokpɔƒe tɔxɛ aɖe. Eyata ate ŋu axɔ tso ŋkeke ʋɛ aɖewo va ɖo kwasiɖa ɖeka hafi emetsonuwo nagatrɔ ava. Wò ɖɔkta ana nànya.

Nukae ANCA ƒe dodokpɔ me tsonuawo fia? Aleke mase egɔmee?

Esiae nye akpa vevitɔ kekeake. Wò ɖɔktae aƒo nu na wò tso ANCA dodokpɔa me tsonu kple alesi wokpɔa ŋusẽ ɖe wò lãmesẽ dzii ŋu.

• Ne emetsonuwo nye ``negative``: Esia anya fia be ``autoimmune vasculitis`` nɔnɔme si ŋu míeƒo nu tsoe va yi la mele ŋuwò o.
• Ne emetsonuwo nye ``nyui``: Ateŋu afia be ``autoimmune vasculitis`` le ŋuwò.

Ke hã, nu vevi aɖe li si gɔme wòle be míase le afisia. Ne èdo ANCA kpɔ be dɔlélea le ŋuwò la, mefia le eɖokui si be dɔlélea le ŋuwò o. Wò ɖɔkta ate ŋu abia be woawɔ dodokpɔ bubuwo , abe ʋumenugbagbeviɣidɔ (lãmenugbagbevi aɖe si woɖe hena dodokpɔ), alo ʋudodokpɔ bubuwo ene. Tsɔ kpe ɖe eŋu la, wonɔa te ɖe nu geɖe dzi dea dzesi dɔlélea, siwo dometɔ aɖewoe nye wò dzesiwo kple dodokpɔ bubuwo me tsonu.

Vevietɔ: ANCA dodokpɔa me tsonu nye dɔlélewo didi ƒe ɖoɖoa ƒe akpa ɖeka ko. Meɖea dɔléle aɖe fiana le eɖokui si o. Wò ɖɔkta abu esia ŋu kpe ɖe nu bubu geɖewo ŋu, abe wò dzesiwo, dodokpɔ bubuwo me tsonu, kple wò atikewɔwɔ ŋutinya ene.

Eyata nukae nye nu vevitɔ kekeake si dzi wòle be míaɖo ŋkui tso esia me?

``Antineutrophil Cytoplasmic Antibodies'', alo ``ANCA'' dodokpɔ, nye ʋudodokpɔ vevi aɖe si kpena ɖe ɖɔktawo ŋu wokpɔa ``autoimmune vasculitis'' ƒomevi aɖewo, nɔnɔme siwo me mía ŋutɔwo ƒe dɔlélenutsiŋutete dzea míaƒe ʋukawo dzi le.

Wò ɖɔkta aɖe nusita wòle be nàwɔ dodokpɔ sia kple nusi emetsonuwo afia na wò la me na wò. Eya ta, mègavɔ̃ alo ake ɖi o. Ne nya aɖe le asiwò alo mèse nane gɔme o la, bia wò ɖɔkta enumake. Anyo wu be nàna nànya ne èle nyametsotsowo wɔm tso wò lãmesẽnyawo ŋu.

` (ANCA dodokpɔ), ANCA dodokpɔ, ʋudodokpɔ, ʋukawo ƒe dɔléle, dɔlélenutsiŋutete ƒe dɔlélewo, dɔlékuiwutikewo, neutrophils, ʋukawo ƒe dɔdzẽ