He maʻi ʻaʻai anei ʻo MGUS (Monoclonal Gammopathy of Undetermined Significance)? E kamaʻilio maʻalahi kākou e pili ana.

Malia paha ua loaʻa iā ʻoe kahi hoʻāʻo koko no kekahi maʻi ʻē aʻe. A i ʻole he nānā lapaʻau maʻamau makahiki paha. I kēlā manawa, ua haʻi aku ke kauka iā ʻoe, "He protein ʻē kou i loko o kou koko i kapa ʻia ʻo 'M protein', a kapa mākou i kēia maʻi ʻo MGUS." Ke lohe kekahi i kahi mea e like me kēia, ua pūʻiwa iki lākou a makaʻu. He mea maʻamau loa ia no nā nīnau he nui e hiki mai ana i ka noʻonoʻo, e like me 'He maʻi kanesa kēia?', 'He aha ka mea e hiki mai iaʻu i kēia manawa?', 'Aia kekahi lāʻau lapaʻau no kēia?' Akā, mai hopohopo. I kēia lā, e kamaʻilio mākou e pili ana i ke ʻano o MGUS, he mea weliweli maoli anei ia, a me nā mea a mākou e hana ai e pili ana i kēia maʻi ma ke ʻano maʻalahi loa e hiki ai iā ʻoe ke hoʻomaopopo.

He aha maoli ka MGUS?

I ka ʻōlelo maʻalahi, ʻo MGUS (Monoclonal Gammopathy of Undetermined Significance) kahi kūlana kahi e hana ai kou koko i kahi protein ʻano ʻē. Kāhea mākou i kēia protein ʻano ʻē ʻo ka protein M. Hiki ke ʻike ʻia kēia ma o kahi hoʻāʻo koko a i ʻole kekahi manawa he hoʻāʻo mimi.

ʻAe, e hele hohonu iki kākou a ʻike pehea e hana ai kēia.

E noʻonoʻo he pūʻali koa pale ko kākou i loko o ko kākou kino. ʻO kekahi ʻano koa kūikawā i loko o kēia pūʻali koa he mau pūnaewele plasma . He ʻano koko keʻokeʻo kēia. ʻO kā lākou hana nui ka hana ʻana i nā mea kaua protein kūikawā i kapa ʻia he mau antibodies e hakakā aku i nā germs e hoʻoulu ai i ka maʻi (bacteria, viruses, a pēlā aku) e komo i loko o ko kākou kino. ʻO kēia mau antibodies ka mea e pale ai iā kākou mai ka maʻi ma ka hopu ʻana a me ka luku ʻana i nā germs.

Akā i loko o kekahi me MGUS, hele iki kekahi o kēia mau cell plasma i kahi 'hewa'. ʻO ia hoʻi, ma kahi o ka hana ʻana i nā antibodies maʻamau a olakino, hoʻomaka kēia mau cell e hana i nā nui he nui o kahi protein like, pono ʻole, a ʻano ʻē. ʻO ia ka mea a mākou e kapa nei he protein M.

Aia kekahi mau hōʻailona o MGUS?

Eia ka mea kupaianaha. ʻAʻohe o lākou hōʻailona i ka nui o ka poʻe me MGUS . ʻO ia ke kumu e ʻike pinepine ʻia ai ke ʻano ma ka hanana, i ka wā o kahi hoʻāʻo koko i hana ʻia no kekahi kumu ʻē aʻe. ʻAʻole paha ʻoe e ʻike i kekahi ʻokoʻa. No laila, he mea maʻamau ka manaʻo, "Ua maikaʻi wau," ke ʻike ʻoe he MGUS kou. ʻO ia no ka mea, aia kēia mau protein M ma laila wale nō i loko o ke koko, me ka ʻole o ka hōʻeha ʻana i ke kino.

No ke aha e ulu ai ʻo MGUS? He aha nā kumu pilikia?

ʻO kaʻoiaʻiʻo, ʻaʻole maopopo i nā kauka ke kumu e hoʻomaka koke ai kēia mau cell plasma e hana ma kēia ʻano ʻē. He mea pohihihi nō ia. Akā ua ʻike ʻia e ka noiʻi he ʻoi aku ka nui o ka pilikia o kekahi poʻe i ka loaʻa ʻana o kēia maʻi.

