Ke hana nui nei anei kou kelepa pituitary? (Hyperpituitarism) E kamaʻilio maʻalahi kākou e pili ana i kēia!

Ua ʻike koke anei ʻoe i nā loli nui i kou kino? Malia paha ua piʻi koke kou kaumaha, ua loli kou helehelena, a ua luhi paha ʻoe i ka lā a pau me ka nānā ʻole i ka nui o kou hiamoe ʻana? Hoʻopoina pinepine mākou i kēia mau mea, me ka manaʻo he mea maʻamau lākou. Akā, ua ʻike anei ʻoe ma hope o kekahi o kēia mau mea, aia paha kahi loli i ka hana o kahi gland liʻiliʻi, akā koʻikoʻi loa i loko o ko mākou lolo. ʻO ia ka mea a mākou e kamaʻilio nei i kēia lā.

He aha ka inoa o kēia kelepa pituitary? No ke aha he mea nui loa ia?

E noʻonoʻo i kou kino e like me kahi ʻoihana nui. ʻO ke poʻo luna o kēlā ʻoihana, ke poʻo nāna e kāohi i nā mea āpau, ʻo ia ka pituitary gland . He gland liʻiliʻi kēia, e like me ka nui o ka pī, aia ma ke kumu o ko kākou lolo, e like me ka nui o ka cherry. ʻOiai he liʻiliʻi ia, hana nui kāna hana. ʻO ia ke kumu i kapa ʻia ai i kekahi manawa ʻo "master gland."

I ka ʻōlelo maʻalahi, hoʻomalu ia i ka hana o nā kelepa endocrine ʻē aʻe i loko o ko mākou kino. No ka laʻana, ʻo ke kelepa thyroid, nā kelepa adrenal, a me kā mākou ʻōnaehana hānau hou, e like me nā ovaries a i ʻole nā ​​​​testes, ua hoʻomalu ʻia e nā hormones i hoʻokuʻu ʻia e ka pituitary gland.

E like me ka thermostat i loko o ko mākou hale. Nānā mau ia i ka mahana o loko o ka hale a mālama i ka mahana ma ka pae like ma ka hoʻohuli ʻana i ka AC a i ʻole ka mea hoʻomehana i ke ahi a pio paha, ʻeā? Ma ke ʻano like, nānā mau ka pituitary gland i nā pae hormone i loko o ko mākou kino a hoʻouna i nā hōʻailona i nā glands ʻē aʻe e hoʻokuʻu i nā hormones e pono ai i ka manawa kūpono.

No laila he aha kēia hyperpituitarism?

I ka ʻōlelo maʻalahi, ʻo Hyperpituitarism ka wā e hana nui ai ke kelepa pituitary i ʻōlelo ʻia ma luna, e hoʻokuʻu ana i nā hormones i loko o ko kākou koko ma mua o ka mea e pono ai. Ua like ia me ke luna o ka ʻoihana e hana nui ana a hoʻopilikia i nā mea āpau.

ʻO ka hapa nui o ka manawa, ʻo ia hoʻi, ma kahi o 99% o ka manawa, ʻo ke kumu he puʻupuʻu liʻiliʻi, ʻaʻole maʻi kanesa (benign). Ma nā ʻōlelo lapaʻau, kapa mākou i kēia he pituitary adenoma . Hoʻoulu kēia puʻupuʻu i ka gland a hoʻoulu iā ia e hana i nā hormones ma mua o ka mea e pono ai.

Nā hormones i hana ʻia e ka pituitary gland a me kā lākou hana

ʻEkolu mau ʻāpana nui o ka pituitary gland. Hoʻokuʻu kēlā me kēia ʻāpana i nā hormones like ʻole. E nānā kākou i ko lākou ʻano a me nā mea e hana ʻia iā lākou.

Nā maʻi e hiki ke hana ma muli o ka nui o ka pituitary gland

ʻOkoʻa ke ʻano o ka maʻi e kū mai ana ma muli o ka hormone i hana nui ʻia e ka pituitary gland. E nānā kākou i nā kūlana nui i ʻike ʻia.

• ʻO Cushing's Syndrome: Inā hana nui ʻia ka hormone ACTH, piʻi nui ka pae o ka cortisol i loko o ko mākou kino. Ua kapa ʻia kēia ʻo Cushing's Syndrome.
• Acromegaly: Hana ʻia kēia ʻano ke hana nui ʻia ka hormone ulu (GH) i ka wā makua. ʻO kēia ke kumu o ka ulu nui ʻana o nā iwi o nā lima, nā wāwae, a me ke alo. Inā hana ʻia kēia i ka wā kamaliʻi, ua kapa ʻia ʻo ia he gigantism .
• Hyperthyroidism: Inā nui ka TSH i hana ʻia (he mea kākaʻikahi kēia), lilo ka thyroid gland i mea hana nui a wikiwiki ka metabolism o ke kino.
• Prolactinoma: ʻO kahi puʻupuʻu (adenoma) i loko o nā pūnaewele e hana ana i ka hormone prolactin ke kumu o ka hana nui ʻana o ka hormone. Hiki i kēia ke loaʻa ka hopena koʻikoʻi i ke olakino hānau hou.

He aha nā hōʻailona o kēia mau maʻi?

He ʻokoʻa nā hōʻailona e hele mai me kēlā me kēia o kēia mau kūlana. Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​​​he mea nui loa ia e ʻike i ke kauka.

Pehea ka hopena o kēia kūlana i nā keiki?

He mea kākaʻikahi loa ka hyperpituitarism i nā keiki. Inā loaʻa ia, ʻo ia ke kumu o kahi adenoma pituitary liʻiliʻi. ʻO ke ʻano maʻamau o ka puʻupuʻu i nā keiki he puʻupuʻu hana prolactin (Prolactinomas).

• No nā kaikamāhine: Hiki ke lohi ka wā ʻōpiopio, ka pau ʻana o ka menstruation (amenorrhea), a me ka hana ʻole o ka ovarian.
• Nā Keikikāne: ʻOi aku ka nui o ka ulu ʻana o nā puʻupuʻu nui (macroprolactinomas). Ma muli o ka nui o kēia mau puʻupuʻu, hiki iā lākou ke kaomi i nā aʻalolo i loko o ka lolo, e hoʻoulu ai i ka ʻeha poʻo a me nā pilikia ʻike. Hiki iā lākou ke hoʻoulu i ka lohi o ka wā ʻōpiopio a me nā pilikia ulu.

Pehea e ʻike ai ke kauka i kēia maʻi?

Ke haʻi mai ʻoe iā mākou e pili ana i kāu mau hōʻailona, ​​e nānā pono mua ke kauka iā ʻoe. A laila, hana paha lākou i kekahi mau hoʻokolohua e hōʻoia i ka maʻi.

1. Nā hoʻāʻo koko a me ka mimi: E ana kēia i nā pae o nā hormones i loko o kou koko a me ka mimi paha. No ka laʻana, e nānā lākou i kāu mau pae o ka prolactin, cortisol, a me ka hormone ulu.

2. Nā Kiʻi Kiʻi:Inā loaʻa kahi ʻano ʻē i nā pae hormone, hana ʻia kahi scan e nānā i kahi puʻupuʻu pituitary. ʻO ka scan maʻamau i hoʻohana ʻia no kēia he scan MRI (Magnetic Resonance Imaging) . No kekahi kanaka ʻaʻole hiki ke loaʻa kahi MRI (e.g. kekahi me ka pacemaker), hiki ke hana ʻia kahi scan CT (Computed Tomography) .

3. Nā hoʻokolohua kūikawā: I kekahi manawa, no ka ʻike pololei ʻana i nā kūlana e like me Cushing's syndrome, pono paha nā hoʻokolohua kūikawā, e like me ke ana ʻana i nā pae cortisol salivary.

He aha nā lāʻau lapaʻau?

ʻO ke ʻano o ka mālama ʻana no kēia maʻi e pili ana i nā mea e like me ke ʻano o kou maʻi, ka nui o ka puʻupuʻu, a me kou olakino holoʻokoʻa. ʻEkolu mau koho lapaʻau nui.

1. Lāʻau lapaʻau

I ka manawa pinepine, ʻo ka lāʻau lapaʻau mua ka lāʻau lapaʻau. Hoʻohana ʻia kēia mau lāʻau lapaʻau i:

• Ke kāohi nei i nā pae hormone.
• I kekahi manawa hoʻemi i ka nui o ka puʻupuʻu.
• He kūpono loa nā lāʻau lapaʻau, ʻoi aku hoʻi no ka prolactinoma. ʻOi aku ma mua o 80% o ka poʻe e hoʻi i nā pae hormone maʻamau.

2. ʻOki kino

Inā ʻaʻole hiki i nā lāʻau lapaʻau ke kāohi i ka puʻupuʻu, a inā ua ulu nui ka puʻupuʻu e hoʻopilikia i ka ʻike, ʻo ka hana aʻe e wehe i ka puʻupuʻu ma ke ʻoki ʻana.

• ʻO ke ʻoki maʻamau i kapa ʻia he transsphenoidal adenomectomy . Pili kēia i ka hana ʻana i kahi ʻoki liʻiliʻi ma o ka ihu a i loko paha o ka lehelehe luna e hiki ai i ka pituitary gland a wehe i ka puʻupuʻu me ka ʻole o ka hōʻino ʻana i ka lolo.
• Inā hana ʻia kēia ʻoki e ke kauka ʻoki akamai, ʻoi aku ka nui o ka holomua ma mua o 80%.

3. Hoʻōla Lapaʻau

Hoʻohana ʻia ka lāʻau lapaʻau radiation inā koe kekahi ʻāpana o ka puʻupuʻu ma hope o ke ʻoki ʻana, a inā ʻaʻole hiki ke ʻoki ʻia.

• Hoʻopili kēia i ke kuhikuhi ʻana i nā kukuna ikehu kiʻekiʻe i ka puʻupuʻu a me ka luku ʻana i kēlā mau pūnaewele.
• Hiki i nā ʻano hana hou e like me ka stereotactic therapy ke hōʻemi nui i ka hōʻino ʻana i nā ʻiʻo olakino a puni.

Hiki ke olakino me kēia maʻi?

ʻAe, ʻoiaʻiʻo nō. Hiki ke mālama maikaʻi ʻia ka hapa nui o nā kūlana i hoʻokumu ʻia e ka hyperpituitarism me nā lāʻau lapaʻau a me nā lāʻau lapaʻau ʻē aʻe. ʻO ka mea nui loa, ʻo ia ke ʻimi i ke aʻo lapaʻau i ka wā e ʻike ʻia ai nā hōʻailona a hahai pololei i ka lāʻau lapaʻau i kuhikuhi ʻia. Pono paha kekahi mau kūlana i ka lāʻau lapaʻau lōʻihi a i ʻole ka nānā ʻana o ke kauka. Eia nō naʻe, me ka mālama pono ʻana, hiki i ka hapa nui o ka poʻe ke ola olakino, hauʻoli, a me ke ola maʻamau.