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🩺 Skin rashes and dermatitis

Dealing with stubborn eczema flare-ups? Here is what you need to know about Crisaborole ointment

Dr. Priya Sammani (MBBS)
Medically Reviewed by Dr. Priya Sammani (MBBS) ✓ Medically Reviewed
📅 Updated: Oct 21, 2026 • ⏱ 8 min read • Editorial Policy
Dealing with stubborn eczema flare-ups? Here is what you need to know about Crisaborole ointment
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Dealing with red, irritated patches of skin that itch day and night can feel exhausting. If you or your child struggles with eczema, finding the right daily comfort makes all the world of difference. Your doctor may suggest a special prescription ointment called Crisaborole to help calm these stubborn skin flare-ups.

Living with chronic skin irritation affects your sleep, your mood, and your daily comfort. Understanding your medicine helps you use it safely and get the best possible results for your skin. Let us walk through everything you need to know about Crisaborole ointment in plain, simple English.

Key Takeaways at a Glance

  • What it is: Crisaborole is a prescription skin ointment used to treat mild-to-moderate eczema, also known as atopic dermatitis.
  • How it works: It calms an overactive immune system in your skin to reduce redness, swelling, and intense itching.
  • Safe use: Apply a thin layer only to the affected skin areas as directed by your doctor. Never take it by mouth.
  • Age limits: Doctors can sometimes prescribe it for infants as young as 3 months old with careful guidance.
  • When to get help: Contact your doctor right away if you notice severe burning, rash, or signs of a serious allergic reaction.
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What is Crisaborole Ointment?

Simply put, Crisaborole is a prescription medicine that comes in a tube as a skin ointment. Doctors prescribe it mainly for a common skin condition called eczema, known in medical terms as atopic dermatitis. It helps control uncomfortable symptoms like swelling, redness, nagging itching, and rash.

Think of your immune system as your body's personal security guard. Sometimes, this guard works a bit too hard and accidentally attacks your own healthy skin cells. This overactivity is what causes the angry red patches and irritation of eczema.

Crisaborole steps in to calm down that overactive immune response right at the source. By soothing the immune cells in your skin, it helps lower inflammation and stops the cycle of discomfort. You will often see this medicine sold under the popular brand name Eucrisa.

Things to Tell Your Doctor Before Using This Medicine

Before you start using Crisaborole ointment, you must share your complete medical background with your doctor. Giving your care team this information keeps you safe and helps prevent unwanted complications.

  • Allergies: Tell your doctor if you ever had an allergic reaction to Crisaborole, any other medicines, foods, dyes, or preservatives.
  • Pregnancy: Let your doctor know right away if you are pregnant, planning to become pregnant, or suspect you might be expecting.
  • Breastfeeding: Inform your doctor if you are currently breastfeeding your baby so they can advise you on safety.

How to Use This Ointment Correctly

To get the best healing results from your medicine, you need to apply it properly every single day. Follow your doctor's instructions closely and ask questions if anything feels unclear.

  • Skin use only: This medicine is meant only for your skin. Never take it by mouth or swallow it.
  • Wash your hands: Wash your hands thoroughly with soap before and after applying the cream. However, if you are treating your hands, do not wash them right away after application.
  • Protect your eyes: Keep the ointment away from your eyes. If it accidentally gets into your eyes, flush them right away with clean water.
  • Follow your schedule: Use the medicine exactly as your doctor prescribed, at the same times every day. Do not use more often or in larger amounts than told.
  • Apply a thin film: Put a thin layer of the ointment on the affected skin areas. You do not need to layer it on thickly.
  • Keep going: Continue using the ointment until your doctor tells you to stop. Do not stop early just because your skin starts looking better.

Can Young Children Use This Ointment?

Yes, doctors can sometimes prescribe Crisaborole for infants as young as 3 months old. However, treating babies requires special care and specific medical supervision. Because infant skin absorbs medicines differently, you must follow your pediatrician's instructions word for word.

Possible Side Effects

Like all medicines, Crisaborole can cause some mild side effects in certain people. Knowing what to watch for helps you stay calm and take action when needed.

Side Effect Type Description and Action
Seek Medical Help Right away Severe allergic reactions including skin rash, intense itching, swelling of the lips, tongue, face, or throat, and trouble breathing.
Severe Skin Reaction Intense burning, stinging, raw skin peeling, or fluid leaking at the application site. Contact your doctor right away.
Mild Skin Irritation (Common) Mild stinging, redness, or dryness when first applying the cream. These symptoms usually fade away after a few days of regular use.

