Thaum cov kws kho mob kuaj pom tias koj muaj mob qog noj ntshav hauv lub mis, koj tus kws kho mob yuav pom zoo kom siv tshuaj chemotherapy. Nws yog ib qho ib txwm muaj uas yuav ntshai thiab ntxhov siab me ntsis thaum koj hnov qhov no. Tab sis thaum koj tau txais kev qhia txog cov kev kho mob no, koj tuaj yeem kov yeej qhov kev ntshai ntawd. Muaj ntau hom kev kho mob chemotherapy sib txawv. Cov neeg sawv cev alkylating yog ib qho ntawm cov tshuaj tseem ceeb uas siv rau mob qog noj ntshav hauv lub mis. Yog li, cia peb tham txog qhov no kom meej thiab yooj yim heev hnub no.
Cov tshuaj no hu ua Alkylating Agents ua haujlwm li cas tiag?
Yuav kom nkag siab qhov no, peb yuav tsum xav txog cov hlwb qog noj ntshav ua ntej. Cov hlwb qog noj ntshav yog cov hlwb uas faib thiab loj hlob sai heev yam tsis muaj kev tswj hwm. Cov tshuaj alkylating yog ib qho ntawm thawj cov tshuaj uas tau tshawb pom tawm tsam mob qog noj ntshav. Lawv tseem siv dav niaj hnub no.
Hais yooj yim xwb, hom tshuaj no ua haujlwm los ntawm kev tiv thaiv cov hlwb qog nqaij hlav kom tsis txhob ua cov ntawv theej ntawm lawv tus kheej, uas yog, los ntawm kev faib thiab loj hlob. Nws ua qhov no los ntawm:
Txhua lub cell muaj daim blueprint tiav, lossis "blueprint," ntawm lub cell ntawd. Peb hu ua DNA no. Yam uas cov alkylating agents ua yog mus ncaj qha rau thiab txuas lawv tus kheej rau DNA ntawm lub cell mob qog noj ntshav . Ib yam li ib qho yuam sij tsis tuaj yeem ua haujlwm yog tias koj lo rau lwm qhov, thaum cov tshuaj no khi rau DNA, lub cell ntawd tsis tuaj yeem faib.
Thaum cov cell faib tsis ua li no, cov cell mob qog noj ntshav maj mam tuag. Hauv kev kho mob, peb hu cov txheej txheem no apoptosis . Uas yog, programmed cell death.
Lwm yam tshwj xeeb ntawm cov tshuaj no yog tias lawv tuaj yeem tawm tsam thiab rhuav tshem cov cell mob qog noj ntshav txhua theem ntawm nws lub neej voj voog. Qhov no hu ua 'cell-cycle phase nonspecific'. Yog li ntawd, lawv muaj txiaj ntsig zoo rau ntau hom mob qog noj ntshav, tshwj xeeb tshaj yog cov uas loj hlob sai.
Cov tshuaj no yuav muab rau koj ua ib lub tshuaj ntsiav lossis ua cov kua ntsev los ntawm cov leeg ntshav (IV - intravenous). Feem ntau, koj tus kws kho mob yuav muab cov tshuaj no ua ke nrog lwm cov tshuaj chemotherapy (kev kho mob ua ke).
Cov Alkylating Agents yog dab tsi?
Cov tshuaj no muab faib ua ntau pawg tseem ceeb. Txawm hais tias cov npe ntawm cov no nyuaj me ntsis los xij, nws yog qhov zoo kom paub vim tias koj yuav pom ib qho ntawm cov no teev nyob rau ntawm koj daim ntawv tshuaj.
| Pawg Tshuaj | Cov tshuaj uas koom nrog pawg ntawd (Piv txwv) |
|---|---|
| Cov kua nitrogen | bendamustine, chlorambucil, cyclophosphamide , ifosfamide, mechlorethamine, melphalan |
| Cov khoom siv Ethylenamine thiab methylenamine | altretamine, thiotepa |
| Cov tshuaj alkyl sulfonates | busulfan |
| Cov tshuaj Triazenes | dacarbazine, procarbazine, temozolomide |
| Cov neeg sawv cev uas muaj platinum | cov tshuaj carboplatin , cisplatin, oxaliplatin |
| Nitrosoureas | carmustine, lomustine, streptozocin |
Ntawm cov no, cov tshuaj hu ua Nitrosoureas yog ib hom tshuaj tshwj xeeb me ntsis. Vim tias cov tshuaj no tuaj yeem hla dhau txheej tiv thaiv hu ua 'ntshav-lub hlwb thaiv' uas tiv thaiv peb lub hlwb. Feem ntau cov tshuaj tsis tuaj yeem hla dhau qhov thaiv no. Yog li ntawd, lawv tseem ceeb thaum kho cov mob qog noj ntshav hauv lub hlwb.
