Ède dzesii kpɔ be ɖeɖi tea viwòa ŋu ɣesiaɣi eye wòbiãna ŋutɔa? Ɣeaɖewoɣi la, míesusuna be alea tututue wòle le ɖevi suewo gome, gake ɖewohĩ susu aɖe le megbe nɛ si míenya o. Egbea míele nu ƒom tso ʋu ƒe nɔnɔme si mebɔ o, gake wòle vevie ŋutɔ be woanya alea ŋu. Woyɔa esia be Diamond-Blackfan Anemia (DBA).
Kpuie ko la, nukae nye Diamond-Blackfan Anemia (DBA)?
Esia nye ʋumedɔ si mebɔ kura o. Kpuie ko la, nusi dzɔnae nye be míaƒe ƒumeŋuɖui mete ŋu wɔa ʋumenugbagbevi dzĩ siwo sɔ o. Ènyaa, ʋumenugbagbevi dzĩ siawoe tsɔa ɔksidzin yia míaƒe ŋutilã katã me. Eyata ne womesɔ gbɔ o la, ekpɔa ŋusẽ gã aɖe ɖe ŋutilã ƒe dɔwɔwɔ dzi.
DBA nye domenyiŋusẽfianu ƒe dɔléle . Esia fia be domenyiŋusẽfianu ƒe tɔtrɔ gbɔe nɔnɔmea tsona. Domenyiŋusẽfianu ƒe tɔtrɔ siawoe afia alesi gbegbe dzesiawo nu sẽe. Edzea vidzĩ siwo ade ɖeka le 500,000 ɖesiaɖe me le xexeame katã. Togbɔ be enye dɔléle si nɔa ame ƒe agbemeŋkekewo katã me hã la, ne wozã atike nyuitɔ la, woate ŋu aɖu dzesiawo dzi eye woate ŋu anɔ agbe nyui .
Nukae nye dɔléle sia ƒe dzesiwo?
Ʋusɔgbɔdɔ le amesiame kloe si ŋu DBA le ŋu. Ema fia be ʋu ƒe anyimanɔmanɔ. Dzesiawo ate ŋu asẽ ŋutɔ na ame aɖewo, eye woate ŋu asẽ ŋutɔ na ame bubuwo. Mina míalé ŋku ɖe dzesi vevi siwo woate ŋu akpɔ ŋu.
| Dzesi si dzena | Numeɖeɖe bɔbɔe aɖe |
|---|---|
| Ɖeɖiteameŋu | Esi wònye be ŋutilã mexɔa oxygen agbɔsɔsɔme si hiã o ta la, zi geɖe la, alɔ̃ le wuwòm eye ɖeɖi tea ŋuwò akpa be yeate ŋu awɔ naneke o. |
| Ŋutilã ƒe blɔ (Pallor) . | Vevietɔ asibidɛwo, nuyiwo, kple ŋku te ƒe akpawo dzena abe ɖe wole ɣie ene. Esia tso ʋumenugbagbevi dzĩwo ƒe anyimanɔmanɔ gbɔ, si wɔnɛ be ʋua ƒe amadede dzĩ dzi ɖena kpɔtɔna. |
| Dzi ƒe tsotso kabakaba (Tachycardia) . | Ne ɔksidzin mesu ŋutilãa ƒe lãkusiwo si o la, ele be dzia nawɔ dɔ sesĩe wu be wòaɖo esi mesɔ gbɔ o la teƒe. Esia wɔnɛ be dzia ʋãna kabakaba. |
| Yagbɔgbɔ sesẽ | Eva sesẽna be woagbɔ ya ɣeaɖewoɣi, abe ne wole azɔli zɔm kpuie alo le atrakpui aɖe liam ene. |
| Nuɖuɖudzroame kple gbɔdzɔgbɔdzɔ | Àte ŋu ade dzesii hã be nuɖuɖu megadzroa wò o eye wò gbɔdzɔ. |
| Taɖuame kple abɔ kple afɔwo ƒe vuvu | Ame aɖewo hã ate ŋu akpɔ dzesiwo abe taɖuame kple abɔ kple afɔwo ƒe vuvu ene. |
Nukatae esia le dzɔdzɔm?
Tsɔe be agbalẽ aɖe li si me mɔfiamewo le ku ɖe nusianu si le míaƒe ŋutilã me, si woyɔna be míaƒe domenyiŋusẽfianu ŋu. Domenyiŋusẽfianu ƒomevi aɖe li si naa mɔfiamewo le ʋumenugbagbevi dzĩwo wɔwɔ ŋu si woyɔna be ``ribosomal protein genes.`` DBA dzɔna ne tɔtrɔ le domenyiŋusẽfianu mawo me. Emegbe ʋumenugbagbevi dzĩwo wɔwɔ ƒe ɖoɖoa medzɔna nyuie o.
