Peb txhua tus paub txog kev ntshai thiab kev ntxhov siab uas los ntawm kev hnov los ntawm tus kws kho mob tias ib tug tswv cuab lossis phooj ywg muaj teeb meem ntshav loj lossis mob qog ntshav. Tab sis ua tsaug rau kev nce qib hauv kev kho mob niaj hnub no, muaj cov kev kho mob muaj zog uas tuaj yeem kho cov kab mob zoo li no. Ib qho kev kho mob cawm siav hu ua "Allogeneic Stem Cell Transplant." Txawm hais tias lub npe yuav zoo li nyuaj, cia peb tham txog qhov tshwm sim hauv qhov no yooj yim heev .
Kev hloov pauv hlwb allogeneic yog dab tsi tiag?
Hais yooj yim xwb, qhov no suav nrog kev tshem tawm cov hlwb noob uas muaj mob, ua haujlwm tsis zoo ntawm koj lub cev thiab hloov lawv nrog cov hlwb noob uas noj qab nyob zoo, sib xws los ntawm lwm tus (tus neeg pub).
Tam sim no cia peb piav qhia qhov no ntxiv me ntsis.
- Cov Qog Ntshav: Peb kuj tuaj yeem hu cov no ua "cov qe ntshav niam" vim tias cov qe ntshav no zoo li lub Hoobkas uas tsim tag nrho lwm cov qe ntshav hauv peb lub cev (cov qe ntshav liab, cov qe ntshav dawb, cov qe ntshav dawb). Cov qe ntshav no feem ntau pom muaj nyob hauv peb cov pob txha.
- Allogeneic: Lo lus no txhais tau tias "tau txais los ntawm lwm tus." Qhov no txhais tau tias kev kho mob siv cov hlwb los ntawm tus neeg pub dawb uas noj qab nyob zoo, sib haum, tsis yog koj li.
Xav txog tias peb cov pob txha pob txha zoo li ib daim teb uas muaj av zoo. Nws yog nyob rau hauv daim teb no uas peb cov qe ntshav loj hlob. Tab sis nyob rau hauv ib tug kab mob zoo li leukemia, daim teb no yuav lwj, thiab cov nroj tsuag (cov qe mob cancer) loj hlob es tsis yog cov qoob loo zoo. Yog li, nyob rau hauv qhov kev kho mob no, cov av uas lwj (cov qe pob txha uas muaj kab mob) raug tshem tawm tag nrho thiab hloov nrog cov av tshiab, noj qab haus huv, thiab muaj av zoo (cov qe ntshav ntawm tus neeg pub dawb). Tom qab ntawd, cov qe ntshav noj qab haus huv pib loj hlob hauv cov av tshiab ntawd.
Txoj kev kho mob no muaj zog heev thiab kho tau qee yam kab mob loj heev. Feem ntau cov kws kho mob siv txoj kev kho mob no thaum lwm yam kev kho mob tsis ua haujlwm lossis thaum tus kab mob rov qab los dua.
Kev kho mob no siv rau hom mob twg?
Feem ntau siv rau cov kab mob ntsig txog cov ntshav thiab lub cev tiv thaiv kab mob. Nov yog qee cov kab mob tseem ceeb.
| Mob nkeeg | Ib qho lus piav qhia yooj yim |
|---|---|
| Kab mob qog ntshav Lymphoblastic loj heev (ALL) | Lymphocytes, ib hom qe ntshav dawb uas pom muaj nyob rau hauv cov ntshav thiab pob txha, dhau los ua cov qe mob qog noj ntshav. |
| Kab mob ntshav dawb Acute Myeloid Leukemia (AML) | Mob qog noj ntshav uas tsim los ntawm cov hlwb myeloid. |
| Aplastic Anemia | Kev puas tsuaj rau cov pob txha pob txha ua rau lub cev tsis tsim cov qe ntshav tshiab txaus. |
| Lymphoma | Ib qho mob qog nqaij hlav uas tshwm sim hauv lub cev lymphatic. |
| Myelodysplastic Syndrome | Kev tsim cov qe ntshav dawb tsis tu ncua hauv cov pob txha. |
| Kab mob hlwb Sickle | Ib yam kab mob uas los ntawm noob caj ces uas ua rau cov qe ntshav liab hloov pauv thiab lawv txoj haujlwm tsis zoo. |
Koj npaj li cas rau kev kho mob?
Vim qhov no yog ib qho kev kho mob loj, pab pawg kho mob yuav ua ntau qhov kev kuaj ua ntej kom paub tseeb tias koj lub cev tuaj yeem tiv taus nws.
- Kev kuaj ntshav: Tej yam xws li kev suav ntshav tag nrho (CBC) yog ua los xyuas cov qib ntawm cov qe ntshav liab, cov qe ntshav dawb, thiab cov platelets.
