Ua lohe paha ʻoe i kahi ʻano maʻi kanesa koʻikoʻi a laha ʻole e ulu ana i loko o nā puʻupaʻa, ʻoi aku hoʻi i nā poʻe ʻōpio? ʻAʻole paha. ʻO Renal Medullary Carcinoma kēia, a i ʻole RMC no ka pōkole. ʻOiai ʻaʻole ia he mea maʻamau loa, he mea nui loa ia e makaʻala iā ia, ʻoi aku hoʻi no kekahi poʻe. ʻOiai he kumuhana koʻikoʻi kēia, mai makaʻu. E kamaʻilio kākou e pili ana i ia mea ma ke ʻano maʻalahi a maopopo i kēia lā.
He aha maoli ka RMC?
I ka ʻōlelo maʻalahi, ʻo Renal Medullary Carcinoma (RMC) kahi ʻano maʻi ʻaʻai puʻupaʻa. Akā he mea kakaikahi loa ia, he ʻino loa, a pālahalaha koke. ʻO ka mea maʻamau ia i nā poʻe ʻōpio, ʻoiai ka poʻe me ke ʻano koko i kapa ʻia ʻo 'sickle cell disease' a i ʻole 'sickle cell trait'.
Ke kamaʻilio mākou e pili ana i ke kanesa puʻupaʻa, ʻo ke ʻano maʻamau ka `renal cell carcinoma`. ʻO RMC kekahi ʻano o `renal cell carcinoma`. Akā, ʻaʻole hoʻokahi o 100 mau maʻi kanesa puʻupaʻa e loaʻa i kēia maʻi RMC. He mea kākaʻikahi ia.
He aha ke kumu o kēia maʻi kanesa?
ʻAʻole i loaʻa i nā kānaka ʻepekema a me nā kauka ke kumu pololei 100% o kēia, akā hoʻokahi mea nui i ʻike ʻia.
Aia i loko o ko kākou mau puʻupaʻa kahi ʻāpana i kapa ʻia ʻo ka `renal medulla`. I kekahi manawa, loaʻa i ke kanaka me ke ʻano `sickle cell` nā hunaola koko ʻulaʻula e loli ana i ke ʻano sickle. Ke hana ʻia kēia, hiki i nā hunaola ke pili pū a ālai i nā kīʻaha koko ma ka ʻāpana `renal medulla` o ka puʻupaʻa.
ʻO kēia ālai ʻana i ke kahe koko e hōʻino i nā cell ma ia wahi. ʻOi aku hoʻi, ua hōʻino ʻia kahi gene i kapa ʻia ʻo `INI1` (i kapa ʻia hoʻi ʻo `SMARCB1`) i loko o kēlā mau cell. Hana kēia gene `INI1` ma ke ʻano he `kiaʻi` e pale ana i nā cell mai ka lilo ʻana i maʻi kanesa. Ke nānā ʻia nā cell maʻi kanesa RMC, ʻaʻole i loaʻa kēia gene `INI1` i loko o lākou. No laila, nānā nā kauka i ke alo o kēia gene `INI1` e hōʻoia inā he RMC kahi puʻupuʻu a ʻaʻole paha.
Aia nō hoʻi au i ka pilikia o ka loaʻa ʻana o RMC?
He mea paʻakikī ke ʻōlelo pololei i ka mea nāna e loaʻa i kēia. ʻO ka loaʻa ʻana o kekahi o kou ʻohana me RMC ʻaʻole ia e hoʻonui i kou pilikia o ka loaʻa ʻana. ʻO ia hoʻi, ʻaʻole ia he mea e holo i loko o nā ʻohana.
ʻO ke kumu pilikia nui ka maʻi koko i kapa ʻia ʻo `sickle hemoglobinopathy`. ʻO ia hoʻi, ka loaʻa ʻana o ka `sickle cell disease` a i ʻole `sickle cell trait`. Akā, he mea kakaikahi loa , hiki i ka poʻe me kēia mau kūlana ke loaʻa iā RMC. Ua kapa ʻia ʻo ia ʻo "renal cell carcinoma, unclassified with medullary phenotype" (RCCU-MP).
