He mea paʻakikī ke hoʻopuka i nā huaʻōlelo i ka makaʻu a me ka hopohopo e ʻike ai kekahi i ka wā e ʻike ʻia ai he maʻi kanesa. Akā me ka holomua o ka ʻepekema lapaʻau, i kēia lā aia nā ʻano hana holomua a kūleʻa hoʻi e mālama ai i ka maʻi kanesa. ʻAʻole e like me ka wā ma mua, i kēia manawa aia nā lāʻau lapaʻau kikoʻī e kuhikuhi ana a hoʻouka wale i nā hunaola kanesa. I kēia lā, ke kamaʻilio nei mākou e pili ana i kahi ʻano hana lapaʻau koʻikoʻi i hoʻohana ʻia no ka maʻi kanesa colorectal. ʻO ia ka Monoclonal Antibody Therapy.
He aha kēia mau antibodies monoclonal?
Ma mua o ko kākou hoʻomaopopo ʻana i kēia, e nānā kākou i ka ʻōnaehana pale kūlohelohe o ko kākou kino ponoʻī. Ke komo mai kahi mea hoʻouka kaua o waho, e like me ka germ a i ʻole ka virus, i loko o ko kākou kino, hana kā kākou ʻōnaehana pale i nā protein kūikawā e ʻimi a luku iā lākou. Kāhea mākou i kēia mau antibodies. Ua like ia me kahi pūʻali koa e pale ana i kahi ʻāina.
I kēia manawa, e noʻonoʻo ʻoe he "hui pūʻali koa kūikawā" kēia i hoʻomaʻamaʻa kūikawā ʻia a ʻike pehea e hoʻouka ai i hoʻokahi wale nō pahuhopu. ʻO nā Antibodies Monoclonal kekahi mea like. He mau antibodies kikoʻī kēia i hana ʻia ma ke ʻano hana i loko o kahi keʻena hoʻokolohua. Ua hoʻolālā ʻia lākou e ʻimi i hoʻokahi pahuhopu, hoʻopili iā ia, a luku iā ia. I kēia hihia, ʻo kēlā pahuhopu he cell kanesa.
ʻO ka pōmaikaʻi nui o kēia lāʻau lapaʻau, ʻo ia kona pololei . Ua like ka chemotherapy kuʻuna me ka pōkā. ʻOiai e pepehi ana i nā hunaola kanesa, hiki iā ia ke hōʻino i nā hunaola olakino i loko o ko kākou kino. ʻO ia ke kumu e hoʻoulu ai ka chemotherapy i nā hopena ʻaoʻao e like me ka hāʻule ʻana o ka lauoho a me ka luhi. Akā, ua like ka lāʻau Monoclonal Antibody me kahi "missile alakaʻi." Hele pololei ia i ke hunaola kanesa. No laila, hiki iā ʻoe ke manaʻo i nā hopena ʻaoʻao liʻiliʻi.
Nā lāʻau lapaʻau e hoʻōki i ke "ala ola" o ka maʻi kanesa
ʻAʻole wale ka maʻi kanesa he puʻu o nā pūnaewele. Ua like ia me kahi hale hana liʻiliʻi. Pono ia i ka meaʻai e ulu ai, e nui aʻe. No ka loaʻa ʻana o kēia meaʻai, hana nā pūnaewele kanesa i nā kīʻaha koko hou no lākou iho. I ka lāʻau lapaʻau, kapa mākou i kēia kaʻina hana he angiogenesis . Ma o kēia mau kīʻaha koko e loaʻa ai i ke kanesa ka meaʻai e pono ai e ola.
No laila, ʻo ka mea a kekahi mau antibodies monoclonal e hana ai, ʻo ia ke kāohi i ka hoʻokumu ʻia ʻana o kēlā mau kīʻaha koko. Ua like ia me ke ʻoki ʻana i ka "lako" o ka wahie i ke kanesa. ʻO kahi lāʻau lapaʻau nui i kēia papa ʻo Bevacizumab (Avastin) .
Pehea ka hana ʻana o Avastin?
Hoʻokuʻu nā hunaola kanesa i kahi hōʻailona kūikawā i kapa ʻia ʻo Vascular Endothelial Growth Factor (VEGF) . Ke loaʻa kēia hōʻailona, hoʻomaka ke kino e hana i nā kīʻaha koko hou. Hana ka lāʻau ʻo Avastin ma ke ālai ʻana i kēlā hōʻailona VEGF. Pale kēia i ke kanesa mai ka hana ʻana i nā kīʻaha koko hou. A laila, me ka ʻole o ka hānai ʻana, lohi a oki paha ka ulu ʻana o ke kanesa.
He lāʻau lapaʻau i ʻae ʻia ʻo Avastin no ke kanesa colon i laha (metastasized) i nā ʻāpana ʻē aʻe o ke kino. ʻOiai ʻaʻole ia e ho'ōla piha i ke kanesa, ua hōʻike nā noiʻi ua hoʻonui ʻo Avastin, i ka wā i hāʻawi ʻia me ka chemotherapy, i ka manawa ola o nā maʻi ma kahi o ʻelima mahina.
ʻO kekahi o nā lāʻau hou o kēia papa e komo pū ana me `Fruquintinib (Fruzaqla), `ramucirumab (Cyramza)` a me `ziv-aflibercept (Zaltrap).` Hana pū kēia mau mea ma ke keakea ʻana i ka ʻōnaehana hōʻailona VEGF.
Pehea e hāʻawi ʻia ai ʻo Avastin a me kona mau hopena ʻaoʻao
He lāʻau lapaʻau ʻo Avastin i hāʻawi ʻia ma o ka intravenous a i ʻole IV. Hāʻawi pinepine ʻia i kēlā me kēia ʻelua a ʻekolu pule me ka chemotherapy. ʻO ka mea nui e hoʻomanaʻo ai, ʻo kēia lāʻau lapaʻau e hoʻonui i nā hopena o ka chemotherapy, akā ʻaʻole i hōʻike ʻia kona hopena i ka wā e hāʻawi wale ʻia ai i nā poʻe maʻi me ka maʻi ʻaʻai colon.
He mea nui loa e kamaʻilio ākea me kāu kauka e pili ana i kekahi ʻehaʻeha āu e ʻike ai ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau a i ka wā o ia lāʻau.
| Nā hopena ʻaoʻao hiki ke loaʻa iā Bevacizumab (Avastin) | |
|---|---|
| Nā hopena ʻaoʻao maʻamau i ʻike pinepine ʻia | |
| Manaʻo luhi a make ke ola | ʻEha poʻo |
| Ke koko kiʻekiʻe | Makemake nui |
| Ka maʻi ʻōpū (ʻeha ʻōpū) | |
| Nā hopena ʻaoʻao koʻikoʻi e pono e hōʻike koke ʻia i ke kauka | |
| Ka puka ʻana o ke kolona (pono paha ke ʻoki ʻana) | Ka hōʻino ʻana o nā puʻupaʻa a me ka hoʻonui ʻia o ka protein i loko o ka mimi |
| ʻO ka hōʻeha puʻuwai a i ʻole ka ʻeha umauma | Hoʻemi ʻia ka ho'ōla ʻana o nā ʻeha (no laila ʻaʻole pono e hoʻohana koke ʻia ma hope o ke ʻoki ʻana) |
| Nā pilikia kahe koko nui a i ʻole ke kāpili ʻana o ke koko | |
Nā lāʻau lapaʻau e hoʻopau i ka "kuhi ulu" i loko o nā pūnaewele kanesa
E kamaʻilio kākou e pili ana i kekahi ʻano antibody monoclonal ʻē aʻe. ʻAʻole hana kēia mau mea e like me kā mākou i ʻōlelo ai ma mua. Hoʻopili pololei kēia mau lāʻau i kahi protein kikoʻī ma luna o ka ʻili o nā hunaola kanesa. Ua kapa ʻia ʻo ia ʻo Epidermal Growth Factor Receptor (EGFR) .
I ka ʻōlelo maʻalahi, ua like kēia EGFR me kahi "kuhi" e haʻi ana i ke kelepona kanesa e "ulu, ulu." Ma kahi o 75% o nā maʻi kanesa colon i loaʻa kēia protein EGFR.
Hana nā lāʻau lapaʻau ʻo cetuximab (Erbitux) a me panitumumab (Vectibix) ma ke kau ʻana i kēlā "switch" i kapa ʻia ʻo EGFR a hoʻopau iā ia. Pale kēia i ka hōʻailona kūlohelohe e haʻi ana i nā cell e ulu mai ka launa pū ʻana me ke kuapo. ʻO ka hopena, ua pau ka ulu ʻana o nā cell cancer.