- Kev kuaj plawv: Ib qho echocardiogram (kom pom tias lub plawv ua haujlwm zoo li cas) thiab electrocardiogram (EKG) kom pom lub plawv dhia.
- Yuav muaj kev kuaj mob los xyuas seb lub siab thiab lub raum ua haujlwm li cas .
- Kev Kuaj Mob Pob Txha: Yog tias koj muaj mob qog noj ntshav, yuav muab ib qho qauv me me ntawm cov pob txha coj mus kuaj kom paub txog qhov xwm txheej ntawm tus kab mob thiab qhov kev pheej hmoo ntawm kev rov qab los.
Thaum twg tag nrho cov kev kuaj no tau ua tiav lawm thiab txiav txim siab tias koj yog tus neeg sib tw zoo, qhov tseem ceeb tshaj plaws ntawm kev kho mob, hu ua "pre-transplant conditioning," pib. Qhov no suav nrog kev siv tshuaj chemotherapy ntau lossis kev kho mob hluav taws xob rau tag nrho lub cev. Qhov no tuaj yeem yog lub sijhawm nyuaj. Tab sis nws yog qhov tseem ceeb.
Vim li cas qhov kev kho mob ua ntej no thiaj li tseem ceeb?
- Nws rhuav tshem cov hlwb mob qog noj ntshav uas tseem tshuav hauv koj lub cev.
- Nws tshem tawm cov hlwb qub thiab muaj mob ntawm koj cov pob txha thiab ua chaw rau cov hlwb tshiab loj hlob.
- Nws ua rau koj lub cev tiv thaiv kab mob tsis muaj zog ib ntus. Qhov no yog ua los tiv thaiv koj lub cev kom tsis txhob tawm tsam thiab tsis lees txais cov hlwb tshiab uas pub dawb.
Koj yuav tau nyob hauv tsev kho mob ib lossis ob lub lis piam rau qhov kev kho mob no.
Muaj dab tsi tshwm sim rau hnub hloov hlwb?
Cov txheej txheem ntawm kev hloov hlwb yeej yooj yim heev thiab tsis mob , ib yam li kev pub ntshav.
Pawg kws kho mob yuav muab ib lub raj tshwj xeeb ntxig rau hauv ib txoj hlab ntshav loj hauv koj lub hauv siab sab saud. Qhov no hu ua Central Venous Catheter (CVC) . Lub hnab uas muaj cov hlwb noob zoo los ntawm tus neeg pub dawb txuas nrog lub raj no. Tom qab ntawd cov hlwb maj mam nkag mus rau hauv koj lub cev, los ntawm koj cov ntshav, thiab rau hauv koj cov pob txha, zoo li cov kua ntsev.
Cov txheej txheem no siv sijhawm li 30 feeb txog ib teev. Thaum lub sijhawm no, pab pawg kws kho mob yuav zaum ntawm koj ib sab thiab saib xyuas koj cov ntshav siab thiab koj lub plawv dhia. Qee zaum, tej zaum yuav muaj cov kev mob tshwm sim me me.
- Kev xav txias
- Ua pa nyuaj me ntsis
- Kub taub hau
Tiamsis feem ntau cov no tsis yog qhov loj heev.
Tom qab kho mob tas lawm, muaj dab tsi tshwm sim?
Lub sijhawm tseem ceeb tshaj plaws rau kev rov zoo pib tom qab kev hloov pauv stem cell. Koj yuav tsum tau nyob hauv tsev kho mob lossis nyob ze rau nws ob peb lub lis piam ntxiv.
- Kev tswj hwm lub cev tiv thaiv kab mob: Koj yuav txuas ntxiv muab cov tshuaj tiv thaiv kab mob kom tiv thaiv koj lub cev kom tsis txhob tawm tsam cov hlwb tshiab thiab kom tiv thaiv cov hlwb tshiab kom tsis txhob tawm tsam koj lub cev.
- Kev hloov ntshav: Nws yuav siv sijhawm me ntsis rau cov hlwb tshiab kom pib ua haujlwm thiab tsim cov hlwb liab thiab cov ntshav platelets tshiab. Thaum lub sijhawm ntawd, koj yuav xav tau kev hloov ntshav.
- Kev Tiv Thaiv Kab Mob: Koj lub cev tiv thaiv kab mob tsis muaj zog heev thaum lub sijhawm no, yog li ntawd yuav tsum tau saib xyuas tshwj xeeb rau kev tiv thaiv koj tus kheej ntawm cov kab mob bacterial thiab viral.
Cov txheej txheem uas cov hlwb tshiab mus rau cov pob txha, nyob ntawd, thiab pib tsim cov hlwb ntshav tshiab hu ua "engraftment." Qhov no yuav siv sijhawm li 10 txog 14 hnub.
Yuav siv sijhawm ntev npaum li cas thiaj rov zoo tag nrho?
