He mea maʻamau i kekahi ke makaʻu iki i ka lohe ʻana i ka huaʻōlelo kanesa umauma. Akā, ʻo ka mea nui e pono ai kākou e ʻike, ʻaʻole like nā kanesa umauma a pau. He ʻano like ʻole o lākou. I kēia lā, e kamaʻilio kākou e pili ana i kahi ʻano i ʻoi aku ka laha ʻole a pono e nānā kūikawā ʻia i ka wā o ka mālama ʻana. Kāhea mākou i kēia ʻo 'Triple-Negative Breast Cancer' (TNBC no ka pōkole). ʻO ka lohe ʻana i kēia inoa, he mea paʻakikī paha iā ʻoe, akā, mai makaʻu. E kamaʻilio maʻalahi mākou e pili ana i kēia, ma ke ʻano hiki iā ʻoe ke hoʻomaopopo.
No ke aha i kapa ʻia ai kēia ʻo 'Triple-Negative'?
ʻAe, e hoʻomaka kākou me ke ʻano o kēia inoa. No ka hoʻomaopopo ʻana i kēia, pono mākou e loaʻa kahi manaʻo iki pehea e hana ai nā hunaola maʻi ʻaʻai umauma maʻamau.
E noʻonoʻo ʻoe ua like nā pūnaewele i loko o ko kākou kino me nā puka. Loaʻa i kēlā mau puka nā laka e paʻa ai nā kī. I ka lāʻau lapaʻau, kapa mākou i kēia mau puka kī he 'nā mea loaʻa'. Ke hele mai nā kī e kūlike me kēia mau mea loaʻa a pili, loaʻa i kēlā mau pūnaewele kekahi mau leka.
ʻEkolu ʻano o nā mea loaʻa i mea nui i ka maʻi ʻaʻai umauma.
1. Nā Mea Loaʻa Estrogen (ER): Pili kēia mau mea me ka hormone wahine estrogen.
2. Nā Mea Loaʻa Progesterone (PR): Pili kēia me kekahi hormone wahine ʻē aʻe i kapa ʻia ʻo progesterone.
3. Nā Mea Loaʻa HER2: He mea loaʻa kēia e hoʻopaʻa ai i kahi protein i kapa ʻia ʻo HER2. Hoʻomalu kēia protein i ka ulu ʻana o nā hunaola umauma.
I loko o nā ʻano maʻi ʻaʻai umauma he nui, hoʻokahi, ʻelua, a i ʻole ʻekolu o kēia mau mea loaʻa i hoʻonui nui ʻia. ʻO ke ʻano kēia, kōkua kēia mau hormones a me nā protein i ka ulu ʻana o nā hunaola maʻi ʻaʻai. Ua like ia me ka hoʻohui ʻana i ka wahie i ke ahi. No laila, ke mālama nā kauka i kēia mau hunaola, kuhikuhi lākou i kēia mau mea loaʻa a hāʻawi iā lākou i nā lāʻau lapaʻau e ālai iā lākou (lāʻau lapaʻau i kuhikuhi ʻia). Pani kēia mau lāʻau i kēlā mau 'puka kī'. A laila, ʻaʻole loaʻa i nā hunaola maʻi ʻaʻai nā leka e pono ai lākou e ulu.
I ka ʻōlelo maʻalahi, ʻo ke ʻano o ka 'triple-negative' ʻaʻole i loaʻa i kēia mau cell cancer nā mea loaʻa ʻekolu i ʻōlelo ʻia ma luna (estrogen, progesterone, a me HER2) . ʻO ke ʻano o ka 'Negative' ʻo ia hoʻi ʻaʻole. He 'triple-negative' ia no ka mea ʻaʻohe ona mea ʻekolu.
I kēia manawa, ua maopopo paha iā ʻoe kahi o ka pilikia? ʻAʻole hana nā lāʻau lapaʻau maʻamau e kuhikuhi ana i nā mea loaʻa no kēia ʻano maʻi kanesa. No ka mea, ʻaʻohe mea loaʻa e kuhikuhi ai. ʻO kēia ka pilikia nui me ke kanesa TNBC. Akā, ʻaʻole ia he manaʻo ʻaʻole hiki ke mālama ʻia. Aia kekahi mau lāʻau lapaʻau kūpono ʻē aʻe no kēia, a e kamaʻilio mākou e pili ana i kēlā ma hope.
He aha nā hōʻailona o kēia maʻi kanesa?
