Pono anei mākou e hopohopo e pili ana i ka maʻi ʻaʻai ovarian epithelial?

Ua lohe paha ʻoe i ke Kanesa ʻOvarian Epithelial? He mea paʻakikī paha ke kani ʻana o ka inoa, akā he ʻano maʻi ʻovarian ia i maʻamau i waena o nā wahine. E kamaʻilio maʻalahi kākou e pili ana i ia mea, ma ke ʻano hiki iā ʻoe ke hoʻomaopopo. No ka mea, he mea nui loa ka makaʻala i nā mea e like me kēia.

He aha ke Kanesa Ovarian Epithelial?

I ka ʻōlelo maʻalahi, ʻo ke kanesa ovarian epithelial ke ʻano maʻamau o ke kanesa ovarian. Hoʻomohala kēia kanesa i loko o ka uhi lahilahi o waho o ka ovary, i kapa ʻia ʻo epithelial tissue. E noʻonoʻo iā ia e like me kahi membrane lahilahi e hoʻopuni ana i ka ovary.

ʻAʻole wale ia, akā i kekahi manawa hiki i kēia maʻi kanesa ke ulu i loko o ka uhi o nā ʻōpū fallopian a i ʻole i loko o ka peritoneum, ka ʻiʻo e uhi ana i nā ʻōpū i loko o ka ʻōpū. Hoʻokomo pū nā kauka i ka maʻi kanesa ʻōpū fallopian a me nā maʻi kanesa peritoneal mua i ka māhele like me ke kanesa ovarian epithelial no ka mea ua like loa nā hōʻailona a me nā lāʻau lapaʻau no kēia mau kūlana.

Pehea ka maʻamau o kēia maʻi kanesa?

ʻO ke kanesa ovarian ka lua o ke kanesa gynecological maʻamau, ma hope o ke kanesa uterine/endometrial. Loaʻa i ka wahine maʻamau he 1 i loko o 78 mau manawa e loaʻa ai ke kanesa ovarian i kona ola.

I ka makahiki 2021 wale nō, ua ʻike ʻia ma mua o 21,400 mau kānaka me ka maʻi ʻaʻai ovarian. ʻEiwa o loko o ka ʻumi o kēia mau mea i hōʻike ʻia he maʻi ʻaʻai ovarian epithelial. He mea maʻamau kēia maʻi ʻaʻai i waena o nā wahine ma luna o 65 mau makahiki.

He aha nā ʻano o ke kanesa ovarian epithelial?

Ma kahi o ʻekolu hapahā o nā maʻi ʻaʻai ovarian epithelial he mau carcinomas ovarian serous kiʻekiʻe (HGSOC). ʻO ke ʻano o "kiʻekiʻe" ʻo ia hoʻi, ulu a laha koke kēia mau hunaola maʻi ʻaʻai ma mua o nā maʻi ʻaʻai "haʻahaʻa".

Manaʻo nā loea lapaʻau e ulu mālie kēia ʻano HGSOC i ka wā mua, akā hiki ke hala a hiki i ʻeono makahiki a me ka hapa no ka laha ʻana mai nā ʻōpū fallopian a i nā ovaries. Akā i ka wā e hiki ai i nā ovaries, laha koke loa ia. Hoʻopilikia pinepine ia i ka uhi o ka lua ʻōpū (peritoneum) a me nā ʻāpana ʻē aʻe o ke kino. Ma kahi o 70% o nā maʻi HGSOC i ʻike ʻia me ka maʻi ma ke kahua 3 a i ʻole 4. ʻO ke ʻano kēia ua pālahalaha ke kanesa ma mua o ka puʻupuʻu mua a i kēia manawa ua lilo ia i kanesa metastatic.

