Loaʻa pinepine iā ʻoe nā ʻōhū ma kou kino? E aʻo kākou e pili ana i kēia (Marginal Zone Lymphoma - MZL)?

Loaʻa iā ʻoe i kekahi manawa nā puʻupuʻu e like me kēia ma kou kino? A i ʻole ke luhi nei ʻoe me ke kumu ʻole, a i ʻole ke manaʻo nei ʻoe e emi ana kou kaumaha? ʻO ka hapa nui o ka manawa, hiki i kēia mau mea ke lilo i mau mea maʻamau, akā i kekahi manawa hiki iā lākou ke lilo i hōʻailona o kahi maʻi e pono ai ka nānā ʻana. I kēia lā e kamaʻilio mākou e pili ana i kahi ʻano lymphoma kakaʻikahi i kapa ʻia ʻo `(Marginal Zone Lymphoma - MZL)` pono mākou a pau e makaʻala. Mai hopohopo, e kamaʻilio mākou e pili ana i kēia me ka maʻalahi a ma ke ʻano hiki iā ʻoe ke hoʻomaopopo.

He aha ka `(Marginal Zone Lymphoma - MZL)`? I ka ʻōlelo maʻalahi...

ʻO Marginal Zone Lymphoma kahi inoa maʻamau no kekahi mau ʻano lymphoma kakaʻikahi e ulu mālie ana, ʻo ia hoʻi, ʻaʻole lākou e laha koke, a no kahi hui o nā maʻi kanesa i kapa ʻia ʻo Non-Hodgkin Lymphoma. Hoʻomohala pinepine kēia mau mea i loko o ka ʻiʻo lymphoid, ʻo ia kekahi ʻāpana o ka ʻōnaehana pale o ko mākou kino. Loaʻa i kēia mau ʻiʻo kahi ʻano o ke koko keʻokeʻo i kapa ʻia ʻo nā cell B. Ua ʻike anei ʻoe ua like nā cell B me nā kiaʻi o ke kino, kahi ʻano cell e kōkua i ka pale ʻana iā mākou mai nā maʻi? Loaʻa lākou i loko o kā mākou mau lymph nodes (i kapa ʻia hoʻi he lymph nodes) a me ka spleen.

I kēia manawa, e nānā, i loko o kā mākou mau lymph nodes aia nā wahi liʻiliʻi i kapa ʻia ʻo `(lymphoid follicles)`. ʻElua mau ʻāpana o kēia mau `(lymphoid follicles)` - ʻo kekahi i kapa ʻia ʻo `(mantle zone)` a ʻo kekahi i kapa ʻia ʻo `(marginal zone)`. E like me ka hoʻohui ʻana i kahi papa ʻē aʻe i kahi keke, aia kēia `(marginal zone)` a puni ka `(mantle zone)`. Hoʻokumu ʻia ka `(Marginal Zone Lymphoma)` i ka wā e loli ai nā `(B cells)` i loko o kēlā `(marginal zone)`, ʻo ia hoʻi, ke loli nei lākou, lilo i mau cell ʻano ʻē, a hoʻomaka e hoʻonui me ka hiki ʻole ke kāohi.

ʻO kēia kūlana, ʻo "Marginal Zone Lymphoma", ʻike pinepine ʻia i nā poʻe ma luna o 60 mau makahiki. He mea maʻamau iki nō hoʻi ia i nā kāne ma mua o nā wahine.

He aha nā ʻano nui o ka `(Marginal Zone Lymphoma)`?

ʻEkolu mau ʻano nui o `(MZL)`. E nānā kākou i ke ʻano o lākou:

1. Mucosa-assisted lymphoid tissue (MALT) lymphoma: ʻO kēia ke ʻano maʻamau o MALT. I kekahi manawa kapa ʻia ʻo ia e nā kauka he extranodal marginal cell lymphoma. ʻO ke ʻano o "Extranodal" ke hoʻomaka ia ma waho o nā lymph nodes. Hiki i kēia ʻano lymphoma ke hoʻomaka ma ka ʻili o ka ʻōpū (gastric MALT), a i ʻole ma nā māmā, ka ʻili, ka thyroid, nā ʻōpū salivary, nā ʻōpū, a i ʻole nā ​​​​wahi a puni nā maka (non-gastric MALT).