The most important rule to remember is that if you feel any unusual symptoms not listed here, talk openly with your doctor right away.

More Important Facts to Know

What If You Miss a Dose?

If you forget to apply your ointment, put it on as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose completely. Just stick to your normal routine and never apply two doses at the same time to make up for a missed one.

What If You Use Too Much?

If you think you applied more ointment than recommended, or if someone accidentally swallows the medicine (especially a small child), take action quickly. Contact your local emergency services, call 911 (US/Canada) or 999 (UK), or head straight to your nearest hospital emergency department.

Does It Interact With Other Medicines?

Crisaborole ointment rarely interacts with other drugs because it stays mostly in your skin. Even so, never put other creams, lotions, or home remedies on top of your treated skin without asking your doctor first. Always give your doctor a complete list of any vitamins, herbal supplements, or other medicines you take.

How to Store and Throw Away Your Ointment Safely

  • Storage: Store your tube of ointment safely out of the reach of children and family pets. Keep it at room temperature, away from excessive heat and damp moisture.
  • Disposal: Safely throwing away expired or leftover medicine protects your household. Ask your pharmacist or doctor about community drug take-back programs in your area.
  • Household trash disposal: If you must throw it in the trash, squeeze the remaining ointment out of the tube. Mix it with unappealing waste like used coffee grounds or dirt, seal it inside a secure bag, and place it in your household bin.
  • Protect others: Never flush old medicine down the toilet or sink, as this keeps curious kids and pets safe from accidental exposure.

When to Seek Emergency Medical Help

Call 911 (US/Canada), 999 (UK), or go to your nearest Emergency Department right away if you experience signs of a severe allergic reaction, such as sudden swelling of your face, lips, tongue, or throat, or if you experience sudden trouble breathing after applying the ointment.

💡 Take-Home Message

  • Crisaborole is a prescription skin ointment that calms overactive immune responses in eczema to reduce itching and swelling.
  • Always share your allergy history, pregnancy status, and breastfeeding details with your doctor before starting treatment.
  • Apply a thin layer of the cream only to the affected skin zones and keep it safely away from your eyes.
  • Contact your doctor right away if you develop severe burning, swelling, or signs of a serious allergic reaction.
  • Never stop your treatment or apply alternative creams without checking with your doctor first.

❓ FAQ

Frequently Asked Medical Questions (FAQ)

Evidence-based clinical answers to common patient questions

How long does it take for Crisaborole ointment to work on eczema?

Most people start noticing an improvement in their skin redness and itching within the first week of regular use. However, you should continue applying it exactly as your doctor instructed until they advise you to stop, even if your skin looks clearer.

Can I use Crisaborole ointment on my face or eyelids?

You should only apply Crisaborole to your face or eyelids if your doctor specifically instructs you to do so. Skin on the face is much thinner and sensitive, and you must take extra care to keep the ointment out of your eyes.

Is Crisaborole a steroid cream?

No, Crisaborole is a non-steroidal prescription ointment. It belongs to a class of medicines called phosphodiesterase 4 (PDE4) inhibitors, meaning it targets inflammation differently than traditional steroid creams.

What should I do if the ointment stings when I apply it?

Mild stinging or burning is common during the first few days when you start applying the cream to raw eczema patches. If the stinging becomes severe, painful, or does not go away after several days, contact your doctor for advice.

Can I use moisturizers along with Crisaborole ointment?

Yes, moisturizing is an important part of managing eczema. However, check with your doctor before layering other creams or moisturizers directly over your medicated areas to ensure they do not interfere with the treatment.

📚

Verified Scientific & Medical References (PubMed / WHO)

✓ Peer-Reviewed Sources
  1. National Health Service (NHS). Atopic eczema - Treatment: nhs.uk/conditions/atopic-eczema/treatment.
  2. Mayo Clinic. Eczema - Diagnosis and treatment: mayoclinic.org.
  3. Cleveland Clinic. Crisaborole Ointment: Uses and Side Effects: clevelandclinic.org.
  4. U.S. Food and Drug Administration (FDA). Eucrisa (crisaborole) prescribing information: fda.gov.
  5. National Institutes of Health (NIH) / PubMed. Topical Crisaborole in Atopic Dermatitis: ncbi.nlm.nih.gov/pmc/.
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⚠️ Important: Medical articles and information on Nirogi Lanka are strictly for educational and awareness purposes and do not substitute professional medical advice, diagnosis, or treatment. Always consult a qualified physician for any medical concerns.