He ala hou e ʻike ai i ka maʻi kanesa: ʻO nā mea āpau e pili ana i ka biopsy wai!

Ua lohe paha ʻoe i ka huaʻōlelo "liquid biopsy "? Malia paha ua haʻi aku kāu kauka iā ʻoe e pili ana i ia mea, a ua heluhelu paha ʻoe e pili ana i ia mea ma kekahi wahi. He ʻano hoʻāʻo koʻikoʻi loa kēia no ka ʻike ʻana a me ka mālama ʻana i ka maʻi ʻaʻai. No laila, e kamaʻilio kākou e pili ana i ia mea me ka maʻalahi a me ka maopopo i kēia lā. ʻAʻohe mea e makaʻu ai, ua like ia me kāu hoaaloha e wehewehe ana i kahi mea iā ʻoe.

He aha kēia biopsy wai? He mea maʻalahi loa ia!

I ka ʻōlelo maʻalahi, he hoʻāʻo ka biopsy wai e lawe ana i kahi koko liʻiliʻi . Hiki i kēia ke ʻike inā he mau puʻupuʻu kanesa. E noʻonoʻo i ka ulu ʻana o kahi puʻupuʻu kanesa, hiki i nā ʻāpana liʻiliʻi ke haki a komo i loko o kou koko. ʻO kēlā mau ʻāpana ka mea a kēia biopsy wai e ʻike ai.

Ke nānā nei kēia hoʻāʻo i ʻelua mau mea nui:

• Nā Pūnaewele Puʻupuʻu Kaʻapuni (CTC): ʻO kēia nā pūnaewele kanesa e hemo ana mai ka puʻupuʻu a hele i loko o kou koko, e like me nā kiu liʻiliʻi.
• ʻO ka DNA puʻupuʻu e kaapuni ana (ctDNA): ʻO kēia nā ʻāpana DNA e haki ana mai nā hunaola kanesa a komo i loko o ke koko. E like me kou ʻike, ua like ka DNA me kahi puke e loaʻa ana ke code genetic e kāohi ana i ke ʻano o kā mākou mau hunaola. No laila, hiki i kēia mau ʻāpana o ka ctDNA ke haʻi mai iā mākou i nā mea he nui e pili ana i ka maʻi kanesa.

ʻO ke alo o kēia mau `(CTCs)` a i ʻole `(ctDNA)` i loko o kou koko he hōʻike ia aia kahi puʻupuʻu kanesa ma kekahi wahi o kou kino. Eia kekahi, ʻoiai hāʻawi pū kēia mau ʻāpana i ka `(ʻike genetic )` o ke kanesa, he mea kōkua nui ia i kāu kauka i ka hoʻoholo ʻana i ka lāʻau lapaʻau kūpono loa iā ʻoe.

He hoʻāʻo hou ka biopsy wai. Loaʻa iā ia ka hiki ke hana i kahi ʻokoʻa nui i ke kahua o ka mālama ʻana i ka maʻi kanesa. Aia kekahi mau hoʻohana i ʻae ʻia e ka US Food and Drug Administration (FDA). Ke hoʻomau nei ka noiʻi ʻana i kēia.

He aha ka ʻokoʻa ma waena o ka biopsy wai a me ka biopsy maʻamau a mākou i ʻike ai?

Ua lohe paha ʻoe i kahi biopsy maʻamau. I loko o ia mea, lawe ke kauka i kahi ʻāpana liʻiliʻi o ka ʻiʻo pololei mai kahi puʻupuʻu kanesa a hoʻāʻo iā ia i loko o kahi keʻena hoʻokolohua e ʻike ai inā he mau hunaola kanesa i loko.

Eia nō naʻe, i loko o kahi biopsy wai, ʻaʻole i lawe pololei ʻia kahi ʻāpana o ka puʻupuʻu . Akā, hoʻohana ʻia ia e ʻimi i nā hōʻike o ke kanesa, ʻo ia hoʻi nā hunaola kanesa "CTCs" a i ʻole DNA kanesa "ctDNA" a mākou i kamaʻilio ai ma mua, i loko o ke koko.