Inā ʻoe e nānā i nā helu helu:
- ʻOi aku ka maʻamau i nā kāne ma mua o nā wahine.
- Hoʻopilikia pinepine ia i ka puʻupaʻa ʻākau.
- ʻIke pinepine ʻia ka maʻi i ka wā ʻōpiopio, ma waena o 11 a me 39 mau makahiki.
He mea nui i nā poʻe ʻōpio, ʻoiai ka poʻe me ka maʻi sickle cell a i ʻole ke ʻano o ka sickle cell, e makaʻala i kēia mau hōʻailona, no ka mea, hiki i ka ʻike mua ʻana ke maʻalahi i ka mālama ʻana. Inā loaʻa nā hōʻailona, e ʻike koke i ke kauka.
He aha nā hōʻailona o RMC?
Aia kekahi mau hōʻailona maʻamau o kēia maʻi. Inā loaʻa iā ʻoe kekahi a ʻoi aku paha o kēia mau mea, ʻoi aku ka maikaʻi o ka ʻimi ʻana i ke kōkua lapaʻau i ka wā hikiwawe loa.
| Hōʻailona | Wehewehena |
|---|---|
| ʻEha ma ka ʻāpana puʻupaʻa | He ʻeha mau ma nā ʻaoʻao ʻelua o ka ʻōpū a ma ke kua lalo (ma luna pono o ka ʻūhā). |
| Koko i loko o ka mimi | Mimi poni, ʻulaʻula, a ʻeleʻele paha. I kekahi manawa aia ke koko i ʻike ʻole ʻia e ka maka. |
| ʻŌpū ʻōpū | He puʻu a puʻu paha e like me ka puʻu ma kekahi ʻaoʻao o ka ʻōpū. |
| ʻO ka pohō kaumaha me ke kumu ʻole | ʻO ka pohō kaumaha wikiwiki i ka manawa pōkole, me ka ʻole o ka hoʻoikaika ʻana. |
| Ka wela pinepine a me ka hou ʻana i ka pō | Inā loaʻa iā ʻoe ke kuni pinepine no ke kumu ʻole a hou nui ʻoe i ka pō a pulu kou mau lole moe. |
Pehea e ʻike ai ke kauka i kēia?
Ke haʻi mai ʻoe iā mākou e pili ana i kāu mau hōʻailona, ʻo ka mea mua a ke kauka e hana ai, ʻo ia ke nānā iā ʻoe. A laila hiki iā ʻoe ke hahai i kēia mau ʻanuʻu.
1.ʻO ke scan Ultrasound: Hiki i kēia ke hāʻawi i kahi manaʻo paʻakikī inā he mea e like me ka puʻupuʻu i loko o nā puʻupaʻa.
2. CT a MRI scan paha: Inā kānalua ʻia kahi puʻupuʻu, hiki ke kauoha ʻia kahi CT scan a MRI paha e kiʻi i kahi kiʻi maopopo o ka puʻupuʻu. Ma muli o kēia mau kiʻi, hiki i ke kauka ke hoʻoholo i ka nui o kona hiki ke lilo i maʻi kanesa.
3. Biopsy: Inā kānalua nui ʻia ka maʻi kanesa, hana ʻia kēia hoʻāʻo e hōʻoia iā ia. Pili kēia i ke komo ʻana i kahi nila lahilahi i loko o ka ʻāpana o ka puʻupaʻa, e lawe ana i kahi ʻāpana liʻiliʻi loa o ka ʻiʻo a nānā iā ia ma lalo o kahi microscope.
4. Hoʻāʻo ʻana i ka hoʻoilina: Nānā ʻia nā pūnaewele i lawe ʻia mai ka biopsy no ke alo o ka gene `INI1` e hakakā ana i ka maʻi kanesa a mākou i kamaʻilio ai ma mua.
