Ua noʻonoʻo paha ʻoe i kou manaʻo ke māʻona ʻoe? Ke ʻai mākou, ma hope o kekahi manawa manaʻo mākou "ʻAe, ua lawa ia." He aha ka mea e hoʻokumu ai i kēia manaʻo? No laila no ke aha i manaʻo ʻole ai kekahi poʻe i ka māʻona ʻaʻole pili i ka nui o kā lākou ʻai ʻana? ʻO Leptin kekahi mea nui ma hope o kēia mau mea a pau. He hormone kēia he mea nui loa no ka kaohi ʻana i ke kaumaha o ko mākou kino. E kamaʻilio kākou e pili ana i kēia lā me ka maʻalahi a me ka pololei.
He aha ka Leptin, ma ka ʻōlelo maʻalahi?
I ka ʻōlelo maʻalahi, ʻo ka leptin kahi hormone i hana ʻia e nā hunaola momona o kou kino (ʻiʻo adipose). Ua kapa ʻia hoʻi ia ʻo ka "hormone satiety." ʻO kāna hana nui ka hoʻouna ʻana i kahi hōʻailona i kou lolo e ʻōlelo ana, "ʻAe, ua lawa kou ikehu, e hoʻōki i ka ʻai ʻana." Penei ke kōkua ʻana o ka leptin i ka mālama ʻana i ke kaumaha o ke kino paʻa i ka wā lōʻihi.
Ua ʻike nā kānaka ʻepekema i ka hormone leptin i ka makahiki 1994, ʻo ia hoʻi, nui ka noiʻi e hana ʻia nei ma luna. Ke noiʻi ʻia nei ka pilina o Leptin ʻaʻole wale i ka hoʻokele kaumaha, akā i nā maʻi e like me ka maʻi Alzheimer, ke olakino hānau hou, a me ka hānau ʻole.
Ke lohe ʻoe i ka huaʻōlelo "kaohi kaumaha," manaʻo paha ʻoe, "ʻĀ ... no laila hiki iā mākou ke kaohi i ka leptin a hoʻemi i ke kaumaha." Akā ʻo ka ʻoiaʻiʻo, ʻo ka kaohi ʻana i kēia hormone i ke ala a mākou e makemake ai ʻaʻole ia he mea maʻalahi e like me kā mākou e manaʻo nei.
Pehea e hana ai ka leptin i loko o ko mākou kino?
ʻO ka hana nui a Leptin ke kōkua i ka mālama ʻana i ke kaumaha o ko kākou kino. ʻO ia hoʻi, e hana i kahi kaulike lōʻihi ma waena o ka nui o ka meaʻai a kākou e ʻai ai a me ka ikehu a ko kākou kino e hoʻolilo ai. Hoʻōki ʻo Leptin iā kākou mai ka pōloli pono ʻole. Kōkua ia i ka pale ʻana i ke kino mai ka hōʻailona ʻana i ka pōloli ke ʻole ia e pono i ka ikehu (calories).
Hana nui ʻo Leptin ma ka hoʻopilikia ʻana i kahi ʻāpana o ko kākou lolo i kapa ʻia ʻo ka hypothalamus. Eia nō naʻe, aia nā mea loaʻa ma nā ʻāpana ʻē aʻe o ke kino e pane ana i ka leptin.
ʻO ka mea nui loa, ʻaʻole ka leptin e kāohi i ko kākou pōloli mai kekahi pāʻina a i kekahi. Akā, hana ia e kāohi i ka ʻai ʻana i ka meaʻai a me ka hoʻolilo ʻana i ka ikehu i ka wā lōʻihi, e mālama ana i ke kaumaha o ke kino i paʻa.
E noʻonoʻo e hoʻāʻo nei ʻoe e hōʻemi i ke kaumaha. I ka emi ʻana o ka momona o kou kino, e emi pū ana hoʻi kāu pae leptin. Hoʻouna kēia i kahi hōʻailona i kou lolo ua pōloli ʻoe. Hoʻoulu kēia iā ʻoe e pōloli loa a loaʻa nā makemake. Hiki i kēia ke alakaʻi iā ʻoe e ʻai hou aku me ka ʻike ʻole. ʻO kēia kekahi o nā kumu he paʻakikī loa ka hōʻemi ʻana i ke kaumaha.
Pehea e kāohi ʻia ai nā pae leptin?
Hoʻopuka ʻia a hoʻokuʻu ʻia ka leptin i loko o ke kahe koko e ka ʻiʻo adipose keʻokeʻo i loko o ko kākou kino. No laila, pili pono ka nui o ka leptin i loko o kou koko i ka nui o ka momona i loko o kou kino.
- Inā he nui kou momona o ke kino:He kiʻekiʻe nā pae leptin.
- Inā haʻahaʻa ka momona o ke kino: haʻahaʻa nā pae leptin.
