Ðe wò ŋutilã wɔa insulin? Mina míakpɔe ɖa to C-peptide dodokpɔa dzi!

Ènya be dodokpɔ aɖe li si ate ŋu ana míanya nyatakaka vevi geɖe tso míaƒe ŋutilã ƒe ŋutete be wòawɔ lãmetsi aɖe si woyɔna be insulin ŋua? Woyɔa esia be C-peptide dodokpɔ. Ðewohĩ mèse dodokpɔ sia ŋkɔ kpɔ o. Gake ate ŋu anɔ vevie ŋutɔ na amesi ŋu suklidɔ le alo wòsusu be suklidɔ le ye ŋu. Mina míaƒo nu tso C-peptide dodokpɔa ŋu egbea, alo?

Nukae nye C-peptide? Nukatae wòle vevie na mí?

Kpuie ko la, C-peptide nye nu sue aɖe si míaƒe dɔgbo, ŋutinu si míeyɔna be ``Pancreas'' le Eŋlisigbe me, wɔna ne ewɔa lãmetsi si nye insulin. Ele abe nu sue aɖe si dona tso dɔwɔƒe aɖe ne wowɔ nu vevi aɖe ene. Eyata, míaƒe dɔgboe wɔa C-peptide kple insulin siaa le agbɔsɔsɔ ɖeka me.

Fifia ɖewohĩ èle biabiam be, "Ekema nukae nye insulin?" Insulin nye lãmetsi vevi aɖe ŋutɔ si kpɔa sukli alo sukli ƒe agbɔsɔsɔ si le míaƒe ʋu me dzi. Insulin ye kpena ɖe míaƒe ŋutilã ƒe lãmenugbagbeviwo ŋu be woazã sukli si míekpɔna ne míeɖu nu abe ŋusẽ ene.

Azɔ kpɔ ɖa, amesiwo ŋu suklidɔ Ƒomevi 1 le mate ŋu awɔ insulin kura o. Eyata ele be woado insulin ɖe gota. Gake amesiwo ŋu suklidɔ Ƒomevi 2 le wɔa insulin ya, gake agbɔsɔsɔa mesɔ gbɔ o, alo ŋutilã ƒe lãmenugbagbeviwo mewɔa nu ɖe ​​insulin ma ŋu nyuie o (míeyɔa esia hã be ``Insulin ƒe tsitretsitsi''). Ɣeaɖewoɣi la, suklidɔ Ha 2 lia hã ƒe insulin wɔwɔ dzi ɖena kpɔtɔna le ɣeyiɣi aɖe megbe eye wòhiãna be woano insulin le gota.

Esiae nye esime C-peptide dodokpɔa va le vevie. Elabena, ne ame aɖe no insulin tso gota gɔ̃ hã la, C-peptide meva kpe ɖe insulin ma ŋu o. Ne wowɔ insulin le ŋutilãa me ko hafi wowɔa C-peptide. Eyata, to dodokpɔ sia dzi la, míaƒe ɖɔktawo ate ŋu anya insulin agbɔsɔsɔme si tututu wowɔna le wò ŋutɔ wò ŋutilã me, le wò ŋutɔ wò dɔgbo me. Eyae nye be ate ŋu ade vovototo insulin si ŋutilãa wɔ (Endogenous insulin) kple insulin si wozãna abe atike ene (Exogenous insulin) dome.

Wogayɔa dodokpɔ sia be:

• Peptide insulin si do ƒome kple wo nɔewo
• Insulin C-peptide si wotsɔ wɔa dɔe
• Proinsulin C-peptide si wotsɔ wɔa dɔe

Aleke C-peptide ƒe agbɔsɔsɔ do ƒome kple suklidɔ?

Nu ɖeka si wòle be wòanɔ susu me na mí enye be C-peptide dodokpɔ ɖeɖe mate ŋu anyae kple kakaɖedzi ne suklidɔ le ame aɖe ŋu alo mele eŋu o. Ðeko wògblɔna na wò nenye be wò dɔgbo te ŋu wɔa eya ŋutɔ ƒe insulin alo mate ŋu awɔe o, alo agbɔsɔsɔme si wòzãna.