2. Nodal marginal zone lymphoma: Hoʻopilikia kēia ʻano i kou mau lymph nodes . ʻO ia hoʻi, kou mau lymph nodes. Akā i kekahi manawa hiki ke ʻike ʻia i loko o kou iwi iwi.

3. Splenic marginal zone lymphoma: He ʻano kakaikahi kēia. Hoʻopilikia ia i kou spleen, koko, a me ka iwi iwi.

He aha nā hōʻailona o ka `(Marginal Zone Lymphoma)`?

He maʻi lohi pinepine ka ulu ʻana o ka Marginal Zone Lymphoma. No laila, hiki iā ʻoe ke loaʻa i ke ʻano no ka manawa lōʻihi me ka ʻole o nā hōʻailona. ʻOkoʻa nā hōʻailona ma muli o ke ʻano o ka lymphoma. Ma keʻano laulā, hiki i ka Marginal Zone Lymphoma ke hana i nā hōʻailona e like me:

• Kuni (kuni e hele mai me ke kumu ʻole)
• Ka hou nui ʻana i ka pō (nui loa a pulu nā pepa moe)
• ʻO ka pohō kaumaha no ke kumu ʻole (inā ʻoe e pohō kaumaha me ka hoʻāʻo ʻole)

I kekahi manawa kapa mākou i kēia mau "ʻano B."

Nā hōʻailona o ka Lymphoma `(MALT)`

ʻOkoʻa nā hōʻailona o ka `(Extranodal marginal zone lymphoma)` a i ʻole `(MALT)` lymphoma ma muli o kahi i loaʻa ai ka lymphoma. Eia kekahi laʻana, inā loaʻa iā ʻoe ka `(MALT)` lymphoma i loko o kou ʻōpū, hiki iā ʻoe ke ʻike i nā hōʻailona e like me kēia:

• Ka luaʻi a me ka luaʻi
• ʻEha a ʻoluʻolu ʻole paha ka ʻōpū
• Manaʻo piha ʻoiai ma hope o ka ʻai ʻana i kahi meaʻai liʻiliʻi

Inā aia ka lymphoma ma kahi ʻē aʻe ma mua o ka ʻōpū (non-gastric MALT), no ka laʻana ma ka maka, hiki ke ʻike ʻia nā loli ma ka conjunctiva a i ʻole nā ​​​​​​gland lacrimal.

Nā hōʻailona o ka `(Nodal marginal zone lymphoma)`

I kēia ʻano, ʻo ka hōʻailona nui ka pehu ʻana o nā testicles. Eia kekahi, hiki ke ʻike ʻia nā hōʻailona maʻamau i ʻōlelo ʻia ma mua:

• kuni
• Nā hou o ka pō
• ʻO ka pohō kaumaha me ke kumu ʻole

Nā hōʻailona o ka `(Splenic marginal zone lymphoma)`

Hiki i kēia ʻano maʻi ʻaʻai spleen ke hana i nā hōʻailona e like me:

• Luhi a me ka luhi
• Ka nui o ka spleen (hiki ke kaumaha a piha paha ma ka ʻaoʻao hema o luna o ka ʻōpū)
• Nā hou o ka pō
• ʻO ka pohō kaumaha me ke kumu ʻole

He aha nā kumu o ka `(Marginal Zone Lymphoma)`?

ʻO ka maʻamau, loaʻa i ka poʻe me Marginal Zone Lymphoma kahi moʻolelo ʻohana o ka lymphoma, a i ʻole he mau maʻi pinepine paha kā lākou, a i ʻole he mau maʻi autoimmune paha kā lākou. Eia nō naʻe, aia nā kumu kikoʻī no kēlā me kēia ʻano.

• ʻO ka lymphoma MALT: ʻO kēia ka mea maʻamau i hoʻokumu ʻia e nā maʻi bacteria, ʻoiai ʻo H. pylori. Ua lohe paha ʻoe ua hoʻokumu pū ʻia ka gastritis e kēia bacteria. Eia kekahi, ʻo nā maʻi autoimmune e like me ka maʻi Hashimoto (kahi maʻi e hoʻopilikia ai i ka thyroid gland) a i ʻole Sjögren's syndrome (kahi maʻi e hoʻomaloʻo ai i nā glands salivary a me nā waimaka), a me ka mōʻaukala ʻohana o ka lymphoma hiki ke lilo i mea pilikia.
• Splenic marginal zone lymphoma: Pili kēia me ka maʻi hepatitis C a me nā maʻi autoimmune.
• ʻO ka lymphoma nodal marginal zone: Ua ʻike ʻia kēia e pili ana i ka maʻi Hepatitis C.

Mea nui:ʻAʻole i loaʻa i nā kānaka a pau ka `(MZL)` no kēia mau kumu. Eia kekahi, hiki i kekahi poʻe ke loaʻa iā ia me ka ʻole o kekahi o kēia mau kumu. He mau mea pilikia wale nō kēia.

He aha nā kumu pilikia no ka `(Marginal Zone Lymphoma)`?

E like me ka mea i ʻōlelo ʻia ma mua, ʻo nā kumu pilikia nui ka mōʻaukala ʻohana o ka lymphoma, kekahi mau maʻi (e like me H. pylori, Hepatitis C), a me nā maʻi autoimmune (ka maʻi Hashimoto, ka maʻi Sjögren).

Pehea e ʻike ʻia ai ka Marginal Zone Lymphoma?

E nīnau mua kāu kauka iā ʻoe i kekahi mau nīnau e ʻike ai i kēia maʻi. Hoʻokomo pū kēia i nā hōʻailona āu i loaʻa ai, kou mōʻaukala olakino, a inā paha ua loaʻa i kekahi o kou ʻohana nā maʻi like.

Ma hope o kēlā, pono e hana ʻia kekahi mau hoʻokolohua e hōʻoia i ka maʻi.

He aha nā hoʻokolohua diagnostics?

Hiki ke ʻokoʻa iki nā hoʻokolohua i hana ʻia ma muli o ke ʻano o ka lymphoma, akā ma ke ʻano laulā, hiki ke hana ʻia nā hoʻokolohua aʻe:

• Helu Koko Piha (CBC): Nānā i ka helu o nā ʻano ʻokoʻa o nā cell (nā cell ʻulaʻula, nā cell keʻokeʻo, nā platelets) i loko o ke koko.
• Hoʻāʻo `(LDH - Lactate Dehydrogenase)`: He enzyme kēia e hoʻonui ʻia i loko o ke koko ke hōʻino ʻia nā ʻāpana.
• `(Beta-2 microglobulin)`: Hoʻohana ʻia kēia ma ke ʻano he hōʻailona i nā maʻi ʻaʻai koko.
• Nā hoʻāʻo hana o ke akepaʻa .
• Nā hoʻāʻo hana o ka puʻupaʻa (kiʻiʻo) .
• ʻO ka immunofixation protein serum (IFX): He hoʻāʻo e nānā i nā loli i nā protein i loko o ke koko.
• Nā hoʻāʻo no kekahi mau maʻi bacteria a me viral (e.g., `(H. pylori)`, `(Hepatitis C)`).
• `(CT scan)`: E kiʻi i nā kiʻi kikoʻī o loko o ke kino. E ʻike i nā mea e like me nā lymph nodes pehu a me ka spleen i hoʻonui ʻia.
• Biopsy nila: Hoʻoneʻe ʻia kahi hāpana liʻiliʻi o ka ʻiʻo mai kahi lymph node pehu a i ʻole kahi ʻāpana ʻē aʻe me kahi nila a nānā ʻia ma lalo o kahi microscope. ʻO kēia wale nō ke ala e ʻike pono ai inā loaʻa nā cell lymphoma.
• ʻO ka biopsy iwi: Hana ʻia kēia hoʻāʻo i kekahi manawa e ʻike ai inā ua pālahalaha ka lymphoma i ka iwi.
• Nā hoʻokolohua '(Biopsy)' ʻē aʻe: Ke lawe ʻana i kahi hāpana o nā pūnaewele a i ʻole nā ​​​​ʻiʻo mai kekahi wahi o ke kino i manaʻo ʻia ua hoʻopilikia ʻia a hoʻāʻo iā ia.