I ka hala ʻana o ka manawa, inā piʻi ka momona o kou kino, e piʻi pū ka nui o ka leptin, a inā emi ka momona o kou kino, e emi pū ka nui o ka leptin.
He aha ka mea e hana ai inā kiʻekiʻe loa nā pae leptin? - Leptin Resistance
He nui loa ka momona o ke kino o ke kanaka momona. ʻO ka hopena, ua kiʻekiʻe loa hoʻi ko lākou pae leptin i loko o ke koko. Kāhea mākou i kēia ʻano he hyperleptinemia .
I kēia manawa, ke noʻonoʻo nei paha ʻoe, "Inā kiʻekiʻe ka leptin, pono ʻoe e māʻona, no laila pono ʻoe e kāohi i kāu ʻai ʻana?" Akā ʻo ka ʻaoʻao ʻē aʻe ka ʻoiaʻiʻo. Ke kiʻekiʻe nā pae leptin i loko o ke kino no ka manawa lōʻihi, hoʻomaka ka lolo e pane ʻole i kēlā hōʻailona leptin. Ua like ia me kekahi e hoʻōho mau ana iā mākou a lilo mākou i mea make iā ia ma hope o kekahi manawa. Ua kapa ʻia kēia he kūʻē leptin .
I ka ʻōlelo maʻalahi, ʻo ke kūʻē ʻana o ka leptin ʻo ia hoʻi ʻoiai ua lawa ka leptin i loko o ke kino, ʻaʻole i loaʻa i ka lolo ka hōʻailona "piha".
He aha ka mea e hana ʻia ma muli o kēia?
1. ʻAʻole piha: ʻOiai ua lawa kou momona i loko o kou kino, manaʻo kou lolo ua pōloli mau ʻoe. No laila, hoʻomau ʻoe i ka ʻai ʻana.
2. Ke komo nei ke kino i ke "ʻano pōloli": No ka mea, ʻaʻole i loaʻa i ka lolo ka hōʻailona leptin, manaʻo ka lolo ʻaʻole lawa ka ikehu o ke kino a ke pōloli nei mākou. No laila, no ka mālama ʻana i ka ikehu, emi iho ka basal metabolic rate (BMR) o ke kino. ʻO ia hoʻi, emi iho ka nui o nā calorie āu e puhi ai i kou wā e noho mālie ana.
Ma kēia ʻano, ʻo ke kūʻē ʻana o ka leptin, ma kekahi ʻaoʻao, e hoʻonui i ka pōloli a hoʻonui i ka nui o ka meaʻai i ʻai ʻia, a ma kekahi ʻaoʻao, e emi ana ka wikiwiki o ke puhi ʻana o ke kino i nā calorie. Ke hui pū ʻia kēia mau mea ʻelua, ʻo ka hopena, ʻoi aku ka nui o ke kaumaha.
| Nā hiʻohiʻona nui o ke kū'ē ʻana o Leptin |
|---|
| Ke pōloli mau nei (hyperphagia) ʻoiai he momona iki a ʻaʻohe paha o ke kino. |
| Ka paʻakikī i ka kaohi ʻana i ka ʻai ʻana a me ka hoʻonui ʻana i ka ʻai ʻana. |
Hiki ke hana ʻia kēia mau hōʻailona e nā kumu ʻē aʻe, no laila inā ʻike ʻoe i kēia mau hōʻailona, ʻoi aku ka maikaʻi o ke kamaʻilio ʻana me kāu kauka .
He aha ka mea e hana ai inā e emi iho nā pae leptin?
He maʻi laha ʻole ka hemahema o ka leptin. Hoʻomaka pinepine ia me kahi maʻi genetic i kapa ʻia ʻo ka hemahema leptin congenital . Loaʻa i ke kanaka me kēia maʻi kahi maʻi kahi i hiki ʻole ai i kā lākou mau hunaola momona ke hana i ka leptin.
Ke nele ka leptin, manaʻo ke kino ʻaʻohe momona i loko o ke kino. Hōʻailona kēia i ka lolo e pōloli a hiki ʻole ke kāohi iā ia. ʻO ka hopena, loaʻa i nā keiki ʻōpio me kēia maʻi kahi makemake e ʻai me ka ʻole o ka manaʻo. ʻO ka hopena, lilo lākou i momona loa (papa III momona) i ka wā ʻōpiopio loa a ʻike i ka lohi o ka wā ʻōpiopio.
| Nā kūlana e pili ana paha me nā pae leptin kiʻekiʻe (Hyperleptinemia) | Nā kūlana e pili ana paha me nā pae leptin haʻahaʻa (Hypoleptinemia) |
|---|---|
| Kaumaha | Nā pae insulin kiʻekiʻe (Hyperinsulinemia) |
| ʻAi ʻana i ka meaʻai | Nā ʻano momona koko kaulike ʻole (Dyslipidemia), e.g. cholesterol, triglycerides |
| Maʻi ʻaʻai momona ʻole | Maʻi ake momona |
| Nā maʻi neurodegenerative | Nā maʻi bacteria pinepine |
Hiki ke ana ʻia nā pae leptin i loko o ke koko?
