Ðe nènya nu tso Medullary Thyroid Cancer (MTC), si nye lãkusi me dɔdzẽ ƒomevi aɖe ŋua?

Ðewohĩ èse lãkusi si le abe kpakpaluʋui ene si le wò kɔ ƒe ŋgɔgbe la ŋu nya kpɔ. Ɣeaɖewoɣi la, àte ŋu ase ƒunukpeƒetetedɔ sue aɖe le lãkusi sia me. Alo ɖɔkta ate ŋu akpɔe ne èle wò dom kpɔ. Togbɔ be zi geɖe la, afɔku mele ƒunukpeƒe sia me o hã la, le go siwo mebɔ o me la, ate ŋu anye kansa ƒe dzesi. Egbea la, míaƒo nu tso kansa ƒomevi tɔxɛ aɖe si dzɔna le lãkusi me ŋu, gake mebɔ vie o.

Nukae nye lãkusi me dɔdzẽ (MTC)?

Kpuie ko la, Medullary Thyroid Cancer (MTC) nye kansa si dona le wò lãkusi me. Woyɔa lãkusi sia ƒe akpa si le eme be ‘medulla’ . Lãmenugbagbevi ƒomevi tɔxɛ aɖe le lãkusi sia me, si woyɔna be ‘parafollicular C cells’ . C lãmenugbagbevi siawo wɔa lãmetsi si nye ‘calcitonin’ . Eyata ne C lãmenugbagbevi siawo dze tsitsi gɔme le mɔ si dzi womate ŋu aɖu o nu la, MTC dzɔna. Bu eŋu abe numiemie siwo mèdi o le abɔ me siwo kaka ɖe afisiafi dzi maɖumaɖue ene.

Enye nusi sɔ be nyabiase kple vɔvɔ̃ geɖe nanɔ asiwò ne èse kansa ŋu nya, vevietɔ ne enye kansa ƒomevi si mebɔ o. Gake ɖo ŋku edzi be wò atikewɔlawo ƒe ƒuƒoƒoa le kpli wò le mɔzɔzɔ sia me. Mɔ vovovo geɖewo li siwo dzi woato ada MTC.

Aleke gbegbee medullary thyroid cancer (MTC) bɔe?

Fifia ɖewohĩ ànɔ eŋu bum be, "Oo, ɖe esia nye dɔléle si ame sia ame xɔnaa?" Mega tsi dzi o. Thyroid cancer bɔ ŋutɔ. Gake ƒomevi si ŋu míele nu ƒom tsoe , si nye medullary thyroid cancer (MTC) , mebɔ kura o . Le dukɔ abe United States ene gɔ̃ hã me la, lãkusi me dɔdzẽ siwo katã ŋu woka nya ta le la dometɔ 4% va ɖo 10% koe wokpɔna be MTC. Ema fia be ame siwo ade 1,000 koe wokpɔna be MTC le afima ƒe sia ƒe. Eyata le Sri Lanka la, xexlẽme sia ate ŋu aɖiɖi wu gɔ̃ hã.

Nukae nye medullary thyroid cancer (MTC) ƒe dzesiwo?

Enyo, eyata nukawoe nye MTC ƒe dzesiwo? Menye amesiamee kpɔa dzesi ɖeka ma ke o. Gake ɖewo li siwo bɔ:

• Woate ŋu akpɔ ƒunukpeƒetetedɔ (nodule) aɖe si le wò lãkusi ƒe tame . Esia nye dzesi vevitɔ si dzena le ame 75% va ɖo 95% me ne wokpɔ dɔlélea le wo ŋu. Ate ŋu ase le eɖokui me abe ƒu sue aɖe ene, eye woate ŋu akpɔe ɣeaɖewoɣi ne èlé ŋku ɖe wò kɔ ƒe ŋgɔgbe ŋu.
• Lãmetsiŋusẽ ƒe ʋuka siwo vuvu le kɔ me . Esia hã dzena le ame siwo ade 70% me le dɔlélea didi me. Woate ŋu ase esiawo abe ƒunukpeƒe suesuesuewo ene le kɔa ƒe akpa eveawo.

Gake ƒã ŋutɔ be ne thyroid nodule la lolo la, dzesi siwo gbɔna ate ŋu ado mo ɖa:

• Gbe trɔna, gbeɖiɖi ƒe ɖiɖi.
• Nuɖuɖu mimi sesẽ.
• Yagbɔgbɔ sesẽ.

Nu vevitɔe nye be MTC ate ŋu anɔ ame aɖewo ŋu gake womaɖe dzesi aɖeke afia o ɣeyiɣi didi aɖe. Esia le alea elabena kansa le dɔdzẽa ŋu.Ele sue ŋutɔ. Eyata ne ède dzesi nane si mebɔ o le wò kɔ ŋu la, ele vevie ŋutɔ be nàlé ŋku ɖe eŋu.