Be ɖɔkta nanya kakaɖedzitɔe ne suklidɔ le ŋuwò la, abia tso asiwò be nàwɔ suklidɔ dodokpɔ le ʋu me, alo A1c dodokpɔ, si dzidzea wò ʋumesukli ƒe agbɔsɔsɔ le mama dedie nu le ɣleti etɔ̃ siwo va yi me.

Eyata nukatae ɖɔktawo kafu C-peptide dodokpɔ sia?

Susu geɖe li siwo tae wò ɖɔkta ate ŋu aɖo aɖaŋu be nàwɔ C-peptide dodokpɔ. Mina míalé ŋku ɖe nusiwo wonye ŋu:

• Da suklidɔ ƒomevi si le ŋuwò ɖe hatsotsowo me: si fia be, kpɔe ɖa be enye ƒomevi 1 alo ƒomevi 2 (wowɔa esia kpe ɖe dodokpɔ bubuwo ŋu).
• Kpɔ egbɔ be wò suklidɔtikea le dɔ wɔm nyuie.
• Kpɔe ɖa be wò ŋutilã wɔa insulin si sɔ, alo nenye be èhiã insulin dodo alo insulin pɔmpi.
• Di nusiwo gbɔ suklidɔ ƒe agbɔsɔsɔ si medea ame dzi o tsona: Míeyɔa esia be suklidɔ ƒe ɖiɖi.
• Se vovototo si le insulin si wodona le ememe kple insulin si wodona le gota dome gɔme.
• Ƒã ŋutɔ hafi esia ate ŋu akpe ɖe ame ŋu hã be woana nyatakaka aɖewo tso dɔdzẽ si le dɔgboa me ŋu.

Amekae doa C-peptide dodokpɔ sia kpɔna? Aleke wowɔnɛ?

Zi geɖe la, wò dɔnɔdzikpɔla gbãtɔ alo lãmenugbagbeviwo ƒe dɔwɔwɔ ŋuti nunyala aɖo aɖaŋu be nàwɔ C-peptide dodokpɔ. Zi geɖe la, dɔnɔdzikpɔla alo dodokpɔxɔ ƒe mɔ̃ɖaŋudɔwɔlae wɔa dodokpɔ sia.

Zi geɖe la, wodzidzea C-peptide to ʋuɖeɖe me . Le ɖɔkta ƒe dɔwɔƒe, atikewɔƒe, alo dodokpɔxɔ me la, dɔnɔdzikpɔla aɖe atsɔ aŋe tsɛ aɖe ade ʋuka aɖe me le wò alɔnu eye wòaƒo ʋu sue aɖe nu ƒu ɖe mɔ̃ aɖe me. Àte ŋu ase veve vie ne wotsɔ aŋea de eme, gake mevɔ̃ɖi akpa o.

Ɣeaɖewoɣi la, woate ŋu atsɔ aɖuɖɔtoe awɔ dodokpɔ sia . Gake ne èwɔe nenema la, ele be nàƒo wò aɖuɖɔ katã nu ƒu le gaƒoƒo 24 me. Ne ele alea la, wò ɖɔkta ana nugoe aɖe wò na wò eye wòana mɔfiame wò ku ɖe alesi nàƒoe nu ƒu ahagbugbɔe ana ŋu. Ðewohĩ ahiã be nàtsɔ nugoe la ade teƒe si fa miamiamia, abe fridzi ene. Gake menye ɣesiaɣie ɖɔktawo wɔa aɖuɖɔ dodokpɔ sia o.

Ðe wòhiã be matsi nu adɔ hafi C-peptide dodokpɔ sia?