Aia kekahi mau ʻano maʻamau ʻole o ka maʻi kanesa ovarian epithelial:

• ʻO ke kanesa endometrioid:ʻOi aku ka maʻamau o kēia ʻano i nā poʻe me ka endometriosis, kahi e hoʻopilikia ai i ka uhi o ka ʻōpū (endometrium). Pane maikaʻi ia i ka chemotherapy ma mua o kekahi mau ʻano ʻē aʻe.
• ʻO ka maʻi kanesa ovarian serous haʻahaʻa (LGSOC): He maʻi kanesa ulu lohi kēia. Loaʻa ia i nā wahine ʻōpio (ma waena o 45 a me 57 mau makahiki). He 10% ia o nā maʻi kanesa ovarian epithelial. Hoʻomaka pinepine ka maʻi i ka wā e ʻike ʻia ai, a ʻaʻole ia e pane maikaʻi i ka chemotherapy. ʻOiai ke ulu mālie nei nā maʻi kanesa haʻahaʻa, ʻaʻole lākou e lilo i mau maʻi kanesa kiʻekiʻe.
• ʻO ka maʻi kanesa mucinous: He ʻokoʻa kēia mau puʻupuʻu mai nā ʻano ʻē aʻe a pane maikaʻi i ka lāʻau. He nui lākou (ma kahi o 8 ʻīniha a i ʻole 20 kenimika). Hoʻopilikia pinepine lākou i nā ovaries wale nō.
• ʻO ka maʻi kanesa o ka ʻōpū (OCCC): ʻOi aku ka nui o ka pilikia o nā wahine ʻAsia a me ka poʻe me ka endometriosis i ka loaʻa ʻana o kēia maʻi kanesa. Hoʻomaka pinepine ka maʻi i ka wā e ʻike ʻia ai. ʻAʻole ia e pane maikaʻi i ka chemotherapy.
• ʻO ka carcinoma cell squamous mua (SCC) o ka ovary: ʻO kēia ʻano SCC e ulu pinepine mai nā kūlana benign/noncancerous. No ka laʻana, hiki ke ulu mai nā ovarian cysts, endometriosis, a i ʻole nā ​​​​​​tumor Brenner (nā ulu paʻa, ʻano ʻē i loko o nā ovaries). Inā ʻike ʻia i ka wā mua, pane maikaʻi ia i ka mālama ʻana.

He aha ke kumu o ka maʻi ʻaʻai epithelial ovarian?

ʻO ka ʻoiaʻiʻo, ʻaʻole i ʻike ʻia ke kumu kikoʻī o ka hapa nui o nā maʻi kanesa, me ke kanesa ovarian epithelial. Eia nō naʻe, hōʻike ka noiʻi hou e hoʻomaka ka hapa nui o nā maʻi kanesa ovarian i loko o nā pūnaewele ma nā wēlau o nā tuba fallopian. A laila laha lākou i nā ovaries.

He aha nā kumu pilikia no ka hoʻomohala ʻana i kēia maʻi kanesa?

ʻOi aku ma mua o ka hapalua o ka poʻe i ʻike ʻia me ka maʻi ʻaʻai ovarian ua ʻoi aku ma mua o 65 mau makahiki a ua hala i ka menopause, ʻo ia hoʻi ua pau kā lākou pōʻaiapuni menstrual.

Hiki i kekahi mau kumu ke hoʻonui i ka pilikia o ka loaʻa ʻana o ka maʻi ʻaʻai ovarian. ʻO lākou kēia:

• Inā ua loaʻa kekahi o kou ʻohana i ke kanesa ovarian, ka maʻi umauma, a i ʻole ke kanesa colorectal/colon.
• Inā ua hoʻoilina ʻoe i kahi loli (mutation) i loko o ka gene BRCA.
• Inā ua hoʻoilina ʻoe i kahi gene e pili ana i nā maʻi kanesa ʻohana, e like me Lynch syndrome.
• Inā ʻoe e lawe nei i ka lāʻau lapaʻau hormone e kāohi i nā hōʻailona o ka menopause.
• Ka hānau ʻana o kahi keiki ma hope o 35 mau makahiki a i ʻole ʻaʻole i hāpai i kahi keiki a hiki i ka wā piha.
• Ka momona nui .