Ame siwo ŋu DBA le ƒe 10% va ɖo 25% nyia dome tso wo dzilawo gbɔ. Gake zi geɖe la, enyea dɔléle si dzea egɔme yeyee si medze ƒomea me tɔ aɖeke kpɔ o .
Ðe esia ate ŋu ahe kuxi bubuwo vɛa?
Ẽ, DBA hea lãmesẽkuxi bubu geɖe ƒe afɔku vɛ.
Nu vevitɔe nye be menye nusiawo katã dzɔna ɖe amesiame dzi o. Gake ele vevie ŋutɔ be nànya esia eye nànɔ kadodo me kple wò ɖɔkta.
| Kuxi siwo ate ŋu ado mo ɖa | Nukae ema fia? |
|---|---|
| Vidzidzi ƒe gbɔdzɔgbɔdzɔwo | Ate ŋu adzɔ be woadzii kple kuxi aɖewo le dzi, ayiku, alo abɔ kple afɔwo ŋu. |
| Tsitsi ƒe ʋuʋu | Ðevia ƒe tsitsi ate ŋu ahe ɖe megbe le woƒe ƒexɔxɔ ta. |
| Gayibɔ ƒe agba si gbɔ eme | Ʋudodo enuenu ate ŋu ana iron ƒe agbɔsɔsɔ si le ŋutilãa me nadzi ɖe edzi madzemadzee. |
| Ʋumenugbagbevi bubuwo dzi ɖeɖe kpɔtɔ | Nɔnɔmewo abe ʋumenugbagbevi dzĩwo ƒe ɖiɖi, ʋumenugbagbevi ɣi ƒomevi aɖe, (Neutropenia), ʋumenugbagbevi dzĩwo ƒe ɖiɖi (Thrombocytopenia), alo lãmenugbagbevi ƒomevi ɖesiaɖe si le ʋua me ƒe ɖiɖi (Pancytopenia) ate ŋu ado mo ɖa. |
| Mina míanya afɔku si le kansa xɔxɔ me hã. | |
Amesiwo ŋu DBA le ate ŋu axɔ kansa ƒomevi aɖewo vie wu amehawo katã. Esiawo dometɔ aɖewoe nye:
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Aleke ɖɔktawo wɔna kpɔa esia?
Ne wò ɖɔkta bu fɔ dɔléle sia la, woawɔ dodokpɔ geɖe atsɔ aɖo kpe edzi.
- Ʋu Xexlẽme Blibo (CBC): Esia léa ŋku ɖe ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, ʋumenugbagbevi dzĩwo, kple hemoglobin (hemoglobin) ƒe xexlẽme si le ʋua me ŋu. Le DBA me la, ʋumenugbagbevi dzĩwo kple hemoglobin ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna ŋutɔ.
- Reticulocyte Xexlẽme: Reticulocyte nye ʋumenugbagbevi dzĩ siwo metsi o yeyee. Esiawo ƒe xexlẽme si mede o fia be kuxi aɖe le ƒumeŋuɖui si wɔa ʋumenugbagbevi dzĩwo ŋu.
- Bone Marrow Aspiration and Biopsy: Esia bia be woaɖe ƒumeŋuɖui sue aɖe atsɔ adoe kpɔ le nusuekpɔmɔ̃ me. Esia ate ŋu akpe ɖe ame ŋu wòanya ne ʋumenugbagbevi dzĩwo ƒe wɔwɔ dzi ɖe kpɔtɔ.
Nukawoe nye atikewɔmɔnuawo?
Atikewɔwɔmɔnu vovovowo li na DBA. Ðɔktaa anɔ te ɖe dɔnɔa ƒe nɔnɔme dzi atso nya me le atikewɔwɔ si sɔ wu ŋu.
1. Corticosteroids: Esiawo nye atike siwo nye steroid ƒomevi. Atike siawo doa ŋusẽ ƒumeŋuɖui eye wodzia ʋumenugbagbevi dzĩwo wɔwɔ ɖe edzi. Zi geɖe la, wokpɔa emetsonuwo le kwasiɖa eve va ɖo ene me.
2. Ʋudodo: Kpuie ko la, ʋudodo. Ʋumenugbagbevi dzĩwo nana dɔnɔa tso amesiwo doe gbɔ ate ŋu ana ʋumenugbagbevi dzĩwo ƒe xexlẽme nagaɖo ŋutilãa me kaba. Esia nye atikewɔwɔ si wodzea egɔme zi geɖe ne wonya kpɔ dɔlélea ko.
3. Lãmenugbagbeviwo Dodo Ðe Ame Ŋu: Esia koe nye mɔ si dzi woato ada dɔléle sia keŋkeŋ . Gake esia nye atikewɔwɔ si sesẽ vie, si me afɔku le, eye ate ŋu ade ame ƒe agbe afɔku me. Eyata ɖɔktawo bua dɔnɔ ɖesiaɖe ŋu ɖekaɖeka eye ne ehiã vevie ko hafi wowɔa atike sia ŋudɔ.
Nukae adzɔ le etsɔme? Ke agbenɔƒe ya ɖe?
Ne wowɔ atike na DBA dɔnɔwo nyuie eye atikewɔlawo kpɔ wo dzi edziedzi la, woate ŋu anɔ agbe nyui. Ke hã, esia nye nɔnɔme si hiã beléle na ame le eƒe agbemeŋkekewo katã me. Le ƒe 25 xɔxɔ megbe la, kuxi sesẽwo ƒe afɔkua ate ŋu adzi ɖe edzi vie.
Le agbenɔƒe si wokpɔ mɔ na gome la, etoa vovo tso ame ɖeka gbɔ yi bubu gbɔ. Enɔ te ɖe dzesiawo ƒe sesẽ kple alesi wowɔa nui ɖe atikewɔwɔ ŋu dzi. Numekukuwo ɖee fia be ne wowɔ atike na dɔnɔwo la, dɔnɔ siwo ade 75% nɔa agbe vaseɖe ƒe 50 . Gake esi wònye be esia nye dɔléle si mebɔ kura o ta la, nyatakakawo mesɔ gbɔ o. Wò ɖɔkta koe ate ŋu ana nyatakaka siwo de pɛpɛpɛ wu tso wò nɔnɔmea ŋu.
Ɣekaɣie wòle be makpɔ ɖɔkta?
Ne DBA le ŋuwò alo viwòa ŋu la, ele vevie be nànɔ kadodo me kple wò ɖɔkta edziedzi. Mègato wò atikewɔƒe ƒe ɣeyiɣi siwo nèɖo ɖi la ŋu gbeɖe o.
Azɔ hã, ne èse le ɖokuiwò me be yeƒe dzesiwo le sesẽm ɖe edzi, le kpɔɖeŋu me, ne ɖeɖi te ye ŋu zi ɖeka alo ne dɔlékuiwo va le ye ŋu enuenu , gblɔe na wò ɖɔkta enumake.
Nukae woawɔ ne nɔnɔme kpata aɖe dzɔ?
Ne dzesi siwo gbɔna dometɔ aɖe do mo ɖa la, yi kɔdzi ƒe Dɔwɔƒe si Kpɔa Nudzɔdzɔ Kpatawo Gbɔ (ETU) si te ɖe ŋuwò enumake.
- Akɔtave
- Dɔgbo ƒe vevesese sesẽ
- Taɖuame sesẽ kpata alo ame ƒe susu ƒe dɔwɔwɔ (ate ŋu anye ʋusɔgbɔdɔ ƒe dzesiwo) .
- Ʋu si dona le ame ŋu si dzi womate ŋu aɖu o
Agbenɔnɔ kple agbemedɔléle abe DBA ene, si ŋu ame geɖe mese kpɔ o, mele bɔbɔe o. Ate ŋu agbɔ eme vevietɔ ne ekpɔ ŋusẽ ɖe viwòa dzi. Ðewohĩ àse le ɖokuiwò me be yetsi akogo. Gake ɖo ŋku edzi be menye wò ɖeka koe o. Wò ɖɔkta kple atikewɔha ana kpekpeɖeŋu, aɖaŋuɖoɖo, kple atikewɔwɔ ƒe ɖoɖo si nèhiã la wò.
Gbedasi si Wotsɔ Yi Aƒeme
- Diamond-Blackfan anemia (DBA) nye dɔléle si mebɔ o, si tso domenyiŋusẽfianu me, si gblẽa nu le ʋumenugbagbevi dzĩwo ƒe wɔwɔme le ƒumeŋuɖui me ŋu.
- Dzesi vevitɔwoe nye be eƒe ŋutigbalẽ biã le ʋusɔgbɔdɔ ta, ɖeɖiteameŋu enuenu, kple gbɔgbɔtsixe tsia ame ƒo.
- Woate ŋu aɖu dzesiawo dzi nyuie to steroid-tikewo kple ʋudodo me. Togbɔ be wodoa lãmenugbagbeviwo na ame be wòada gbe le ame ŋu keŋkeŋ hã la, enye atikewɔwɔ si me afɔku le.
- Esi wònye be esia nye ame ƒe agbemeŋkekewo katã ƒe nɔnɔme ta la, ele vevie ŋutɔ be woanɔ ŋku lém ɖe ame ŋu le atikewɔƒewo edziedzi ahawɔ atike nɛ nyuie.
- Ne dɔlélea ƒe dzesiwo alo nyabiase aɖewo le mia alo viwòa ŋu la, mègahe ɖe megbe gbeɖe le nuƒoƒo kple wò ɖɔkta me o.
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