Ua like loa nā hōʻailona o ka maʻi ʻaʻai umauma triple-negative me nā hōʻailona o nā maʻi ʻaʻai umauma ʻē aʻe. Inā ʻike ʻoe i kekahi mea ʻē i loko o kou mau umauma, he mea nui e makaʻala.
Inā loaʻa iā ʻoe kekahi a ʻoi aku paha o kēia mau hōʻailona, mai hopohopo a e ʻike koke i ke kauka. ʻO ka loaʻa ʻana o kēia mau hōʻailona ʻaʻole ia he manaʻo he maʻi kanesa ia, akā he mea naʻauao ke nānā ʻia.
| Hōʻailona | He wehewehe maʻalahi |
|---|---|
| He puʻupuʻu hou a mānoanoa paha i loko o ka umauma | ʻO kekahi mea e like me kahi puʻu i loaʻa ʻole ma laila ma mua, ua paʻa i ka lima. |
| ʻEha umauma a i ʻole ka nipple | ʻEha pinepine, ʻeha i wehewehe ʻole ʻia. |
| Nā loli o ka ʻili o ka umauma | Ka lua ʻana, ka ʻulaʻula, ka mānoanoa, a i ʻole ka maloʻo o ka ʻili, e like me ka ʻili ʻalani. |
| Hoʻohuli ʻana o ka nipple | Pīholo i loko kahi nipple maʻamau ma mua. |
| Hoʻokuʻu ʻia ʻana o ka nipple | Ke kahe nei ke koko a i ʻole kekahi wai ʻē aʻe mai ka nipple i ka wā ʻaʻole ʻoe he makuahine hānai. |
| Pehu ʻana o ka umauma | Ka pehu ʻana o ka umauma, ma ka hapa a i ʻole ma ka ʻāpana. |
| Nā puʻupuʻu ma ka ʻāʻī a kokoke paha i ka iwi ʻāʻī | ʻO nā puʻupuʻu i hoʻokumu ʻia e ka pehu ʻana o nā lymph nodes. |
E hoʻomanaʻo, hiki i ka mammogram maʻamau ke ʻike i ka maʻi kanesa ma mua o ka puka ʻana o nā hōʻailona. No laila, he mea nui loa ka loaʻa ʻana o nā hoʻokolohua kūpono i ka makahiki i ka manawa kūpono.
He aha nā kumu a me nā kumu pilikia no ka hoʻomohala ʻana i kēia maʻi kanesa?
ʻAʻole i loaʻa i nā kānaka noiʻi kahi kumu kikoʻī no kēia maʻi kanesa, akā ua ʻike lākou he pilina ikaika ma waena o ia a me nā genes.
ʻO ka mea nui, aia kahi pilina ikaika ma waena o nā mutations i loko o nā genes BRCA1 a me BRCA2 a me TNBC. ʻO ka maʻamau, ʻo kēia mau genes BRCA ke kuleana no ka kaohi ʻana i ka ulu ʻana o ka maʻi kanesa i loko o ko mākou kino. E like me ka ʻōnaehana paleki o ke kaʻa. Ke loaʻa kahi kīnā a i ʻole ka mutation i loko o kēia mau genes, nalowale ka hiki ke kaohi i ka maʻi kanesa. Hiki iā mākou ke hoʻoilina i kēia mau mutations gene mai ko mākou mau mākua.
Ma waho aʻe o kēia, aia kekahi mau kumu ʻē aʻe e hoʻonui ai i ka pilikia o ka hoʻomohala ʻana i ka maʻi ʻaʻai TNBC.
| Kumu pilikia | Wehewehena |
|---|---|
| Makahiki | ʻOi aku ka maʻamau i nā wahine ʻōpio ma lalo o 40 mau makahiki. (Akā hiki ke ulu i kēlā me kēia makahiki.) |
| Nā hoʻololi ʻana o ka gene BRCA | He kiʻekiʻe loa ka pilikia inā hoʻoilina ʻia kahi hoʻololi ʻana o ka gene BRCA1. |
| Lāhui/ʻano lāhui | Wahi a nā noiʻi i hana ʻia a puni ka honua, ʻoi aku ka maʻamau o kēia maʻi kanesa i waena o nā wahine o ka hanauna ʻApelika a Hispanic paha. |
Pehea e ʻike ai ke kauka i kēia?
Ke hele ʻoe e ʻike i ke kauka e pili ana i kahi puʻupuʻu umauma, e nānā mua ʻo ia i kou mau umauma. A laila, e nīnau lākou iā ʻoe e pili ana i kāu mau hōʻailona. Eia kekahi, e kauoha lākou i kekahi mau hoʻokolohua e hōʻoia i ka maʻi.