Nukatae medullary thyroid cancer (MTC) dzea ame dzi?

Azɔ mina míalé ŋku ɖe nusita MTC sia dzɔna ŋu. Susu geɖewo tae wòle alea ɖo. Vevietɔ la, mɔ eve li siwo dzi MTC tona dzɔna.

MTC si dzɔna ɣeaɖewoɣi

MTC dɔnɔ siwo ade 75% (anɔ abe etɔ̃ le ene ɖesiaɖe me) xɔa nɔnɔmea ɣeaɖewoɣi . Esia fia be MTC menɔ woƒe ƒomea me kpɔ o. Edzɔna ƒome ŋutinya aɖeke manɔmee. Dzɔdzɔmeŋutinunyalawo mekpɔ nusi tututu gbɔ MTC sia si yia edzi ɣeaɖewoɣi tsona haɖe o. Ke hã, ame siwo xɔa MTC le mɔ sia nu ƒe 40% va ɖo 50% ƒe domenyiŋusẽfianu ƒe tɔtrɔ le domenyiŋusẽfianu si woyɔna be ``(RET)`` me . Esia menye nane si wodzi wo kplii o, ke boŋ enye domenyiŋusẽfianu ƒe dɔmawɔmawɔ nyuie si va doa mo ɖa le woƒe tsitsime.

MTC tso dzidzime yi dzidzime

Le go bubu me la, MTC dɔnɔ siwo ade 25% (anɔ abe ɖeka le ene ɖesiaɖe me) ate ŋu akpɔ dɔléle aɖe si ƒe dome wonyi si woyɔna be ‘Multiple Endocrine Neoplasia type 2’ (MEN2) . 'MEN2' ƒe hatsotso sue geɖewo li:

• `(MEN2A)`: Afɔku gã ŋutɔ le amesiwo ŋu dɔléle sia le be woaxɔ MTC (anɔ abe 90%) .
• `(MEN2B)`: `(MEN2B)` ƒe nya aɖewo nye domenyiŋusẽfianu. Gake le go geɖe me la, esia menɔa alea o. Ame siwo ŋu `(MEN2B)` le la ƒe mɔnukpɔkpɔ 100% be woaxɔ MTC le woƒe ɖevime ŋutɔ .

`(MEN2B)` sia ƒe ƒomevi sue bubu aɖe hã li, si woyɔna be `Ƒome ƒe Medullary Thyroid Cancer (FMTC) . Ame siwo ŋu `(FMTC)` le la ƒe domenyiŋusẽfianu ƒe tɔtrɔ `(RET)` le wo si, gake MTC koe woxɔna (eye menye kansa ƒomevi bubuwo o).

Bu eŋu kpɔ, ne wokpɔe be domenyiŋusẽfianu ƒe tɔtrɔ sia si nye ``(RET)`` le wò ƒomea me la, àte ŋu aƒo asa na afɔku gã aɖe to ʋumenugbagbeviɣidɔa ɖeɖeɖa to mɔxexeɖedɔléle nu ƒe dɔwɔwɔ me hafi kansa nadze egɔme.

Aleke wokpɔa dɔdzẽ si le lãkusi me (MTC) dzea sii?

Zi geɖe la, MTC dzena gbã abe ƒunukpeƒetetedɔ ene le lãkusi me. Àte ŋu ase le ɖokuiwò me, alo wò ɖɔkta ate ŋu akpɔe ne èse wò kɔ le dodokpɔ si wowɔna edziedzi me. Ɣeaɖewoɣi la, wokpɔa ƒunukpeƒea le vo me le nɔnɔmetatawo dodokpɔ si wowɔ le susu bubu aɖe ta me.

Ne wò ɖɔkta susui be MTC le ŋuwò la, anɔ eme be woaɖe gbe be woawɔ dodokpɔ siawo:

• Nɔnɔmetatawo dodokpɔ: Esiawo ate ŋu akpe ɖe ame ŋu wòakpɔ ʋumenugbagbeviɣidɔa nyuie. Le kpɔɖeŋu me , thyroid ultrasound , CT scan , kple/alo MRI.Àte ŋu awɔ dodokpɔwo abe esia ene. Abe alesi ko wotsɔa fotoɖemɔ̃ ɖea fotoe ene la, mɔ̃ siawo te ŋu kpɔa nusiwo le ŋutilãa me nyuie.
• Fine needle aspiration (needle biopsy): Anɔ eme be wò ɖɔkta aɖo aɖaŋu be nàɖe lãkusi sue aɖe (biopsy) tso wò thyroid nodule me. Esia bia be woazã aŋe si le sue ŋutɔ. Ewɔna nam abe aŋe sue aɖe si wotsɔ ƒoe ene. Emegbe wodoa lãmenugbagbeviwo ƒe kpɔɖeŋu sia kpɔ le nusuekpɔmɔ̃ me be woakpɔe ɖa be kansadɔlékui aɖewo li hã.
• Ʋudodokpɔ: Esiawo ate ŋu anye dodokpɔ siwo me woadzidze nusiwo le wò ʋu me siwo woyɔna be calcitonin kple carcinoembryonic antigen (CEA) . Zi geɖe la, agbɔsɔsɔ siawo dzina ɖe edzi le amesiwo ŋu MTC le me.

Wò ɖɔkta ateŋu aɖo aɖaŋu hã be nàdo domenyiŋusẽfianu kpɔ akpɔe ɖa be domenyiŋusẽfianu ƒe nɔnɔme aɖe si woyɔna be ``MEN2'' le ŋuwò hã. Ne nenemae la, woate ŋu aɖo aɖaŋu be woado domenyiŋusẽfianu kpɔ na ʋumetɔ bubuwo, elabena esia ate ŋu akpe ɖe ame ŋu wòanya nenye be wole afɔku me.

Nukawoe nye atike siwo wozãna na medullary thyroid cancer (MTC)?

Enyo, azɔ mina míakpɔ atike siwo li na MTC ɖa.

MTC ƒe atikewɔwɔ vevitɔe nye amekoko be woaɖe wò lãkusi bliboa ɖa (total thyroidectomy) . Togbɔ be esia adze abe amekoko gã aɖe ene hã la, eyae nye mɔ nyuitɔ si dzi woato ada kansa sia.

• Lãmetsiŋusẽ ƒe ʋukawo ɖeɖeɖa: Ne ʋumenugbagbeviɣidɔ kaka (kaka) ɖe ʋuka siwo le wò kɔ me la, anɔ eme be amekolaa aɖe wo hã ɖa.
• Lãmetsiŋusẽtike: Le amekoko megbe la, ahiã be nàno atike siwo woatsɔ aɖɔli thyroid hormone le wò agbemeŋkekewo katã me. Esi wònye be lãmetsiŋusẽ siwo thyroid gland wɔna la le vevie na ŋutilãa ta la, ehiã be woana wo le gota le atikekuiwo ƒe nɔnɔme me.

Tsɔ kpe ɖe amekoko ŋu la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàwɔ atike bubuwo, siwo dometɔ aɖewoe nye:

• Kekeli ƒe atikewɔwɔ: Mɔnu si dzi woato atsrɔ̃ kansa lãmenugbagbeviwo to keklẽŋusẽ si me ŋusẽ geɖe le zazã me.
• Chemotherapy: Mɔnu si wozãna tsɔ wua kansa lãmenugbagbeviwo.
• Atikewɔwɔ siwo ŋu woɖo taɖodzinu ɖo: Le MTC ƒe nɔnɔme aɖewo me la, wozãa atike tɔxɛ siwo ku ɖe DNA ƒe tɔtrɔwo ko ŋu. Kpɔɖeŋu aɖewoe nye vandetanib kple cabozantinib .

Ne èda MTC vɔ la, wò ɖɔkta alé ŋku ɖe wò CEA kple Calcitonin ƒe agbɔsɔsɔ ŋu edziedzi to ʋudodokpɔ me. Esia akpe ɖe wo ŋu woanya alesi atikewɔwɔa wɔa dɔe kple nenye be kansa la gatrɔ gbɔ.

MTC nye kansa si ate ŋu asẽ vie wu lãkusi me dɔdzẽ ƒomevi bubu siwo bɔ wu. Gake ne wokpɔe hafi wòkaka ɖe ʋuka siwo le kɔ alo ŋutilã ƒe akpa bubuwo me la, edada, edada, kple edzi ɖuɖu anɔ bɔbɔe wu.

Nukae nye ŋgɔdonya na amesi ŋu medullary thyroid cancer (MTC) le?

Nyagblɔɖi, alo nukpɔsusu, na amesi ŋu MTC le nɔ te ɖe nu geɖe dzi.

• Afisi kansa la le (si fia be afisi kansa la kaka ɖo).
• Ne kansa la kaka (kaka) ɖe ŋutilã ƒe akpa bubuwo.
• Aleke gbegbee woɖe kansa ƒe ƒunukpeƒea le amekokoa me.
• Wò ƒexɔxɔ kple wò lãmesẽ bliboa.

Zi geɖe la , MTC ƒe nyagblɔɖi menyo abe papillary thyroid cancer kple follicular thyroid cancer ene o . Gake ne mia kple wò ɖɔkta miexɔ MTC kaba la, woate ŋu adae keŋkeŋ to amekoko me . Ne dɔlélea tsi megbe gɔ̃ hã la, zi geɖe la, MTC kakana (egblẽna ɖe edzi) vivivi .

Mɔnukpɔkpɔ si li be woahaya ate ŋu aɖiɖi vie na amesiwo le abe esiawo ene:

• Ame siwo xɔ wu ƒe 65.
• Ame siwo le kansa ƒe akpa si de ŋgɔ wu me.
• Amesiwo ƒe kansa mete ŋu ɖe keŋkeŋ le amekoko me o.

Nukae nye agbenɔƒe si medullary thyroid cancer (MTC) xɔna?

Ne míeƒo nu tso amesi ŋu MTC le ƒe agbetsitsi ŋu la, numekuku siwo wowɔ fifia ɖee fia be ƒe atɔ̃ ƒe agbetsitsi le MTC ƒe akpa gbãtɔ, evelia, kple etɔ̃ me anɔ abe 93% ene. Gake le afɔɖeɖe enelia gome la, agbɔsɔsɔ sia ɖiɖina va ɖoa 28%.

Gake nusi le vevie le afisia enye be esi wònye be ame ʋɛ aɖewo koe wogblɔa MTC ƒe dɔléle yeye ƒe sia ƒe ta la, ɖewohĩ agbetsitsi ƒe agbɔsɔsɔ siawo made pɛpɛpɛ tututu o. Wò atikewɔlawo ƒe ƒuƒoƒoa ana nàkpɔ nusi nàkpɔ mɔ na nyuie wu.

Vovototo kae le papillary kple medullary thyroid cancer dome?

Fifia ɖewohĩ èle eŋu bum be, ‘Vovototo kae le MTC sia kple ʋumenugbagbeviɣidɔ bubu mawo dome?’

Papillary thyroid cancer ye nye lãkusi me dɔdzẽ ƒomevi si bɔ wu . Ewɔa 80% le ʋumenugbagbeviɣidɔ si wokpɔna me. Gake medullary thyroid cancer (MTC) mebɔ o .

Vovototo vevitɔ le lãmenugbagbevi siwo me kansa ƒomevi eve siawo dzea egɔme tsoe la me.

• Papillary thyroid cancer dzea egɔme tso follicular cells le wò thyroid gland me siwo wɔa thyroglobulin, si nye protein.
• MTC dona tso C lãmenugbagbevi siwo le lãkusi me siwo wɔa calcitonin, si nye lãmetsiŋusẽ aɖe me.

Nu bubue nye be zi geɖe la, papillary thyroid cancer do ƒome kple keklẽŋusẽ ƒe dɔwɔwɔ, gake kadodo aɖeke mele wo kple MTC dome si me kɔ nenema gbegbe o.

Mlɔeba la, ɖo ŋku esia dzi.

Sese be kansa le ŋuwò, eɖanye ƒomevi ka kee wòɖanye o, nye nusi dzi ŋɔ ŋutɔ. Mí katã míenyae nenema. Gake ne míeƒo nu tso medullary thyroid cancer (MTC) ŋu la, ɖo ŋku edzi be ewɔa nu nyuie ne wodae ne wokpɔe kaba .

Togbɔ be womenya nusi tututu gbɔ MTC ƒe dɔléle akpa gãtɔ tso o hã la, kadodo sẽŋu aɖe le domenyiŋusẽfianu ƒe nɔnɔme aɖewo dome. Eyata ne wokpɔ MTC le ŋuwò alo wò ƒometɔ kplikplikpli aɖe (ƒometɔ si le ɖoƒe gbãtɔ - dzilawo, nɔviwo, viwo) ŋu la, ele vevie ŋutɔ be woado domenyiŋusẽfianu kpɔ. Esia ate ŋu akpe ɖe ŋuwò ŋutɔ kple wò ƒomea.

Ne nya aɖe le asiwò ku ɖe afɔku si le wò MTC xɔxɔ me ŋu la, mègavɔ̃ be yeaƒo nu kple wò ɖɔkta o. Wole klalo ɣesiaɣi be yewoakpe ɖe ŋuwò ahaɖo wò biabiawo ŋu. Nu vevitɔ kekeakee nye be nànɔ nyanya nam, anɔ nyanya nam, eye nàɖe afɔ siwo hiã.

` Medullary thyroid cancer, MTC, thyroid gland, kansa ƒe dzesiwo, domenyiŋusẽfianu dodokpɔ, MEN2, thyroid dɔwɔwɔ