Ẽ, ne wole ʋudodokpɔ sia wɔm na wò la, woate ŋu abia tso asiwò be nàtsi nu adɔ gaƒoƒo 8 va ɖo 12 (tsi ko nyo) . Míeyɔa esia be ``Nutsitsidɔ``. Gake ɣeaɖewoɣi la, wò ɖɔkta ate ŋu adi hã be yealé ŋku ɖe wò C-peptide ƒe agbɔsɔsɔ ŋu ne èɖu nane vɔ eye wò dɔgboa do ŋusẽ vɔ. Zi geɖe la, woléa ŋku ɖe sukli ƒe agbɔsɔsɔ si le ʋu me hã ŋu kpe ɖe C-peptide ƒe agbɔsɔsɔ ŋu.

Azɔ hã, wò ɖɔkta ate ŋu abia tso asiwò be nàdzudzɔ atike aɖewo nono hena ɣeyiɣi aɖe. Eyata anyo wu be nàbia wò ɖɔkta nusi tututu wòle be nàwɔ hafi adoe kpɔ.

Ðe afɔku aɖewo le dodokpɔ sia mea?

Le nyateƒe me la, afɔku boo aɖeke mele ʋudodokpɔ me o. Afɔku aɖeke si wonya mele aɖuɖɔ dodokpɔwo me o. Eyata susu aɖeke meli si ta wòle be míavɔ̃ o.

Ɣeyiɣi didi kae wòxɔna hafi wokpɔa C-peptide dodokpɔa me tsonu?

Dodokpɔ sia me tsonu, si nye nyatakakaa, ate ŋu axɔ tso ŋkeke ɖeka va ɖo atɔ̃ hafi woaɖo. Esia ate ŋu ato vovo le ɖɔkta kple dodokpɔxɔa nu.

Nukae nye asixɔxɔ si sɔ si le C-peptide dodokpɔ ŋu?

Zi geɖe la, wobua didime si le lãmesẽ me na C-peptide dodokpɔ be enye 0.5 ng/mL va ɖo 2.0 ng/mL (alo 0.17 va ɖo 0.83 nmol/L) . Ke hã, nenɔ susu me na wò be asixɔxɔ siawo ate ŋu ato vovo vie tso dodokpɔxɔ ɖeka me yi bubu gbɔ, eyata ele vevie be nàtsɔ wò dɔwɔwɔ me tsonu asɔ kple agbɔsɔsɔ si sɔ le wò nyatakakaa me.

Nukae C-peptide dodokpɔa me tsonu fia?

Enyo, azɔ mina míakpɔ nusi asixɔxɔ siwo le dodokpɔ ŋuti nyatakaka sia me gblɔ.

Ne C-peptide ƒe agbɔsɔsɔ le sue (Low C-peptide) .

Ne wogblɔ be wò C-peptide ƒe agbɔsɔsɔ le sue la, ke susu geɖe ate ŋu anɔ eme:

• Ne sukli ƒe agbɔsɔsɔ le ʋu me dzi ɖe kpɔtɔ eye mèɖu nu nyitsɔ laa o la, ate ŋu asɔ be C-peptide naɖiɖi.
• Gake ate ŋu afia hã be wò ŋutilã mele insulin si sɔ wɔm o .
• Alo, ne èdo insulin ɖe gota la, C-peptide ate ŋu aɖiɖi (elabena C-peptide meva kpe ɖe insulin si wodo ɖe gota ŋu o).
• Nɔnɔme sia, vevietɔ ne sukli sɔ gbɔ ɖe wò ʋu me la, ate ŋu ado ƒome kple atikewɔwɔ me nɔnɔme siwo gbɔna:
• Suklidɔ ƒomevi 1 : Esia le alea elabena ame siawo ƒe dɔgbo mewɔa insulin o.
• Suklidɔ ƒomevi 2 : Esia dzɔna ne dɔgboa mete ŋu wɔa insulin kura o.

Nu bubu si woate ŋu agblɔ tso C-peptide ƒe agbɔsɔsɔ si bɔbɔ ŋue nye be suklidɔ dada mele dɔ wɔm nyuie o .