He aha nā pae o ke kanesa ma `(MZL)`?

ʻO ke ana ʻana i ka pae o ka maʻi kanesa he ala ia e hoʻoholo ai i ka mamao o ka laha ʻana o ke kanesa i loko o ke kino. He mea nui kēia no ka hoʻolālā ʻana i ka mālama ʻana a me ka loaʻa ʻana o kahi manaʻo no ke ala e hiki mai ana o ka maʻi. ʻO nā pae o MZL penei:

• Pae I: Aia ke kanesa ma hoʻokahi wale nō ʻāpana lymph node.
• Pae II:Aia ke kanesa ma ʻelua a ʻoi aku paha mau wahi o ka lymph node ma ka ʻaoʻao hoʻokahi, ma luna a ma lalo paha o ka diaphragm (ka ʻiʻo e hoʻokaʻawale i ko mākou umauma a me ka ʻōpū).
• Pae III: Ua pālahalaha ke kanesa i nā ʻāpana lymph node he nui ma luna a ma lalo o ka diaphragm, ʻo ia hoʻi he mau lymph nodes ma nā ʻaoʻao ʻelua.
• Pae IV: Ua pālahalaha ke kanesa ma waho o ka ʻōnaehana lymphatic i hoʻokahi a ʻoi aku paha o nā ʻōpū ʻē aʻe, e like me ke akepaʻa, nā māmā, a me ka iwi iwi.

He aha nā lāʻau lapaʻau no ka `(Marginal Zone Lymphoma)`?

No ka mea, he maʻi ulu lohi loa ka Marginal Zone Lymphoma, ʻaʻole pono paha kekahi poʻe e hoʻomaka koke i ka lāʻau. Manaʻo pinepine nā kauka i kahi ʻano lapaʻau i kapa ʻia ʻo "watchful waiting" a i ʻole "active surveillance." ʻO ke ʻano kēia e nānā mau ʻia ʻoe a hiki i ka wā e ʻike ʻia ai nā hōʻailona a i ʻole e ʻoi aku ka ʻino o ka maʻi.

Inā pono ka lāʻau lapaʻau, e ʻokoʻa ka lāʻau lapaʻau i hāʻawi ʻia ma muli o ke ʻano o ka lymphoma. ʻO nā lāʻau lapaʻau maʻamau:

• Nā lāʻau lapaʻau: ʻOi loa aku inā ʻo ka bacteria H. pylori ka mea i hoʻokumu ʻia ai ka lymphoma, hāʻawi ʻia nā lāʻau lapaʻau e pepehi i ka bacteria. I nā hihia he nui, hiki i kēia ke ho'ōla i ka lymphoma.
• Chemotherapy: Nā lāʻau lapaʻau i hāʻawi ʻia e pepehi i nā hunaola kanesa.
• Lapaʻau radiation: ʻO ka hoʻohana ʻana i nā kukuna ikehu kiʻekiʻe e luku i nā hunaola kanesa. Hoʻohana pinepine ʻia kēia i ka wā e kūloko ai ka lymphoma.
• Lapaʻau i hoʻolālā ʻia: ʻO kēia nā ʻano lāʻau lapaʻau hou e hana ana ma ke kuhikuhi ʻana i nā molekala kikoʻī i loko o nā pūpū kanesa.
• Immunotherapy: Hoʻoulu i ka ʻōnaehana pale ponoʻī o ke kino e hakakā i nā hunaola kanesa.

Hiki ke ho'ōla loa ʻia ka `(Marginal Zone Lymphoma)`?

Pili maoli kēia i ke ʻano o ka lymphoma, ke kahua, a me kou olakino holoʻokoʻa. No ka laʻana, ʻo ka lymphoma gastric (MALT) i hoʻokumu ʻia e ka maʻi H. pylori he kiʻekiʻe ka manawa e ho'ōla loa ʻia me ka lāʻau antibiotic.

I nā ʻano ʻē aʻe, hiki i ka lāʻau lapaʻau ke hoʻokomo i ka maʻi i loko o ka "remission" . ʻO ke ʻano o ka "Remission" ua nalowale nā ​​​​hōʻailona a ʻaʻole hōʻike nā hoʻokolohua i nā hōʻailona o ka maʻi. Eia nō naʻe, hiki i ka "Marginal Zone Lymphoma" ke hoʻi hou mai i kekahi manawa ("recur") ma hope o ka lāʻau lapaʻau. No laila, e hoʻomau nā kauka i ka nānā ʻana iā ʻoe.

He aha ka nui o ke ola no ka `(Marginal Zone Lymphoma)`?

He mau helu wale nō nā helu ola. Hōʻike lākou i ka pakeneka o ka poʻe e ola ana i ʻelima mau makahiki ma hope o ka hōʻoia ʻana. Akā hiki ke ʻokoʻa mai kēlā kanaka a kēia kanaka. Hiki ke ʻokoʻa kou ʻike.

Wahi a kekahi noiʻi:

• Ma kahi o 88% o ka poʻe me ka extranodal marginal zone lymphoma (MALT) e ola ana i ʻelima mau makahiki ma hope o ka hōʻoia ʻana.
• Ma kahi o 79% o ka poʻe me ka splenic marginal zone lymphoma e ola ana i ʻelima mau makahiki ma hope o ka hōʻoia ʻana.
• Ma kahi o 76.5% o ka poʻe me ka nodal marginal zone lymphoma e ola ana i ʻelima mau makahiki ma hope o ka hōʻoia ʻana.

E hoʻomanaʻo: He mau awelika wale nō kēia. No ka mea, ʻo ka Marginal Zone Lymphoma ka mea maʻamau i ka poʻe ʻelemakule, make ka nui o kēia poʻe mai nā kumu ʻē aʻe ma mua o ka lymphoma. ʻO kāu kauka wale nō ke hāʻawi iā ʻoe i ka ʻike maikaʻi loa e pili ana i kou kūlana. No laila, mai hopohopo wale nō i kēia mau helu helu.

Hiki ke pale ʻia ka Marginal Zone Lymphoma?

ʻAʻole hiki iā mākou ke kāohi i kekahi o nā kumu e kōkua ai i ka ulu ʻana o kēia maʻi, e like me nā maʻi autoimmune a i ʻole nā ​​​​​​mana genetic. Eia nō naʻe, inā he maʻi me ka `(H. pylori)`, hiki ke hoʻemi ʻia i kekahi ʻano ma ka lawe ʻana i ka lāʻau kūpono a me ka lawe ʻana i nā hana e pale aku iā ʻoe iho mai nā maʻi e like me `(Hepatitis C)`.

Āhea wau e ʻike ai i kaʻu kauka?

Inā ua ʻike ʻia ʻoe me ka "Marginal Zone Lymphoma", e ʻike pono i kāu kauka inā:

• Inā ʻike ʻoe i nā loli i kou kino āu e manaʻo nei he mau hōʻailona paha ia o ka Marginal Zone Lymphoma (e.g., ʻike ʻia kahi puʻupuʻu hou, ʻoi aku ka nui o kahi puʻupuʻu e kū nei, ke kuni, ka hou ʻana i ka pō, ka pohō kaumaha).
• Inā e ʻoi aku ka ʻino o kou mau hōʻailona i ka wā e loaʻa ana iā ʻoe ka lāʻau lapaʻau .
• Inā ʻoe i loko o ke kala ʻana a hoʻomaka e ʻike i nā hōʻailona e hoʻi mai ana ka maʻi, he hihia paha ia o ka hoʻi hou ʻana .

