He wehewehe maʻalahi o ka lāʻau lapaʻau no ka nausea a me ka luaʻi: ​​Serotonin Antagonist

ʻO ka luaʻi a me ka luaʻi i hoʻokumu ʻia e ka anesthesia i ka wā o ka chemotherapy, radiation therapy, a i ʻole ke ʻoki ʻana he pilikia nui ia no nā poʻe he nui. ʻO ka ʻoluʻolu ʻole āu e manaʻo ai i nā manawa e like me kēia he mea nui loa ia. No laila i kēia lā e kamaʻilio mākou e pili ana i kahi ʻano lāʻau kūikawā a kāu kauka e hāʻawi ai iā ʻoe e kāohi i kēia kūlana. Ua kapa ʻia kēia mau mea he serotonin antagonists . E nānā kākou i ke ʻano o kēia mau lāʻau, pehea lākou e hana ai, a me nā mea e pono ai mākou e makaʻala i ka wā e hoʻohana ai iā lākou.

He aha kēia mea hoʻouka kaua serotonin?

I ka ʻōlelo maʻalahi, he hui kēia o nā lāʻau lapaʻau i kuhikuhi ʻia e ke kauka e pale a mālama i ka nausea a me ka luaʻi. Ma nā ʻōlelo lapaʻau, kapa mākou i nā antiemetics nā lāʻau lapaʻau i hāʻawi ʻia no ka nausea. No laila, ʻo nā serotonin antagonists kekahi o ia mau hui o nā lāʻau lapaʻau.

Ua ʻike ʻia kēia ʻano lāʻau lapaʻau e kekahi mau inoa ʻē aʻe:

• Nā mea kū'ē i ka serotonin-receptor
• Nā mea kū'ē i ka mea loaʻa 5HT3
• Nā mea pale serotonin

ʻOiai paha he mea paʻakikī iki kēia mau inoa, ua like ke ʻano o lākou a pau. ʻO ia hoʻi, ke ālai nei lākou i kahi kemika i kapa ʻia ʻo serotonin i loko o ko kākou kino i kekahi manawa. E kamaʻilio mākou e pili ana i kēlā me ka maopopo ma hope iki.

He aha nā ʻano lāʻau lapaʻau nui ma kēia māhele?

Aia kekahi mau ʻano lāʻau lapaʻau ma kēia māhele. Ua kuhikuhi paha kāu kauka i kekahi o kēia mau mea iā ʻoe. Hiki ke lawe ʻia kēia mau mea ma ke ʻano he mau pila a i ʻole he mau inikini.

I waena o kēia mau mea , ʻo Ondansetron (Zofran®) kekahi o nā lāʻau lapaʻau i kuhikuhi pinepine ʻia e nā kauka e hoʻōki i ka nausea, ma Sri Lanka a puni ka honua.

I nā kūlana hea e hoʻohana ʻia ai kēia lāʻau lapaʻau?

Ua ʻae mua ʻia kēia lāʻau lapaʻau e pale aku i ka nausea a me ka luaʻi ʻana i hoʻokumu ʻia e kekahi mau lāʻau lapaʻau.

Nā hoʻohana i ʻae nui ʻia:

• Ka luaʻi i hoʻokumu ʻia e ka chemotherapy: Ke komo nā lāʻau anti-cancer i ke kino, nui ka manawa e loaʻa ai ka luaʻi a me ka luaʻi. He kōkua nui kēia mau lāʻau i ka pale ʻana.
• ʻO ka luaʻi i hoʻokumu ʻia e ka radiation therapy: Hiki ke loaʻa ka luaʻi i ka wā o ka radiation therapy e luku ai i nā hunaola kanesa. Hāʻawi ʻia kēia mau mea no kēlā mau hihia.
• ʻO ka nausea ma hope o ke ʻoki ʻana: Hoʻohana ʻia kēia lāʻau lapaʻau e kāohi i ka nausea a me ka luaʻi ʻana i hoʻokumu ʻia e nā hopena o ka anesthesia ma hope o ke ʻoki ʻana.