Cov hom twg feem ntau siv rau mob qog noj ntshav hauv lub mis?
Cov tshuaj hauv pawg ' Nitrogen Mustards' thiab 'Ethylenamine thiab methylenamine derivatives' feem ntau siv rau kev kho mob ntawm ntau theem ntawm mob qog noj ntshav hauv lub mis.
Cytoxan (Cyclophosphamide)
Cov tshuaj no yog ib yam tshuaj uas yog ib feem ntawm pawg "Nitrogen mustard". Koj noj tau ua tshuaj ntsiav los yog muab ua IV rau hauv cov leeg ntshav. Feem ntau nws yog siv rau:
- Tiv thaiv kom tsis txhob muaj mob qog noj ntshav theem pib rov qab los tom qab phais.
- Yog tias mob qog nqaij hlav loj hlob lawm, ua kom lub qog me me ua ntej phais.
- Kho cov mob qog noj ntshav uas mob heev tom qab phais thiab lwm yam kev kho mob.
Thiotepa
Qhov no yog ib qho derivative ntawm 'Ethylenamine'. Nws feem ntau yog muab intravenously. Nws yog siv rau:
- Hauv cov mob qog noj ntshav theem pib, txo qhov kev pheej hmoo ntawm kev rov tshwm sim .
- Kho mob qog noj ntshav theem siab heev.
Carboplatin
Qhov no yog ib yam tshuaj uas muaj platinum. Nws yog tib yam tshuaj platinum uas tau pom zoo rau kev kho mob qog noj ntshav hauv lub mis. 'Carboplatin' feem ntau yog muab rau cov mob qog noj ntshav uas mob hnyav heev, thiab ua ke nrog lwm cov tshuaj chemotherapy. Nws kuj tseem muab ua IV.
Cov tshuaj no muaj tej yam tshwm sim li cas?
Ib qho ntawm cov teeb meem tseem ceeb nrog kev kho mob chemotherapy yog tias nws tsis tuaj yeem qhia qhov txawv ntawm cov hlwb qog noj ntshav thiab cov hlwb noj qab haus huv. Cov tshuaj no tsom mus rau cov hlwb uas faib sai. Cov hlwb qog noj ntshav, zoo li qee cov hlwb noj qab haus huv hauv peb lub cev (piv txwv li, cov hlwb uas ua rau peb cov plaub hau follicle, cov hlwb uas kab hauv peb lub qhov ncauj thiab txoj hnyuv, thiab cov hlwb ntshav), faib sai heev. Yog li cov tshuaj no kuj cuam tshuam rau cov hlwb noj qab haus huv, yog vim li cas lawv ua rau muaj kev phiv.
Cov kev mob tshwm sim no tsis tshwm sim rau txhua tus tib yam. Tej zaum ib txhia neeg yuav muaj ntau dua, tej zaum ib txhia yuav muaj tsawg dua. Tsis txhob txhawj txog qhov no. Koj tus kws kho mob tuaj yeem pab koj tswj hwm feem ntau ntawm cov no.
| Hom kev phiv tshuaj |
|---|
| Cov kev mob tshwm sim uas ntau tus neeg yuav ntsib |
| Xeev siab thiab ntuav, tsis xav noj mov, poob phaus, mob plab, raws plab |
| Kev qaug zog |
| Plaub hau poob, qhov ncauj lossis tus nplaig mob |
| Kev hloov pauv ntawm xim tawv nqaij, xim lossis kev loj hlob ntawm cov rau tes thiab cov rau taw |
| Txo cov qe ntshav dawb (qhov no tuaj yeem ua rau muaj kev pheej hmoo ntawm kev kis kab mob) |
| Cov poj niam lub voj voog tsis sib xws |
| Cov tsos mob loj uas yuav tsum tau qhia rau koj tus kws kho mob tam sim ntawd |
| Kub taub hau, mob khaub thuas, mob caj pas (cov cim qhia txog kev kis kab mob) |
| Kev kho qeeb ntawm cov qhov txhab, kev mob ntshav lossis kev los ntshav tsis zoo li qub |
| Cov quav dub los yog cov quav uas muaj kua qaub, mob thaum tso zis, los yog muaj ntshav hauv cov zis |
| Cov tawv nqaij ua pob khaus, ua pob khaus, khaus |
| Ua pa nyuaj los yog nqos, ua pa luv luv, hnoos |
| O ntawm ob txhais ceg, pob luj taws, lossis taw, mob hauv siab |
| Daj ntawm daim tawv nqaij lossis qhov muag (cov tsos mob ntawm jaundice) |
Xwm txheej ceev!
