Fibrosarcoma: E aʻo hou kākou e pili ana i kēia maʻi kanesa laha ʻole

He aha kou manaʻo ke ʻike ʻoe i kahi puʻupuʻu a puʻupuʻu hou paha ma kou kino, ʻoi aku hoʻi ma kou wāwae a lima paha? ʻO ka hapa nui o ka manawa, manaʻo mākou he mea maʻamau ia a hoʻowahāwahā iā ia. Akā i kekahi manawa, ʻoiai kekahi mea liʻiliʻi e like me ia he mea ia e pono ai mākou e makaʻala. I kēia lā, e kamaʻilio mākou e pili ana i kahi maʻi ʻaʻai laha ʻole e hiki ke ʻike ʻia ma ke ʻano he puʻupuʻu. Ua kapa ʻia kēia he fibrosarcoma.

I ka ʻōlelo maʻalahi, he aha ka fibrosarcoma?

He ʻano maʻi ʻaʻai laha ʻole ka Fibrosarcoma e kū mai ana i loko o nā ʻiʻo palupalu. I ka lāʻau lapaʻau, kapa mākou i kēia ʻo sarcoma. I kēia manawa ke noʻonoʻo nei paha ʻoe i ke ʻano o ka ʻiʻo palupalu. He mea maʻalahi loa ia. ʻO ia ka ʻiʻo e hoʻopili a hoʻopaʻa i nā ʻāpana like ʻole o ko mākou kino. I ka pololei, ʻo nā mea e like me nā tendon a me nā ligaments e hoʻopili i nā mea e like me nā iwi a me nā ʻiʻo i loko o ko mākou kino no kēia mau ʻiʻo hoʻopili.

Hoʻomohala pinepine ʻia ke kanesa Fibrosarcoma i loko o nā ʻiʻo palupalu i loko o ke kino. ʻO ka mea maʻamau ia ma nā wāwae (a puni ka iwi ʻūhā a i ʻole ka iwi ʻūhā), nā lima o luna, nā kuli, a i ʻole ke kino. Hiki ke ulu pinepine ʻia ma ke poʻo a i ʻole ka ʻāʻī. I kekahi manawa, hiki i kēia kanesa ke ulu i loko o nā iwi a i ʻole i loko o nā ʻiʻo hoʻopili fibrous e uhi ana i nā iwi.

Inā loaʻa iā ʻoe a i ʻole kāu keiki kēia hōʻailona, ​​​​​​ʻo ka mea e hiki mai ana e pili ana i nā kumu he nui. ʻO kou mau makahiki, ka nui o ke kanesa, a me kona wahi e loaʻa ai e pāʻani i kahi kuleana. E wehewehe kāu kauka i nā mea āpau ma muli o kāu hōʻailona.

ʻElua ʻano nui o kēia.

Hiki ke hoʻokaʻawale ʻia ʻo Fibrosarcoma i ʻelua ʻano nui. He ʻokoʻa loa kēia mau ʻano ʻelua kekahi i kekahi.

He aha nā hōʻailona o kēia maʻi?

ʻO ka maʻamau, he manawa iki ka lōʻihi no ka ʻike ʻia ʻana o nā hōʻailona o ka fibrosarcoma. No ka mea, ulu kēia mau puʻupuʻu i loko o nā ʻiʻo palupalu i loko o ke kino, ʻaʻole paha ʻoe e ʻike i kekahi mea a hiki i ka ulu ʻana o ka puʻupuʻu a nui e kaomi i kahi aʻalolo kokoke a i ʻole ke kīʻaha koko.

Eia nā hōʻailona i ʻike pinepine ʻia:

• He puʻupuʻu palupalu ʻaʻohe ʻeha a ʻeha iki paha: Hiki ke hana kēia ma nā wāwae, nā lima, a i ʻole ke kino.
• He ʻano ʻūlū a ʻoi paha ka ʻeha ʻoi: I kekahi manawa ʻōlelo mākou "pine a me nā nila." Hiki paha kēia ma muli o ke kaomi ʻana ma luna o kahi aʻalolo kokoke i ka puʻupuʻu.
• ʻO ka pehu ʻana maʻamau: Hiki ke hana ʻia kēia ʻano pehu ʻana i ka wā e hoʻopaʻa ai ka puʻupuʻu i nā kīʻaha koko.

