Do you sometimes feel numbness, pain, or tingling in your hands and feet? While some people think these are normal things, sometimes there may be a serious, rare genetic condition behind them. Today we are talking about an injection called Vutrisiran, which is used to treat such a specific condition. It is most commonly known by the brand name AMVUTTRA.
What kind of medicine is this Vutrisiran?
Simply put, Vutrisiran is a medicine that is used to treat a rare genetic condition called hereditary transthyretin-mediated amyloidosis (hATTR) .
Okay, now you're probably wondering what this disease has with such a long name. Let's explain it simply.
This is a condition that we can inherit from our genes. What happens in this is that a protein called 'transthyretin', which is produced in our liver, changes its shape abnormally, and they clump together and form deposits called 'amyloid' in various parts of the body, especially in the nervous system. These abnormal protein deposits cause damage to the nerves.
That's when the symptoms I mentioned earlier, such as nerve-related pain, numbness in the limbs, a spinning sensation, loss of sensation in the limbs, and weakness, appear.
This drug, called Vutrisiran, works by stopping the production of that abnormal protein. The primary function of this drug is to reduce damage to the nerves and control symptoms.
Things you need to tell your doctor before using the medicine
Before your doctor decides to give you this medicine, he will ask you a few questions. At that time, you should definitely tell him these things without hiding them.
- Allergies: Tell us if you have any allergies to Vutrisiran, any other medicine, food, dyes, or preservatives.
- Pregnancy: If you are pregnant, trying to get pregnant, or suspect you are pregnant, be sure to inform your doctor.
- If you are a breastfeeding mother: If you are a breastfeeding mother, talk to your doctor about that as well.
How do I get the injection?
This is not a medicine you can take at home. It is a subcutaneous injection . You usually need to get this injection every three months.
This is given in a hospital or clinic by a doctor or nursing staff who has been trained for it, so you have nothing to worry about.
What if I miss a dose of medication?
It is very important to get your injection on time for this treatment. If for some reason you are unable to go on your scheduled date, call your doctor or clinic immediately and reschedule. Do not skip your medication.
What if the medicine is taken in too much?
This is given in a hospital setting so the chances of this happening are very low. However, if you suspect that you have overdosed on the medicine, immediately contact the National Poisons Information Centre at the Colombo National Hospital or go to the Emergency Department (ETU) of the nearest hospital.
Things to keep in mind when taking this medicine
Your doctor will be monitoring your condition regularly while you are taking this medication, so it is very important to attend your appointments on time.
- Vitamin A levels: Your vitamin A levels may decrease while taking this medicine. Therefore, your doctor will likely prescribe a vitamin A supplement for you to take daily. It is important to take it exactly as your doctor recommends. Also, talk to your doctor about foods that contain vitamin A (e.g., carrots, sweet potatoes, spinach, eggs).
- Vision changes: If you notice any changes in your vision, such as blurred vision or decreased night vision, don't ignore it. Report it to your doctor immediately .
- Other medications: Tell your doctor about all other medications you are taking (including vitamins, herbal remedies, and supplements). This medication is unlikely to interact with other medications, but it is best to let your doctor know.
What are the possible side effects?
Like any medicine, some people may experience side effects. Not everyone will experience them. However, it is important to be aware of these.
| Vutrisiran side effects | |
|---|---|
| Serious side effects that you should report to your doctor immediately | |
| Allergic Reactions | Skin rash, itching, swelling of the face, lips, tongue or throat. |
| Vision changes | Any changes in vision, such as blurred vision or decreased vision. |
| Difficulty breathing | Shortness of breath, difficulty breathing. |
| Decreased heart rate | Dizziness, feeling dizzy, fainting, extreme fatigue. |
| Side effects that are usually not serious, but should be reported to your doctor if they persist | |
| Joint pain | Joint pain. |
| Injection site discomfort | Redness, pain, or swelling where the injection was given. |
This list does not include all possible side effects. If you notice anything else, talk to your doctor about it.
Take-Home Message
- Vutrisiran is a special injection that treats a rare, genetic neurological condition called hATTR .
- This medicine is given by trained medical staff in a hospital or clinic. You cannot store or use it at home.
- It is very important to tell your doctor about all your allergies and whether you are pregnant or trying to get pregnant before starting treatment.
- When taking this medication, it is essential to take vitamin A supplements as prescribed by your doctor and to report any changes in your vision immediately.
- If you experience any serious side effects such as facial swelling or difficulty breathing, seek medical advice immediately.
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