No wai i hoʻohana ʻia ai ʻo Erbitux lāua ʻo Vectibix?
Ua ʻāpono ʻia kēia mau lāʻau ʻelua no ka maʻi ʻaʻai kolona i laha (metastasized) i nā ʻāpana ʻē aʻe o ke kino. Akā, aia kekahi mea nui loa . Ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau, pono ʻoe e loaʻa i kahi hoʻāʻo genetic kūikawā ('genetic mutation test') o kāu mau cell cancer. ʻO kēlā hoʻāʻo ka mea e hoʻoholo ai inā e hana kēia mau lāʻau no kāu kanesa a i ʻole. ʻAʻole kūpono kēia no nā mea āpau.
Hāʻawi ʻia ʻo Erbitux ma ke ʻano intravenous i hoʻokahi manawa i ka pule. Hāʻawi wale ʻia a i ʻole me ka lāʻau chemotherapy irinotecan (Camptosar). Hāʻawi ʻia ʻo Vectibix i kēlā me kēia ʻelua pule, maʻamau i ka hui pū ʻana me kekahi mau lāʻau chemotherapy ʻē aʻe.
| Nā hopena ʻaoʻao hiki ke loaʻa iā Erbitux lāua ʻo Vectibix | |
|---|---|
| Nā pilikia ʻili: nā pehu e like me ka ʻākena, nā ʻōhū ʻili, ka ʻili maloʻo. (E hoʻomanaʻo, i kekahi manawa hiki i kēia mau hopena ʻili ke lilo i hōʻailona e hana ana ka lāʻau lapaʻau e kūʻē i ke kanesa!) | kuni |
| Manaʻo luhi a make ke ola | Ka paʻa ʻana o ka ʻōpū |
| ʻEha ʻōpū | Nā hopena maʻi e like me ka paʻakikī o ka hanu ʻana a me ke koko haʻahaʻa |
| Nā hopena e kū mai ana i ka wā e hāʻawi ʻia ai ka lāʻau i ke kino | |
He kikoʻī loa kēia mau lāʻau lapaʻau a pau. ʻO kāu kauka wale nō ke hoʻoholo i ka lāʻau lapaʻau maikaʻi loa nou ma muli o ke ʻano o ka maʻi kanesa a me kou olakino. Mai hoʻoholo ma muli o kāu mea i heluhelu ai ma ka pūnaewele a i ʻole ka mea a kekahi i ʻōlelo ai.
Leka Lawe-Home
- ʻO ka Monoclonal Antibody kahi lāʻau lapaʻau kūikawā i hoʻomohala ʻia i loko o kahi keʻena hoʻokolohua e kuhikuhi ana a hoʻouka wale i nā hunaola kanesa.
- Aia nā ʻano hana like ʻole o kēia mau mea. Ke ālai nei kekahi mau lāʻau i ke kahe koko i ke kanesa, aʻo kekahi e hoʻōki i nā hōʻailona a nā hunaola kanesa e hāʻawi ai e ulu.
- ʻAʻole like kēia mau lāʻau lapaʻau no kēlā me kēia kanaka. Ma mua o ka hāʻawi ʻia ʻana o kekahi mau lāʻau lapaʻau, pono paha ʻoe e hana i nā hoʻokolohua genetic kūikawā e ʻike ai inā e hana ka lāʻau lapaʻau no kou maʻi kanesa.
- E like me nā lāʻau lapaʻau āpau, he mau hopena ʻaoʻao kēia. Mai makaʻu iā lākou, akā e kamaʻilio pono me kāu kauka e pili ana iā lākou ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.
- ʻO kāu kauka lapaʻau wale nō ke hāʻawi iā ʻoe i ka ʻōlelo aʻo a me ke alakaʻi maikaʻi loa e pili ana i kāu mālama ʻana i ka maʻi kanesa, no laila he mea nui loa e hahai i kā lākou mau kuhikuhi.
💬 Comments (0)
ʻAʻohe manaʻo i kau ʻia. Hoʻohui i kāu manaʻo ma ʻaneʻi no ka manawa mua.
Hoʻohui i kāu manaʻo