Hiki i kēia mau hōʻailona ke like me nā maʻi ʻē aʻe, ʻaʻole koʻikoʻi loa, no laila hiki i ke kauka ke haʻi maopopo inā paha kēia mau loli ma muli o ka fibrosarcoma a i ʻole kekahi maʻi maʻamau ʻole (benign).

He aha nā kumu a me nā kumu pilikia no ka fibrosarcoma?

ʻAʻole maopopo i nā kānaka noiʻi ke kumu maoli o ka fibrosarcoma. Eia nō naʻe, ua manaʻoʻiʻo ʻia he kuleana ko nā hoʻololi genetic i loko o nā cell. I ka ʻōlelo maʻalahi, loaʻa nā loli i loko o ka DNA i loko o kā mākou mau cell. ʻO kēia mau loli ke kumu o ka māhele wikiwiki ʻana o nā cell me ka ʻole o ke kāohi ʻia, e hana ana i nā puʻupuʻu kanesa.

Ua ʻike ʻia kahi loli hoʻoilina maʻamau i ka fibrosarcoma o nā kamaliʻi, ʻoiai. Ma kahi o 90% o kēia mau mea e pili ana i nā pilikia i loko o ka ʻohana gene NTRK. Ke hana pono ʻole kēia mau genes, hiki ke ulu nā puʻupuʻu kanesa.

Nā mea e hoʻonui ai i ka pilikia

Ua ʻike nā kānaka noiʻi e hiki i kekahi mau kūlana hoʻoilina ke hoʻonui i ka pilikia o ka hoʻomohala ʻana i ka fibrosarcoma.

• ʻO ka polyposis adenomatous ʻohana
• ʻO ka maʻi Li-Fraumeni
• ʻAno Neurofibromatosis 1 `(ʻAno Neurofibromatosis 1)`
• ʻO ka maʻi carcinoma cell basal Nevoid
• ʻO ka Retinoblastoma
• ʻO ka sclerosis tuberous
• ʻO ka maʻi Werner `(Werner syndrome)`

Eia kekahi, hiki ke pili pū kekahi mau kūlana olakino ʻē aʻe me kēia:

• ʻO ka infarction o ka iwi (make ʻana o nā hunaola iwi ma muli o ka emi ʻana o ke kahe koko i nā iwi)
• Ka maʻi iwi mau loa (Chronic osteomyelitis)
• ʻO ka dysplasia fibrous
• ʻO ka maʻi o Paget o ka iwi

Aia kekahi mau mea pilikia e pili ana i ke kaiapuni a me kou mōʻaukala lapaʻau i hala:

• Ma hope o ka loaʻa mua ʻana o ka radiation therapy i ka wahi i loaʻa ai ke kanesa.
• Nā kuni nui ma kahi i loaʻa ai ke kanesa.
• Ka ʻike ʻia ʻana i kekahi mau kemika, e like me ka thorium dioxide, vinyl chloride, a i ʻole arsenic.
• ʻO ka hoʻopili ʻia ʻana i nā ʻāpana metala (e like me chromium, cobalt, nickel) i hoʻokomo ʻia i loko o ke kino ma o ke ʻoki kino.

Pehea e ʻike ai ke kauka i kēia? (Diagnosis)

Hana nā kauka i kekahi mau hoʻokolohua e ʻike ai i ka fibrosarcoma. ʻO ka ʻike mai kēia mau hoʻokolohua e hoʻoholo ai i ke kahua a me ke ʻano o ke kanesa.

• ʻO ke kiʻi MRI (Magnetic Resonance Imaging): ʻO kēia ka hoʻāʻo kiʻi maʻamau i hoʻohana ʻia e ʻike i ka fibrosarcoma. Hiki iā ia ke hōʻike maopopo i ka nui a me kahi o ka puʻupuʻu, a inā paha e hoʻopilikia ana i nā kīʻaha koko a i ʻole nā ​​​​aʻalolo.
• CT scan (Computed Tomography scan): Hoʻohana kēia i kahi moʻo o nā kukuna X a me kahi kamepiula e hana i nā kiʻi ʻekolu-dimensional (3D) o kou mau ʻiʻo palupalu a me nā iwi.
• Biopsy: Pili kēia i ka wehe ʻana i kahi ʻāpana liʻiliʻi o ka ʻiʻo mai ka puʻupuʻu (core needle biopsy) a i ʻole ka puʻupuʻu holoʻokoʻa (excisional biopsy) no ka hoʻokolokolo ʻana. Nānā kekahi pathologist i ka ʻiʻo i loko o kahi keʻena hoʻokolohua e ʻike inā loaʻa nā hunaola kanesa.
• Immunohistochemistry (IHC): He hoʻāʻo hoʻokolohua kūikawā kēia e hoʻohana ana i nā protein i kapa ʻia he antibodies e hōʻoia inā he fibrosarcoma ka puʻupuʻu a i ʻole kekahi ʻano maʻi ʻaʻai palupalu.

