ʻO nā mea e pono ai ʻoe e ʻike e pili ana iā R-CHOP, kahi lāʻau lapaʻau no ka maʻi kanesa (R-CHOP)

Ke ʻike ʻia ʻoe a i ʻole kahi mea aloha i ka maʻi kanesa, he mea maʻamau ke manaʻo iki i ka makaʻu a me ka hopohopo ke kamaʻilio kāu kauka e pili ana i kahi lāʻau e like me R-CHOP. Nui nā nīnau e hiki mai ana i ka noʻonoʻo, e like me ke ʻano o kēia mau huaʻōlelo, pehea ke ʻano o kēia lāʻau, a me ka mea e hiki mai ana ma muli o ia mea. ʻO ia ke kumu, me he mea lā e haʻi ana kāu hoaaloha iā ʻoe e pili ana i ia mea ma nā ʻōlelo maʻalahi, e kamaʻilio mākou e pili ana i nā mea āpau e pili ana i ka lāʻau R-CHOP i kēia lā.

I ka ʻōlelo maʻalahi, he aha ʻo R-CHOP?

He lāʻau lapaʻau ka R-CHOP no ke kanesa. I ka pololei, he hui pū ʻana ia o ʻelima mau lāʻau lapaʻau. Hoʻohana kūikawā ʻia ia no ka mālama ʻana i kahi ʻano kanesa i kapa ʻia ʻo Non-Hodgkin Lymphoma . ʻO kēia hui pū ʻana o nā lāʻau lapaʻau e komo pū ana me ʻekolu mau lāʻau chemotherapy, kahi lāʻau lapaʻau i kuhikuhi ʻia, a me kahi corticosteroid.

Hōʻike kēlā me kēia leka ma kēia inoa i kahi ʻano lāʻau lapaʻau. He mea maʻalahi loa ia, eia kekahi.

Ma muli o ka hapa nui o kēia mau lāʻau lapaʻau he mau lāʻau chemotherapy, kapa pū kekahi poʻe i kēia lāʻau lapaʻau ʻo "R-CHOP chemo." Akā, no ka mea, kōkua ka lāʻau Rituximab i kā mākou ʻōnaehana pale, hiki i kāu kauka ke kapa iā ia he "immuno-chemotherapy."

He aha nā ʻano maʻi e hoʻohana ʻia ai ka lāʻau R-CHOP?

Hoʻohana nui nā kauka iā R-CHOP e mālama i kahi ʻano maʻi kanesa i kapa ʻia ʻo non-Hodgkin lymphoma . He lāʻau lapaʻau maikaʻi loa nō hoʻi ia no kekahi o nā ʻano lymphoma maʻamau, ʻo ia hoʻi ka diffuse large B-cell lymphoma (DLBCL) .

Eia kekahi, hoʻohana ʻia ʻo R-CHOP i nā kūlana aʻe:

• ʻO ka lymphoma follicular holomua
• ʻO ka lymphoma cell mantle
• ʻO ka macroglobulinemia o Waldenstrom

Pehea e hana ʻia ai ka lāʻau lapaʻau? (Treatment Cycle)

E loaʻa iā ʻoe ka lāʻau R-CHOP i nā pōʻaiapuni. ʻO ka maʻamau, ʻekolu pule (21 lā) ka lōʻihi o kēlā me kēia pōʻaiapuni. Ua māhele ʻia kēia pōʻaiapuni i ʻelua ʻāpana:

1. Nā lā lapaʻau: Nā lā i hāʻawi ʻia ai ka lāʻau lapaʻau iā ʻoe.

2. Nā lā hoʻomaha: Nā lā e ʻae ai i kou kino e hoʻōla, ʻo ia hoʻi, e hoʻōla, ma mua o ka pōʻai aʻe.

Pehea nā lā lapaʻau?

Pono ʻoe e lawe i ka lāʻau lapaʻau no ʻelima mau lā. Lawe ʻia ka steroid i kapa ʻia ʻo Prednisone (P) ma ke ʻano he pila. Hāʻawi ʻia nā lāʻau lapaʻau ʻehā ʻē aʻe (R, C, H, O) iā ʻoe ma o ka hoʻokomo ʻana i loko o ke koko (IV). ʻO ke ʻano kēia ua hāʻawi ʻia lākou i loko o kahi aʻa e like me ka saline. Pono ʻoe e hele i kahi haukapila a i ʻole ke keʻena lapaʻau no kēia.