Nā mea e hoʻonui ai i ka pilikia o ka hoʻomohala ʻana iā MGUS

• Makahiki: ʻOi aku ka maʻamau o MGUS i kou wā ʻelemakule. He mea maʻamau loa ia ma hope o 50 mau makahiki. I ka hiki ʻana i 70 mau makahiki, ma kahi o 5 o 100 mau kānaka e loaʻa paha ke ʻano.
• Kāne: ʻOi aku ka nui o nā kāne e hoʻomohala i ka MGUS ma mua o nā wahine.
• Lāhui: ʻOi aku ka maʻamau o kēia ʻano i waena o kekahi mau lāhui, ʻoi aku hoʻi ka poʻe ʻeleʻele .
• Moʻolelo ʻohana: Inā loaʻa i kahi ʻohana pili (makuahine, makuakāne, kaikaina) kahi maʻi koko e like me MGUS a i ʻole myeloma maha , ʻoi aku ka nui o kou pilikia o ka loaʻa ʻana o ke kūlana.
• Nā kumu o ke kaiapuni: ʻO ka poʻe me ka mōʻaukala o ka launa ʻana i nā insecticides a i ʻole nā ​​​​pesticides e piʻi aʻe ka pilikia.
• Nā maʻi ʻē aʻe: Hiki i ka poʻe me kekahi mau maʻi autoimmune ke pilikia.
• Ka ʻike ʻia ʻana i ka radiation: Hiki i ka ʻike ʻia ʻana i ka radiation nui ke lilo i mea pilikia.

He aha nā pilikia e hiki mai ana o MGUS?

ʻO kēia ka mea a nā kānaka a pau e noʻonoʻo nui ai a makaʻu nui ai. E like me ka mea i ʻōlelo ʻia ma mua, ʻaʻole ʻo MGUS he maʻi kanesa. Eia nō naʻe, no kahi poʻe liʻiliʻi, hiki i kēia ʻano ke lilo i maʻi ʻoi aku ka koʻikoʻi i ka hala ʻana o ka manawa.

Ma kahi o 20 a 25 o 100 mau kānaka me MGUS e loaʻa i kahi maʻi koʻikoʻi e pili ana i ke koko. ʻO ia hoʻi, ʻaʻohe pilikia o 75-80 o 100.

ʻO nā maʻi nui e hiki ke ulu i ka holomua ʻana o MGUS:

• ʻO ka Myeloma Nui: ʻO kēia ka pilikia maʻamau. He maʻi ʻaʻai ia o nā cell plasma.
• ʻAmyloidosis: He maʻi kahi e waiho ʻia ai nā protein M i loko o nā ʻano kino like ʻole o ke kino a hōʻino iā lākou.
• Waldenstrom macroglobulinemia: He ʻano maʻi koko kakaikahi kēia.
• ʻO ka maʻi leukemia lymphocytic mau loa: ʻO kekahi ʻano maʻi koko ʻē aʻe.

Eia kekahi, hiki i ka MGUS ke hoʻonui iki i ka pilikia o nā pilikia olakino ʻē aʻe:

• Nā ʻūpā koko
• Pohō a haki paha ka iwi
• Nā maʻi pinepine
• Nā pilikia puʻupaʻa
• Ka hōʻino ʻana o ke aʻalolo (neuropathy peripheral): Hiki i kēia ke hoʻoulu i ka ʻeha a me ke kani ʻana o nā lālā.

Pehea e ʻike ai ke kauka iā MGUS?

E hana kāu kauka i nā hoʻāʻo koko a me ka mimi e nānā i ke alo o ka protein M. Ke hōʻoia ʻia kēlā, e loiloi lākou i ka pilikia o kēia ʻano e lilo i ka maʻi kanesa. E nānā kēia i ʻekolu mau kumu nui:

1. Ka nui o ka protein M i loko o ke koko: Inā ʻoi aku ka nui o ka protein M ma mua o 1.5 g/dL (grams no ka deciliter), ʻoi aku ka kiʻekiʻe o ka pilikia.

2. ʻAno protein M: Aia nā ʻano protein M like ʻole (i kapa ʻia ʻo Immunoglobulin (Ig) ). ʻOi aku ka nui o kekahi mau ʻano e hoʻoulu i nā maʻi koʻikoʻi ma mua o nā mea ʻē aʻe.

3. Nā pae kaulahao māmā serum-free (FLC): ʻO kēia kekahi protein i hana ʻia e nā cell plasma. Hiki i kahi hoʻāʻo koko kūikawā ( hoʻāʻo kaulahao māmā serum-free (FLC) ) ke ʻike i nā pae maʻamau ʻole o kēia mau mea.

ʻO ke kanaka me kēia mau mea ʻekolu a pau, he kiʻekiʻe kona pilikia o ka loaʻa ʻana o ka maʻi kanesa. Akā, ʻo ke kanaka me ka ʻole o kekahi o kēia mau mea, he haʻahaʻa loa kona pilikia. E wehewehe ana kāu kauka iā ʻoe i ka hui pilikia āu e noho nei ma muli o nā hopena o kēia mau hoʻokolohua.

Aia kekahi lāʻau lapaʻau no MGUS?

Eia ka nūhou maikaʻi: ʻAʻole pono ka hapa nui o ka poʻe me MGUS i kekahi lāʻau lapaʻau.

No laila he aha kāu e hana ai? Hana ke kauka i ka mea i kapa ʻia ʻo "kiaʻi makaʻala" a i ʻole "nānā ikaika." I ka ʻōlelo maʻalahi, "kiaʻi makaʻala."

ʻO ia hoʻi, me ka hāʻawi ʻole ʻana iā ʻoe i ka lāʻau lapaʻau, e nānā mau ʻia kāu mau pae protein M koko a me nā mea ʻē aʻe ma kahi papa hana i hoʻonohonoho ʻia.

• ʻO ka maʻamau, ua kauoha ʻia nā hoʻāʻo koko i kēlā me kēia 3 a 6 mau mahina no ka makahiki mua.
• A laila, inā paʻa nā mea āpau, hiki iā ʻoe ke noi no kahi nānā kino i kēlā me kēia 6 mahina a i ʻole hoʻokahi manawa i ka makahiki .

ʻO ke kumu nui o nā nānā maʻamau e like me kēia, ʻo ia ka ʻike ʻana i nā hōʻailona mua o ka lilo ʻana o MGUS i maʻi koʻikoʻi. Inā ʻike ʻia kekahi mau loli, hiki ke hoʻomaka koke i ka lāʻau. He pōmaikaʻi nui kēlā.

Inā loaʻa iā ʻoe kekahi pilikia ʻē aʻe ma waho aʻe o ka MGUS, e like me ka nāwaliwali o ka iwi, e kuhikuhi kāu kauka i kahi lāʻau lapaʻau ʻokoʻa no ia.

I ka manawa hea e pono ai iaʻu ke ʻike i ke kauka?

Inā loaʻa iā ʻoe ʻo MGUS, e hāʻawi kāu kauka iā ʻoe i nā lā kikoʻī no kāu mau nānā ʻana. E hōʻoia e hele i kēlā mau lā. Eia kekahi, inā loaʻa iā ʻoe kekahi mau hōʻailona ʻē, e ʻike koke i kāu kauka, ma mua o ke kali ʻana i kāu manawa hoʻonohonoho keʻena lapaʻau aʻe. Hiki i kēia mau hōʻailona ke hōʻailona e ʻoi aku ka ʻino o kou kūlana.

E makaʻala pono i nā hōʻailona i helu ʻia ma lalo nei.

Hiki ke hopohopo iki ka ʻike ʻana o MGUS. ʻO nā huaʻōlelo "undetermined significance" i loko e haʻi iā ʻoe he nui nā mea a mākou i ʻike ʻole ai e pili ana i ia mea. Ke hoʻomau nei ka noiʻi e ʻike i ke kumu he mea koʻikoʻi ia no kekahi poʻe a ʻaʻole no kekahi.

Akā ʻo ka mea maikaʻi loa, me nā holomua o ka ʻepekema lapaʻau i kēia lā, hiki iā ʻoe ke loiloi i kou pilikia ma mua. A no ka mea ke nānā mau ʻia nei ʻoe, hiki ke ʻike ʻia nā loli i ka wā mua. No laila, ʻo ka mea maikaʻi loa hiki iā ʻoe ke hana, ʻo ia ke hōʻemi i kou makaʻu a hahai pololei i nā ʻōlelo a ke kauka.