Pehea e hoʻoholo ʻia ai nā pae o ka maʻi kanesa?

Hoʻokaʻawale nā ​​kauka i ke kanesa i nā pae e hoʻoholo ai i ka mamao o kona laha ʻana a me kona koʻikoʻi. Hoʻomaopopo kēia i ka nui o ka puʻupuʻu, kona wahi, a inā ua laha. Nānā pū lākou i ke "pae" o ke kanesa. Penei ke ʻano ʻē o nā hunaola kanesa ke nānā ʻia ma lalo o kahi microscope. ʻO nā hunaola e like me ke ʻano ʻē ua manaʻo ʻia he mau kanesa "kiʻekiʻe", hiki ke ʻoi aku ka ikaika.

E wehewehe ana kāu kauka iā ʻoe i ka hopena ma hope o ka mālama ʻana, ma muli o ke kahua o kou maʻi ʻaʻai.

He aha nā lāʻau lapaʻau no kēia?

ʻO ka mālama ʻana no ka fibrosarcoma e pili ana i nā kumu he nui, me kou olakino holoʻokoʻa, kāu mau makemake, a me ke ʻano o ka maʻi kanesa.

Lapaʻau no ka fibrosarcoma ʻano pākeke

• ʻOki kino: Ma kēia kaʻina hana, wehe nā kauka i ka puʻupuʻu kanesa a me kahi liʻiliʻi o nā ʻiʻo olakino a puni ia mea e hōʻoia ʻaʻole i koe nā hunaola kanesa.
• Lapaʻau Radiation: Hiki ke hāʻawi ʻia ka lāʻau lapaʻau radiation ma mua o ke ʻoki ʻana e hoʻēmi i ka puʻupuʻu a i ʻole e luku i nā hunaola kanesa i koe ma hope o ke ʻoki ʻana.
• Kemokalama:ʻOiai ke kuhikuhi nei kekahi mau kauka i kēia lāʻau lapaʻau, ʻaʻole i kūleʻa loa ia no ka fibrosarcoma i hoʻomaka i ka pākeke. ʻAʻole pane maikaʻi kēia ʻano maʻi kanesa i ka chemotherapy.

Lapaʻau no ka fibrosarcoma pēpē

• ʻO ke ʻoki kino: I nā keiki, hiki i ka wehe ʻana i ka puʻupuʻu ke ho'ōla loa i ka maʻi.
• ʻO ka radiation a/a i ʻole chemotherapy: Hoʻohana ʻia kēia mau lāʻau lapaʻau e hoʻēmi i nā puʻupuʻu ma mua o ke ʻoki ʻana a i ʻole e luku i nā cell i koe ma hope. ʻAʻole e like me ke ʻano makua, ʻo ka hapa nui o nā fibrosarcomas kamaliʻi e pane maikaʻi loa i ka chemotherapy.
• Lapaʻau i Hoʻolālā ʻia: Hiki i kēia lāʻau lapaʻau ke hoʻōki i nā pūnaewele mai ka māhele wikiwiki ʻana ma muli o nā pilikia me ka gene `NTRK`. Hiki i kēia ke hoʻēmi i nā puʻupuʻu a maʻalahi ke ʻoki ʻana.

Pehea ke kūlana ma hope o ka mālama ʻana? (Prognosis)

He maikaʻi loa nā hopena no ka fibrosarcoma pēpē. Hiki ke ho'ōla loa ʻia ka hapa nui o kēia mau mea me ka hui pū ʻana o ke ʻoki kino, ka radiation, ka chemotherapy, a i ʻole ka lāʻau lapaʻau i kuhikuhi ʻia. ʻO ka helu ola 10 makahiki ma kahi o 90%. Inā hiki i ke ʻoki kino ke wehe pono i nā koena āpau o ke kanesa, kokoke kēlā helu i ka 100%.