He aha nā hōʻailona o ke kanesa ovarian epithelial?

He pilikia kēia no nā kānaka he nui. ʻAʻole pinepine nā hōʻailona o ka maʻi ʻaʻai ovarian epithelial i nā pae mua. ʻIke ʻia nā hōʻailona ma hope o ka laha iki ʻana o ka maʻi. Ke laha aʻe i ka membrane e uhi ana i nā ʻōpū o ka ʻōpū (peritoneum), hiki i kahi wai wai ke hōʻiliʻili i loko o ka ʻōpū. Ua kapa ʻia kēia he ascites.

Eia kekahi, hiki ke loaʻa nā hōʻailona penei:

• ʻEha ʻōpū.
• Ka paʻakikī i ka ʻai ʻana a i ʻole ka māʻona ma hope o ka ʻai ʻana i kahi liʻiliʻi.
• Ka luaʻi a me ka luaʻi.
• Pehu.
• ʻEha pelvis.

Aia kekahi mau hōʻailona i ʻike pinepine ʻole ʻia:

• Koi aku i ka hoʻōki ʻana i ka mimi a i ʻole ka mimi pinepine ʻana (overactive bladder).
• Ke kahe koko ʻana o ka ʻōpū ma ke ʻano ʻē.

He mea nui: ʻO ka loaʻa ʻana o kēia mau hōʻailona ʻaʻole ia he manaʻo he maʻi kanesa kou. Eia nō naʻe, inā hoʻomau lākou, ʻoi aku ka maikaʻi o ke kipa ʻana i ke kauka no ka ʻōlelo aʻo.

Pehea e ʻike ʻia ai ka maʻi ʻaʻai ovarian epithelial?

ʻO ka mea pōʻino, ʻaʻohe mau hoʻokolohua nānā kikoʻī e hiki ke ʻike i ka maʻi ʻaʻai ovarian i kona mau wā mua. Hana pinepine ʻia ka nānā ʻana inā loaʻa iā ʻoe nā hōʻailona a i ʻole he pilikia kiʻekiʻe. Hiki i kāu kauka ke hana mua i kahi hoʻokolohua pelvic e nānā i nā puʻupuʻu a i ʻole ka pehu ʻana.

A laila, hiki iā ʻoe ke hana i kahi hoʻāʻo koko e nānā i ka pae o kahi protein i kapa ʻia ʻo `CA-125`. ʻO kēia `CA-125` ke kū nei no ka antigen cancer 125. Inā kiʻekiʻe ka pae, pono ʻoe e hana i nā hoʻokolohua hou aku.

Hiki i nā hoʻokolohua kiʻi e like me kēia ke kōkua i ka ʻike ʻana i ka maʻi ʻaʻai ovarian:

• Hoʻāʻo ultrasound transvaginal.
• Hoʻāʻo scan CT.
• Hoʻāʻo MRI (MRI).
• ʻO ke kiʻi ʻana o ka tomography hoʻokuʻu Positron (PET).
• Nā kiʻi X-ray o ka umauma (e ʻike inā ua pālahalaha ke kanesa i nā māmā).

I kekahi manawa, hiki ke hana ʻia kahi kaʻina hana i kapa ʻia he laparoscopy. Ua like kēia me ke ʻoki ʻana, akā hana ʻia me ka ʻole o ka hana ʻana i kahi ʻoki nui. ʻAe kēia i ke kauka e nānā i kou mau kino hānau. Hiki iā lākou ke lawe i kahi hāpana ʻiʻo (biopsy) mai kahi puʻupuʻu e ʻike ai inā he mau hunaola kanesa ma laila. ʻO kēia biopsy wale nō ke ala e ʻike pono ai inā he kanesa ovarian kou.

He aha nā pae o ka maʻi ʻaʻai ovarian epithelial?

ʻO ka ʻike ʻana i ke kahua o ke kanesa e kōkua i nā kauka e hoʻomaopopo i ka holomua o ke kanesa. He mea nui nō hoʻi ia no ka hoʻoholo ʻana inā ua laha ke kanesa a no ka hoʻoholo ʻana i ka lāʻau lapaʻau. Hoʻoholo ʻia ke kahua o ke kanesa e nā hoʻokolohua like i hoʻohana ʻia e ʻike i ke kanesa.

ʻEhā mau pae nui o ka maʻi ʻaʻai ovarian. Loaʻa i kekahi mau pae nā pae liʻiliʻi. ʻO ke kiʻekiʻe o ka helu pae, ʻo ka ʻoi aku ka holomua o ke kanesa.

• Pae 1: Aia ke kanesa i hoʻokahi ovary a i ʻole hoʻokahi fallopian tube.
• Pae 2: Ua pālahalaha ke kanesa i ka ʻōpū a i ʻole ka uhi o ka lua ʻōpū (peritoneal cavity).
• Pae 3: Ua pālahalaha ke kanesa i nā ʻōpū ʻē aʻe ma waho o ke pelvis, i nā lymph nodes, a i ʻole nā ​​​​mea ʻelua.
• Pae 4: Aia nā hunaola kanesa i loko o ke kahe a puni nā māmā, nā lymph node ma ka ʻāpana groin, nā ʻōpū ʻē aʻe, a i ʻole nā ​​​​​​ʻāpana ʻē aʻe o ke kino.

Hiki ke ho'ōla ʻia ke kanesa o ka epithelial ovarian?

Hana nā kauka lapaʻau i kahi ʻoki debulking e wehe i ka nui o ke kanesa e like me ka hiki. Ma hope o kēia e chemotherapy. ʻOiai ka hapa nui o ka poʻe e hoʻōla mua ana, hiki i ka maʻi ke hoʻi hou mai i nā poʻe he nui ma hope.

Hiki paha i nā maʻi mua ke hoʻoholo e wehe wale i ka ovary maʻi a me ka fallopian tube.

No nā poʻe me nā maʻi kanesa holomua, hana pinepine ʻia kahi ʻoki debulking e wehe i nā ʻōpū e like me:

• Ka wehe ʻana i nā ʻōpū fallopian a me nā ovaries ʻelua (bilateral salpingo-oophorectomy).
• Ka wehe ʻana i ka ʻōpū (hysterectomy).
• Ka wehe ʻana i ka ʻiʻo momona (omentum) e uhi ana i ka ʻōpū (omentectomy).
• Ka wehe ʻana i nā kikowaena lymph a puni.
• Ka wehe ʻana i nā ʻāpana maʻi ʻē aʻe (e like me ka ʻōpū liʻiliʻi, ka ʻōpū nui, a i ʻole ka spleen).

He aha nā lāʻau lapaʻau ʻē aʻe?

Ma muli o ke ʻano o ka maʻi kanesa, hiki ke hāʻawi ʻia iā ʻoe i hoʻokahi a ʻoi aku paha o kēia mau lāʻau lapaʻau ma hope o ke ʻoki ʻana:

• Chemotherapy: No ka pepehi ʻana i nā hunaola kanesa. Hoʻohana kēia i nā lāʻau lapaʻau e like me nā hui platinum (carboplatin) a me paclitaxel (Taxol®) a i ʻole docetaxel (Taxotere®).
• Kemotherapy intraperitoneal: No ka mālama ʻana i ke kanesa ovarian pae 3, ua hoʻokomo pololei ʻia nā lāʻau lapaʻau cisplatin a me paclitaxel i loko o ka lua ʻōpū ma o kahi catheter i hoʻokomo ʻia i ke ʻoki (he ʻōmole lahilahi a hakahaka).
• Nā lāʻau lapaʻau i kuhikuhi ʻia: ʻO nā lāʻau lapaʻau e like me Bevacizumab (Avastin®) e kāohi i nā hunaola kanesa mai ka ulu ʻana a me ka hoʻonui ʻana.
• Lapaʻau radiation: Hoʻohana i nā kukuna X-ray ikehu kiʻekiʻe e hoʻopau i nā hunaola kanesa.