I loko o kēia lāʻau lapaʻau, e noho ʻoe ma luna o kahi noho. E hāʻawi kahi mīkini iā ​​ʻoe i ka lāʻau lapaʻau ma o kahi ʻōmole palaki i loko o kahi aʻa koko ma kou lima, lima, a i ʻole ka umauma. I kekahi manawa, i mea e maʻalahi ai ka hoʻomau ʻana i ka loaʻa ʻana o ka lāʻau lapaʻau, ua hoʻokomo ʻia kahi mea liʻiliʻi i kapa ʻia he chemo port ma lalo o ka ʻili o kou umauma.Ua kapa ʻia hoʻi ia he hoʻokahi.

ʻO ka hapa mua o ka mālama ʻana e like me kēia:

• Ma mua o ka hoʻomaka ʻana o ka lāʻau lapaʻau, e hāʻawi ʻia ʻoe i ka lāʻau lapaʻau e hoʻōki i ka luaʻi ʻana a me ka nausea .
• Eia kekahi, hāʻawi ʻia nā lāʻau lapaʻau e pale aku i nā maʻi ʻaleka . He mea maʻamau ka loaʻa ʻana o kahi hopena liʻiliʻi (e.g., ka wela, ka poniuniu) ke hāʻawi ʻia iā ʻoe ka lāʻau Rituximab (R). Eia nō naʻe, pale nui ka lāʻau lapaʻau ma mua i nā hopena koʻikoʻi.

Ke koʻikoʻi o nā lā hoʻomaha

I loko o kahi pōʻaiapuni maʻamau o R-CHOP, loaʻa iā ʻoe he 16 mau lā o ka hoʻomaha ma hope o ʻelima mau lā o ka mālama ʻana. He mea nui loa kēia manawa. No ka mea, i ka wā e luku ai ʻo R-CHOP i nā hunaola kanesa, he mea luhi loa hoʻi ia no ke kino. No laila, he mea maʻamau ke manaʻo luhi loa ma hope o ka mālama ʻana. I loko o kēia mau lā hoʻomaha, he manaʻo maikaʻi ke noi aku i kahi lālā o ka ʻohana a i ʻole hoaaloha e kōkua iā ʻoe me kāu mau hana o kēlā me kēia lā.

I kou wā e hoʻōla ai, inā hiki iā ʻoe ke kino, hiki i kāu kauka ke ʻōlelo aku iā ʻoe e hana i nā hana liʻiliʻi, e like me ka hele wāwae, inu wai nui, a me ka ʻai ʻana i nā meaʻai momona.

Pehea ka lōʻihi e hana ʻia ai kēia lāʻau lapaʻau?

Loaʻa i ka hapa nui o nā kānaka ʻeono mau pōʻaiapuni o R-CHOP. ʻEkolu pule ka lōʻihi o kēlā me kēia pōʻaiapuni, no laila ʻo ka manawa lapaʻau holoʻokoʻa ma kahi o 18 pule. Eia nō naʻe, ʻo ka helu o nā pōʻaiapuni āu e pono ai e pili ana i kou kūlana. Pono paha kekahi poʻe i ʻewalu mau pōʻaiapuni. Manaʻo paha kekahi mau kauka i nā pōʻaiapuni ʻelua pule ma kahi o nā pōʻaiapuni ʻekolu pule.

He aha nā pōmaikaʻi o ka mālama ʻana me R-CHOP?

ʻO ka pōmaikaʻi nui o kēia, ʻaʻole ia he lāʻau hoʻokahi, akā he hui pū ʻana o ʻelima mau lāʻau. Hoʻopau kēlā me kēia o kēia mau lāʻau i nā hunaola kanesa ma nā ʻano like ʻole. No laila, ma kahi o hoʻokahi koa e hakakā ana, ua like ia me kahi pūʻali koa holoʻokoʻa e hui pū ana e hakakā i ka maʻi kanesa.

Kiʻekiʻe loa ka holomua o ka mālama ʻana iā R-CHOP . No ka laʻana, a hiki i ka 70% o ka poʻe me ke ʻano maʻi kanesa i kapa ʻia ʻo DLBCL e hoʻokō i ke kala piha ʻana. ʻO ia hoʻi, nalowale nā ​​​​hōʻailona āpau. Inā ʻaʻole e hoʻi hou ka maʻi no ʻelima mau makahiki, ua manaʻo ʻia ua noa ka hoʻi hou ʻana o ke kanesa.

ʻOiaʻiʻo, ʻaʻole hiki i kēia lāʻau lapaʻau ke hōʻoia e hoʻopau loa ia i ke kanesa a i ʻole e pale iā ia mai ka hoʻi hou ʻana mai i nā kānaka āpau. Eia nō naʻe, ua manaʻo ʻia ʻo R-CHOP kekahi o nā lāʻau lapaʻau palekana a maikaʻi loa i loaʻa no ka lymphoma non-Hodgkin.

Nā hopena ʻaoʻao a me nā pilikia

E like me nā lāʻau lapaʻau a pau, loaʻa iā R-CHOP nā hopena ʻaoʻao. Akā, mai hopohopo. E hāʻawi kāu kauka iā ʻoe i ka lāʻau lapaʻau e pale aku i kēia mau hopena ʻaoʻao nui (e like me ka luaʻi ʻana) a e kāohi i nā mea e like me nā keʻokeʻo koko haʻahaʻa. He mea nui e kamaʻilio ākea e pili ana i kēia mau pilikia me kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.

Nā hopena hoʻokomo

Hiki i nā kānaka he nui ke loaʻa i kahi hopena iki i ka Rituximab i kā lākou pōʻai mua o ka lāʻau lapaʻau. ʻO ia ke kumu e hāʻawi iki ai nā kauka i ka lāʻau i ka wā mua. He mea maʻamau ka manaʻo poniuniu a wela paha, a e nalowale ia ma hope o kekahi manawa. Eia nō naʻe, inā loaʻa iā ʻoe nā hōʻailona o kahi hopena koʻikoʻi, pono ʻoe e ʻimi koke i ke kōkua lapaʻau . ʻO kēia mau hōʻailona:

• ʻŌhū ʻili
• ʻĀnai
• Ka pehu ʻana o ka waha a i ʻole nā ​​lehelehe
• Manaʻo e like me ka ʻū ʻana o kou puʻu

E nānā pono nā limahana lapaʻau iā ʻoe i ka wā e hāʻawi ʻia ana ka lāʻau lapaʻau iā ʻoe. Eia nō naʻe, inā ʻike ʻoe i kekahi o kēia mau hōʻailona ma hope o kou hoʻi ʻana i ka home, e hele koke i ka ʻOihana Pilikia (ETU) o ka haukapila.

Nā hopena ʻaoʻao maʻamau

Hiki i nā lāʻau lapaʻau āpau i loko o R-CHOP ke hana i nā hopena ʻaoʻao. Akā, ʻaʻole i loaʻa i nā kānaka a pau. He ʻokoʻa ia mai kēlā kanaka a kēia kanaka. E nānā kākou i nā hopena ʻaoʻao maʻamau a pehea e hana ai me lākou.

Eia kekahi, hiki ke loaʻa nā hopena ʻaoʻao ʻē aʻe:

• ʻEha waha
• ʻEha poʻo
• Ka paʻa ʻana o ka ʻōpū a i ʻole ka maʻi kahe
• ʻĀʻī puʻuwai
• Nāwaliwali o nā ʻiʻo
• ʻAʻole hiki ke hiamoe
• Nā loli o ke ʻano
• Nā palpitations o ka puʻuwai

Nā hopena lōʻihi e hiki mai ana ma hope o ka mālama ʻana

Nalo ka hapa nui o nā hopena ʻaoʻao i ka hala ʻana o kekahi manawa ma hope o ka pau ʻana o ka lāʻau lapaʻau.

Eia nō naʻe, ma muli o nā kumu e like me ka ikaika o ka lāʻau lapaʻau āu e loaʻa ai, hiki i ka lāʻau R-CHOP ke hoʻonui iki i kou pilikia o ka loaʻa ʻana o nā maʻi puʻuwai a i ʻole nā ​​ʻano maʻi ʻē aʻe i ka wā e hiki mai ana. Hiki iā ia ke hoʻopilikia i ka hānau keiki . ʻO ia hoʻi, inā ʻoe e hoʻolālā nei e loaʻa nā keiki i ka wā e hiki mai ana, e kamaʻilio me kāu kauka e pili ana i kēia ma mua. Hiki paha iā ʻoe ke kūkākūkā i nā koho e like me ka hoʻopaʻa ʻana i kāu mau hua a i ʻole ka sperm.

He aha ka ʻokoʻa ma waena o R-CHOP a me CHOP?

I ka ʻōlelo maʻalahi, ʻo R-CHOP kahi mana i hoʻomaikaʻi ʻia o ka lāʻau CHOP. Ua hoʻolauna ʻia ʻo CHOP i nā makahiki 1990 a ʻo ia ka lāʻau lapaʻau maikaʻi loa no ka lymphoma non-Hodgkin i kēlā manawa.

Akā i ka hoʻomaka ʻana o nā makahiki 2000, ua hoʻohui nā kānaka noiʻi i ka lāʻau lapaʻau i kuhikuhi ʻia ʻo Rituximab (R) i ka regimen CHOP. Ua hoʻonui hou kēia hoʻohui i ka nui o ka ho'ōla. I kēia lā, ʻo R-CHOP ka lāʻau lapaʻau kūpono loa, e pani ana iā CHOP.