ʻO ka biopsy maʻamau i kēia manawa ke ala maikaʻi loa e hoʻoholo ai inā loaʻa ka maʻi kanesa. Ua kapa ʻia hoʻi ia ʻo ke "kūlana gula."

I loko o kahi biopsy wai, ʻoiai inā loaʻa iā ʻoe ka maʻi kanesa, ʻaʻohe hōʻoia 100% e hiki iā ʻoe ke ʻike i nā hōʻailona o ia mea i loko o kahi hāpana koko hoʻokahi. Eia nō naʻe, inā ʻike ʻia ka maʻi kanesa i loko o kahi biopsy wai, he waiwai nui ka ʻike e hāʻawi ai e pili ana i nā hunaola kanesa, a hiki ke kōkua nui i nā kauka i ka hoʻolālā ʻana i ka lāʻau.

I nā hihia hea e hana ʻia ai kahi biopsy wai?

Hiki i kāu kauka ke kuhikuhi i kahi biopsy wai i nā hihia aʻe:

• Inā loaʻa iā ʻoe ka maʻi kanesa metastatic i pālahalaha i nā ʻāpana ʻē aʻe o kou kino a ʻaʻole hana kāu lāʻau lapaʻau o kēia manawa e like me ka mea i manaʻo ʻia. ʻO ka maʻi kanesa metastatic kahi ʻano maʻi kanesa ʻoi aku ka ikaika i pālahalaha a puni kou kino. Ke pālahalaha ia e like me kēia, ʻoi aku ka nui o ka haki ʻana o nā ʻāpana o ke kanesa a komo i loko o kou koko.

Hiki i ke kauka ke kauoha i kahi biopsy wai e ʻike i nā mea e like me:

• E hoʻoholo i ka wānana: Hiki i nā biopsies wai ke ʻike i nā pūnaewele puʻupuʻu e kaapuni ana (CTCs) no nā ʻano maʻi kanesa he nui. ʻO ka helu haʻahaʻa o nā pūnaewele kanesa i loko o ke koko e hōʻike ana i kahi wānana maikaʻi aʻe. ʻO ka helu kiʻekiʻe o nā pūnaewele kanesa e hōʻike ana i kahi wānana ʻoi aku ka maikaʻi ʻole. No laila, hiki i kāu kauka ke hana i kēia hoʻāʻo i kēlā me kēia manawa e nānā i kou kūlana a hoʻoponopono i kāu lāʻau lapaʻau inā pono.
• E hoʻoholo i nā lāʻau lapaʻau: Aia nā lāʻau lapaʻau e pili ana i kekahi mau hunaola kanesa (lāʻau lapaʻau i kuhikuhi ʻia). ʻO ke ʻano kēia, inā loaʻa i kahi hunaola kanesa kahi hewa (mutation) i loko o kāna DNA, hiki ke hāʻawi ʻia i kahi lāʻau lapaʻau i hoʻolālā ʻia e hoʻouka i kēlā hewa. Hiki i kahi biopsy wai ke ʻike i kēia mau hewa. A laila hiki i kāu kauka ke hāʻawi iā ʻoe i kahi lāʻau lapaʻau e pili pono ana i kēlā hewa.

Eia kekahi, hiki iā ʻoe ke loaʻa i kahi biopsy wai ʻoiai inā ʻaʻole hiki ke ʻike ʻia ka maʻi kanesa ma kahi biopsy maʻamau. ʻO kēia no ka mea he hana invasive ka biopsy maʻamau ma mua o ka biopsy wai. ʻAʻole paha ʻoe i olakino maikaʻi e hana i kahi biopsy. A i ʻole, ma muli o ka wahi o ka puʻupuʻu, he mea paʻakikī paha ke wehe i kahi ʻāpana me ka ʻole o ka hōʻino ʻana i nā ʻōpū koʻikoʻi kokoke.

He aha nā hoʻokolohua biopsy wai i ʻāpono ʻia e ka FDA?