Hiki ke pale ʻia ke kanesa o ka epithelial ovarian?

Ua hōʻike ʻia nā noiʻi e hiki i nā wahine e lawe ana i nā pila hoʻomalu hānau hormonal no ʻelima mau makahiki a ʻoi aku paha ke hōʻemi i ko lākou pilikia o ka hoʻomohala ʻana i ka maʻi ʻaʻai ovarian ma kahi o ka hapalua.

Hiki i kekahi mau ʻoki kino ke hōʻemi i ka pilikia o ka maʻi kanesa. ʻO ke ʻoki kino e pale aku i ka maʻi kanesa ua kapa ʻia ʻo ke ʻoki kino prophylactic. Pili kēia i ka wehe ʻana i nā ʻōpū fallopian a me nā ovaries, me ka ʻōpū a i ʻole me ka ʻole. Manaʻo pinepine ʻia kēia no nā wahine i loaʻa i ka pilikia kiʻekiʻe ma muli o ka mōʻaukala ʻohana (e like me ka poʻe me ka BRCA mutation a i ʻole Lynch syndrome). Eia nō naʻe, ʻōlelo aʻo nā kauka e hana ʻia kēia mau kaʻina hana inā pono ke kauka. ʻO kēia no ka mea hiki i ka wehe ʻana i nā ovaries ke kumu i ka menopause mua, hiki ke loaʻa ka hopena maikaʻi ʻole i ke kino.

ʻAʻole hiki i kēia mau ʻoki kino ke hoʻopau loa i ka pilikia o ka maʻi kanesa. Loaʻa paha i kekahi poʻe ka maʻi kanesa i ʻike ʻole ʻia i ka wā o ke ʻoki kino. Hiki i ka poʻe me nā hoʻololi ʻana o ka gene BRCA ke hoʻomohala i ka maʻi kanesa peritoneal mua ʻoiai inā ua wehe ʻia kā lākou mau ʻōpū fallopian a me nā ovaries. E nīnau i kāu kauka e pili ana i ka hoʻāʻo BRCA e ʻike inā loaʻa iā ʻoe ka gene BRCA.

He aha ka manaʻolana no ka poʻe me ka maʻi ʻaʻai ovarian epithelial?

Ma mua o 13,000 mau kānaka e make ana i ka maʻi ʻaʻai ovarian i kēlā me kēia makahiki. ʻO ia ke kumu nui ʻelima o ka make ʻana o ka maʻi kanesa i waena o nā wahine. Eia nō naʻe, aia ka manaʻolana no nā lāʻau lapaʻau hou i kēia manawa i nā hoʻokolohua lapaʻau. Ke hana pū nei nā kānaka noiʻi e ʻike i ka maʻi i ka wā mua.

Inā ʻike ʻia ka maʻi ʻaʻai ovarian epithelial ma mua o kona laha ʻana, ʻoi aku ka nui o ke ola ʻelima makahiki ma mua o 90%. Eia nō naʻe, i ka wā e laha ai ke kanesa (metastasized), hāʻule kēia helu i kahi o 30%.

He nui nā kumu e hoʻopilikia i ka prognosis o kahi maʻi kanesa:

• Ke ʻano o ka laha ʻana o ke kanesa.
• Ka holomua o ka lāʻau lapaʻau.
• ʻO ka wahi, ka nui, a me ka helu o nā puʻupuʻu kanesa (ke kahua o ke kanesa).

Āhea ʻoe e ʻike ai i ke kauka?

Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​e ʻike koke i ke kauka:

• Nā loli i ke alapine (frequency) a i ʻole ka wikiwiki o ka mimi ʻana.
• Ka nalowale ʻana o ka makemake a i ʻole ka māʻona ma hope o ka ʻai ʻana i kahi liʻiliʻi.
• ʻEha mau ka ʻeha ma ka ʻōpū a i ʻole ka pelvic no ke kumu ʻole.