Yog tias koj muaj ib qho ntawm cov tsos mob hauv qab no, mus rau chav kho mob ceev (ETU) ze tshaj plaws tam sim ntawd lossis hu rau 1990 lub tsheb thauj neeg mob:
* Cov rooj zaum dub
* Kev ntshav uas tsis tuaj yeem nres
* Ua pa nyuaj heev
* Mob hauv siab
* Cov cim qhia txog kev ua xua hnyav (xws li o ntawm lub ntsej muag, daim di ncauj)
Tsis tshua muaj, cov tshuaj alkylating no tuaj yeem ua rau peb cov pob txha puas tsuaj. Cov pob txha yog qhov chaw uas peb lub cev tsim cov qe ntshav tshiab. Muaj kev pheej hmoo me me ntawm kev mob qog noj ntshav lwm yam, xws li leukemia, vim yog qhov kev puas tsuaj no. Qhov kev pheej hmoo no feem ntau nce me ntsis thaum cov tshuaj ntau ntxiv. Tsis txhob txhawj txog qhov no yam tsis tsim nyog.Ua ntej pib kho mob, tham nrog koj tus kws kho mob txog cov hau kev los txo qhov kev pheej hmoo ntawm kev mob qog noj ntshav thib ob zoo li no. Nws yuav muab tag nrho cov lus qhia rau koj uas koj xav tau.
Lwm yam uas yuav tsum xav txog thaum kho mob
Vim tias cov tshuaj no muaj zog heev, nws yog ib qho tseem ceeb uas yuav tsum qhia rau koj tus kws kho mob txog koj keeb kwm kev kho mob kom nws thiaj li kho tau txoj kev kho mob kom haum rau koj thiab txo cov kev mob tshwm sim. Nco ntsoov tham txog cov hauv qab no nrog koj tus kws kho mob:
- Txog txhua yam kev ua xua uas koj muaj (xws li tshuaj, khoom noj).
- Txog tej yam vitamins, cov tshuaj ntxiv, lossis cov tshuaj ntsuab uas koj siv.
- Txog koj cov mob raum lossis siab .
- Yog tias koj tau txais kev kho mob chemotherapy ua ntej, qhia rau peb txog nws.
- Yog tias koj cev xeeb tub, pub niam mis, lossis npaj yuav muaj menyuam sai sai no .
- Yog tias koj muaj kev phais mob yav tom ntej, tham txog qhov ntawd.
Ua raws li koj tus kws kho mob cov lus qhia kom meej, tshwj xeeb tshaj yog tias koj noj tshuaj. Yog tias koj tsis nco qab noj ib koob tshuaj, noj koob tshuaj tom ntej raws li tau teem tseg. Tsis txhob noj ob koob tshuaj ib zaug kom them rau koob tshuaj uas koj tsis nco qab. Ib txwm nrog koj tus kws kho mob tham ua ntej tso tseg kev kho mob.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov tshuaj alkylating yog ib hom tshuaj kho mob qog noj ntshav muaj zog uas ua rau cov DNA ntawm cov hlwb qog noj ntshav puas tsuaj thiab tiv thaiv lawv kom tsis txhob faib.
- Vim tias cov tshuaj no cuam tshuam rau ob qho tib si cov hlwb qog noj ntshav thiab cov hlwb noj qab haus huv uas faib sai sai, lawv tuaj yeem ua rau muaj kev phiv xws li xeev siab thiab plaub hau poob. Cov no tuaj yeem tswj tau.
- Nws yog ib qho tseem ceeb heev uas yuav tsum tham nrog koj tus kws kho mob txog koj keeb kwm kev mob nkeeg, lwm yam tshuaj uas koj noj, thiab kev ua xua.
- Yog tias koj muaj cov tsos mob hnyav xws li ua pa nyuaj lossis los ntshav hnyav, mus rau chav kho mob ceev (ETU) tam sim ntawd.
- Koj yuav tsum tsis txhob hloov qhov ntau npaum li cas ntawm cov tshuaj lossis tsum tsis txhob kho mob yam tsis tau koj tus kws kho mob qhia.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus