Ðe nèsea veve ɖe atike si naa alɔ̃dɔdɔ ame nua? Mina míasrɔ̃ nu tso (Pseudocholinesterase Deficiency) ŋu?

Ðe vɔvɔ̃ ɖo wò vie le atike si naa alɔ̃dɔdɔ wò hena dɔwɔwɔ na wò ŋu kpɔa? Enye nusi sɔ be ame aɖewo nase le wo ɖokui me nenema. Gake bu nusi adzɔ ne atike siwo naa alɔ̃dɔdɔ wò dometɔ aɖewo mesɔ na wò ŋutilã tututu o ŋu kpɔ. Egbea míele nu ƒom tso nɔnɔme ɖeka si mebɔ o, gake wòle vevie ŋutɔ si ŋu wòle be míanya nu tsoe ŋu. Ema nye nɔnɔme si woyɔna be `(Pseudocholinesterase Deficiency)`.

Nukae nye `(Pseudocholinesterase ƒe Gbɔdzɔgbɔdzɔ)`? Mina míase egɔme bɔbɔe, alo?

Enyo, ŋkɔ sia ɖi didi vie, alo? Mina míana wòanɔ bɔbɔe. `(Pseudocholinesterase)` nye enzyme tɔxɛ aɖe `(Enzyme)` le míaƒe ŋutilã me. Dɔ vevi siwo `(Enzyme)` sia wɔna dometɔ ɖekae nye be wòagbã (si nye `(metabolize)`) le ŋutilã me atike aɖewo siwo wonana be woatsɔ aɖe lãmekawo dzi akpɔtɔ , vevietɔ ne wodo alɔ̃ na mí (míeyɔa esiawo be `(Choline esters)`). Bu eŋu kpɔ be ne wole dɔ wɔm na wò la, ehiã be wò lãmekawo natɔtɔ hena ɣeyiɣi aɖe. Esiawoe nye atike siwo wonana ɖe ema ta.

Fifia, le nɔnɔme si woyɔna be `(Pseudocholinesterase Deficiency)` me la, nusi dzɔna enye be `(Enzyme)` sia si woyɔna be `(Pseudocholinesterase)` le wò ŋutilã me la mewɔa dɔ nyuie o , alo mele dɔ wɔm nyuie o . Nukae dzɔna ɣemaɣi? Atike siwo wonana be lãmekawo naɖe dzi ɖi (`(Succinylcholine)` kple `(Mivacurium)` nye esia ƒe kpɔɖeŋu eve) la, womeɖea wo ɖa le ŋutilãa me kaba o. Wonɔa ŋutilãa me ɣeyiɣi didi aɖe.

Esia wɔe be wò lãmekawo ate ŋu anɔ ƒoƒom ɣeyiɣi didi aɖe le atike si wua alɔ̃dɔdɔ vɔ megbe, eye gbɔgbɔ gɔ̃ hã ate ŋu asesẽ na wò. Esia fia be ɖewohĩ màte ŋu aʋuʋu alo agbɔ ya le ɖokuiwò si o vaseɖe esime atikeawo ƒe ŋusẽkpɔɖeamedzi nu nayi.

Aleke gbegbee nɔnɔme sia bɔe?

Le nyateƒe me la, nɔnɔme sia si woyɔna be `(Pseudocholinesterase Deficiency)` mebɔ nenema gbegbe o . Le mamã dedie nu la, ame siwo ade ame 3,200 alo 5,000 ɖesiaɖe me koe kpɔa nɔnɔme sia. Eyae nye xexlẽme sue aɖe ŋutɔ.

Nukawoe nye dzesiawo? Aleke nèwɔ de dzesi esia?

Ame akpa gãtɔ siwo ŋu dɔléle sia le menyae o vaseɖe esime woxɔ atike si naa alɔ̃dɔdɔ si meyɔ va yi, si woyɔna be ``Choline esters.'' Ɣemaɣie dzesi vevitɔwo dzena:

• Lãmetsi siwo ɖea dzi ɖi akpa (i.e., agbe mele wo me o) hena ɣeyiɣi didi wu alesi woakpɔ mɔe le dzɔdzɔme nu.
• Lãmetsi siwo kpena ɖe ŋuwò nègbɔa ya gɔ̃ hã megawɔa dɔ o hena ɣeyiɣi aɖe .

Ate ŋu axɔ gaƒoƒo ʋɛ aɖewo hafi dzesi siawo nu naɖiɖi. Ɣeyiɣi sia toa vovo tso ame ɖeka gbɔ yi bubu gbɔ. Le ɣeyiɣi sia me la, wò atikewɔlawo ƒe ƒuƒoƒoa ana nànɔ atike si naa alɔ̃dɔdɔ ame me eye wòakpe ɖe ŋuwò nàgbɔ ya to ``yagbɔgbɔmɔ̃'', si nye gbɔgbɔmɔ̃ si wowɔ, vaseɖe esime nàte ŋu agbɔ ya le ɖokuiwò si.

Nukawoe gbɔ wòtsona? Aleke esia dzɔnae?

Nɔnɔme sia (Pseudocholinesterase Deficiency) ateŋu anye domenyinyi (i.e. domenyinyi), alo ateŋu adze egɔme emegbe le agbe me..

Nusiwo gbɔ wòtso ƒe domenyinu

Ame siwo wodzi kple nɔnɔme sia la ƒe tɔtrɔ, alo tɔtrɔ, le domenyiŋusẽfianu si woyɔna be `(BCHE)` me. `(BCHE)` domenyiŋusẽfianu siae gblɔna na míaƒe ŋutilã be wòawɔ enzyme `(Pseudocholinesterase)`. Eyata ne tɔtrɔ va domenyiŋusẽfianu sia me la, wò ŋutilã mewɔa enzyme sia ƒe akpa sue aɖe ko, alo ɖewohĩ mawɔe kura o.

Nusiwo gbɔ wòtsona le agbe me (Acquired) .

Ɣeaɖewoɣi la, nɔnɔme sia (Pseudocholinesterase Deficiency) ate ŋu adzɔ le agbe me katã. Ate ŋu atso dɔléle vovovowo kple atike aɖewo gbɔ.

Dɔléle aɖewo siwo ate ŋu ahe nɔnɔme sia vɛ:

• Nunyuimakpɔɖui
• Nuveviwɔame sesẽ siwo woxɔna le dzobibi me
• Ayikudɔléle
• Aklãdɔléle
• Hypothyroidism (ʋumenugbagbeviɣidɔ si mewɔa dɔ nyuie o) .
• Kansa
• Fufɔfɔ

Atike aɖewo siwo ate ŋu ana dɔléle sia ƒe afɔkua nadzi ɖe edzi dometɔ aɖewoe nye:

• MAO mɔxenuwo (e.g. Phenelzine (Nardil®)) .
• Vidzidzinutsitikewo (Fɔxenu siwo woano) .
• Echothiophate ŋkumeɖonu
• Metoclopramide ƒe atike
• Cyclophosphamide si wotsɔna ƒoa ʋu
• Pyridostigmine ƒe atike

Aleke ɖɔktawo dea dzesi esiae?

Ne esesẽna na wò be nàɖu wò lãmekawo dzi alo nàgbɔ le atike si wua alɔ̃dɔdɔ megbe la, wò ɖɔkta ate ŋu asusui be pseudocholinesterase ƒe anyimanɔmanɔ le ŋuwò. Be woaɖo kpe esia dzi la, woate ŋu awɔ ʋudodokpɔ atsɔ akpɔe ɖa be enzyme si nye pseudocholinesterase ƒe agbɔsɔsɔ le asiwò.

Ne dɔléle sia le wò ƒomea me la, ɖɔkta ate ŋu ado domenyiŋusẽfianu kpɔ be yeakpɔe ɖa be dɔléle sia le ŋuwò hã. Esia bia be woaɖe ʋu ahalé ŋku ɖe eŋu be (BCHE) domenyiŋusẽfianu ƒe tɔtrɔ le ŋuwò hã.

Ne wò ɖɔkta susu be dɔléle sia le ŋuwò la, woazã lãmekawo ƒe gbɔɖemetike ƒomevi bubu siwo meɖoa ŋu ɖe enzyme ``Pseudocholinesterase'' ŋu o.

Nukae nye atikewɔwɔa?

Ne `(Pseudocholinesterase Deficiency)` ƒe dzesiwo dze le ŋuwò le atike si wua alɔ̃dɔdɔ na wò vɔ megbe la, àte ŋu ahiã be woakpɔ egbɔ kpata. Atikewɔlawo ƒe ƒuƒoƒoa alé ŋku ɖe ŋuwò nyuie vaseɖe esime nàhaya. Ne ehiã la, woana nànɔ atike si naa alɔ̃dɔdɔ ame me eye woazã mɔ̃ si nye `` mechanical ventilation`` atsɔ akpe ɖe ŋuwò nàgbɔ vaseɖe esime nàte ŋu agbɔ le ɖokuiwò si.

Nukae wòle be nàkpɔ mɔ na ne dɔléle sia le ŋuwò?

Ne wokpɔe be `(Pseudocholinesterase Deficiency)` le ŋuwò la, nu nyuitɔ si nàte ŋu awɔe nye be nàna wò ɖɔktawo nanya nu tso eŋu – vevietɔ ɖɔkta siwo akpɔ wò be woawɔ dɔ na wò .

Azɔ hã, ele be nàgblɔ nya sia hã na wò ƒomea., emegbe woate ŋu ado wo hã kpɔ be `(BCHE)` domenyiŋusẽfianu ƒe tɔtrɔ le wo ŋu hã. Ne nenemae la, ele be woana woƒe ɖɔktawo hã nanya hafi awɔ dɔ aɖeke na wo.

Anyo hã be nàdo atikewɔgbalẽvi ƒe asigɛ ale be ɖɔktawo nate ŋu anya ne ehiã be woawɔ dɔ na wò kpata.

Ðe woate ŋu axe mɔ ɖe esia nua?

Pseudocholinesterase ƒe anyimanɔmanɔ nye dɔléle si wodzina si womate ŋu axe mɔ na o. Gake ne wò ƒomea me tɔ aɖe le eŋu la, woate ŋu ado wò kpɔ be BCHE domenyiŋusẽfianu ƒe tɔtrɔ le ŋuwò hã hafi woawɔ atike si naa alɔ̃dɔdɔ wò. Esia ate ŋu akpe ɖe ame ŋu be woaxe mɔ ɖe kuxiwo nu le amekoko me.

Ne domenyiŋusẽfianu ƒe tɔtrɔ le ŋuwò la, anɔ eme be wò ɖɔkta adzo le Choline esters la dzi eye wòatia atike bubu si naa alɔ̃dɔdɔ ame. Rocuronium ye nye atike si wozãna wu na amesiwo ŋu Pseudocholinesterase Deficiency le.

Àte ŋu aɖe afɔku si le Acquired Pseudocholinesterase Deficiency xɔxɔ me dzi akpɔtɔ le wò tsitsime to nɔnɔme siwo le eme, abe nunyuimakpɔɖui alo ayikudɔ si nɔa anyi didi (CKD) ene dada me. Azɔ hã, ne èle atike aɖewo zãm si ɖea enzyme Pseudocholinesterase ƒe dɔwɔwɔ dzi kpɔtɔna la, àte ŋu aƒo nu kple wò ɖɔkta tso wò atikewo tɔtrɔ ŋu.

Nukae nye atike siwo tsi tre ɖe eŋu, si fia be atike kawoe menyo be woazã na amesiwo ŋu dɔléle sia le o?

Ne wokpɔe be `(Pseudocholinesterase Deficiency)` le ŋuwò la, ele be nàƒo asa na atike siwo naa alɔ̃dɔdɔ ƒomevi siwo gbɔna :

• Succinylcholine `(Suksinilkolin)`
• Mivacurium ƒe dɔléle
• Procaine ƒe atike
• Chloroprocaine ƒe atike
• Benzocaine ƒe atike
• Tetracaine si woyɔna be tetracaine

Nya siwo wòle be nàbia wò ɖɔkta

Ne dɔléle aɖe le ŋuwò si woyɔna be ``Pseudocholinesterase Deficiency'', eɖanye be wodzi wò kple esia alo wòva xɔe emegbe o, àte ŋu abia nya aɖewo wò ɖɔkta abe:

• Nukawo tututue nye atike siwo tsi tre ɖe eŋu nam, si fia be atike kawoe wòle be maƒo asa na?
• Ðe nɔnɔme sia nye nane si wodzim kplii loo alo dɔléle bubu aɖe gbɔe wòtsoa?
• Ðe wònyo be woawɔ domenyiŋusẽfianu ƒe dodokpɔ le nye ƒomea ŋua?

Amekoko yiyi ate ŋu anye nuteɖeamedzi vie. Mía dometɔ geɖe ƒe susu katã le amekokoa ŋu ale gbegbe be míebua alesi wòate ŋu awɔ nuvevi ame le atike si naa alɔ̃dɔdɔ ame ŋu gɔ̃ hã ŋu o. Atike aɖeke meli na Pseudocholinesterase Deficiency o. Gake ne ènya ne exɔe la, ate ŋu akpe ɖe ŋuwò nàƒo asa na lãmekawo ƒe gbɔdzɔgbɔdzɔ hena ɣeyiɣi aɖe kple gbɔgbɔtsixetsixe si ate ŋu ado mo ɖa le amekoko vɔ megbe. Ne Pseudocholinesterase Deficiency le ŋuwò la, gblɔe na wò ƒomea me tɔwo. Woate ŋu ado domenyiŋusẽfianu hã kpɔ eye woaƒo asa na kuxi ɖesiaɖe si mehiã o si ate ŋu ado mo ɖa le woƒe lãmesẽmɔzɔzɔa me.

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Eyata, `(Pseudocholinesterase Deficiency)` nye ŋkɔ dziŋɔ vie, gake ele vevie ŋutɔ be nànyae. Vevietɔ ne woawɔ dɔ na wò, alo ne wò ƒomea me tɔ aɖe to nane si le abe esia ene me kpɔ , anyo wu be nàƒo nu tso esia ŋu na wò ɖɔktawo. Ðo ŋku edzi be zi geɖe la, sidzedze nye akpoxɔnu nyuitɔ kekeake si ate ŋu aɖe mí tso kuxi siwo mehiã o me!

` Alɔ̃dɔdɔ, pseudocholinesterase, enzyme ƒe anyimanɔmanɔ, amekoko ƒe kuxiwo, domenyiŋusẽfianu ƒe nɔnɔme, lãmekawo ƒe dɔmawɔmawɔ nyuie, atike siwo naa alɔ̃dɔdɔ