Pehea lā wau e mālama ai i koʻu olakino?

I ka wā e noho ana me kahi maʻi e like me MZL, he mea nui loa ka mālama ponoʻī. Eia kekahi mau mea hiki iā ʻoe ke hana:

• E hoʻokele i ke kaumaha: ʻO kekahi poʻe me MZL ʻaʻohe hōʻailona a ʻaʻole pono paha ka lāʻau lapaʻau. ʻOiai he mea maikaʻi kēlā, hopohopo paha ʻoe e pili ana i ka "āhea e ʻoi aku ka ʻino?" ʻO ka hoʻoikaika kino, ka hoʻolohe ʻana i ke mele, ka hana yoga, a i ʻole ke komo ʻana i kahi leʻaleʻa āu e hauʻoli ai hiki ke kōkua iā ʻoe e hoʻomaha.
• Inu wai lawa: Hiki i nā lāʻau lapaʻau maʻi kanesa a me ko lākou mau hopena ʻaoʻao ke hoʻomaloʻo i ke kino, no laila e hoʻāʻo e inu i ka liʻiliʻi he 8 mau aniani wai i ka lā.
• E ʻai i ka meaʻai kaulike: E hoʻokomo i nā meaʻai momona e like me nā huaʻai, nā mea kanu, nā nati, a me nā huahana waiū i kāu papaʻai. E ʻai i nā meaʻai liʻiliʻi ma kahi o nā meaʻai nui.

He aha nā nīnau e pono iaʻu e nīnau aku i kaʻu kauka?

Hiki iā ʻoe ke nīnau i ke kauka i nā nīnau penei:

• He aha ke ʻano o ka "Marginal Zone Lymphoma" i loaʻa iaʻu?
• He aha ke kahua o koʻu maʻi?
• Pono anei au i ka lāʻau lapaʻau koke?
• Inā pono ka lāʻau lapaʻau, he aha ka lāʻau lapaʻau āu e ʻōlelo ai a no ke aha?
• He aha nā hopena ʻaoʻao o kēia mau lāʻau lapaʻau?
• Aia kekahi mau hoʻokolohua lapaʻau e hiki iaʻu ke komo?
• He aha kāu e haʻi mai ai iaʻu e pili ana i ka wānana o koʻu maʻi?

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

ʻO ka Marginal Zone Lymphoma (MZL) kahi ʻano lymphoma laha ʻole, lohi ka ulu ʻana, a hāʻule i loko o ka māhele o Non-Hodgkin Lymphoma. Aia kekahi mau ʻano lymphoma, a ʻokoʻa nā hōʻailona, ​​​​ka lāʻau lapaʻau, a me ka prognosis ma muli o ke ʻano. ʻO ka mea nui loa, no ka mea, lohi loa ka holomua o ka maʻi, ʻaʻole pono kekahi poʻe i ka lāʻau lapaʻau no nā makahiki. No kekahi poʻe, hiki i ka lāʻau lapaʻau ke hoʻokuʻu i ka maʻi i ka hoʻomaha ʻana.

Inā loaʻa iā ʻoe kēia maʻi, ʻoi aku ka maikaʻi o ka hopohopo ʻole, akā e kamaʻilio me kāu kauka a loaʻa ka ʻike i kūpono i kou kūlana. E wehewehe kāu kauka iā ʻoe pehea e pili ai kēia maʻi i kou kino a me nā koho lapaʻau i loaʻa. E hoʻomanaʻo, ʻaʻole ʻoe hoʻokahi, a aia nā kauka a me kāu poʻe aloha e hiki ke kōkua iā ʻoe.

ʻO ka Lymphoma Marginal Zone, MZL, Non-Hodgkin Lymphoma, Lymphoma, Kanesa, MALT Lymphoma, nā pūnaewele B, H. pylori, Chemotherapy, Nā kikowaena Lymph