- Inā nalowale ka gene `INI1`, ua ʻike ʻia ʻo ia ʻo RMC.
- Inā nalowale ka gene `INI1` a ʻaʻohe maʻi `sickle cell` o ka mea maʻi, ua ʻike ʻia ʻo ia he `RCCU-MP`.
- Inā loaʻa ka gene `INI1` , ʻaʻole ia he RMC, akā he ʻano puʻupuʻu ʻokoʻa.
He aha nā lāʻau lapaʻau no kēia?
No ka mea, he maʻi kanesa wikiwiki ka RMC a he maʻi ʻino hoʻi, pono e wikiwiki a ikaika like ka mālama ʻana.
- Kemoterapi: ʻO kēia ka lāʻau lapaʻau mua loa. Pili ia i ka hāʻawi ʻana i ke kino i nā lāʻau lapaʻau e pepehi ai i nā hunaola kanesa.
- ʻOki kino: Wehe ʻana i ka puʻupuʻu kanesa a me ka puʻupaʻa paha i hoʻopilikia ʻia.
- Lapaʻau Radiation: Ke luku ʻana i nā hunaola kanesa me ka hoʻohana ʻana i nā kukuna radiation ikaika.
No ka mea he mea kakaikahi kēia maʻi, ke hoʻomau nei ka noiʻi. Ke ʻimi mau nei nā kānaka ʻepekema i nā lāʻau lapaʻau hou a ʻoi aku ka maikaʻi no RMC.
Aia kekahi ala e pale aku ai i ka RMC?
ʻO ka mea pōʻino, ʻaʻohe ala i ʻike ʻia e pale aku ai i ka ulu ʻana o RMC, a ʻaʻohe hoʻāʻo e ʻike ai ma mua o ka puka ʻana o nā hōʻailona.
ʻO ka mea maikaʻi loa hiki iā ʻoe ke hana, ʻo ia ke makaʻala . Inā ʻike ʻoe he maʻi cell sickle kou a i ʻole ke ʻano o ka cell sickle, e makaʻala i nā hōʻailona i ʻōlelo ʻia ma luna. Inā he mau hopohopo kāu, e ʻike koke i kāu kauka.
I ka manawa pinepine, i ka wā e ʻike ʻia ai kēia maʻi, ua laha mua ke kanesa i nā lymph nodes a i ʻole nā kikowaena ʻē aʻe e like me nā māmā, ke akepaʻa, a me nā iwi. No laila, ʻo ka ʻike mua ʻana ke ala maikaʻi loa e hoʻokō ai i nā hopena maikaʻi loa.
Leka Lawe-Home
- ʻO ka Renal Medullary Carcinoma (RMC) kahi ʻano maʻi puʻupaʻa kakaikahi loa akā he koʻikoʻi loa ia e hoʻopilikia nui ana i ka poʻe ʻōpio.
- ʻO ke kumu pilikia nui no ka hoʻomohala ʻana i kēia, ʻo ia ka loaʻa ʻana o kahi maʻi koko i kapa ʻia ʻo
sickle cell diseasea i ʻolesickle cell trait. - ʻO ka ʻeha kua/ʻōpū, ke koko i loko o ka mimi, kahi puʻu i loko o ka ʻōpū, a me ka pohō kaumaha i wehewehe ʻole ʻia nā hōʻailona nui.
- Inā loaʻa iā ʻoe ka maʻi sickle cell a loaʻa iā ʻoe kekahi a ʻoi aku paha o nā hōʻailona i luna, e ʻike koke i kāu kauka me ka hoʻokaʻulua ʻole.
- I kēia maʻi, ʻo ka ʻike mua ʻana a me ka hoʻomaka ʻana i ka lāʻau lapaʻau ka manawa kūpono loa e hoʻopakele ai i nā ola.
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