ʻO nā hoʻokolohua i ʻāpono ʻia e ka U.S. Food and Drug Administration (FDA) ʻo ia nā mea i noiʻi pono ʻia a hōʻoia ʻia he palekana a pololei. Aia nō kekahi mau hoʻokolohua biopsy wai i ke kahua noiʻi. ʻEhā mau hoʻokolohua nui i ʻāpono ʻia e ka FDA i kēia manawa:

1. Hoʻāʻo Cell Search® Circulating Tumor Cell (CTC): Hoʻāʻo kēia no nā CTC. ʻUma, prostateHoʻohana ʻia kēia e loaʻa ai kahi manaʻo no ke kūlana o ka poʻe me ka maʻi ʻaʻai i laha i ka colon a i ʻole ka rectum. Inā he kakaikahi nā CTC i loko o ke koko, he hōʻailona maikaʻi kēlā. Inā he nui nā CTC, he mea maikaʻi ʻole ia.

2. cobas® EGFR Mutation Test v2: Hoʻāʻo kēia no ka ctDNA. ʻIke ia i kahi mutation i loko o ka gene i kapa ʻia ʻo EGFR, kahi mea maʻamau i ka maʻi ʻaʻai māmā ʻaʻole liʻiliʻi (NSCLC). Hiki i kēia ʻike ke kōkua i kāu kauka e hoʻoholo i ka lāʻau lapaʻau maikaʻi loa e kuhikuhi i kēlā mutation.

3. Guardant360® CDx: Ke nānā nei hoʻi kēia i ka ctDNA. Hoʻohana ʻia ia e ʻike i nā kīnā genetic i maʻamau i nā hunaola kanesa. Kōkua kēia i ke kauka e koho i ka lāʻau lapaʻau kūpono loa.

4. FoundationOne® Liquid CDx: Ke nānā nei hoʻi kēia i ka ctDNA. Kōkua kēia i ka ʻike ʻana i nā kīnā genetic (nā mutations) i nā ʻano maʻi kanesa like ʻole. Kōkua kēia i ke kauka e hoʻoholo i ka lāʻau lapaʻau kūpono loa.

Pehea e hana ʻia ai kahi biopsy wai? He ʻeha anei?

He hoʻāʻo koko maʻalahi loa ka biopsy wai. E like me kāu e hāʻawi ai i kahi hāpana koko no kahi hoʻāʻo koko maʻamau. E lawe ke kauka a kahu maʻi paha i kahi hāpana koko mai kou lima a hoʻouna aku i kahi keʻena hoʻokolohua no ka hoʻāʻo ʻana.

Ma ke keʻena hoʻokolohua, hoʻokaʻawale kahi mīkini i kou koko i nā ʻāpana cell (ʻāpana paʻa) a me ka plasma (ʻāpana wai). A laila, ʻimi kahi pathologist, he loea i hoʻomaʻamaʻa ʻia e kālailai i nā hāpana wai a me nā ʻiʻo, i nā hōʻailona o ka maʻi ma ka ʻāpana plasma, i kapa ʻia ʻo CTCs a i ʻole ctDNA.

He ʻeha anei kēia? ʻAʻole, ua like ka manaʻo o ka biopsy wai me ka hāʻawi ʻana i ke koko. Ke hoʻokomo ʻia ka nila i loko o kou lima, hiki iā ʻoe ke manaʻo i kahi ʻano ʻūlū iki, e like me ke nahu ʻia e kahi ʻanuʻu. Akā nalo koke kēlā ʻeha.

ʻO kahi pōmaikaʻi o ka biopsy wai, ʻo ia ke kaʻina hana i emi iki ka invasive a me ka ʻeha ma mua o ka biopsy maʻamau.

He aha ka ʻōlelo a nā hopena o kēia hoʻāʻo?

Hōʻike nā hopena o ka hoʻāʻo iā ʻoe inā loaʻa i kāu hāpana koko nā `(CTCs)` a i ʻole `(ctDNA)` (`maikaʻi`) a i ʻole (`maikaʻi ʻole`) .

• Inā he "maikaʻi" ka hopena , ʻo ia hoʻi, aia nā mea i ʻōlelo ʻia i loko o ke koko. A laila, hiki i kēia mau hoʻokolohua ke kōkua i ka ʻike ʻana i ke ʻano o ka maʻi kanesa āu. Ma ke ʻano kūikawā, hiki i nā hoʻokolohua e ʻimi ana i ka "(ctDNA)" ke ʻike i nā kīnā genetic maʻamau e pili ana i kekahi mau ʻano kanesa.