Qhov no yog ib qho txheej txheem ntev heev. Nws yuav siv sijhawm ob xyoos lossis ntau dua kom rov zoo tag nrho. Nws yuav siv sijhawm li ib xyoos rau koj lub cev tiv thaiv kab mob kom rov zoo.
Kev pheej hmoo tshwj xeeb uas yuav tsum paub txog: Kab mob Graft vs. Host Disease (GVHD)
Qhov no yog qhov teeb meem feem ntau ntawm kev hloov pauv allogeneic. Hais yooj yim xwb, nws tshwm sim thaum cov hlwb tiv thaiv kab mob tshiab los ntawm tus neeg pub (qhov graft) tawm tsam koj lub cev cov hlwb thiab cov nqaij (tus tswv tsev) . Nws zoo li "tus qhua tawm tsam tus tswv tsev."
Qhov no yuav tsis hnyav heev los yog me me xwb. Yog vim li ntawd cov tshuaj uas tiv thaiv kab mob thiaj li raug muab tas li. Koj yuav tsum paub txog cov tsos mob ntawm tus mob no.
Cov tsos mob uas yuav tsum tau qhia rau koj tus kws kho mob tam sim ntawd
Thaum koj mus tsev tom qab kho mob tas, koj yuav tsum ceev faj txog qee cov tsos mob. Yog tias muaj ib qho ntawm cov no tshwm sim, hu rau koj pab neeg kho mob tam sim ntawd.
| Pawg tsos mob | Cov yam ntxwv uas yuav tsum tau saib xyuas |
|---|---|
| Cov tsos mob ntawm Graft vs. Host Disease (GVHD) yuav muaj xws li: | |
| Mob plab | Mob plab, xeev siab thiab ntuav, raws plab (mob plab) |
| Tawv nqaij thiab qhov muag | Tawv nqaij khaus khaus, tawv nqaij thiab/lossis qhov muag daj (jaundice) |
| Tej zaum yuav yog cov cim qhia txog kev kis kab mob | |
| Cov yam ntxwv dav dav | Kub taub hau txog 38 Celsius (100.4 Fahrenheit) lossis siab dua, mob khaub thuas |
| Kev ua pa | Hnoos, txham, ntswg ntws, ua pa nyuaj |
| Lwm yam nta | Kiv taub hau, tso zis ntau zaus, lossis kub hnyiab thaum tso zis |
Qhov txawv ntawm "allogeneic" thiab "autologous" transplants
Tej zaum koj twb tau hnov txog kev hloov hlwb ntawm tus kheej (autologous stem cell transplant). Qhov txawv tseem ceeb ntawm ob qho no yog qhov chaw ntawm cov hlwb.
- Allogeneic: Cov cell tau txais los ntawm lwm tus (tus neeg pub).
- Autologous: Cov cell raug coj los ntawm tus neeg mob . Qhov no txhais tau tias tus neeg mob cov stem cell noj qab haus huv raug sau ua ntej thiab tom qab ntawd muab rov qab rau lawv tom qab kev kho mob chemotherapy ntau.
Kev hloov pauv allogeneic tuaj yeem kho tau qee yam kab mob uas ua rau tuag taus. Feem ntau, cov kev hloov pauv cawm txoj sia no yog ua los ntawm cov neeg pub dawb uas peb tsis paub uas peb yeej tsis tau ntsib. Qee zaum, cov tswv cuab hauv tsev neeg dhau los ua cov neeg pub dawb. Txawm hais tias muaj kev pheej hmoo rau kev kho mob no, cov txiaj ntsig kuj siab heev. Koj tus kws kho mob yuav piav qhia txhua yam no rau koj thiab pab koj txiav txim siab uas zoo tshaj plaws rau koj.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Kev hloov hlwb pob txha allogeneic yog kev hloov cov hlwb pob txha uas muaj mob nrog cov hlwb pob txha los ntawm tus neeg pub dawb uas noj qab nyob zoo.
- Qhov no yog ib txoj kev kho mob muaj zog uas siv rau cov kab mob ntshav hnyav xws li leukemia, lymphoma, thiab aplastic anemia.
- Nws yog ib qho tseem ceeb heev uas yuav tsum npaj lub cev nrog kev siv tshuaj chemotherapy ntau lossis kev kho mob hluav taws xob ua ntej kev kho mob.
- Qhov teeb meem tseem ceeb uas tuaj yeem tshwm sim tom qab kev kho mob yog Graft vs. Host Disease (GVHD), thiab nws yog ib qho tseem ceeb uas yuav tsum paub txog qhov no thiab cov cim qhia ntawm kev kis kab mob.
- Qhov no yog ib qho txheej txheem kho mob ntev, thiab nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob lossis pab pawg kho mob tam sim ntawd txog txhua yam teeb meem.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus