ʻO nā mea āpau āu e makemake ai e ʻike e pili ana i ka hoʻāʻo thyroxine (T4)!

Ua lohe paha ʻoe i ke kelepa thyroid? Malia paha ua noi kāu kauka iā ʻoe e hana i kahi hoʻokolohua i kapa ʻia ʻo T4. No laila, he aha kēia T4? No ke aha i hana ʻia ai kēia hoʻokolohua? Loaʻa paha iā ʻoe nā nīnau e like me kēia. I kēia lā, e kamaʻilio mākou e pili ana i kēia hoʻokolohua T4 ma ke ʻano maʻalahi hiki iā ʻoe ke hoʻomaopopo.

He aha ka hoʻāʻo T4 (thyroxine)?

I ka ʻōlelo maʻalahi, he hoʻāʻo koko koʻikoʻi ka hoʻāʻo T4 (thyroxine) e nānā i ka hana maikaʻi o kāu kelepa thyroid . Hiki iā ia ke kōkua i ka ʻike ʻana i nā maʻi e pili ana i ka thyroid.

E noʻonoʻo, ʻo ke kelepa thyroid he kelepa liʻiliʻi e like me ke ʻano o ka pepeke aia ma ke alo o kou ʻāʻī, ma luna pono o kou iwi ʻāʻī. He ʻāpana ia o ka ʻōnaehana endocrine o ko mākou kino. ʻO ia ka kelepa e hana i nā hormones thyroid a hoʻokuʻu iā lākou i loko o ke kahe koko. A laila hele kēia mau hormones ma ke kahe koko a hoʻopilikia i nā ʻano kino like ʻole o ko mākou kino.

ʻO Thyroxine, i ʻike ʻia hoʻi ʻo T4 , ka hormone nui loa i hoʻokuʻu ʻia e kou kelepa thyroid. Inā kiʻekiʻe a haʻahaʻa paha ka nui o ka T4 i loko o kou koko, hiki iā ia ke hōʻailona o ka maʻi thyroid.

Hoʻāʻo nā kauka i nā pae T4 ma ka lawe ʻana i kahi hāpana koko. Loaʻa kēia thyroxine (T4) i ʻelua ʻano:

• Paʻa ʻia ʻo T4: Hoʻopaʻa ʻia kēia i nā protein, no laila ʻaʻole hiki ke komo maʻalahi i loko o nā ʻiʻo o ke kino.
• T4 manuahi: ʻO kēia ka T4 "manuahi" e komo i loko o nā ʻiʻo o ke kino a hana i kāna hana.

No laila, aia kekahi mau hoʻokolohua e ana i nā pae T4. ʻO kahi hoʻokolohua koko e ana i ka T4 manuahi a me ka T4 paʻa ua kapa ʻia he hoʻokolohua T4 holoʻokoʻa . ʻO kekahi mau hoʻokolohua koko e ana wale i ka T4 manuahi. ʻO ka ʻoiaʻiʻo, hoʻohana pinepine nā kauka i ka hoʻokolohua T4 manuahi e nānā i ka hana thyroid no ka mea ʻoi aku ka pololei ma mua o ka hoʻokolohua T4 holoʻokoʻa.

E hana paha kāu kauka i kahi hoʻāʻo TSH (Thyroid-Stimulating Hormone) me kāu hoʻāʻo T4. ʻO TSH kahi hormone i hana ʻia e kāu pituitary gland . Hoʻoulu kēia TSH i kāu thyroid gland e hana i nā hormones T4 a me T3 (triiodothyronine) .

ʻO kaʻoiaʻiʻo, ʻo ke ala maikaʻi loa e loiloi ai i ka hana thyroid me kahi hoʻāʻo TSH. Ke hui pū ʻia me kahi hoʻāʻo TSH, hiki i nā hoʻāʻo T4 ke hāʻawi i kahi kiʻi pololei o ka hana thyroid. ʻAʻole paha e pono ke ana i nā pae T4 i nā maʻi thyroid āpau.

Aia kekahi mau inoa ʻē aʻe no ka hoʻāʻo T4:

• ʻO ka thyroxine manuahi
• Ka nui o ka hoʻohuihui T4
• Pale Thyroxine
• Ka nui o ka T4 manuahi
• Papa kuhikuhi T4 manuahi (FTI)

He aha ka thyroxine (T4) a he aha kāna hana?

ʻO Thyroxine (T4), i ʻike ʻia hoʻi ʻo tetraiodothyronine , ʻo ia ka hormone nui i hoʻokuʻu ʻia i loko o ke kahe koko e kou kelepa thyroid. Hoʻokuʻu pū ka kelepa thyroid i kahi liʻiliʻi o kahi hormone i kapa ʻia ʻo triiodothyronine (T3) . Ma muli o ka hana pū ʻana o T4 a me T3, ua kapa pinepine ʻia lāua ʻelua he "hormones thyroid."

I kēia manawa, e nānā, he mau kemika nā hormones e hoʻonohonoho i nā hana like ʻole i loko o ko kākou kino. Lawe lākou i nā leka ma o ke koko i ko kākou mau ʻōpū, nā ʻiʻo, a me nā ʻiʻo ʻē aʻe. Hōʻike kēia mau hōʻailona i ko kākou kino i ka mea e hana ai a me ka wā e hana ai.

ʻAʻole hana ka T4 i hoʻokuʻu ʻia e kou kelepa thyroid, ʻo ia hoʻi, ʻaʻole ia e hoʻopilikia pololei i nā cell o kou kino. Eia nō naʻe, hoʻololi kou akepaʻa a me nā puʻupaʻa i ka hapa nui o kēia thyroxine i triiodothyronine (T3) , kahi hormone hana e hoʻopilikia i nā cell o kou kino.

I ka hui pū ʻana, hoʻomalu ʻo T4 a me T3 i kekahi mau hana koʻikoʻi loa i loko o ko kākou kino. Eia kekahi mau laʻana:

• Ka wikiwiki o ka Metabolic: ʻO kēia ka wikiwiki e hoʻololi ʻia ai ka meaʻai āu e ʻai ai i ikehu.
• Ka hana o ka puʻuwai a me ka ʻōnaehana hoʻoheheʻe.
• Ka hoʻomalu ʻana i nā ʻiʻo.
• Ka ulu ʻana o ka lolo.
• Ka mālama ʻana i ka iwi.

ʻO ka thyroxine hana

Kuhikuhi nā kauka i kahi ʻano synthetic o ka thyroxine i kapa ʻia ʻo levothyroxine e mālama i ka hypothyroidism , kahi kūlana i hana ʻole ai ke kelepa thyroid. Hiki ke kuhikuhi ʻia me ke ʻoki kino a me nā lāʻau lapaʻau ʻē aʻe no kekahi mau ʻano maʻi kanesa thyroid.

No ke aha e pono ai iaʻu kahi hoʻāʻo T4 (thyroxine)?

Hoʻohana nā kauka i nā hoʻokolohua T4 e loiloi i ka maikaʻi o ka hana ʻana o kou thyroid. Eia kekahi mau kumu e kauoha ai kāu kauka i kahi hoʻokolohua T4 (me kahi hoʻokolohua TSH):

• Inā loaʻa iā ʻoe kahi hopena kūpono ʻole o ka hoʻāʻo thyroid-stimulating hormone (TSH) , e noiʻi hou aku.
• E ʻike i ka hyperthyroidism ( ka nui o ka thyroid gland) a i ʻole ka hypothyroidism (ka underactive thyroid gland).
• Inā ʻoe e lawe ana i ka lāʻau lapaʻau hoʻololi hormone thyroid (lāʻau lapaʻau), e nānā i kāu mau pae T4.
• E nānā i nā pēpē hānau hou no ka hypothyroidism.
• E loiloi no nā kūlana ʻē aʻe e like me ka goiter ( puʻupuʻu ʻāʻī), nā nodules thyroid ( nā puʻupuʻu i loko o ke kelepa thyroid), a me nā pilikia me kāu kelepa pituitary a i ʻole hypothalamus .
• E nānā inā haʻahaʻa nā pae hormone thyroid ma muli o ke kumu e pili ana i ka pituitary (hypothyroidism waena).

Eia hou, kauoha pinepine nā kauka i nā hoʻokolohua T4 manuahi ma mua o nā hoʻokolohua T4 holoʻokoʻa . I kekahi mau kūlana kūikawā, e like me ka wā hāpai, pono paha kahi hoʻokolohua T4 holoʻokoʻa ma mua o kahi hoʻokolohua T4 manuahi.

ʻO wai ka mea e hana i ka hoʻāʻo koko T4 (thyroxine)?

ʻO ka maʻamau, hana kahi phlebotomist i ke kaha koko, ʻo ia hoʻi ke kaha koko no ka hoʻāʻo koko T4. Eia nō naʻe, hiki i kekahi limahana mālama ola kino i aʻo ʻia e kaha koko ke hana i kēia. A laila hoʻouna lākou i ka hāpana koko i kahi lab. Ma laila, hoʻomākaukau kahi ʻepekema keʻena lapaʻau i ka hāpana a hoʻāʻo iā ia me ka hoʻohana ʻana i nā mīkini i kapa ʻia he analyzers .

Pehea e hoʻomākaukau ai no ka hoʻāʻo T4 (thyroxine)?

ʻAʻole pono ʻoe e hana i kekahi mea kūikawā no ka hoʻāʻo T4. Eia nō naʻe, ma muli o ke kumu o ka hoʻāʻo ʻana, pono paha ʻoe e hoʻōki i ka lawe ʻana i kekahi mau lāʻau lapaʻau a i ʻole nā ​​​​mea hoʻohui. Eia nō naʻe, e hāʻawi kāu kauka iā ʻoe i nā ʻōlelo kikoʻī e pili ana i kēia.

He mea nui: ʻO Biotin kahi mea hoʻohui i kūʻai ʻia ma luna o ke kauka e hiki ai ke hana i kekahi mau hoʻokolohua thyroid e ʻike ʻia he ʻano ʻē, ʻoiai inā he maʻamau maoli lākou. No laila, ua ʻōlelo ʻia e hoʻōki ʻoe i ka lawe ʻana i nā mea hoʻohui biotin 3 a 5 mau lā ma mua o kekahi hoʻokolohua koko e pili ana i ka thyroid .

He aha ka mea e manaʻo ai i ka wā o ka hoʻāʻo koko T4 (thyroxine)?

Ke loaʻa iā ʻoe kahi hoʻāʻo koko a i ʻole e huki ʻia kou koko, hiki iā ʻoe ke manaʻo i nā mea e like me:

• E noho ʻoe ma kahi noho. A laila e nānā kahi phlebotomist i kou mau lima a koho i kahi aa koko maʻalahi e hiki ai. Aia kēia ma ka ʻaoʻao o loko o kou lima, ma hope pono o kou kuʻekuʻe lima.
• Ke loaʻa kahi aʻa koko, e hoʻomaʻemaʻe ʻia a disinfect ka wahi.
• A laila hoʻokomo ʻia kahi nila liʻiliʻi i loko o kou aa koko a lawe ʻia kahi hāpana koko. Hiki paha iā ʻoe ke manaʻo i kahi ʻano ʻūlū iki i kēia manawa.
• Ma hope o ke hoʻokomo ʻia ʻana o ka nila, e hōʻiliʻili ʻia kahi koko liʻiliʻi i loko o kahi ʻōmole hoʻāʻo.
• Ma hope o ka hōʻiliʻili ʻia ʻana o ke koko, wehe ʻia ke kui a kau ʻia kahi ʻāpana pulupulu a gauze paha ma luna o ka wahi i hana ʻia e hoʻōki i ke kahe ʻana o ke koko.
• A laila ua kau ʻia kahi kāʻei ma ka wahi. A laila ua pau kāu hana.

ʻO ka maʻamau, ʻaʻole iʻoi aku ma mua o ʻelima mau minuke kēia kaʻina hana holoʻokoʻa.

He aha kāu e manaʻo ai ma hope o ka hoʻāʻo ʻana o ka T4 (thyroxine)?

Ma hope o ka lawe ʻana o ka phlebotomist i kāu hāpana koko, hoʻouna ʻia ia i kahi keʻena hoʻokolohua no ka hoʻāʻo ʻana. Ke loaʻa nā hopena o ka hoʻāʻo, e haʻi aku kāu kauka iā ʻoe i nā hopena.

He aha nā pilikia o ka hoʻāʻo koko T4 (thyroxine)?

He ʻāpana maʻamau a pono hoʻi nā hoʻāʻo koko i nā hoʻokolohua lapaʻau a me nā nānā ʻana. He liʻiliʻi loa nā pilikia o kahi hoʻāʻo koko T4 . Hiki iā ʻoe ke ʻike i kekahi mau palapū a ʻeha paha ma kahi i huki ʻia ai ke koko, akā e emi koke kēia.

Āhea wau e ʻike ai i nā hopena o kaʻu hoʻāʻo T4 (thyroxine)?

I ka hapanui o nā hihia, pono ʻoe e loaʻa i kāu mau hopena hoʻāʻo T4 i loko o hoʻokahi a ʻelua paha mau lā ʻoihana . Eia nō naʻe, hiki ke lōʻihi ka manawa.

He aha nā hopena o kahi hoʻokolohua T4 (thyroxine)?

ʻO nā hōʻike hoʻāʻo koko, me nā hōʻike hoʻāʻo T4, aia mau i kēia mau ʻike:

• ʻO ka inoa o ka hoʻāʻo koko a i ʻole ka mea i ana ʻia i loko o kou koko.
• ʻO ka helu a i ʻole ke ana o kāu hopena hoʻāʻo koko.
• ʻO ia ka pae ana maʻamau no ka hoʻāʻo.
• ʻIke e hōʻike ana inā he maʻamau a ʻano ʻē paha kāu hopena, a i ʻole kiʻekiʻe a haʻahaʻa paha.

He aha nā pae T4 manuahi maʻamau?

ʻOkoʻa nā pae maʻamau o ka T4 manuahi ma muli o kou mau makahiki . Ma keʻano laulā, ʻo nā pae maʻamau no ka T4 manuahi i nā poʻe olakino penei:

• Nā keiki a hiki i 5 mau makahiki: 0.8 - 2.8 nanograms no ka deciliter (ng/dL)
• Nā keiki 6 a 15 mau makahiki: 0.8 - 2.1 ng/dL
• Nā ʻōpio kāne 16 a 17 mau makahiki: 0.8 - 2.8 ng/dL
• Nā wahine ʻōpio 16 a 17 mau makahiki: 0.8 - 1.5 ng/dL
• Nā mākua ma luna o 18 mau makahiki: 0.9 - 1.7 ng/dL

Nānā: Hiki ke ʻokoʻa iki nā pae maʻamau no ka T4 manuahi ma waena o nā keʻena hoʻokolohua. E hōʻoia e nānā i ka pae kuhikuhi no kāu mau hopena, e like me ka mea i helu ʻia ma kāu hōʻike keʻena hoʻokolohua. Inā he mau nīnau kāu e pili ana i kāu mau hopena, e nīnau i kāu kauka.

He aha ka mea e hana ai inā kiʻekiʻe loa nā pae T4 (thyroxine)?

Inā ʻoi aku ke kiʻekiʻe o kāu mau pae T4 a i ʻole ka T4 manuahi ma mua o ka maʻamau, he hōʻailona paha ia o kahi maʻi i kapa ʻia ʻo thyrotoxicosis . Hiki ke hana ʻia kēia e kekahi mau mea, me ka hyperthyroidism ( overactive thyroid gland), ka mumū o ka thyroid gland (thyroiditis) , a me ka lawe ʻana i ka nui o ka lāʻau thyroid.

Hoʻonui ka Thyrotoxicosis i ka wikiwiki o kāu metabolism . Hiki i kēia ke lilo i mea weliweli i kou olakino. ʻO kekahi o nā hōʻailona o ka thyrotoxicosis:

• Ka pohō kaumaha me ke kumu ʻole.
• Hoʻonui pinepine ʻia o ka hele ʻana i ka lua.
• Ka puʻuwai wikiwiki a kūpono ʻole paha (arrhythmia) .

Inā loaʻa iā ʻoe nā hōʻailona o ka thyrotoxicosis, he mea nui loa ia e hoʻokaʻaʻike aku i kāu kauka.

ʻOiai he maʻamau nā pae T4 manuahi, ʻo nā kūlana ʻē aʻe e hiki ai ke hoʻokiʻekiʻe i nā pae T4 holoʻokoʻa e komo pū me ka hāpai ʻana a meʻO ka lawe ʻana i nā pila hoʻomalu hānau i loaʻa ka estrogen . I nā hihia ʻelua, ʻo kēia no ka mea kiʻekiʻe nā pae estrogen. Hoʻonui ka Estrogen i ka nui o ka protein e hoʻopaʻa ai i ka T4, kahi e hoʻonui ai i ka T4 holoʻokoʻa (ʻo ia hoʻi, ka hoʻopaʻa ʻana o ka T4 manuahi + protein).

He aha ka mea e hana ai inā hāʻule haʻahaʻa loa nā pae T4 (thyroxine)?

Inā haʻahaʻa kāu mau pae T4 ma mua o ka maʻamau, hōʻike pinepine ia i ka hypothyroidism (kahi thyroid gland hana ʻole). Hiki i ka hypothyroidism ke loaʻa i kekahi mau kumu. ʻO nā laʻana e komo pū me kekahi mau maʻi autoimmune , ka loaʻa ʻole o ka iodine lawa i kāu meaʻai, a me ka hoʻohana ʻana i kekahi mau lāʻau lapaʻau.

Hoʻolohi ka hypothyroidism i kāu metabolism. ʻO kekahi o nā hōʻailona:

• Luhi.
• ʻAʻole hiki ke hoʻomanawanui i ke anu.
• Haʻahaʻa ka helu o ka puʻuwai.
• Piʻi ke kaumaha.

Inā loaʻa iā ʻoe nā hōʻailona o ka hypothyroidism, he mea nui loa ia e kamaʻilio me kāu kauka.

Pono anei au e hopohopo inā haʻahaʻa a kiʻekiʻe paha ka hopena o kaʻu hoʻāʻo T4 (thyroxine)?

ʻO ka maʻamau, pololei nā hopena o ka hoʻāʻo T4 manuahi. Eia nō naʻe, hiki i kekahi mau mea ke hoʻopilikia i nā hopena. Eia kekahi laʻana:

• Kekahi mau lāʻau lapaʻau a i ʻole nā ​​​​mea hoʻohui.
• Ka hāpai ʻana.
• Ka maʻi nui a i ʻole ka ʻai pono ʻole.

E noʻonoʻo kāu kauka i kēia mau mea i ka wehewehe ʻana i kāu mau hopena.

Inā ʻaʻole kūpono kāu mau hopena hoʻāʻo T4, hiki i kāu kauka ke kauoha i nā hoʻāʻo thyroid hou aʻe e kōkua i ka hana ʻana i kahi hōʻailona. Hiki i kēia mau hoʻāʻo ke komo pū me:

• Hoʻāʻo T3 (Triiodothyronine) (ʻo kekahi hormone thyroid ʻē aʻe).
• Hoʻāʻo TSH (Hōmona Hoʻoulu Thyroid).
• Nā hoʻāʻo e ʻike i ka maʻi ʻo Graves (kahi maʻi autoimmune e hoʻoulu ai i ka hyperthyroidism).
• Nā hoʻāʻo e ʻike i ka maʻi o Hashimoto (kahi maʻi autoimmune e hoʻoulu ai i ka hypothyroidism).

Pehea e pili ai nā pae TSH (hormone hoʻoulu thyroid) a me T4 (thyroxine) kekahi i kekahi?

Hoʻopili pololei nā pae TSH a me T4 kekahi i kekahi, ʻoiai ʻo ka hormone hoʻoulu thyroid (TSH) ke hoʻoulu i ka hana ʻana o thyroxine (T4), a ʻo nā pae T4 kiʻekiʻe no kekahi manawa e kāohi i ka hoʻokuʻu ʻana o TSH.

Ke loaʻa iā ʻoe nā hoʻokolohua koko e nānā i kāu hana thyroid a me nā pae TSH, hiki i nā pae like ʻole o kēlā me kēia hormone ke hōʻike i nā kūlana like ʻole. E nānā kākou pehea e hana ai kēlā.

TSH haʻahaʻa a me ka T4 maʻamau

ʻO nā pae TSH haʻahaʻa a me nā pae T4 maʻamau i manaʻo ʻia he subclinical hyperthyroidism.ʻO ke ʻano o "Subclinical" ʻaʻole ia he hōʻailona o ke kūlana, a i ʻole ʻaʻole i hoʻomaka nā hōʻailona. Ua hōʻike ʻia nā noiʻi ma kahi o 16% o ka heluna kanaka e ʻeha nei i kēia kūlana o ka subclinical hyperthyroidism.

Inā hōʻike nā hopena o kāu hoʻāʻo koko i kēia mau hopena, e hoʻomau paha kāu kauka i ka nānā ʻana i kāu mau pae e ʻike inā loli lākou a alakaʻi i ka hyperthyroidism clinical.

TSH haʻahaʻa a me T4 kiʻekiʻe

ʻO ka haʻahaʻa o nā pae TSH a me nā pae T4 kiʻekiʻe e hōʻike pinepine ana i ka hyperthyroidism . ʻO kēia no ka mea ke hana nei kāu kelepa thyroid i ka nui o ka T4 ma muli o kahi pilikia. ʻO kēia keu T4 e pale aku i kou hypothalamus mai ka hoʻokuʻu ʻana i ka TSH.

TSH haʻahaʻa a me T4 haʻahaʻa

Inā haʻahaʻa nā pae TSH a me T4, hōʻike ia he pilikia me kāu kelepa pituitary . No ka laʻana, ʻaʻole paha e hoʻokuʻu ana kekahi mea e like me ka adenoma pituitary nui i ka TSH lawa e hoʻoulu ai i ka hana ʻana o T4. He hui pū ʻana o nā hopena he kakaikahi kēia.

TSH kiʻekiʻe a me ka T4 maʻamau

Ke kiʻekiʻe nā pae TSH a maʻamau nā pae T4, manaʻo pinepine ʻia he subclinical hypothyroidism (i kapa ʻia hoʻi he mild thyroid failure). Hoʻopilikia kēia maʻi ma waena o 3% a me 8% o ka heluna kanaka.

Inā hōʻike nā hopena o kāu hoʻāʻo koko i kēia mau hopena, e hoʻomau paha kāu kauka i ka nānā ʻana i kāu mau pae e ʻike inā loli lākou a alakaʻi i ka hypothyroidism clinical.

TSH kiʻekiʻe a me ka T4 haʻahaʻa

Inā kiʻekiʻe nā pae TSH a haʻahaʻa nā pae T4, hōʻike pinepine ia i ka hypothyroidism ( ka thyroid hana ʻole ma muli o kahi pilikia mua me ka thyroid gland). ʻO kēia no ka mea aia kahi pilikia me kou thyroid gland e hoʻemi ana i ka hana ʻana o T4, a ke pane nei kāu pituitary gland ma ka hoʻokuʻu ʻana i ka TSH nui loa e hoʻoulu i ka thyroid gland e hana hou aku i ka T4.

ʻO ka TSH kiʻekiʻe a me ka T4 kiʻekiʻe

Inā kiʻekiʻe nā pae TSH a me T4, hōʻike ia he pilikia me kāu kelepa pituitary . ʻO ke ʻano kēia ke hoʻokuʻu nei ka kelepa pituitary i ka TSH nui loa, a laila e hoʻoulu ai i kāu kelepa thyroid e hana i ka nui o ka T4. He hui pū ʻole loa kēia o nā hopena.

Nā mea āu e hoʻomanaʻo ai mai kēia mau mea a pau (Leka Lawe-Home)

He mea maʻamau ke makaʻu ke ʻike ʻoe i kahi hopena hoʻāʻo ʻē. Akā, mai hopohopo . ʻO nā maʻi thyroid, ʻoiai ka hypothyroidism, he mea maʻamau loa ia a hiki ke mālama ʻia.E haʻi aku kāu kauka iā ʻoe inā pono nā hoʻokolohua hou aʻe e ʻike i ke kumu o kahi pae T4 maʻamau ʻole. Mai kānalua e nīnau a i ʻole e hoʻonohonoho i kahi manawa me kāu kauka e kūkākūkā hou aku i kāu mau hopena. He mea nui e hoʻomaopopo ʻia e pili ana i kou olakino.

ʻO ka Thyroxine, ka hoʻāʻo T4, ka thyroid, ka hormone, TSH, hypothyroidism, hyperthyroidism