ʻEhia ka lōʻihi e loaʻa ai nā hopena? Pehea ka pololei o ka biopsy wai?

Pono e loaʻa nā hopena hoʻāʻo i loko o ʻelua a ʻekolu mau pule .

I kēia manawa, e nānā kākou i ka pololei o kēia. Nā hoʻokolohua biopsy wai i ʻāpono ʻia e ka FDA, no ke aha lākou i hoʻolālā ʻia ai, a hana pololei i kēlā hana.

• Hiki i ke kauka ke loaʻa kahi manaʻo no ke kūlana o kou maʻi i ka wā e hiki mai ana a nānā i ke kūlana o kou maʻi ma o nā hoʻokolohua `(CTC)`.
• No ka mea, hiki i nā hoʻokolohua "(ctDNA)" ke ʻike i nā kīnā genetic i loko o ka DNA o nā hunaola kanesa, kōkua lākou i ka hoʻoholo ʻana i nā hoʻoholo lapaʻau.

Eia nō naʻe, ʻaʻole hiki ke hilinaʻi mau ʻia kahi biopsy wai e ʻike i ka maʻi kanesa me ka maopopo 100% . Pono kahi biopsy maʻamau e hōʻoia i ke alo o ka maʻi kanesa.

ʻO nā hoʻokolohua biopsy wai he wahi ia o ka noiʻi a me ka hoʻomohala ikaika ʻana i kēia manawa. ʻO ka hiki ke ʻike a nānā i ke kanesa me kahi hoʻokolohua koko maʻalahi he mea nui ia. Ke hana nei ka noiʻi e hoʻomohala i nā hoʻokolohua biopsy wai e hiki ke ʻike i ke kanesa ma mua o kona ulu ʻana. Eia nō naʻe, pono ka noiʻi hou aku e hoʻomaopopo i ka hiki piha o nā biopsies wai. Ke kōkua nei lākou i ka ʻike ʻana i kekahi mau ʻano kanesa a hana i nā hoʻoholo lapaʻau i nā hihia kikoʻī. I ka wā e hiki mai ana, ʻoi aku ka nui o nā pono o lākou.

ʻO ka mea hope loa, nā mea e pono ai mākou e hoʻomanaʻo

ʻAe, ua kamaʻilio nui mākou e pili ana i ka biopsy wai. Eia kekahi mau mea e hoʻomanaʻo ai:

• He hoʻokolohua hou ka biopsy wai e nānā ana i nā māka maʻi ʻaʻai i loko o ke koko .
• Hiki i kēia ke ʻike i nā `(CTCs)` (nā hunaola kanesa) a me nā `(ctDNA)` (DNA kanesa).
• ʻAʻohe pilikia nui a ʻeha paha e like me ka biopsy maʻamau.
• Kōkua kēia i ka loaʻa ʻana o kahi manaʻo no ke kūlana o ka maʻi kanesa i ka wā e hiki mai ana a e hoʻoholo i ka lāʻau lapaʻau .
• Aia kekahi mau hoʻokolohua i ʻāpono ʻia e ka FDA.
• Eia nō naʻe, no ka hōʻoia pono ʻana i ka maʻi kanesa, pono paha kahi biopsy maʻamau .
• He ʻenehana kēia e hoʻomohala mau nei a hiki ke lilo i mea pono loa i ka wā e hiki mai ana.

ʻO ka mea nui loa, inā he mau nīnau a hopohopo paha kāu e pili ana i kēia, e kamaʻilio pono me kāu kauka. Hiki iā ia ke wehewehe i nā mea āpau iā ʻoe ma ke ʻano kūpono loa iā ʻoe.

Manaʻolana wau he mea pono kēia ʻike iā ʻoe! E ola kino!

ʻO ka Biopsy Wai, Kanesa, ʻIke ʻana i ke Kanesa, ctDNA, CTC, Hoʻāʻo Koko, Lapaʻau ʻana i ke Kanesa