ʻOi aku ka paʻakikī o ka fibrosarcoma i ka wā makua. Hoʻomaopopo pinepine ʻia kēia mau puʻupuʻu ma hope o ko lākou ulu nui ʻana e hoʻopilikia i nā aʻalolo a i ʻole ke kahe koko. E like me nā maʻi kanesa āpau, alakaʻi ka ʻike mua ʻana i nā hopena maikaʻi aʻe. Ke holomua ka maʻi kanesa, lilo ia i mea paʻakikī ke mālama. Ma kahi o ka hapalua o nā maʻi e loaʻa hou paha ka maʻi ma hope o ka mālama ʻana.

Inā loaʻa iā ʻoe kēia maʻi, pehea ʻoe e mālama ai iā ʻoe iho?

Manaʻo ka poʻe he nui ua nele lākou i ke kōkua ke ʻike ʻia lākou he maʻi kanesa. ʻO kekahi o nā ala maikaʻi loa e hoʻoponopono ai i kēia mau manaʻo, ʻo ia ka mālama ʻana iā ʻoe iho i ka wā a ma hope o ka mālama ʻana. Eia kekahi mau mea hiki iā ʻoe ke hana:

• E hoʻomaopopo i kāu hoʻolālā hahai: E nīnau i kāu kauka i ka mea e manaʻo ai i ka wā o ka hoʻōla ʻana a me nā manawa hahai.
• E Hoʻokele i ka Hopohopo: He mea nui nā nānā mau ʻana ma hope o ka mālama ʻana no ka ʻike mua ʻana i ka hoʻi hou ʻana o ka maʻi kanesa. Akā hiki iā ia ke hoʻoulu i ka hopohopo. E kamaʻilio me ke kākāʻōlelo e pili ana i ia mea.
• E noi i ke kōkua: Pono ʻoe i ke kōkua i ka wā o kāu mālama ʻana. Ke kali nei paha kāu poʻe aloha e kōkua iā ʻoe. E haʻi iā lākou pehea e hiki ai iā ʻoe ke kōkua.
• E kālele ana i nā hana olakino maikaʻi: He mea nui loa ka ʻai ʻana i nā meaʻai momona, ka hoʻoikaika kino lawa, a me ka hiamoe maikaʻi.
• E hoʻomaha:Hiki i nā lāʻau lapaʻau no ke kanesa a me ke kanesa ke hoʻoluhi iā ʻoe. E hoʻolālā e hoʻomaha nui i ka wā e hiki ai i ka wā lapaʻau.
• E hakakā i ke kaumaha: ʻO nā mea e like me ka noʻonoʻo ʻana, nā hoʻomaʻamaʻa hoʻomaha, a me nā hoʻomaʻamaʻa hanu hohonu e hiki ke kōkua i ka hōʻemi ʻana i ke kaumaha.

Āhea ʻoe e pono ai e ʻike i ke kauka?

Ma hope o ka lāʻau lapaʻau, e ʻike pinepine ʻoe i kāu kauka i kēlā me kēia ʻekolu mahina no nā makahiki ʻelua mua a laila ma nā manawa lōʻihi iki no ʻehā a ʻelima mau makahiki. Inā hoʻi hou ka fibrosarcoma, ka mea e hana pinepine ʻia i loko o nā makahiki ʻelima mua, e kōkua kēia papa hana i ka ʻike ʻana i kekahi hoʻi hou ʻana i ka wā mua.

Pono ʻoe e hoʻokaʻaʻike aku i kāu kauka i kēlā me kēia manawa ke loaʻa iā ʻoe nā puʻupuʻu hou a i ʻole ka ʻeha hou.

Āhea ʻoe e pono ai e hele i ka Emergency Treatment Unit (ETU)?

Hoʻopilikia ka nui o nā lāʻau lapaʻau maʻi kanesa i kāu ʻōnaehana pale, kahi e hoʻonui ai i kou pilikia o ka maʻi. Eia kekahi mau hōʻailona e koi ai iā ʻoe e hele i ka Emergency Department (ETU) i ka wā o ka mālama ʻana:

• He kuni o 38.3 kekelē Celsius (100.4 Fahrenheit) a ʻoi aku paha.
• Ke anu nei a me ka haʻalulu.
• ʻŪhū me ka huʻa.
• ʻEha ʻōpū.
• Ka maʻi pākī mau.
• Ka luaʻi mau ʻana a me ka luaʻi ʻana.