He aha nā nīnau āu e nīnau ai i kāu kauka?

Hiki iā ʻoe ke nīnau i ke kauka i nā nīnau penei:

• Pono anei au e hana i kahi hoʻokolohua BRCA?
• He aha ke ʻano o ka maʻi ʻaʻai ovarian epithelial i loaʻa iaʻu?
• He aha ka lāʻau lapaʻau maikaʻi loa noʻu?
• He aha nā hopena ʻaoʻao o nā lāʻau lapaʻau?
• Aia anei au i ka pilikia o ka maʻi kanesa metastatic? Pehea e hiki ai iaʻu ke hōʻemi i kēlā pilikia?
• Pono anei au e hopohopo e pili ana i nā pilikia?

He aha ke ʻano ʻoi loa o ka maʻi ʻaʻai ovarian?

ʻO ke kanesa ovarian serous kiʻekiʻe (HGSOC) he ʻano maʻi ovarian ikaika loa. ʻOiai ke ulu mālie nei kēia kanesa i ka wā mua ma nā ʻōpū fallopian, pālahalaha koke ia ke hiki i nā ovaries. ʻO ka mea pōʻino, he nui ka poʻe me HGSOC i loaʻa i ka maʻi ovarian holomua/metastatic ke ʻike ʻia lākou.

Hiki paha ke loaʻa nā cysts ovarian epithelial ʻaʻole cancerous (benign)?

ʻAe. ʻO ka ʻoiaʻiʻo, ʻaʻole ka hapa nui o nā ʻōpū ovarian epithelial he maʻi kanesa. Ua kapa ʻia kekahi mau ʻōpū he mau ʻōpū borderline a i ʻole nā ​​​​ʻōpū proliferating atypical. Ua kapa ʻia kēia mau mea ma mua he mau ʻōpū malignant low.

I loko o nā puʻupuʻu palena, ulu nā pūnaewele ʻano ʻē i loko o ka ʻiʻo epithelial akā ʻaʻole e hoʻouka i nā ʻiʻo kākoʻo o ka ovary (stroma). Loaʻa pinepine kēia mau pūnaewele i loko o ka ovary ponoʻī a ʻaʻole pinepine e lilo i maʻi kanesa. Inā ulu ka maʻi kanesa, ʻekolu o ka ʻehā he pae 1 (i hoʻopaʻa ʻia i ka ovary a maʻalahi ke mālama). Hoʻopilikia pinepine kēia mau puʻupuʻu i ka poʻe ʻōpio.

Leka Lawe-Home

ʻO ke kanesa ovarian epithelial ke ʻano maʻamau o ke kanesa ovarian. Hoʻokomo pū ia i ke kanesa o ka tuba fallopian a me ke kanesa peritoneal mua. He kakaikahi nā hōʻailona o ke kanesa ovarian i kona mau pae mua. Ua ʻoi aku ka lōʻihi o ka maʻi e ʻike ʻia i ka manawa e ʻike ʻia ai. He ʻoiaʻiʻo loa kēia no ke ʻano maʻamau o ke kanesa epithelial, i kapa ʻia ʻo `HGSOC`.

Inā he kiʻekiʻe kou pilikia o ka loaʻa ʻana o ka maʻi ʻaʻai ovarian (e like me ka mōʻaukala ʻohana), he mea nui e nīnau i kāu kauka inā kūpono nā hana prophylactic iā ʻoe. E mālama mau i kou kino. Mai hoʻowahāwahā i nā hōʻailona ʻē. E ʻimi i ke aʻo lapaʻau.

ʻO ke kanesa ovarian, ke kanesa epithelial, ke olakino wahine, nā hōʻailona kanesa, ka mālama ʻana i ke kanesa, ka gene BRCA, gynecology