- Mammogram: He hoʻokolokolo X-ray o ka umauma.
- ʻO ke kaʻina hana Ultrasound o ka umauma: He kaʻina hana e hoʻohana ana i nā nalu kani e kiʻi i nā kiʻi o nā ʻiʻo i loko o ka umauma.
- MRI o ka umauma: He kaʻina hana e hoʻohana ana i kahi kahua magnetic a me nā nalu lekiō e hana i nā kiʻi ʻoi aku ka maopopo a me nā kikoʻī.
Inā hōʻike kēia mau scan i ka maʻi kanesa, ʻo ka hoʻāʻo koʻikoʻi aʻe he biopsy . Pili kēia i ka lawe ʻana i kahi ʻāpana liʻiliʻi loa o ka ʻiʻo mai ka puʻupuʻu kānalua me ka hoʻohana ʻana i kahi nila liʻiliʻi a nānā iā ia ma lalo o kahi microscope.
ʻO ka biopsy wale nō ke ala e hōʻoia 100% inā he maʻi kanesa kēia a ʻaʻole paha. Eia kekahi, ʻo ke ala wale nō e ʻike pono ai inā he TNBC kēia, ʻo ia ke nānā ʻana i kēia ʻāpana o ka ʻiʻo a ʻike inā loaʻa iā ia nā mea loaʻa ʻekolu a mākou i kamaʻilio ai (ER, PR, HER2).
Eia kekahi, hiki i kāu kauka ke kuhikuhi iā ʻoe no ka hoʻāʻo genetic e nānā i nā hoʻololi genetic, e like me BRCA. Hoʻohana ʻia kēia ʻike āpau e hoʻoholo ai i ke kahua o kou maʻi ʻaʻai a hoʻomohala i ka hoʻolālā lapaʻau kūpono loa nāu.
He aha nā lāʻau lapaʻau no kēia?
ʻOiai aia nā pilikia i ka mālama ʻana i ka maʻi ʻaʻai TNBC, aia i kēia manawa he nui nā lāʻau lapaʻau kūpono loa i loaʻa. E ʻōlelo aku kāu kauka oncology i ka hoʻolālā lapaʻau maikaʻi loa e pili ana i kou kūlana.
ʻO ka lāʻau lapaʻau nui ka wehe ʻana i ka puʻupuʻu kanesa ma o ke ʻoki ʻana. Eia kekahi, hiki ke hoʻohana pū ʻia kekahi a ʻoi aku paha o kēia mau lāʻau lapaʻau.
- ʻO Chemotherapy: ʻO kēia kekahi o nā lāʻau lapaʻau nui a maikaʻi loa no TNBC. Hāʻawi ʻia ka Chemotherapy ma mua o ke ʻoki ʻana e hoʻēmi i ka puʻupuʻu (neoadjuvant chemotherapy) a ma hope o ke ʻoki ʻana e pepehi i nā hunaola kanesa i koe a pale i ka hoʻi hou ʻana mai o ka maʻi (adjuvant chemotherapy).
- Lapaʻau Radiation: Ma hope o ke ʻoki ʻana, kuhikuhi ʻia nā kukuna ikehu kiʻekiʻe i kahi i loaʻa ai ke kanesa e luku i nā hunaola kanesa i koe.
- Immunotherapy: He lāʻau lapaʻau hou kēia. Hana ia ma ka hoʻoulu ʻana i ka ʻōnaehana pale ponoʻī o ko mākou kino e ʻike a hoʻouka i nā hunaola kanesa. No kekahi mau maʻi TNBC, hiki ke hāʻawi ʻia kēia lāʻau lapaʻau me ka chemotherapy e hoʻokō i nā hopena maikaʻi loa.
- Lapaʻau i Kūkuhi ʻia: No nā poʻe maʻi TNBC me nā hoʻololi ʻana o ka gene BRCA, hoʻohana ʻia nā lāʻau lapaʻau kikoʻī e like me nā mea hoʻopaʻa PARP . Hana kēia mau mea ma ka hoʻopilikia ʻana i ka hiki o nā hunaola kanesa ke hoʻoponopono iā lākou iho.
Aia i kēia manawa he nui nā hoʻokolohua lapaʻau e hana ʻia ana a puni ka honua no TNBC. Ke ʻike mau ʻia nei nā lāʻau lapaʻau hou a me nā lāʻau lapaʻau hou. No laila, hiki iā mākou ke loaʻa ka manaʻolana maikaʻi no ka wā e hiki mai ana o kēia maʻi.