Nɔnɔme bubuwo li siwo me C-peptide ƒe agbɔsɔsɔ hã dzi ɖena kpɔtɔna ne sukli ƒe agbɔsɔsɔ le ʋu me dzi ɖe kpɔtɔ:

• Addison ƒe dɔléle : Esia nye nɔnɔme si me wò adrenal glands mewɔa lãmetsi siwo nye cortisol kple aldosterone wòde edeƒe o. Zi geɖe la, esia wɔnɛ be sukli si le ʋu me dzi ɖena kpɔtɔna.
• Aklãdɔléle .
• Insulin nana tso egodo (dodo/gbɔgbɔ) `(Exogenous insulin)` .

C-peptide ƒe agbɔsɔsɔ si sɔ gbɔ

Azɔ mina míakpɔ nusi adzɔ ne nyatakakaa ɖee fia be wò C-peptide ƒe agbɔsɔsɔ sɔ gbɔ wu alesi wòle dzɔdzɔmee. Esia ate ŋu afia be wò ŋutilã le insulin wɔm fũ akpa . Nɔnɔme siwo ate ŋu ahe esia vɛ dometɔ aɖewoe nye esi:

• Cushing ƒe dɔlélea: Esia nye ne wò ŋutilã wɔa lãmetsi si nye cortisol fũ akpa.
• Insulin ƒe dɔlélenutsiŋutete : Le esia me la, togbɔ be insulin le ŋutilãa me hã la, lãmenugbagbeviwo mewɔa nu ɖe ​​eŋu nyuie o. Eyata ŋutilãa wɔa insulin geɖe wu.
• Potassium ƒe agbɔsɔsɔ si bɔbɔ ɖe ʋu me (Hypokalemia) .
• Suklidɔ ƒomevi 2 : Esia ate ŋu adzɔ, vevietɔ le eƒe gɔmedzedze, ne ŋutilãa dze agbagba be yeawɔ insulin geɖe.
• Dɔdzẽ si le dɔgboa me : Le kpɔɖeŋu me, insulinoma.
• Ayikuwo ƒe dɔmawɔmawɔ nyuie : Esi wònye be woɖea C-peptide ɖa le ŋutilãa me to ayikuwo dzi ta la, ne ayikuawo mele dɔ wɔm nyuie o la, C-peptide ƒe agbɔsɔsɔ le ʋua me ate ŋu adzi ɖe edzi.

Vevietɔ: Ne C-peptide dodokpɔa ɖee fia be C-peptide aɖeke mele eme kura o la, efia be ahiã godoo be nàno insulin le gota. Woate ŋu awɔ esia to insulin dodo alo insulin pɔmpi dzi.

Gbedasi si Wotsɔ Yi Aƒeme

Enyo, eyata mele mɔ kpɔm be fifia èse C-peptide dodokpɔ si ŋu míeƒo nu tsoe la gɔme nyuie wu.

• C-peptide nye nane si dzidzea insulin agbɔsɔsɔme si míaƒe ŋutilã wɔna.
• Esia kpena ɖe ame ŋu wòdea vovototo suklidɔ ƒomevi 1 kple ƒomevi 2 dome .
• Wozãnɛ hã tsɔ kpɔa alesi suklidɔ dadawo wɔa dɔe .
• Esia kpena ɖe ame ŋu hã be woanya atikewɔwɔ me nɔnɔme bubu aɖewo .

Ne wò ɖɔkta bia tso asiwò be nàwɔ C-peptide dodokpɔ sia la, kpɔ egbɔ be yebiae nusi tututu wòle be nàwɔ kple nusi màwɔ o hafi nàdoe kpɔ. Mègavɔ̃ naneke o, dodokpɔ bɔbɔe aɖe koe nye esia si naa nyatakaka veviwo tso wò lãmesẽ ŋu. Nu vevitɔe nye be nàƒo nu tso nusianu ŋu na wò ɖɔkta ahabia wò nyawo.

` C-peptide, suklidɔ, insulin, dɔgbo, ʋudodokpɔ, lãmetsiŋusẽ, lãmesẽ