Hāʻawi kūpono ʻia kēia lāʻau lapaʻau no nā pākeke a me nā keiki.

Nā hoʻohana ʻē aʻe (Hoʻohana ma waho o ka lepili):

I kekahi manawa, kuhikuhi nā kauka i kēia mau lāʻau lapaʻau no nā kūlana ʻē aʻe ma mua o nā mea i ʻae ʻia. Kāhea mākou i kēia 'hoʻohana ma waho o ka lepili'.

• Ka mālama ʻana i ka nausea ma hope o ke ʻoki ʻana: Hāʻawi ʻia kēia lāʻau lapaʻau e pale aku i ka nausea a ma hope hoʻi o ka hana ʻana.
• Maʻi kakahiaka: Loaʻa i kekahi poʻe ka nausea a me ka luaʻi nui i ka wā hāpai mua. Inā ʻaʻole holo pono nā lāʻau ʻē aʻe, hiki ke hāʻawi ʻia kēia lāʻau lapaʻau ma lalo o ka nānā pono ʻana a ke kauka.

Pehea e hana ai kēia lāʻau lapaʻau? E nānā kākou iā ia ma ke ʻano ʻepekema.

No ka hoʻomaopopo ʻana i kēia, pono mua mākou e hoʻomaopopo wale i ke ʻano o ka 'serotonin' a me nā 'serotonin receptors'.

E noʻonoʻo i kēia ʻano: he ʻelele ka serotonin, a he neurotransmitter paha, i loko o ko kākou kino. Kōkua kēia ʻelele i ka hoʻoponopono ʻana i nā mea he nui, me ko kākou ʻano, ka hiamoe, a me ka ʻai ʻana. ʻO ka mea kupanaha, 90% o kēia serotonin i loaʻa i loko o nā paia o ko kākou ʻōpū a me nā ʻōpū (ʻōnaehana gastrointestinal).

I kēia manawa, pehea lā e hiki mai ai ka nausea? Ma muli o kekahi mea e like me ka mālama ʻana i ka maʻi kanesa, hoʻokuʻu koke nā pūnaewele i loko o ko kākou ʻōpū i ka nui o ka serotonin. Hoʻopaʻa kēia serotonin keu i nā mea loaʻa i loko o nā ʻōpū a hoʻouna i kahi leka i ka lolo "ke hana nei kekahi mea ʻē ma ʻaneʻi." Wehewehe ka lolo i kēia leka he "nausea."

No laila he aha ka hana a ka lāʻau 'serotonin antagonist' a mākou e hāʻawi aku nei iā ʻoe? Ua like kēia lāʻau me kahi kī hewa i loko o kahi laka. Hoʻokomo ia i loko o ka laka (receptor), akā ʻaʻole ia e hoʻāla i ka laka. Eia kekahi, no ka mea aia i loko o ka laka, ʻaʻole ia e ʻae i ke kī kūpono (serotonin) e komo mai a hoʻopili i ka laka.

ʻO ia hoʻi, ke ālai nei kēia lāʻau lapaʻau i nā mea loaʻa 5-HT3 e pili ana ka serotonin. ʻO ke ʻano kēia, ʻaʻohe wahi e hele ai ka serotonin keu a hoʻopaʻa ʻia. ʻO ka hopena, ua pau ka leka nausea i ka lolo, a ua emi iho ka manaʻo o ka nausea a me ka luaʻi.

He aha nā hopena ʻaoʻao maʻamau?

E like me nā lāʻau lapaʻau āpau, hiki i kēia mau lāʻau ke hana i kekahi mau hopena ʻaoʻao liʻiliʻi, akā ʻaʻole pinepine kēia mau mea i mea koʻikoʻi.

Inā hoʻopilikia nui kēia mau hopena ʻaoʻao iā ʻoe, e kamaʻilio me kāu kauka e pili ana i ia mea.

Aia kekahi mau pilikia kūikawā e makaʻala ai?

ʻOiai he palekana loa kēia ʻano lāʻau lapaʻau, aia kekahi mau mea e pono ai mākou e makaʻala nui.