Nā mea e noʻonoʻo ai ma hope o ka mālama ʻana
Ma hope o ke ʻoki ʻana a i ʻole kekahi lāʻau lapaʻau ʻē aʻe, hiki ke loaʻa nā pilikia i kekahi manawa. No ka laʻana, hiki ke loaʻa ka maʻi i ka ʻeha ʻoki a i ʻole ke kūkulu ʻia ʻana o kahi ʻūpā koko. No laila, inā ʻike ʻoe i kekahi o kēia mau hōʻailona, e kelepona koke aku i kāu kauka.
| I ka manawa e ʻimi koke ai i ke aʻo lapaʻau | |
|---|---|
| Nā hōʻailona o kahi maʻi |
|
| Nā hōʻailona o ke koko koko | ʻO ka pehu ʻeha o ka wāwae, ka pilikia o ka hanu ʻana. |
| Nā hopena ʻaoʻao nui loa | Inā koʻikoʻi loa nā hopena ʻaoʻao o ka lāʻau lapaʻau (e like me ka luaʻi ʻana, ka maʻi pākī). |
Nā mea hiki iā ʻoe ke hana e noho olakino i ka wā o ka mālama ʻana
He ʻike kaumaha loa ka mālama ʻana i ka maʻi kanesa, ma ke kino a me ka noʻonoʻo. Aia kekahi mau mea e hiki ke kōkua iā ʻoe e ʻoluʻolu iki i kēia manawa.
- Hoʻoikaika kino māmā: Hiki i nā hana māmā e like me ka hele wāwae a me ka yoga ke kōkua i ka hōʻemi ʻana i ke kaumaha a hāʻawi pū i kou kino i kahi hoʻoikaika maikaʻi o ka ikehu.
- ʻAi maikaʻi: E ʻai i ka ʻai momona e komo pū ana me nā protein lean (iʻa, moa), nā huaʻai, nā mea kanu, nā legumes, a me nā palaoa piha (laiki ʻeleʻele, oatmeal). E inu nui i ka wai.
- Ka mālama ʻana i ke kaumaha olakino: Ua hōʻike ʻia e ka noiʻi ʻana he kākoʻo maikaʻi ka mālama ʻana i ke kaumaha olakino e kūpono iā ʻoe no ka mālama ʻana.
- Kākoʻo noʻonoʻo:E kamaʻilio me kou ʻohana a me kou mau hoaaloha pili e pili ana i kou mau manaʻo, makaʻu, a me kou hopohopo. Inā pono, e ʻimi i ke kōkua o ke kākāʻōlelo olakino noʻonoʻo.
Inā koʻikoʻi nā hopena ʻaoʻao o ka lāʻau lapaʻau, mai hilahila e kamaʻilio me kāu hui lapaʻau e pili ana i ia mea. Ua kūpaʻa lākou e kākoʻo iā ʻoe i kēia manawa paʻakikī.
Leka Lawe-Home
- ʻO ke kanesa umauma triple-negative (TNBC) kahi ʻano kikoʻī o ke kanesa umauma i nele i nā mea loaʻa ʻekolu: estrogen, progesterone, a me HER2.
- No laila, ʻaʻole kūpono ka lāʻau lapaʻau hormone maʻamau a me nā lāʻau lapaʻau i hoʻopaʻa ʻia me HER2 no kēia.
- Inā ʻike ʻoe i kekahi mau loli ʻē i kou umauma (he puʻupuʻu, ʻeha, loli ʻili), mai hopohopo a e ʻike koke i ke kauka. ʻO ka wikiwiki o ka ʻike ʻia ʻana, ʻoi aku ka holomua o ka lāʻau.
- Nui nā lāʻau lapaʻau kūpono no kēia, me ka chemotherapy, ke ʻoki kino, ka radiation therapy, a me nā lāʻau lapaʻau hou e like me ka immunotherapy.
- ʻOiai he maʻi paʻakikī kēia, me ka holomua o ka lāʻau lapaʻau hou, ke ʻike mau ʻia nei nā lāʻau lapaʻau hou. No laila, mai hoʻopau i ka manaʻolana.
- E hilinaʻi i kāu hui lapaʻau, e pane pololei i kā lākou mau nīnau, a e nīnau iā lākou e pili ana i kou mau hopohopo. ʻAʻole ʻoe hoʻokahi i kēia huakaʻi.
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