ʻAe, hiki i kahi hoʻāʻo koko maʻalahi ke ana i nā pae leptin. Eia naʻe, ʻaʻole kēia he hoʻāʻo a nā kauka e kauoha pinepine ai. Hana ʻia ia i nā hihia kūikawā wale nō. Eia kekahi laʻana:
- Inā momona loa ke keiki ʻōpiopio.
- Inā hoʻomau ka pōloli hiki ʻole ke kāohi ʻia e ke kanaka momona.
ʻO ka maʻamau, hiki i nā pae leptin olakino ke kū mai:
- Wahine: 0.5 - 15.2 ng/mL (nanograms no ka mililita)
- Kāne: 0.5 - 12.5 ng/mL
Hiki ke ʻokoʻa iki kēia mau waiwai mai ka hale hana a i ka hale hana, no laila inā he kānalua kou e pili ana i nā waiwai i loko o kāu hōʻike, e nīnau i kāu kauka .
Pehea e hoʻololi ai i nā pae leptin?
ʻAʻohe ala maoli e hoʻonui ai i nā pae leptin e hōʻemi i ka pōloli, no ka mea, pili pono nā pae leptin i ka nui o ka momona i loko o kou kino.
Eia nō naʻe, aia kekahi mau mea e hiki ke kōkua i ka hana leptin a me nā kaulike hormonal ʻē aʻe:
1. E hiamoe pono: Ua ʻike ʻia kekahi noiʻi e hoʻonui ka nele i ka hiamoe i ka hormone pōloli ghrelin a hoʻemi i ka hormone māʻona leptin. No laila, ʻo ka loaʻa ʻana o ka hiamoe maikaʻi a lawa i kēlā me kēia lā he mea nui loa ia no ke kaulike hormonal.
2. E ʻai i ka meaʻai olakino: Manaʻo kekahi mau noiʻi e hiki i nā pae kiʻekiʻe o nā triglycerides, kahi ʻano momona i loko o ke koko, ke hoʻopilikia i ka leptin e hiki ana i ka lolo. ʻOiai aia nō nā manaʻo like ʻole e pili ana i kēia, ʻoi aku ka maikaʻi o ka ʻai ʻana i ka meaʻai kaulike e komo pū ana me nā mea kanu, nā huaʻai, ka fiber, ka protein maikaʻi, a me nā momona olakino, me ka hoʻemi ʻana i ke kō, ka palaoa, a me nā meaʻai i hana ʻia .
3. E hoʻoikaika kino mau: Ua hōʻike ʻia e ka noiʻi hiki i ka hoʻoikaika kino ke kōkua i ka hōʻemi ʻana i ke kūʻē ʻana o ka leptin. ʻO ia hoʻi, hiki i ka hoʻoikaika kino ke hoʻomaikaʻi i ka ʻike leptin i loko o ka lolo.
ʻO ka mea nui, ʻaʻole ka leptin i loaʻa i ka meaʻai. He hormone ia a ko kākou kino e hana ai iā lākou iho. No laila, ʻaʻohe mea e like me ka "ʻai nui ʻana i ka leptin."
Inā ʻoe e hopohopo nei e pili ana i kou kaumaha, a i ʻole makemake ʻoe i ke alakaʻi no ka hoʻemi ʻana i ke kaumaha ma ke ʻano olakino, ʻoi aku ka maikaʻi o ke kamaʻilio ʻana me kāu kauka . Inā pono, hiki iā ia ke kuhikuhi iā ʻoe i kahi endocrinologist.
Leka Lawe-Home
- ʻO Leptin ka hormone "piha" i hana ʻia e nā hunaola momona o ko kākou kino. Hōʻike ia i ka lolo ua lawa kā kākou meaʻai.
- I ka piʻi ʻana o ka momona o kou kino, piʻi pū kekahi nā pae leptin.
- ʻO ka pilikia nui i ka momona ʻaʻole ia ka nele o ka leptin, akā he kūlana i kapa ʻia ʻo "leptin resistance," kahi i pane ʻole ai ka lolo i ka leptin.
- Hoʻonui ka pale ʻana o ka leptin i ka pōloli a hōʻemi i ka puhi ʻana o ka calorie i loko o ke kino, hiki ke alakaʻi i ka loaʻa hou ʻana o ke kaumaha.
- ʻO ka lawa ʻana o ka hiamoe, ka ʻai olakino, a me ka hoʻoikaika kino e kōkua i ka mālama ʻana i ka hana leptin a me ke kaulike hormonal holoʻokoʻa.
- Inā he mau hopohopo kāu e pili ana i kou kaumaha a i ʻole nā ʻano ʻai, e nīnau mau i kāu kauka no ka ʻōlelo aʻo.
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