Nā pilikia o ka puʻuwai

Akahele loa nā kauka i ka hāʻawi ʻana i kēia lāʻau lapaʻau i nā poʻe me kekahi mau maʻi puʻuwai no ka mea hiki iā ia ke loaʻa kahi hopena liʻiliʻi i ka mele o ka puʻuwai. Inā loaʻa iā ʻoe kekahi o kēia mau maʻi, e hōʻoia e haʻi i kāu kauka.

• ʻO ka maʻi QT lōʻihi
• Nā hewa o ka puʻuwai (Ventricular arrhythmia)
• ʻO kekahi ʻano maʻi puʻuwai ʻē aʻe

ʻO ka maʻi Serotonin - He mea nui loa kēia!

He kūlana koʻikoʻi kēia, akā he mea kakaikahi loa, e kū mai ana i ka wā e kiʻekiʻe loa ai ka nui o ka serotonin i loko o ko mākou kino.

Hiki ke hoʻonui ʻia kēia pilikia inā ʻoe e lawe i nā lāʻau lapaʻau ʻē aʻe e hoʻopilikia i nā pae serotonin (e like me kekahi mau antidepressants) ʻoiai e lawe ana i nā antagonists serotonin. ʻO kēia no ka mea ke ālai kēia mau lāʻau i nā mea loaʻa serotonin, piʻi ka nui o ka serotonin manuahi i loko o ke koko.

He mea nui loa e hoʻomaopopo i kāu kauka inā ʻoe e lawe ana i nā lāʻau lapaʻau aʻe:

• Nā SSRI
• Nā SNRI
• ʻO Mirtazapine
• Nā mea hoʻopaʻa monoamine oxidase (MAOI)

He aha nā hōʻailona o ka maʻi serotonin? Hiki i kēia mau hōʻailona ke ʻano mai ka ʻoluʻolu a i ka ʻino.

E hoʻohana i ka wā hāpai (Pregnancy)

ʻAʻole pili kēia mau lāʻau lapaʻau me kahi pilikia koʻikoʻi o nā kīnā hānau i loko o ka ʻōpū i ka wā hāpai. Eia nō naʻe, ua hōʻike ʻia kahi piʻi iki o ka pilikia o kekahi mau kīnā hānau o ka puʻuwai a me ka lolo. No laila, inā makemake ʻoe i kēia mau lāʻau lapaʻau i ka wā hāpai, e kūkākūkā kāu kauka i nā pono a me nā pilikia me ʻoe ma mua o ka hoʻoholo ʻana.

Āhea wau e kāhea aku ai i kaʻu kauka?

Inā hoʻomau ʻoe i ka hoʻohana ʻana i kēia lāʻau lapaʻau, he mea nui e ʻike i kāu kauka i nā manawa maʻamau e nānā i ka pono o ka lāʻau lapaʻau. Eia kekahi, e kamaʻilio me kāu kauka i nā kūlana aʻe:

• Inā hoʻopilikia nā hopena ʻaoʻao iā ʻoe: Inā hoʻopilikia loa nā mea e like me ke poʻo ʻeha a me ka paʻa ʻana i ka paʻa.
• Inā ʻaʻole e emi ka nausea a me ka luaʻi: ​​Inā ʻaʻole e emi ka nausea a i ʻole e ʻoi aku ka ʻino ʻoiai ke lawe nei i ka lāʻau lapaʻau.
• Inā makemake ʻoe e hoʻōki i ka lawe ʻana i ka lāʻau lapaʻau: Mai hoʻōki i ka lawe ʻana i ka lāʻau lapaʻau me ka ʻole o ke noi ʻana aku i kāu kauka.

He mea hoʻonāukiuki maoli ka luaʻi. Akā ʻo ka nūhou maikaʻi, aia nā lāʻau lapaʻau kūpono, e like me nā mea hoʻopilikia serotonin, e kāohi iā ia. Inā he mau nīnau kāu e pili ana i kēia, mai makaʻu e nīnau i kāu kauka.